SSN3 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

While active INO1 is associated with Cdk8(-) Mediator, during INO1 transcriptional memory, Cdk8(+) Mediator recruits poised RNAPII PIC lacking the Kin28 CTD kinase.
Title: Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory.

with Srb10 clearing mostly inactive Gcn4 molecules at the promoter that are enriched for sumoylation of the activation domain, and Pho85 clearing molecules unbound to the UAS that include both fully functional and inactive Gcn4 species.
Title: Accumulation of a threonine biosynthetic intermediate attenuates general amino acid control by accelerating degradation of Gcn4 via Pho85 and Cdk8.

The function of the Mediator tail module component Med3, which is required for transcription activation, is suppressed by the kinase activity of the Cdk8 module.
Title: Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.

the detailed architecture of Cdk8 module, and suggest the Cdk8 module could positively regulate transcription by modulating Mediator conformation.
Title: Structural flexibility and functional interaction of Mediator Cdk8 module.

discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression
Title: Emerging roles of Cdk8 in cell cycle control.