Gene Symbol | SMC3 |
Entrez Gene ID | 853371 |
Full Name | cohesin subunit SMC3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » SMC3 cDNA ORF clone
Gene Symbol | SMC3 |
Entrez Gene ID | 853371 |
Full Name | cohesin subunit SMC3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181507.1 | NP_012461.1 | cohesin subunit SMC3 |
SMC3 | XP_002805863.1 | |
Mus musculus (house mouse) | Smc3 | NP_031816.2 |
Rattus norvegicus (Norway rat) | Smc3 | NP_113771.2 |
Canis lupus familiaris (dog) | SMC3 | XP_851818.2 |
Eremothecium gossypii | AGOS_AAL182W | NP_982360.1 |
Homo sapiens (human) | SMC3 | NP_005436.1 |
Pan troglodytes (chimpanzee) | SMC3 | XP_508031.3 |
Bos taurus (cattle) | SMC3 | NP_776720.1 |
Saccharomyces cerevisiae (baker's yeast) | SMC3 | NP_012461.1 |
Gallus gallus (chicken) | SMC3 | NP_989848.1 |
Drosophila melanogaster (fruit fly) | Cap | NP_523374.2 |
Caenorhabditis elegans (roundworm) | smc-3 | NP_001255118.1 |
Schizosaccharomyces pombe (fission yeast) | psm3 | NP_593260.1 |
Arabidopsis thaliana (thale cress) | TTN7 | NP_180285.4 |
Oryza sativa (rice) | Os02g0133300 | NP_001045803.1 |
Oryza sativa (rice) | Os02g0133400 | NP_001172788.1 |
Xenopus tropicalis (tropical clawed frog) | smc3 | XP_002939544.2 |
Danio rerio (zebrafish) | smc3 | NP_999854.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006388 | XP_316422.3 |
Kluyveromyces lactis | KLLA0A00286g | XP_451012.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_04988 | XP_003712488.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L
The EMBO journal15(9)2031-49(1996 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Smc3 deacetylation by Hos1, triggered by Scc1 cleavage, facilitates efficient dissolution of sister chromatid cohesion during early metaphase.
Title: Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase.
A reversible association between Smc1 and Smc3 coiled coils is regulated by lysine acetylation and is required for cohesin association with the DNA.
Title: A Reversible Association between Smc Coiled Coils Is Regulated by Lysine Acetylation and Is Required for Cohesin Association with the DNA.
We identified a large number of mutations in the CC region of both Smc1 and Smc3... we introduced them to the yeast Smc1 and Smc3 CC domains and characterized the effect of these mutant alleles on cohesin's function. We identified a missense mutation in the region of the kink domain of Smc3, which was previously identified in kidney carcinoma
Title: Identification of a region in the coiled-coil domain of Smc3 that is essential for cohesin activity.
Study shows that cohesin's release from the DNA is mediated by disengagement of the Smc3/Scc1 interface involving interaction between the SMC ATPase heads and is inhibited by Smc3 acetylation.
Title: Releasing Activity Disengages Cohesin's Smc3/Scc1 Interface in a Process Blocked by Acetylation.
These results also suggest that Eco1 promotes cohesion by modulating the ATPase cycle of DNA-bound cohesin in a state that is permissive for DNA tethering and refractory to Wpl1 inhibition.
Title: The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.
The following SMC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi02637 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181507.1 | |
Accession Version | NM_001181507.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3693bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | cohesin subunit SMC3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001142). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTATATCA AAAGGGTGAT AATTAAGGGT TTTAAAACCT ACAGGAACGA AACCATTATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_012461.1 |
CDS | 1..3693 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181507.1 |
1 | ATGTATATCA AAAGGGTGAT AATTAAGGGT TTTAAAACCT ACAGGAACGA AACCATTATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. |