Gene Symbol | MSH2 |
Entrez Gene ID | 854063 |
Full Name | mismatch repair ATPase MSH2 |
Synonyms | PMS5 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MSH2 cDNA ORF clone
Gene Symbol | MSH2 |
Entrez Gene ID | 854063 |
Full Name | mismatch repair ATPase MSH2 |
Synonyms | PMS5 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183344.1 | NP_014551.1 | mismatch repair ATPase MSH2 |
Rattus norvegicus (Norway rat) | Msh2 | NP_112320.1 |
Gallus gallus (chicken) | MSH2 | XP_426110.4 |
Saccharomyces cerevisiae (baker's yeast) | MSH2 | NP_014551.1 |
Kluyveromyces lactis | KLLA0F02706g | XP_455202.1 |
Eremothecium gossypii | AGOS_AFR603C | NP_986150.1 |
Schizosaccharomyces pombe (fission yeast) | msh2 | XP_001713136.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00879 | XP_003718090.1 |
Danio rerio (zebrafish) | msh2 | NP_998689.1 |
Arabidopsis thaliana (thale cress) | MSH2 | NP_566804.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010282 | XP_319476.4 |
Homo sapiens (human) | MSH2 | NP_000242.1 |
Canis lupus familiaris (dog) | MSH2 | XP_538482.2 |
Bos taurus (cattle) | MSH2 | NP_001029756.1 |
Mus musculus (house mouse) | Msh2 | NP_032654.1 |
Drosophila melanogaster (fruit fly) | spel1 | NP_001246031.1 |
Neurospora crassa | NCU02230 | XP_959643.1 |
Xenopus tropicalis (tropical clawed frog) | msh2 | XP_002935427.2 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Dujon B, Albermann K, Aldea M, Alexandraki D, Ansorge W, Arino J, Benes V, Bohn C, Bolotin-Fukuhara M, Bordonn? R, Boyer J, Camasses A, Casamayor A, Casas C, Ch?ret G, Cziepluch C, Daignan-Fornier B, Dang DV, de Haan M, Delius H, Durand P, Fairhead C, Feldmann H, Gaillon L, Kleine K
Nature387(6632 Suppl)98-102(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Msh2-Msh3 hops over nucleosomes and other protein roadblocks, but maintains sufficient contact with DNA to recognize a single lesion. Msh2-Msh6 slides without hopping and is largely blocked by protein roadblocks.
Title: Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.
By detecting Pol2 and Msh2 dynamics within the same strain, we established that the mismatch recognition complex binds origins and spreads to adjacent regions with the replisome.
Title: The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.
Msh2-Msh6 localizes PCNA to repair sites after mispair recognition.
Title: PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.
Data suggest that bot hATP and structure-specific repair substrates cooperate to direct Msh2-Msh3-mediated repair and provide an explanation for the msh3Y942A separation-of-function phenotype.
Title: ATP binding and hydrolysis by Saccharomyces cerevisiae Msh2-Msh3 are differentially modulated by mismatch and double-strand break repair DNA substrates.
a comparative study of Msh2-Msh3 and Msh2-Msh6 for mispair binding, sliding clamp formation, and Mlh1-Pms1 recruitment
Title: Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.
The following MSH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi03230 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183344.1 | |
Accession Version | NM_001183344.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2895bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | mismatch repair ATPase MSH2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001147). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCCTCCA CTAGGCCAGA GCTAAAATTC TCTGATGTAT CAGAGGAGAG AAACTTCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_014551.1 |
CDS | 1..2895 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001183344.1 |
1 | ATGTCCTCCA CTAGGCCAGA GCTAAAATTC TCTGATGTAT CAGAGGAGAG AAACTTCTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV. |
Life with 6000 genes. |