ULP2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	ULP2
Entrez Gene ID	854780
Full Name	SUMO protease ULP2
Synonyms	SMT4
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001179381.1	NP_012233.1	SUMO protease ULP2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.
Churcher C, Bowman S, Badcock K, Bankier A, Brown D, Chillingworth T, Connor R, Devlin K, Gentles S, Hamlin N, Harris D, Horsnell T, Hunt S, Jagels K, Jones M, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Rowley N, Skelton J, Smith V, Barrell B
Nature387(6632 Suppl)84-7(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ulp2 promotes rDNA silencing by opposing STUbL-mediated degradation of silencing proteins
Title: Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity.

Extra copies of ChrI and ChrXII appear quickly following loss of active Ulp2 and can be eliminated following reintroduction of ULP2, suggesting that aneuploidy is a reversible adaptive mechanism to counteract loss of the SUMO protease
Title: Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy.

Ulp2 controls the dynamic range of SUMO chain lengths by trimming them from the distal ends
Title: In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.

mis-regulation is accompanied by a severe, recombination-dependent, block to chromosome segregation, revealing a critical role for Ulp2p in allowing sister chromatids to disjoin following HR DNA repair.
Title: The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.

C-terminal region of Ulp2 is phosphorylated during mitosis in a Cdc5-dependent manner.
Title: The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.

The following ULP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ULP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi03803	NM_001179381.1 Latest version!	Saccharomyces cerevisiae S288C SUMO protease ULP2 (ULP2), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$629.30 $899.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ULP2 ( NM_001179381.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_012233.1 Saccharomyces cerevisiae S288C SUMO protease ULP2 (ULP2), partial mRNA.

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CloneID	OSi03803
Clone ID Related Accession (Same CDS sequence)	NM_001179381.1
Accession Version	NM_001179381.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3105bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	SUMO protease ULP2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001141). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGTCTGCCA GAAAACGCAA GTTTAATAGT CTCAAACCGC TAGACACCTT GAACAGCTCT 
CGTGCCAGCT CTCCAAGGTC CTCTGCTTCT CTACCGCCCA AAAGATATAA CACTTTTCGT 
AAGGATCCGA AAATCGTTGA TCATCTAAAC AATGCTTCTA CAAAGGATTT CTTACCAGTT 
TTGAGTATGA ACAGCGAGAG TAAGAGGCAG ATCGAATTGT CGGATAATGA TGTTGATAAT 
AATGATGAAG GTGAAGGCGT CAACAGTGGC TGTTCAGATC AAGATTTTGA ACCTTTGCAA 
AGCTCTCCTT TGAAAAGACA CTCATCACTC AAAAGCACTT CCAATGGTCT TTTGTTCCAA 
ATGTCTAATA ATCTGGGGAA TGGTTCACCG GAACCGGCAG TAGCGAGCAC TTCTCCAAAT 
GGCTCAATTA TTTCCACTAA ACTAAATTTG AACGGCCAAT TTTCTTGCGT TGATTCGAAA 
ACATTGCGAA TTTATCGGCA TAAAGCACCA TGCATAATGA CTTTTGTCTC AGATCATAAT 
CATCCGAAAT TTTCATTGTA TTTTCAACAA TCGGTGATCT ACAATTCACA AGTTAATCTG 
CTTGATGATG TTGAATTGAT AATTTTAGAT AAGAAGAACT CTTTTATGGC TATAATTTTA 
AAAGATCTGA AAAAGGTCAA GATGATACTA GACGTGAATA ACTCTTCAAT CAACATTAAC 
ACGAACATCT TGATATGGTC CACTGCAAGC TCCGCTTCAA ATAAAAAAAT AAAGTCTATT 
AAAAGATTCC TGTTGATGTC ATATTCTTCG TCGATAAAAG TCGAAATTTT AGATCATAAA 
GAGCAGATTT TGGAAAGACT AAAACATCTG ATTCATCCTA TTTCTTCGTC ATCACCTTCA 
TTGAACATGG AAAGGGCAAT AAACTCCACT AAAAATGCAT TCGACTCTTT AAGACTTAAA 
AAAACTAAAC TTTCTACTAA TGATGATGAA AGTCCGCAAA TTCATACTCA TTTCTTATCA 
AACAAACCTC ATGGTTTGCA ATCCTTAACA AAAAGGACTC GTATTGCCAG CCTTGGGAAA 
AAAGAGCATT CAATATCTGT TCCAAAATCG AATATTTCAC CCTCAGATTT CTACAACACT 
AACGGGACAG AAACTTTACA ATCCCACGCA GTTTCACAAC TAAGACGTTC AAATAGATTT 
AAAGATGTTT CGGATCCAGC AAACTCAAAT TCAAATTCAG AATTTGATGA TGCAACTACG 
GAATTTGAAA CACCAGAACT GTTTAAACCT AGCCTCTGTT ACAAATTCAA CGATGGTTCA 
AGCTATACTA TAACAAATCA AGATTTCAAG TGTCTTTTCA ATAAGGATTG GGTTAATGAT 
AGCATTTTGG ATTTTTTTAC AAAATTTTAC ATTGAATCAT CTATTGAAAA GTCAATTATC 
AAAAGAGAGC AAGTTCACTT AATGTCCTCT TTTTTTTACA CGAAACTAAT TAGTAATCCA 
GCAGATTATT ATTCTAATGT AAAAAAGTGG GTTAACAATA CTGATTTGTT TTCTAAAAAG 
TACGTTGTTA TACCAATTAA CATAAGTTAT CATTGGTTTA GTTGCATTAT AACAAACTTG 
GATGCGATCT TGGATTTTCA TCAAAACAAA GATAAAAACG ATGCCATCAA CTCCGATGAG 
ATTTCTATAA ATAATCCTCT GGTTAATATT TTGACTTTCG ACTCGTTGAG GCAAACTCAT 
TCAAGAGAAA TTGATCCAAT AAAAGAATTT CTCATATCCT ATGCACTTGA TAAATATTCA 
ATTCAACTGG ATAAAACACA AATCAAAATG AAAACGTGTC CAGTTCCACA ACAACCTAAT 
ATGAGCGATT GTGGTGTTCA TGTTATTTTG AATATTAGAA AATTTTTTGA AAATCCGGTG 
GAAACAATTG ATGTATGGAA GAATTCTAAG ATTAAAAGTA AGCACTTCAC CGCAAAAATG 
ATTAATAAAT ATTTTGATAA AAATGAAAGA AATAGTGCGA GAAAGAATTT AAGGCATACT 
CTAAAACTCT TACAACTCAA TTACATCAGC TATCTGAAAA AAGAAAATTT ATATGAAGAA 
GTTATGCAAA TGGAGGAGAA AAAAAGCACC AATATCAACA ATAATGAAAA TTACGACGAT 
GACGATGAAG AAATTCAAAT CATTGAAAAT ATAGATCAAA GCAGTAAAGA TAATAACGCG 
CAGTTAACCT CGGAACCTCC CTGCTCACGA TCATCCAGTA TTTCAACAAC AGAAAGAGAG 
CCGACAGAGT TGCATAATTC CGTAGTACGA CAGCCCACCG GTGAAATAAT AACTGATAAT 
GAAGATCCCG TTCGCGCTGC TTCTCCAGAA ACAGCATCCG TTTCTCCTCC CATACGTCAC 
AATATTTTAA AGAGTTCATC TCCTTTCATA TCAGAAAGTG CGAATGAAAC TGAACAAGAA 
GAATTTACGT CACCATACTT TGGAAGGCCG TCTTTAAAGA CGAGGGCTAA GCAGTTTGAA 
GGCGTTTCGT CACCAATAAA AAACGATCAA GCCCTGTCAT CCACCCATGA TATTATGATG 
CCGTCGCCTA AACCTAAAAG GATTTACCCA AGCAAAAAAA TCCCACAACT TTCCTCGCAT 
GTTCAATCTC TATCGACTGA TTCTATGGAA CGCCAATCTA GTCCCAATAA TACCAACATT 
GTAATTTCAG ATACAGAACA AGATTCGAGG TTAGGAGTGA ATTCTGAAAG TAAAAATACT 
AGTGGTATTG TTAACAGGGA TGACTCGGAC GTCAATTTAA TTGGTAGTTC ACTACCTAAT 
GTAGCGGAAA AAAATCATGA CAACACTCAG GAAAGTAATG GTAATAATGA CAGTCTTGGT 
AAAATACTTC AAAATGTTGA CAAAGAACTG AACGAAAAGT TGGTTGATAT TGATGATGTG 
GCATTTAGTA GTCCAACTAG GGGTATTCCA AGAACCAGCG CGACAAGCAA GGGATCAAAT 
GCACAACTTC TCTCTAATTA TGGAGATGAA AATAACCAGT CTCAAGATTC TGTTTGGGAT 
GAGGGCAGAG ATAATCCTAT ACTCTTGGAA GATGAAGACC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_012233.1
CDS	1..3105
Translation	MSARKRKFNSLKPLDTLNSSRASSPRSSASLPPKRYNTFRKDPKIVDHLNNASTKDFLPVLSMNSESKRQIELSDNDVDNNDEGEGVNSGCSDQDFEPLQSSPLKRHSSLKSTSNGLLFQMSNNLGNGSPEPAVASTSPNGSIISTKLNLNGQFSCVDSKTLRIYRHKAPCIMTFVSDHNHPKFSLYFQQSVIYNSQVNLLDDVELIILDKKNSFMAIILKDLKKVKMILDVNNSSININTNILIWSTASSASNKKIKSIKRFLLMSYSSSIKVEILDHKEQILERLKHLIHPISSSSPSLNMERAINSTKNAFDSLRLKKTKLSTNDDESPQIHTHFLSNKPHGLQSLTKRTRIASLGKKEHSISVPKSNISPSDFYNTNGTETLQSHAVSQLRRSNRFKDVSDPANSNSNSEFDDATTEFETPELFKPSLCYKFNDGSSYTITNQDFKCLFNKDWVNDSILDFFTKFYIESSIEKSIIKREQVHLMSSFFYTKLISNPADYYSNVKKWVNNTDLFSKKYVVIPINISYHWFSCIITNLDAILDFHQNKDKNDAINSDEISINNPLVNILTFDSLRQTHSREIDPIKEFLISYALDKYSIQLDKTQIKMKTCPVPQQPNMSDCGVHVILNIRKFFENPVETIDVWKNSKIKSKHFTAKMINKYFDKNERNSARKNLRHTLKLLQLNYISYLKKENLYEEVMQMEEKKSTNINNNENYDDDDEEIQIIENIDQSSKDNNAQLTSEPPCSRSSSISTTEREPTELHNSVVRQPTGEIITDNEDPVRAASPETASVSPPIRHNILKSSSPFISESANETEQEEFTSPYFGRPSLKTRAKQFEGVSSPIKNDQALSSTHDIMMPSPKPKRIYPSKKIPQLSSHVQSLSTDSMERQSSPNNTNIVISDTEQDSRLGVNSESKNTSGIVNRDDSDVNLIGSSLPNVAEKNHDNTQESNGNNDSLGKILQNVDKELNEKLVDIDDVAFSSPTRGIPRTSATSKGSNAQLLSNYGDENNQSQDSVWDEGRDNPILLEDEDP

Target ORF information:

RefSeq Version	NM_001179381.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C SUMO protease ULP2 (ULP2), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001179381.1

ORF Insert Sequence:

ATGTCTGCCA GAAAACGCAA GTTTAATAGT CTCAAACCGC TAGACACCTT GAACAGCTCT 
CGTGCCAGCT CTCCAAGGTC CTCTGCTTCT CTACCGCCCA AAAGATATAA CACTTTTCGT 
AAGGATCCGA AAATCGTTGA TCATCTAAAC AATGCTTCTA CAAAGGATTT CTTACCAGTT 
TTGAGTATGA ACAGCGAGAG TAAGAGGCAG ATCGAATTGT CGGATAATGA TGTTGATAAT 
AATGATGAAG GTGAAGGCGT CAACAGTGGC TGTTCAGATC AAGATTTTGA ACCTTTGCAA 
AGCTCTCCTT TGAAAAGACA CTCATCACTC AAAAGCACTT CCAATGGTCT TTTGTTCCAA 
ATGTCTAATA ATCTGGGGAA TGGTTCACCG GAACCGGCAG TAGCGAGCAC TTCTCCAAAT 
GGCTCAATTA TTTCCACTAA ACTAAATTTG AACGGCCAAT TTTCTTGCGT TGATTCGAAA 
ACATTGCGAA TTTATCGGCA TAAAGCACCA TGCATAATGA CTTTTGTCTC AGATCATAAT 
CATCCGAAAT TTTCATTGTA TTTTCAACAA TCGGTGATCT ACAATTCACA AGTTAATCTG 
CTTGATGATG TTGAATTGAT AATTTTAGAT AAGAAGAACT CTTTTATGGC TATAATTTTA 
AAAGATCTGA AAAAGGTCAA GATGATACTA GACGTGAATA ACTCTTCAAT CAACATTAAC 
ACGAACATCT TGATATGGTC CACTGCAAGC TCCGCTTCAA ATAAAAAAAT AAAGTCTATT 
AAAAGATTCC TGTTGATGTC ATATTCTTCG TCGATAAAAG TCGAAATTTT AGATCATAAA 
GAGCAGATTT TGGAAAGACT AAAACATCTG ATTCATCCTA TTTCTTCGTC ATCACCTTCA 
TTGAACATGG AAAGGGCAAT AAACTCCACT AAAAATGCAT TCGACTCTTT AAGACTTAAA 
AAAACTAAAC TTTCTACTAA TGATGATGAA AGTCCGCAAA TTCATACTCA TTTCTTATCA 
AACAAACCTC ATGGTTTGCA ATCCTTAACA AAAAGGACTC GTATTGCCAG CCTTGGGAAA 
AAAGAGCATT CAATATCTGT TCCAAAATCG AATATTTCAC CCTCAGATTT CTACAACACT 
AACGGGACAG AAACTTTACA ATCCCACGCA GTTTCACAAC TAAGACGTTC AAATAGATTT 
AAAGATGTTT CGGATCCAGC AAACTCAAAT TCAAATTCAG AATTTGATGA TGCAACTACG 
GAATTTGAAA CACCAGAACT GTTTAAACCT AGCCTCTGTT ACAAATTCAA CGATGGTTCA 
AGCTATACTA TAACAAATCA AGATTTCAAG TGTCTTTTCA ATAAGGATTG GGTTAATGAT 
AGCATTTTGG ATTTTTTTAC AAAATTTTAC ATTGAATCAT CTATTGAAAA GTCAATTATC 
AAAAGAGAGC AAGTTCACTT AATGTCCTCT TTTTTTTACA CGAAACTAAT TAGTAATCCA 
GCAGATTATT ATTCTAATGT AAAAAAGTGG GTTAACAATA CTGATTTGTT TTCTAAAAAG 
TACGTTGTTA TACCAATTAA CATAAGTTAT CATTGGTTTA GTTGCATTAT AACAAACTTG 
GATGCGATCT TGGATTTTCA TCAAAACAAA GATAAAAACG ATGCCATCAA CTCCGATGAG 
ATTTCTATAA ATAATCCTCT GGTTAATATT TTGACTTTCG ACTCGTTGAG GCAAACTCAT 
TCAAGAGAAA TTGATCCAAT AAAAGAATTT CTCATATCCT ATGCACTTGA TAAATATTCA 
ATTCAACTGG ATAAAACACA AATCAAAATG AAAACGTGTC CAGTTCCACA ACAACCTAAT 
ATGAGCGATT GTGGTGTTCA TGTTATTTTG AATATTAGAA AATTTTTTGA AAATCCGGTG 
GAAACAATTG ATGTATGGAA GAATTCTAAG ATTAAAAGTA AGCACTTCAC CGCAAAAATG 
ATTAATAAAT ATTTTGATAA AAATGAAAGA AATAGTGCGA GAAAGAATTT AAGGCATACT 
CTAAAACTCT TACAACTCAA TTACATCAGC TATCTGAAAA AAGAAAATTT ATATGAAGAA 
GTTATGCAAA TGGAGGAGAA AAAAAGCACC AATATCAACA ATAATGAAAA TTACGACGAT 
GACGATGAAG AAATTCAAAT CATTGAAAAT ATAGATCAAA GCAGTAAAGA TAATAACGCG 
CAGTTAACCT CGGAACCTCC CTGCTCACGA TCATCCAGTA TTTCAACAAC AGAAAGAGAG 
CCGACAGAGT TGCATAATTC CGTAGTACGA CAGCCCACCG GTGAAATAAT AACTGATAAT 
GAAGATCCCG TTCGCGCTGC TTCTCCAGAA ACAGCATCCG TTTCTCCTCC CATACGTCAC 
AATATTTTAA AGAGTTCATC TCCTTTCATA TCAGAAAGTG CGAATGAAAC TGAACAAGAA 
GAATTTACGT CACCATACTT TGGAAGGCCG TCTTTAAAGA CGAGGGCTAA GCAGTTTGAA 
GGCGTTTCGT CACCAATAAA AAACGATCAA GCCCTGTCAT CCACCCATGA TATTATGATG 
CCGTCGCCTA AACCTAAAAG GATTTACCCA AGCAAAAAAA TCCCACAACT TTCCTCGCAT 
GTTCAATCTC TATCGACTGA TTCTATGGAA CGCCAATCTA GTCCCAATAA TACCAACATT 
GTAATTTCAG ATACAGAACA AGATTCGAGG TTAGGAGTGA ATTCTGAAAG TAAAAATACT 
AGTGGTATTG TTAACAGGGA TGACTCGGAC GTCAATTTAA TTGGTAGTTC ACTACCTAAT 
GTAGCGGAAA AAAATCATGA CAACACTCAG GAAAGTAATG GTAATAATGA CAGTCTTGGT 
AAAATACTTC AAAATGTTGA CAAAGAACTG AACGAAAAGT TGGTTGATAT TGATGATGTG 
GCATTTAGTA GTCCAACTAG GGGTATTCCA AGAACCAGCG CGACAAGCAA GGGATCAAAT 
GCACAACTTC TCTCTAATTA TGGAGATGAA AATAACCAGT CTCAAGATTC TGTTTGGGAT 
GAGGGCAGAG ATAATCCTAT ACTCTTGGAA GATGAAGACC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.
Nature387(6632 Suppl)84-7(1997 May)
Churcher C,Bowman S,Badcock K,Bankier A,Brown D,Chillingworth T,Connor R,Devlin K,Gentles S,Hamlin N,Harris D,Horsnell T,Hunt S,Jagels K,Jones M,Lye G,Moule S,Odell C,Pearson D,Rajandream M,Rice P,Rowley N,Skelton J,Smith V,Barrell B

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

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ULP2 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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