ARR1 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an active transcriptional regulator.
Title: Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.

Leu26 is required for Yap8 binding to DNA and that this residue together with Asn31, hinder Yap1 response element recognition by Yap8, thus narrowing its DNA-binding specificity.
Title: Two residues in the basic region of the yeast transcription factor Yap8 are crucial for its DNA-binding specificity.

Yap8p requires distinct DNA-binding motifs to induce gene expression and propose that this fact contributed towards a separation of function between AP-1 proteins during evolution
Title: Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p.

ARR1 is degraded by the ubiquitin-proteasome pathway in untreated cells, whereas arsenite-exposure results in its stabilization and gene activation.
Title: Regulation of the arsenic-responsive transcription factor Yap8p involves the ubiquitin-proteasome pathway.