IST3 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.
Churcher C, Bowman S, Badcock K, Bankier A, Brown D, Chillingworth T, Connor R, Devlin K, Gentles S, Hamlin N, Harris D, Horsnell T, Hunt S, Jagels K, Jones M, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Rowley N, Skelton J, Smith V, Barrell B
Nature387(6632 Suppl)84-7(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

RES is a 71 kDa heterotrimer composed of the 3 proteins Pml1p, Bud13p and Snu17p. We solved the 3-dimensional structure of the core of the RES complex as well as the 2 dimers, Snu17p-Bud13p and Snu17p-Pml1p
Title: Retention and splicing complex (RES) - the importance of cooperativity.

An extended binding interface has been described between the Snu17p RNA recognition motif and Bud13p of the retention and splicing complex.
Title: A novel protein-protein interaction in the RES (REtention and Splicing) complex.

Snu17p RRM binds multiple ligand proteins and acts as a platform that displays functional modules of the ligands, including forkhead-associated domain of Pml1p and conserved polylysine motif of Bud13p
Title: An unusual RNA recognition motif acts as a scaffold for multiple proteins in the pre-mRNA retention and splicing complex.

It is shown that IST3, previously linked to splicing, is required for efficient processing of the MATa1 message, particularly the first intron.
Title: Single-gene deletions that restore mating competence to diploid yeast.