Gene Symbol | DNL4 |
Entrez Gene ID | 854166 |
Full Name | DNA ligase (ATP) DNL4 |
Synonyms | LIG4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » DNL4 cDNA ORF clone
Gene Symbol | DNL4 |
Entrez Gene ID | 854166 |
Full Name | DNA ligase (ATP) DNL4 |
Synonyms | LIG4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183424.1 | NP_014647.1 | DNA ligase (ATP) DNL4 |
Rattus norvegicus (Norway rat) | Lig4 | NP_001099565.1 |
Drosophila melanogaster (fruit fly) | Lig4 | NP_572907.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_12899 | XP_003712808.1 |
Bos taurus (cattle) | LIG4 | NP_001178055.1 |
Saccharomyces cerevisiae (baker's yeast) | DNL4 | NP_014647.1 |
Eremothecium gossypii | AGOS_ACR008W | NP_983411.1 |
Gallus gallus (chicken) | LIG4 | NP_001025987.1 |
Kluyveromyces lactis | KLLA0D01089g | XP_453119.1 |
Neurospora crassa | NCU06264 | XP_962868.1 |
Mus musculus (house mouse) | Lig4 | NP_795927.2 |
Danio rerio (zebrafish) | lig4 | NP_001096593.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000623 | XP_310455.4 |
Arabidopsis thaliana (thale cress) | ATLIG4 | NP_568851.2 |
Homo sapiens (human) | LIG4 | NP_001091738.1 |
Pan troglodytes (chimpanzee) | LIG4 | XP_003314254.1 |
Canis lupus familiaris (dog) | LIG4 | XP_005634152.1 |
Schizosaccharomyces pombe (fission yeast) | lig4 | NP_587888.2 |
Xenopus tropicalis (tropical clawed frog) | lig4 | NP_001016981.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Dujon B, Albermann K, Aldea M, Alexandraki D, Ansorge W, Arino J, Benes V, Bohn C, Bolotin-Fukuhara M, Bordonn? R, Boyer J, Camasses A, Casamayor A, Casas C, Ch?ret G, Cziepluch C, Daignan-Fornier B, Dang DV, de Haan M, Delius H, Durand P, Fairhead C, Feldmann H, Gaillon L, Kleine K
Nature387(6632 Suppl)98-102(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study also uncovered an important role for Rev3 and Rev7 (but not for Pol32) subunits of polymerase z in the survival of cells undergoing telomere losses and forming palindromes
Title: Telomere Dysfunction Triggers Palindrome Formation Independently of Double-Strand Break Repair Mechanisms.
Dnl4 BRCT1 domain supports DNA double-strand breaks recruitment and NHEJ in a manner distinct from Lif1 binding and reveal a complexity of Dnl4 BRCT domain functions in support of stable DNA double-strand breaks association.
Title: Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding.
These findings indicate that Dnl4 can promote mutagenic end joining independently of its catalytic activity, likely by a mechanism that involves Cdc9.
Title: Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity.
lack of DNL4 rescues the short chronologic life span of the yme1 mutant.
Title: Accumulation of linear mitochondrial DNA fragments in the nucleus shortens the chronological life span of yeast.
Consistently, dnl4 cells displayed altered fork structures at the replication fork barrier, leading us to propose an as yet unrecognized role for Dnl4 in the maintenance of ribosomal DNA stability.
Title: DNA ligase 4 stabilizes the ribosomal DNA array upon fork collapse at the replication fork barrier.
The following DNL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi03320 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183424.1 | |
Accession Version | NM_001183424.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2835bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | DNA ligase (ATP) DNL4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001147). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGATATCAG CACTAGATTC TATACCCGAG CCCCAAAACT TTGCGCCTAG TCCAGATTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_014647.1 |
CDS | 1..2835 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001183424.1 |
1 | ATGATATCAG CACTAGATTC TATACCCGAG CCCCAAAACT TTGCGCCTAG TCCAGATTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV. |
Life with 6000 genes. |