PLC1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	PLC1
Entrez Gene ID	855860
Full Name	phosphatidylinositol phospholipase C
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001184082.1	NP_015055.1	phosphatidylinositol phospholipase C

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PLCD4	XP_526029.2
Canis lupus familiaris (dog)	PLCD4	XP_536069.4
Mus musculus (house mouse)	Plcd4	NP_001074925.1
Gallus gallus (chicken)	LOC424214	XP_004942927.1
Magnaporthe oryzae (rice blast fungus)	MGG_02444	XP_003709233.1
Neurospora crassa	NCU01266	XP_960744.2
Arabidopsis thaliana (thale cress)	PLC4	NP_200678.2
Xenopus tropicalis (tropical clawed frog)	plcd4	XP_004917687.1
Bos taurus (cattle)	PLCD4	NP_001039954.1
Danio rerio (zebrafish)	plcd4a	XP_694028.4
Eremothecium gossypii	AGOS_ACR024W	NP_983427.1
Schizosaccharomyces pombe (fission yeast)	plc1	NP_594734.1
Homo sapiens (human)	PLCD4	NP_116115.1
	PLCD4	XP_001091368.2
Rattus norvegicus (Norway rat)	Plcd4	NP_542419.1
Saccharomyces cerevisiae (baker's yeast)	PLC1	NP_015055.1
Kluyveromyces lactis	KLLA0D00638g	XP_453100.1

Gene Ontology
Bibliography

Related articles in PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Plc1p and InsPs are required for normal acetyl-CoA homeostasis, which, in turn, regulates global histone acetylation.
Title: Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation.

The results show that MHO1 is a novel synthetic lethal interactor with PLC1, and that both gene products are required for proliferation (MHO1).
Title: MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth.

Plc1p affects transcription of Mcm1p-dependent genes,probably by a mechanism involving regulation of chromatin remodeling complexes.
Title: Role of Plc1p in regulation of Mcm1p-dependent genes.

Mutations in PLC1 and components of the RSC complex exhibit strong genetic interactions and display synthetic growth defect, altered nuclear morphology, and higher frequency of minichromosome loss.
Title: Plc1p is required for proper chromatin structure and activity of the kinetochore in Saccharomyces cerevisiae by facilitating recruitment of the RSC complex.

Genes regulated by Plc1p do not correlate with gene sets regulated by Swi/Snf or RSC chromatin remodeling complexes but show correlation with genes controlled by Msn2p.
Title: Saccharomyces cerevisiae phospholipase C regulates transcription of Msn2p-dependent stress-responsive genes.

The following PLC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi04737	NM_001184082.1 Latest version!	Saccharomyces cerevisiae S288C phosphatidylinositol phospholipase C (PLC1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLC1 ( NM_001184082.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_015055.1 Saccharomyces cerevisiae S288C phosphatidylinositol phospholipase C (PLC1), partial mRNA.

Price & Availability↑

CloneID	OSi04737
Clone ID Related Accession (Same CDS sequence)	NM_001184082.1
Accession Version	NM_001184082.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2610bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	phosphatidylinositol phospholipase C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001148). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGACTGAAA GTGCTATAGA TGACCAAAGG TTTAATCTTA CAAAGGAGTT ACAACGACAC 
TCATGCAGAG ATCAAGGGAA AATAACACAA AAGGATGATG CTTTAGATTT TATAAGTTAC 
AGTTCTTTTC AATCCTCTTT TAATACTGAC CAAAAAAGCG CGAACAATGG AAGTACTGTG 
AGAAGAAGCA TAAGGTCGAT TTTTAGAAGA GCAGCCGAAT TGCCTAGAGT CCATATGGGG 
CCTCTTACTT ATTCACATGG GATAAATGAG CTTGTTAACA AGAAATTAAG AAAAGACTGT 
GATCTCAGCA CGCTATGTCG CGTATTGCAA AGAGGAATCA GGATGATTAG GATGACAAGA 
AGAAGAAGGA AGTTCTATGA ATTTAAATTA ATCAATAACA ACGGGCAAAT AATATGGAAA 
GATGGTTCGA AGTATCTGGA ATTAGACTCC GTTAAAGACA TCAGAATCGG TGATACGGCG 
AGTACTTATC AAGAGGAAGT AGATCCGAAA AGATTGAGAT CGGACAGTAA ACTTTGGATT 
GCTATTATTT ATAAGGTTTC CAACAAATTG AAAGCGTTAC ACGTAGTTGC TTTGAATGAA 
TTGGACTTTA ACACATTCTT AAGCTGCATT TGCGGTTTAG TGAAGTTAAG GAGGGAATTA 
ATGGAAAGCA TACTTTTGCC TGATAATTCG CAATTCGCTA GGATACATTG GCAAATTACT 
GTTTCTGAAA AAGAGGAAGA TGAGAAAAAG GACACATTGA GCTTTGCAGA TGTGAAGAAA 
CTATGTGATA AATTTCATAT TTATGTGTCA ACTGGTCAAT TGTTAGAGTT TTTCCAATTA 
GCAGACATCA ATCATAACGG ACTATTAAAT TATTTTGAAT TTGAAAAGTT CATTAAAATC 
TTAAAGAATA GGAAAGAGGT AAATATGATT TGGTCTAAAT TTACAAAACC TCCACACTCC 
CACTTATCAT TTGAAAATTT TTTTCAATTT TTAATTACAG AGCAGCATGA GCAAGTGGAT 
CGTCAAACTG CATGGTCATA TTTTATTAAG TACAGAGAAC CGACTCAGCT GACGATGGGG 
CAAGATGGTT TTACCAAGTT CTTGAAGGAG CAACCATATT TGGTGGAGGT TAAAGAGGAG 
TTATATTCAA AGCCATTAAA CCATTATTTT ATTGCATCTT CACATAATAC TTATTTATTG 
GGGAAACAAA TTGCAGAAAC TCCATCTGTG GAGGGATATA TTCAAGTCCT ACAACAAGGT 
TGTAGGTGCG TAGAAATTGA TATATGGGAT GGTGAAAATG GGCCAGTGGT ATGCCATGGA 
TTTTTAACGT CAGCTATTCC CTTAAAAACA GTTATACGCG TGATAAAGAA GTACGCTTTT 
ATAACGTCTC CGTATCCTTT GATTATTTCA CTGGAAATAA ACTGTAACAA GGATAATCAA 
AAATTGGCAA GCCTGATAAT GAGAGAGGTT TTAGCAGAAC AGCTGTACTT TGTTGGCACA 
AGAACTGATA AACTGCCATC ACCAAGGGAA TTAAAACATA AAATACTGTT GAAATCCAAG 
AAGACGAGTG AAGCAACTAG AGGTCTTAGC GTTAATGAGC CATTTCCATC TTCTTTTAGT 
TCTTCTTACG AATCAGCTAA TGAACAGGAA TTAAGAATGA AAGATGACTC CACGAACAGT 
AGTAGCGCAA CAAATTCTTC TAGTATGCAA CGCATCAAAA GAATTGGATT AAAAAAGCAC 
GCTGATATAA TTAATGATGT TTCTAACATT TCTGGAATAC ATGGCATCAA GTTCAGGAAT 
TTCTCTTTAC CAGAGTCCAA AACGATAGCG CATTGTTTTT CACTGAATGA GCGCAAAGTA 
GAATACATGA TAAAAGACAA ACACTTAAAA TTATCGTTGG ATAAACATAA TAGAAGATAT 
TTGATGAGAG TCTATCCTCA CGTTTTACGA TACAAATCAT CAAATTTTAA CCCAATACCT 
TTTTGGAAGG CCGGTGTACA AATGGTGGCT ACGAATTGGC AAACTAATGA TATTGGACAG 
CAACTTAATC TGGCAATGTT TCAAATATTA GATCACCAAC CTGATGGAAG TTTTAAATCA 
GGATACGTGC TAAAACCAAA AAAGTTGCTA CCTGTAGTAA CAAAGGCGAA AATGATTCCA 
TTAATTTACG AACATTTTGA AAATGGTAGT GATCCTGTTA CTGTTAAAAT TCGAATTTTA 
TCTACACAGT TATTGCCCAG ATTGAATGAT ACATCGCCAA GCAGAAATAA CACCAATTCC 
TTTGTTAAAG TGGAGTTTCA TACCGATGAC GAGCCGACAA TGCCCATCTC AATCGATAAG 
GGTACAAGGA TTTCTGCCAC TGAAGCATCC ACTAAGAGTT CTCAAGGGAA TGGATTCAAC 
CCAATATGGG ATGCTGAAGT TTCTATCACA TTGAAAGATA CAGACCTCAC ATTTATAAAA 
TTCATGGTTA TCTCTGAAGA GACCCAGATT GCATCTGTTT GCCTTAAGCT GAACTATTTG 
AGGATGGGAT ATCGTCACAT TCCGTTGTTT AACATGGAGG GGGAACAATA CATATTTTGC 
ACTTTATTTA TTCATACACA AATTTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_015055.1
CDS	1..2610
Translation	MTESAIDDQRFNLTKELQRHSCRDQGKITQKDDALDFISYSSFQSSFNTDQKSANNGSTVRRSIRSIFRRAAELPRVHMGPLTYSHGINELVNKKLRKDCDLSTLCRVLQRGIRMIRMTRRRRKFYEFKLINNNGQIIWKDGSKYLELDSVKDIRIGDTASTYQEEVDPKRLRSDSKLWIAIIYKVSNKLKALHVVALNELDFNTFLSCICGLVKLRRELMESILLPDNSQFARIHWQITVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQLLEFFQLADINHNGLLNYFEFEKFIKILKNRKEVNMIWSKFTKPPHSHLSFENFFQFLITEQHEQVDRQTAWSYFIKYREPTQLTMGQDGFTKFLKEQPYLVEVKEELYSKPLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENGPVVCHGFLTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTRTDKLPSPRELKHKILLKSKKTSEATRGLSVNEPFPSSFSSSYESANEQELRMKDDSTNSSSATNSSSMQRIKRIGLKKHADIINDVSNISGIHGIKFRNFSLPESKTIAHCFSLNERKVEYMIKDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQILDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEHFENGSDPVTVKIRILSTQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNGFNPIWDAEVSITLKDTDLTFIKFMVISEETQIASVCLKLNYLRMGYRHIPLFNMEGEQYIFCTLFIHTQIL

Target ORF information:

RefSeq Version	NM_001184082.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C phosphatidylinositol phospholipase C (PLC1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001184082.1

ORF Insert Sequence:

ATGACTGAAA GTGCTATAGA TGACCAAAGG TTTAATCTTA CAAAGGAGTT ACAACGACAC 
TCATGCAGAG ATCAAGGGAA AATAACACAA AAGGATGATG CTTTAGATTT TATAAGTTAC 
AGTTCTTTTC AATCCTCTTT TAATACTGAC CAAAAAAGCG CGAACAATGG AAGTACTGTG 
AGAAGAAGCA TAAGGTCGAT TTTTAGAAGA GCAGCCGAAT TGCCTAGAGT CCATATGGGG 
CCTCTTACTT ATTCACATGG GATAAATGAG CTTGTTAACA AGAAATTAAG AAAAGACTGT 
GATCTCAGCA CGCTATGTCG CGTATTGCAA AGAGGAATCA GGATGATTAG GATGACAAGA 
AGAAGAAGGA AGTTCTATGA ATTTAAATTA ATCAATAACA ACGGGCAAAT AATATGGAAA 
GATGGTTCGA AGTATCTGGA ATTAGACTCC GTTAAAGACA TCAGAATCGG TGATACGGCG 
AGTACTTATC AAGAGGAAGT AGATCCGAAA AGATTGAGAT CGGACAGTAA ACTTTGGATT 
GCTATTATTT ATAAGGTTTC CAACAAATTG AAAGCGTTAC ACGTAGTTGC TTTGAATGAA 
TTGGACTTTA ACACATTCTT AAGCTGCATT TGCGGTTTAG TGAAGTTAAG GAGGGAATTA 
ATGGAAAGCA TACTTTTGCC TGATAATTCG CAATTCGCTA GGATACATTG GCAAATTACT 
GTTTCTGAAA AAGAGGAAGA TGAGAAAAAG GACACATTGA GCTTTGCAGA TGTGAAGAAA 
CTATGTGATA AATTTCATAT TTATGTGTCA ACTGGTCAAT TGTTAGAGTT TTTCCAATTA 
GCAGACATCA ATCATAACGG ACTATTAAAT TATTTTGAAT TTGAAAAGTT CATTAAAATC 
TTAAAGAATA GGAAAGAGGT AAATATGATT TGGTCTAAAT TTACAAAACC TCCACACTCC 
CACTTATCAT TTGAAAATTT TTTTCAATTT TTAATTACAG AGCAGCATGA GCAAGTGGAT 
CGTCAAACTG CATGGTCATA TTTTATTAAG TACAGAGAAC CGACTCAGCT GACGATGGGG 
CAAGATGGTT TTACCAAGTT CTTGAAGGAG CAACCATATT TGGTGGAGGT TAAAGAGGAG 
TTATATTCAA AGCCATTAAA CCATTATTTT ATTGCATCTT CACATAATAC TTATTTATTG 
GGGAAACAAA TTGCAGAAAC TCCATCTGTG GAGGGATATA TTCAAGTCCT ACAACAAGGT 
TGTAGGTGCG TAGAAATTGA TATATGGGAT GGTGAAAATG GGCCAGTGGT ATGCCATGGA 
TTTTTAACGT CAGCTATTCC CTTAAAAACA GTTATACGCG TGATAAAGAA GTACGCTTTT 
ATAACGTCTC CGTATCCTTT GATTATTTCA CTGGAAATAA ACTGTAACAA GGATAATCAA 
AAATTGGCAA GCCTGATAAT GAGAGAGGTT TTAGCAGAAC AGCTGTACTT TGTTGGCACA 
AGAACTGATA AACTGCCATC ACCAAGGGAA TTAAAACATA AAATACTGTT GAAATCCAAG 
AAGACGAGTG AAGCAACTAG AGGTCTTAGC GTTAATGAGC CATTTCCATC TTCTTTTAGT 
TCTTCTTACG AATCAGCTAA TGAACAGGAA TTAAGAATGA AAGATGACTC CACGAACAGT 
AGTAGCGCAA CAAATTCTTC TAGTATGCAA CGCATCAAAA GAATTGGATT AAAAAAGCAC 
GCTGATATAA TTAATGATGT TTCTAACATT TCTGGAATAC ATGGCATCAA GTTCAGGAAT 
TTCTCTTTAC CAGAGTCCAA AACGATAGCG CATTGTTTTT CACTGAATGA GCGCAAAGTA 
GAATACATGA TAAAAGACAA ACACTTAAAA TTATCGTTGG ATAAACATAA TAGAAGATAT 
TTGATGAGAG TCTATCCTCA CGTTTTACGA TACAAATCAT CAAATTTTAA CCCAATACCT 
TTTTGGAAGG CCGGTGTACA AATGGTGGCT ACGAATTGGC AAACTAATGA TATTGGACAG 
CAACTTAATC TGGCAATGTT TCAAATATTA GATCACCAAC CTGATGGAAG TTTTAAATCA 
GGATACGTGC TAAAACCAAA AAAGTTGCTA CCTGTAGTAA CAAAGGCGAA AATGATTCCA 
TTAATTTACG AACATTTTGA AAATGGTAGT GATCCTGTTA CTGTTAAAAT TCGAATTTTA 
TCTACACAGT TATTGCCCAG ATTGAATGAT ACATCGCCAA GCAGAAATAA CACCAATTCC 
TTTGTTAAAG TGGAGTTTCA TACCGATGAC GAGCCGACAA TGCCCATCTC AATCGATAAG 
GGTACAAGGA TTTCTGCCAC TGAAGCATCC ACTAAGAGTT CTCAAGGGAA TGGATTCAAC 
CCAATATGGG ATGCTGAAGT TTCTATCACA TTGAAAGATA CAGACCTCAC ATTTATAAAA 
TTCATGGTTA TCTCTGAAGA GACCCAGATT GCATCTGTTT GCCTTAAGCT GAACTATTTG 
AGGATGGGAT ATCGTCACAT TCCGTTGTTT AACATGGAGG GGGAACAATA CATATTTTGC 
ACTTTATTTA TTCATACACA AATTTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Nature387(6632 Suppl)103-5(1997 May)
Bussey H,Storms RK,Ahmed A,Albermann K,Allen E,Ansorge W,Araujo R,Aparicio A,Barrell B,Badcock K,Benes V,Botstein D,Bowman S,Br?ckner M,Carpenter J,Cherry JM,Chung E,Churcher C,Coster F,Davis K,Davis RW,Dietrich FS,Delius H,DiPaolo T,Hani J

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

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PLC1 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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