Gene Symbol | RAD53 |
Entrez Gene ID | 855950 |
Full Name | serine/threonine/tyrosine protein kinase RAD53 |
Synonyms | LSD1,MEC2,SPK1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » RAD53 cDNA ORF clone
Gene Symbol | RAD53 |
Entrez Gene ID | 855950 |
Full Name | serine/threonine/tyrosine protein kinase RAD53 |
Synonyms | LSD1,MEC2,SPK1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183967.1 | NP_015172.1 | serine/threonine/tyrosine protein kinase RAD53 |
Homo sapiens (human) | CHEK2 | NP_001005735.1 |
Rattus norvegicus (Norway rat) | Chek2 | NP_446129.1 |
Saccharomyces cerevisiae (baker's yeast) | RAD53 | NP_015172.1 |
Bos taurus (cattle) | CHEK2 | NP_001029703.1 |
Gallus gallus (chicken) | CHEK2 | NP_001073576.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009784 | XP_318879.3 |
Caenorhabditis elegans (roundworm) | CELE_T08D2.7 | NP_508060.1 |
Caenorhabditis elegans (roundworm) | chk-2 | NP_001024271.1 |
Kluyveromyces lactis | KLLA0F11143g | XP_455587.1 |
CHEK2 | XP_001101658.1 | |
Mus musculus (house mouse) | Chek2 | NP_057890.1 |
Danio rerio (zebrafish) | chek2 | NP_956339.1 |
Pan troglodytes (chimpanzee) | CHEK2 | XP_003317205.1 |
Canis lupus familiaris (dog) | CHEK2 | XP_005636447.1 |
Drosophila melanogaster (fruit fly) | lok | NP_724241.1 |
Eremothecium gossypii | AGOS_ACR142W | NP_983544.2 |
Xenopus tropicalis (tropical clawed frog) | chek2 | NP_001119996.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Rad53 prevents the generation of excessive ssDNA under replication stress by coordinating DNA unwinding with synthesis of both strands.
Title: Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.
Rad53 can display active conformations and phosphor-priming confers functionally relevant autophosphorylation.
Title: Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation.
By performing a genetic screen, we identify rad53 and tel1 mutant alleles that suppress both the DNA damage hypersensitivity and the resection defect of sae2Delta cells through an Sgs1-Dna2-dependent mechanism
Title: Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity.
Rad53-mediated regulation of Rrm3 and Pif1 DNA helicases contributes to prevention of aberrant fork transitions under replication stress.
Title: Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.
INO80 can activate Rad53 kinase activity in an Ies4-phosphorylation-dependent manner in the absence of known activators such as Rad9.
Title: Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex.
The following RAD53 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAD53 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04821 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183967.1 | |
Accession Version | NM_001183967.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2466bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | serine/threonine/tyrosine protein kinase RAD53 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001148). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGAAAATA TTACACAACC CACACAGCAA TCCACGCAGG CTACTCAAAG GTTTTTGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_015172.1 |
CDS | 1..2466 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001183967.1 |
1 | ATGGAAAATA TTACACAACC CACACAGCAA TCCACGCAGG CTACTCAAAG GTTTTTGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
Life with 6000 genes. |