Gene Symbol | XRN1 |
Entrez Gene ID | 852702 |
Full Name | chromatin-binding exonuclease XRN1 |
Synonyms | DST2,KEM1,RAR5,SEP1,SKI1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » XRN1 cDNA ORF clone
Gene Symbol | XRN1 |
Entrez Gene ID | 852702 |
Full Name | chromatin-binding exonuclease XRN1 |
Synonyms | DST2,KEM1,RAR5,SEP1,SKI1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181038.1 | NP_011342.1 | chromatin-binding exonuclease XRN1 |
Homo sapiens (human) | XRN1 | NP_061874.3 |
Mus musculus (house mouse) | Xrn1 | NP_036046.2 |
Rattus norvegicus (Norway rat) | Xrn1 | XP_217233.5 |
Caenorhabditis elegans (roundworm) | xrn-1 | NP_496945.3 |
Schizosaccharomyces pombe (fission yeast) | exo2 | NP_593482.1 |
XRN1 | XP_001112305.1 | |
Saccharomyces cerevisiae (baker's yeast) | XRN1 | NP_011342.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_12403 | XP_003715558.1 |
Canis lupus familiaris (dog) | XRN1 | XP_005634594.1 |
Danio rerio (zebrafish) | xrn1 | NP_957327.2 |
Drosophila melanogaster (fruit fly) | pcm | NP_001162796.1 |
Eremothecium gossypii | AGOS_ADL046C | NP_984050.1 |
Neurospora crassa | NCU06678 | XP_960925.2 |
Gallus gallus (chicken) | XRN1 | XP_422596.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004430 | XP_313715.5 |
Xenopus tropicalis (tropical clawed frog) | xrn1 | XP_002937144.2 |
Pan troglodytes (chimpanzee) | XRN1 | XP_001161640.1 |
Bos taurus (cattle) | XRN1 | NP_001192964.1 |
Kluyveromyces lactis | KLLA0F22385g | XP_456080.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Br?ckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K
Nature387(6632 Suppl)81-4(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Xrn1 facilitates the generation of ssDNA and checkpoint activation at uncapped telomeres. Xrn1 also maintains telomere length independently of ssDNA generation by downregulating the amount of Rif1.
Title: Regulation of telomere metabolism by the RNA processing protein Xrn1.
Studies indicate important roles of the exoribonucleases DIS3L2 and XRN1 in cellular function, viability and disease.
Title: The roles of the exoribonucleases DIS3L2 and XRN1 in human disease.
Xrn1p co-evolves with totiviruses to maintain its potent antiviral activity and limit viral propagation in Saccharomyces yeasts
Title: XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts.
the mechanism for intron turnover requires healing of the 5' termini of linear introns by the tRNA ligase Rlg1 and destruction by the cytoplasmic tRNA quality control 5'-to-3' exonuclease Xrn1, which has specificity for RNAs with 5' monophosphate
Title: Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.
Xrn1 is required for Snf1-dependent mRNA homeostasis in response to nutrient availability.
Title: Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling.
The following XRN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XRN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi02079 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181038.1 | |
Accession Version | NM_001181038.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4587bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | chromatin-binding exonuclease XRN1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001139). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGGTATTC CAAAATTTTT CAGGTACATC TCAGAAAGAT GGCCCATGAT TTTACAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_011342.1 |
CDS | 1..4587 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181038.1 |
1 | ATGGGTATTC CAAAATTTTT CAGGTACATC TCAGAAAGAT GGCCCATGAT TTTACAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. |
Life with 6000 genes. |