Gene Symbol | CHK1 |
Entrez Gene ID | 852577 |
Full Name | serine/threonine protein kinase CHK1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » CHK1 cDNA ORF clone
Gene Symbol | CHK1 |
Entrez Gene ID | 852577 |
Full Name | serine/threonine protein kinase CHK1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001178622.1 | NP_009833.1 | serine/threonine protein kinase CHK1 |
Bos taurus (cattle) | CHEK1 | NP_001091492.1 |
Gallus gallus (chicken) | STT3A | NP_989676.1 |
Saccharomyces cerevisiae (baker's yeast) | CHK1 | NP_009833.1 |
Eremothecium gossypii | AGOS_AEL185C | NP_984676.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03729 | XP_003716151.1 |
Xenopus tropicalis (tropical clawed frog) | chek1 | XP_002937561.2 |
Homo sapiens (human) | CHEK1 | NP_001265.2 |
Rattus norvegicus (Norway rat) | Chek1 | NP_536325.1 |
Caenorhabditis elegans (roundworm) | chk-1 | NP_001024233.1 |
Kluyveromyces lactis | KLLA0F01276g | XP_455137.1 |
Schizosaccharomyces pombe (fission yeast) | chk1 | NP_588070.1 |
LOC713358 | XP_001111431.2 | |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008118 | XP_317338.4 |
Pan troglodytes (chimpanzee) | CHEK1 | XP_001146296.1 |
Mus musculus (house mouse) | Chek1 | NP_031717.2 |
Neurospora crassa | NCU08346 | XP_965249.2 |
Canis lupus familiaris (dog) | CHEK1 | XP_852191.1 |
Danio rerio (zebrafish) | chek1 | NP_956487.1 |
Drosophila melanogaster (fruit fly) | grp | NP_723986.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete DNA sequence of yeast chromosome II.
Feldmann H, Aigle M, Aljinovic G, Andr? B, Baclet MC, Barthe C, Baur A, B?cam AM, Biteau N, Boles E, Brandt T, Brendel M, Br?ckner M, Bussereau F, Christiansen C, Contreras R, Crouzet M, Cziepluch C, D?molis N, Delaveau T, Doignon F, Domdey H, D?sterhus S, Dubois E, Dujon B, El Bakkoury M, Entian KD, Feurmann M, Fiers W, Fobo GM, Fritz C, Gassenhuber H, Glandsdorff N, Goffeau A, Grivell LA, de Haan M, Hein C, Herbert CJ, Hollenberg CP, Holmstr?m K, Jacq C, Jacquet M, Jauniaux JC, Jonniaux JL, Kalles?e T, Kiesau P, Kirchrath L, K?tter P, Korol S, Liebl S, Logghe M, Lohan AJ, Louis EJ, Li ZY, Maat MJ, Mallet L, Mannhaupt G, Messenguy F, Miosga T, Molemans F, M?ller S, Nasr F, Obermaier B, Perea J, Pi?rard A, Piravandi E, Pohl FM, Pohl TM, Potier S, Proft M, Purnelle B, Ramezani Rad M, Rieger M, Rose M, Schaaff-Gerstenschl?ger I, Scherens B, Schwarzlose C, Skala J, Slonimski PP, Smits PH, Souciet JL, Steensma HY, Stucka R, Urrestarazu A, van der Aart QJ, van Dyck L, Vassarotti A, Vetter I, Vierendeels F, Vissers S, Wagner G, de Wergifosse P, Wolfe KH, Zagulski M, Zimmermann FK, Mewes HW, Kleine K
The EMBO journal13(24)5795-809(1994 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Chk1 has a redundant role in the control of DIC or that DIC is redundant for maintaining genome stability
Title: Suppression of allelic recombination and aneuploidy by cohesin is independent of Chk1 in Saccharomyces cerevisiae.
We suggest a novel model for Chk1 activation where Cdc28 regulates the constitutive interaction of Rad9 and Chk1. The Rad9/Chk1 complex is then recruited at sites of DNA damage where activation of Chk1 requires additional DDR-specific protein kinases.
Title: Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.
a single amino acid substitution in the C terminus, which could lead to an allosteric change in Chk1, allows it to bypass the requirement of the conserved ATR(Mec1) phosphorylation sites for checkpoint function.
Title: ATRMec1 phosphorylation-independent activation of Chk1 in vivo.
RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
Title: The Saccharomyces cerevisiae checkpoint genes RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
The observations in the chk1Delta/chk1Delta mutant strain suggest that constitutive nonhomologous end-joining is involved in the repair of BLM-induced DSBs.
Title: Roles of Saccharomyces cerevisiae RAD17 and CHK1 checkpoint genes in the repair of double-strand breaks in cycling cells.
The following CHK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01970 | |
Clone ID Related Accession (Same CDS sequence) | NM_001178622.1 | |
Accession Version | NM_001178622.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | serine/threonine protein kinase CHK1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001134). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAGTCTCT CGCAGGTGTC ACCTTTACCC CATATCAAGG ATGTTGTTTT AGGAGATACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_009833.1 |
CDS | 1..1584 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001178622.1 |
1 | ATGAGTCTCT CGCAGGTGTC ACCTTTACCC CATATCAAGG ATGTTGTTTT AGGAGATACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete DNA sequence of yeast chromosome II. |