Gene Symbol | GCS1 |
Entrez Gene ID | 851372 |
Full Name | Gcs1p |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » GCS1 cDNA ORF clone
Gene Symbol | GCS1 |
Entrez Gene ID | 851372 |
Full Name | Gcs1p |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180286.1 | NP_010055.1 | Gcs1p |
Homo sapiens (human) | ARFGAP1 | NP_060679.1 |
Saccharomyces cerevisiae (baker's yeast) | GCS1 | NP_010055.1 |
Pan troglodytes (chimpanzee) | ARFGAP1 | XP_001148867.1 |
Gallus gallus (chicken) | ARFGAP1 | NP_001026028.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_01745 | XP_003714742.1 |
Neurospora crassa | NCU07734 | XP_961984.1 |
Bos taurus (cattle) | ARFGAP1 | NP_001068732.1 |
Rattus norvegicus (Norway rat) | Arfgap1 | NP_659558.1 |
Kluyveromyces lactis | KLLA0D18942g | XP_453901.1 |
Eremothecium gossypii | AGOS_ABL164C | NP_982783.1 |
ARFGAP1 | XP_002798103.1 | |
Canis lupus familiaris (dog) | ARFGAP1 | XP_005635338.1 |
Danio rerio (zebrafish) | arfgap1 | NP_001007304.1 |
Schizosaccharomyces pombe (fission yeast) | SPCC622.14 | NP_588186.2 |
Mus musculus (house mouse) | Arfgap1 | NP_665703.2 |
Xenopus tropicalis (tropical clawed frog) | arfgap1 | NP_001123813.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ALPS and the predicted AH region are involved in the regulation and function of Gcs1p by interacting with membrane phospholipids and vesicle proteins.
Title: Identification of a second amphipathic lipid-packing sensor-like motif that contributes to Gcs1p function in the early endosome-to-TGN pathway.
The ArfGAP Gcs1p accelerates vesicle (v)-target membrane (t)-SNARE complex formation in vitro, indicating that ArfGAPs may act as folding chaperones.
Title: Interaction of SNAREs with ArfGAPs precedes recruitment of Sec18p/NSF.
These results suggest that Cdc50p-Drs2p plays an important role in the Arf1p/Gcs1-mediated formation of clathrin-coated vesicles for the retrieval pathway from early endosomes to the trans-Golgi network.
Title: The functional relationship between the Cdc50p-Drs2p putative aminophospholipid translocase and the Arf GAP Gcs1p in vesicle formation in the retrieval pathway from yeast early endosomes to the TGN.
Taken together, these results indicate that GCS1 is essential for sporulation and suggest that GCS1 positively regulates SPO14.
Title: The Arf-GTPase-activating protein Gcs1p is essential for sporulation and regulates the phospholipase D Spo14p.
Release of Arl1p from membranes in cells requires the hydrolysis of bound GTP, which is accelerated by Gcs1p.
Title: Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments.
The following GCS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GCS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00928 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180286.1 | |
Accession Version | NM_001180286.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Gcs1p | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCAGATT GGAAAGTGGA CCCAGATACC CGCAGGCGTC TTTTGCAATT GCAAAAGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010055.1 |
CDS | 1..1059 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180286.1 |
1 | ATGTCAGATT GGAAAGTGGA CCCAGATACC CGCAGGCGTC TTTTGCAATT GCAAAAGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |