CDC19 cDNA ORF clone, Saccharomyces cerevisiae S288C

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.
Bussey H, Kaback DB, Zhong W, Vo DT, Clark MW, Fortin N, Hall J, Ouellette BF, Keng T, Barton AB
Proceedings of the National Academy of Sciences of the United States of America92(9)3809-13(1995 Apr)

Reversible aggregation protects Cdc19 from stress-induced degradation, thereby allowing cell cycle restart after stress.
Title: Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress.

Data show that the pyruvate-forming enzyme Pyk1 was tethered to heterologous pyruvate-converting enzymes, lactate dehydrogenase and alpha-acetolactate synthase, to producelactic acid and 2,3-butanediol, respectively.
Title: Redirection of pyruvate flux toward desired metabolic pathways through substrate channeling between pyruvate kinase and pyruvate-converting enzymes in Saccharomyces cerevisiae.

CDC19 allele from the Htg(+)Saccharomyces cereviseae strain had 7 base changes resulting in silent mutations in its coding region. The base changes increased pyruvate kinase activity and activation of energy metabolism to maintain cellular homeostasis.
Title: CDC19 encoding pyruvate kinase is important for high-temperature tolerance in Saccharomyces cerevisiae.

In yeast the major PKA phosphorylation site of Pyk1 is Ser22. Phosphorylation of Ser22 leads to a Pyk1 enzyme that is more active in the absence of fructose 1,6-bisphosphate
Title: Characterization of yeast pyruvate kinase 1 as a protein kinase A substrate, and specificity of the phosphorylation site sequence in the whole protein.