Gene Symbol | ISU1 |
Entrez Gene ID | 855968 |
Full Name | iron-binding protein ISU1 |
Synonyms | NUA1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » ISU1 cDNA ORF clone
Gene Symbol | ISU1 |
Entrez Gene ID | 855968 |
Full Name | iron-binding protein ISU1 |
Synonyms | NUA1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183949.1 | NP_015190.1 | iron-binding protein ISU1 |
Pan troglodytes (chimpanzee) | ISCU | XP_509343.2 |
Canis lupus familiaris (dog) | LOC477527 | XP_534722.1 |
Mus musculus (house mouse) | Iscu | NP_079802.1 |
Drosophila melanogaster (fruit fly) | CG9836 | NP_649840.1 |
Oryza sativa (rice) | Os01g0662600 | NP_001043783.1 |
Oryza sativa (rice) | Os05g0568100 | NP_001056355.1 |
Xenopus tropicalis (tropical clawed frog) | iscu | NP_989088.1 |
Bos taurus (cattle) | ISCU | NP_001069151.1 |
Danio rerio (zebrafish) | iscub | NP_001017800.2 |
Caenorhabditis elegans (roundworm) | Y45F10D.4 | NP_502658.1 |
Saccharomyces cerevisiae (baker's yeast) | ISU1 | NP_015190.1 |
Danio rerio (zebrafish) | si:ch211-191d15.2 | NP_001003632.1 |
Saccharomyces cerevisiae (baker's yeast) | ISU2 | NP_014869.3 |
Eremothecium gossypii | AGOS_ACR112C | NP_983514.1 |
Neurospora crassa | NCU05778 | XP_960038.1 |
Homo sapiens (human) | ISCU | NP_998760.1 |
Rattus norvegicus (Norway rat) | Iscu | NP_001099406.1 |
Gallus gallus (chicken) | ISCU | XP_003642230.2 |
Arabidopsis thaliana (thale cress) | ISU1 | NP_193953.1 |
Arabidopsis thaliana (thale cress) | ISU2 | NP_186751.1 |
ISCU | XP_001103180.1 | |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005813 | XP_315834.2 |
Kluyveromyces lactis | KLLA0D07161g | XP_453380.1 |
Schizosaccharomyces pombe (fission yeast) | isu1 | NP_592967.1 |
Arabidopsis thaliana (thale cress) | ISU3 | NP_192317.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Proteomic and metabolomic comparisons revealed that the xylose-metabolizing mutant strains exhibit altered metabolic pathways relative to the parental strain when grown in xylose. Further analyses revealed that interacting mutations in HOG1 and ISU1 unexpectedly elevated mitochondrial respiratory proteins and enabled rapid aerobic respiration of xylose and other non-fermentable carbon substrates.
Title: Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae.
Isu is a substrate of the Lon-type protease and that it is protected from degradation by Nfs1, the sulfur donor for Fe-S cluster assembly, as well as by Jac1, the J-protein Hsp70 cochaperone that functions in cluster transfer from Isu. Nfs1 and Jac1 variants known to be defective in interaction with Isu were also defective in protecting Isu from degradation.
Title: Protection of scaffold protein Isu from degradation by the Lon protease Pim1 as a component of Fe-S cluster biogenesis regulation.
Studied the structure and dynamics of the yeast Isu1-Jac1 complex.
Title: Molecular modeling of the binding modes of the iron-sulfur protein to the Jac1 co-chaperone from Saccharomyces cerevisiae by all-atom and coarse-grained approaches.
The eukaryotic forms are critical for Fe-S cluster assembly whereas prokaryotic forms are more dispensable. We found that a key to this difference is a single amino acid in the scaffold protein Isu1 at position 141.
Title: Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism.
Fe/S cluster synthesis on Isu1 requires the ferredoxin Yah1
Title: Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin.
The following ISU1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ISU1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04837 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183949.1 | |
Accession Version | NM_001183949.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | iron-binding protein ISU1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001148). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGCTTCCTG TTATAACGAG ATTTGCAAGG CCTGCTCTGA TGGCCATCAG ACCTGTGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_015190.1 |
CDS | 1..498 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001183949.1 |
1 | ATGCTTCCTG TTATAACGAG ATTTGCAAGG CCTGCTCTGA TGGCCATCAG ACCTGTGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
Life with 6000 genes. |