Gene Symbol | DOA1 |
Entrez Gene ID | 853667 |
Full Name | Doa1p |
Synonyms | UFD3,ZZZ4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » DOA1 cDNA ORF clone
Gene Symbol | DOA1 |
Entrez Gene ID | 853667 |
Full Name | Doa1p |
Synonyms | UFD3,ZZZ4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001179778.1 | NP_012709.1 | Doa1p |
Gallus gallus (chicken) | PLAA | XP_424941.2 |
Danio rerio (zebrafish) | plaa | NP_997855.1 |
Schizosaccharomyces pombe (fission yeast) | lub1 | NP_596478.2 |
Arabidopsis thaliana (thale cress) | AT3G18860 | NP_850612.1 |
Homo sapiens (human) | PLAA | NP_001026859.1 |
Drosophila melanogaster (fruit fly) | Plap | NP_001245829.1 |
Neurospora crassa | NCU00880 | XP_964796.2 |
Canis lupus familiaris (dog) | PLAA | XP_531963.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008620 | XP_314716.4 |
PLAA | XP_001105698.1 | |
Bos taurus (cattle) | PLAA | NP_001098805.1 |
Saccharomyces cerevisiae (baker's yeast) | DOA1 | NP_012709.1 |
Eremothecium gossypii | AGOS_AER448W | NP_985303.2 |
Pan troglodytes (chimpanzee) | PLAA | XP_520517.2 |
Mus musculus (house mouse) | Plaa | NP_766283.2 |
Rattus norvegicus (Norway rat) | Plaa | NP_446318.3 |
Kluyveromyces lactis | KLLA0B14410g | XP_452172.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_14014 | XP_003721359.1 |
Xenopus tropicalis (tropical clawed frog) | plaa | NP_001116275.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete DNA sequence of yeast chromosome XI.
Dujon B, Alexandraki D, Andr? B, Ansorge W, Baladron V, Ballesta JP, Banrevi A, Bolle PA, Bolotin-Fukuhara M, Bossier P, Bou G, Boyer J, Bultrago MJ, Cheret G, Colleaux L, Dalgnan-Fornler B, del Rey F, Dlon C, Domdey H, D?sterhoft A, D?sterhus S, Entlan KD, Erfle H, Esteban PF, Feldmann H, Fernandes L, Robo GM, Fritz C, Fukuhara H, Gabel C, Gaillon L, Carcia-Cantalejo JM, Garcia-Ramirez JJ, Gent NE, Ghazvini M, Goffeau A, Gonzal?z A, Grothues D, Guerreiro P, Hegemann J, Hewitt N, Hilger F, Hollenberg CP, Horaitis O, Indge KJ, Jacquier A, James CM, Jauniaux C, Jimenez A, Keuchel H, Kirchrath L, Kleine K, K?tter P, Legrain P, Liebl S, Louis EJ, Maia e Silva A, Marck C, Monnier AL, M?stl D, M?ller S, Obermaier B, Oliver SG, Pallier C, Pascolo S, Pfeiffer F, Philippsen P, Planta RJ, Pohl FM, Pohl TM, P?hlmann R, Portetelle D, Purnelle B, Puzos V, Ramezani Rad M, Rasmussen SW, Remacha M, Revuelta JL, Richard GF, Rieger M, Rodrigues-Pousada C, Rose M, Rupp T, Santos MA, Schwager C, Sensen C, Skala J, Soares H, Sor F, Stegemann J, Tettelin H, Thierry A, Tzermia M, Urrestarazu LA, van Dyck L, Van Vliet-Reedijk JC, Valens M, Vandenbo M, Vilela C, Vissers S, von Wettstein D, Voss H, Wiemann S, Xu G, Zimmermann J, Haasemann M, Becker I, Mewes HW
Nature369(6479)371-8(1994 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Upon DNA damage Wss1/Cdc48/Doa1 ternary complex is recruited to sumoylated targets and catalyzes SUMO chain extension through a newly recognized SUMO ligase activity.
Title: Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates.
Small-angle X-ray scattering combined with molecular docking and biochemical analysis yield the solution structure of the Doa1/PFU:Hse1/SH3 complex and suggest that hydrogen bonding is a major determinant in the interaction of Doa1/PFU with Hse1/SH3.
Title: Molecular determinants of the interaction between Doa1 and Hse1 involved in endosomal sorting.
DOA1 is important for cell cycle entry by supplying ubiquitin, and the RAD6-BRE1 pathway functions downstream of DOA1/ubiquitin but upstream of CDC28, by promoting transcription of cyclins
Title: A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.
A structural comparison of Doa1 with Ufd2 revealed that they share a similar ARM-like repeat, supporting a model in which Doa1 and Ufd2 compete for Cdc48 binding and may dictate the fate of ubiquitinated proteins in the proteasome pathway
Title: Crystal structure of a PFU-PUL domain pair of Saccharomyces cerevisiae Doa1/Ufd3.
Data show that the yeast Ubp3-Bre5 deubiquitination complex interacts with both the chaperone-like Cdc48, a major actor of the ubiquitin and proteasome system, and Ufd3, a ubiquitin-binding cofactor of Cdc48.
Title: Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy.
The following DOA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DOA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi02887 | |
Clone ID Related Accession (Same CDS sequence) | NM_001179778.1 | |
Accession Version | NM_001179778.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2148bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Doa1p | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001143). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGGATATC AATTGAGTGC AACACTTAAA GGGCACGATC AGGACGTCAG GGATGTGGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_012709.1 |
CDS | 1..2148 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001179778.1 |
1 | ATGGGATATC AATTGAGTGC AACACTTAAA GGGCACGATC AGGACGTCAG GGATGTGGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete DNA sequence of yeast chromosome XI. |