Gene Symbol | UBP8 |
Entrez Gene ID | 855263 |
Full Name | ubiquitin-specific protease UBP8 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » UBP8 cDNA ORF clone
Gene Symbol | UBP8 |
Entrez Gene ID | 855263 |
Full Name | ubiquitin-specific protease UBP8 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182730.1 | NP_013950.1 | ubiquitin-specific protease UBP8 |
Canis lupus familiaris (dog) | USP22 | XP_005620237.1 |
Bos taurus (cattle) | USP22 | NP_001160039.1 |
Gallus gallus (chicken) | USP22 | XP_004945238.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012119 | XP_320409.4 |
Saccharomyces cerevisiae (baker's yeast) | UBP8 | NP_013950.1 |
Danio rerio (zebrafish) | usp22 | NP_001038713.1 |
Schizosaccharomyces pombe (fission yeast) | ubp8 | NP_592992.1 |
Xenopus tropicalis (tropical clawed frog) | usp22 | NP_001192175.1 |
Eremothecium gossypii | AGOS_AFR551W | NP_986098.2 |
Neurospora crassa | NCU02375 | XP_959796.2 |
Pan troglodytes (chimpanzee) | USP22 | XP_003953155.1 |
Mus musculus (house mouse) | Usp22 | NP_001004143.2 |
Drosophila melanogaster (fruit fly) | not | NP_524140.2 |
Oryza sativa (rice) | Os04g0647300 | NP_001054070.2 |
Homo sapiens (human) | USP22 | NP_056091.1 |
Rattus norvegicus (Norway rat) | Usp22 | NP_001178573.1 |
Kluyveromyces lactis | KLLA0C06974g | XP_452509.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03527 | XP_003716392.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B
Nature387(6632 Suppl)90-3(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
an unexpected role for Sgf11 in compensating for the absence of structural features that maintain the active conformation of Ubp8.
Title: A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity.
Ubp8 can deubiquitinate Snf1, a highly conserved AMP-activated serine/threonine protein kinase that serves as an energy sensor in the cell.
Title: Ubp8 and SAGA regulate Snf1 AMP kinase activity.
study reports the 1.90 angstrom resolution crystal structure of the deubiquitinating module (DUBm)- which contains Ubp8 bound to Sgf11, Sus1 and Sgf73- bound to ubiquitin aldehyde, as well as the 2.45 angstrom resolution structure of the uncomplexed DUBm
Title: Structural insights into the assembly and function of the SAGA deubiquitinating module.
Structural and functional analyses reveal a central role of Sgf11 and Sgf73 in activating Ubp8 for deubiquitinating histone H2B and demonstrate how a DUB can be allosterically regulated by its nonsubstrate partners.
Title: Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
mechanism by which H2B ubiquitylation acts as a barrier to Ctk1 association with active genes, while subsequent deubiquitylation by Ubp8 triggers Ctk1 recruitment at the appropriate point in activation
Title: H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex.
The following UBP8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBP8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04218 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182730.1 | |
Accession Version | NM_001182730.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1416bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | ubiquitin-specific protease UBP8 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001145). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAGCATTT GTCCACATAT ACAGCAAGTA TTTCAGAATG AAAAGTCTAA AGATGGGGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013950.1 |
CDS | 1..1416 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001182730.1 |
1 | ATGAGCATTT GTCCACATAT ACAGCAAGTA TTTCAGAATG AAAAGTCTAA AGATGGGGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. |
Life with 6000 genes. |