Gene Symbol | TSA1 |
Entrez Gene ID | 854980 |
Full Name | thioredoxin peroxidase TSA1 |
Synonyms | TPX1,ZRG14 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » TSA1 cDNA ORF clone
Gene Symbol | TSA1 |
Entrez Gene ID | 854980 |
Full Name | thioredoxin peroxidase TSA1 |
Synonyms | TPX1,ZRG14 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182386.1 | NP_013684.1 | thioredoxin peroxidase TSA1 |
Mus musculus (house mouse) | Prdx2 | NP_035693.3 |
Anopheles gambiae (African malaria mosquito) | TPX2 | XP_308081.2 |
Arabidopsis thaliana (thale cress) | AT3G11630 | NP_187769.1 |
Arabidopsis thaliana (thale cress) | 2-Cys Prx B | NP_568166.1 |
Saccharomyces cerevisiae (baker's yeast) | TSA1 | NP_013684.1 |
Pan troglodytes (chimpanzee) | PRDX2 | XP_003953433.1 |
Bos taurus (cattle) | PRDX2 | NP_777188.1 |
Schizosaccharomyces pombe (fission yeast) | tpx1 | NP_588430.1 |
Homo sapiens (human) | PRDX2 | NP_005800.3 |
Canis lupus familiaris (dog) | PRDX2 | XP_003639771.1 |
Rattus norvegicus (Norway rat) | Prdx2 | NP_058865.1 |
Danio rerio (zebrafish) | prdx2 | NP_001002468.1 |
Drosophila melanogaster (fruit fly) | Jafrac1 | NP_477510.1 |
Caenorhabditis elegans (roundworm) | prdx-2 | NP_001122604.1 |
Oryza sativa (rice) | Os02g0537700 | NP_001047050.1 |
Xenopus tropicalis (tropical clawed frog) | prdx2 | NP_989001.1 |
PRDX2 | XP_001109216.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B
Nature387(6632 Suppl)90-3(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Study found that Tsa1 and Hsp70 physically interact and that hyperoxidation of Tsa1 by hydrogen peroxide is required for the recruitment of the Hsp70 chaperones and the Hsp104 disaggregase to misfolded and aggregated proteins during aging, but not heat stress.
Title: Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins.
The critical molecular event allowing the Tsa1 to chaperone switch is the enzyme assembly into high molecular weight structures brought about by enzyme hyperoxidation and sulfinylation.
Title: In vivo parameters influencing 2-Cys Prx oligomerization: The role of enzyme sulfinylation.
Tsa1 localises to the sites of protein aggregation and protects against protein-aggregate-induced oxidative stress.
Title: The yeast peroxiredoxin Tsa1 protects against protein-aggregate-induced oxidative stress.
It appears to control the cellular reactive oxygen species.
Title: Requirement of peroxiredoxin on the stationary phase of yeast cell growth.
Tsa1, the major peroxiredoxin, is required for telomere length maintenance.
Title: Deletion of the major peroxiredoxin Tsa1 alters telomere length homeostasis.
The following TSA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi03972 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182386.1 | |
Accession Version | NM_001182386.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | thioredoxin peroxidase TSA1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001145). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGTCGCTC AAGTTCAAAA GCAAGCTCCA ACTTTTAAGA AAACTGCCGT CGTCGACGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013684.1 |
CDS | 1..591 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001182386.1 |
1 | ATGGTCGCTC AAGTTCAAAA GCAAGCTCCA ACTTTTAAGA AAACTGCCGT CGTCGACGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. |
Life with 6000 genes. |