Gene Symbol | BRE1 |
Entrez Gene ID | 851485 |
Full Name | E3 ubiquitin-protein ligase BRE1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » BRE1 cDNA ORF clone
Gene Symbol | BRE1 |
Entrez Gene ID | 851485 |
Full Name | E3 ubiquitin-protein ligase BRE1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180133.1 | NP_010209.1 | E3 ubiquitin-protein ligase BRE1 |
Saccharomyces cerevisiae (baker's yeast) | BRE1 | NP_010209.1 |
Eremothecium gossypii | AGOS_AER074W | NP_984934.1 |
Kluyveromyces lactis | KLLA0B02981g | XP_451665.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Rad6-Bre1 pathway regulates both telomere length and recombination through its role in histone H2B lysine 123 mono-ubiquitination
Title: Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection.
Results identified Rai1, in regulating early transcription elongation genome-wide and a novel role for the histone modifier, Bre1, in regulating Pol II dynamics at polyA sites.
Title: Subgenic Pol II interactomes identify region-specific transcription elongation regulators.
Studied structure of C-terminal fragment of yeast Bre1 RING domain.
Title: Structure of the yeast Bre1 RING domain.
Data show that E3 ligase Bre1 RING domain directs ubiquitin-conjugating enzyme E2 Rad6 to monoubiquitinate histone H2B Lys-123.
Title: Monoubiquitination of histone H2B is intrinsic to the Bre1 RING domain-Rad6 interaction and augmented by a second Rad6-binding site on Bre1.
inappropriate Bre1 levels lead to defects in gene regulation
Title: Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription.
The following BRE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BRE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01031 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180133.1 | |
Accession Version | NM_001180133.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2103bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | E3 ubiquitin-protein ligase BRE1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGACGGCCG AGCCTGCTAC TAAGAAGATC AAGCTAGAAT TAAGCGATCC TAGTGAACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010209.1 |
CDS | 1..2103 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180133.1 |
1 | ATGACGGCCG AGCCTGCTAC TAAGAAGATC AAGCTAGAAT TAAGCGATCC TAGTGAACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |