Gene Symbol | MAD2 |
Entrez Gene ID | 853422 |
Full Name | spindle checkpoint protein MAD2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MAD2 cDNA ORF clone
Gene Symbol | MAD2 |
Entrez Gene ID | 853422 |
Full Name | spindle checkpoint protein MAD2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181464.3 | NP_012504.3 | spindle checkpoint protein MAD2 |
Danio rerio (zebrafish) | mad2l1 | NP_001017739.1 |
Kluyveromyces lactis | KLLA0D09438g | XP_453482.1 |
Pan troglodytes (chimpanzee) | MAD2L1 | XP_003310508.1 |
MAD2L1 | XP_001097054.2 | |
Saccharomyces cerevisiae (baker's yeast) | MAD2 | NP_012504.3 |
Eremothecium gossypii | AGOS_ACR043W | NP_983446.1 |
Gallus gallus (chicken) | MAD2L1 | NP_001264678.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08269 | XP_003715816.1 |
Arabidopsis thaliana (thale cress) | MAD2 | NP_189227.1 |
Homo sapiens (human) | MAD2L1 | NP_002349.1 |
Bos taurus (cattle) | MAD2L1 | NP_001178442.1 |
Mus musculus (house mouse) | Mad2l1 | NP_062372.2 |
Drosophila melanogaster (fruit fly) | mad2 | NP_647991.1 |
Schizosaccharomyces pombe (fission yeast) | mad2 | NP_596370.1 |
Oryza sativa (rice) | Os04g0486500 | NP_001053138.1 |
Canis lupus familiaris (dog) | LOC476070 | XP_533278.2 |
Rattus norvegicus (Norway rat) | Mad2l1 | NP_001100064.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000751 | XP_311286.5 |
Caenorhabditis elegans (roundworm) | mdf-2 | NP_001023563.1 |
Neurospora crassa | NCU05781 | XP_960041.2 |
Xenopus tropicalis (tropical clawed frog) | mad2l1 | NP_001096528.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L
The EMBO journal15(9)2031-49(1996 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mad2 recruitment to the kinetochore and it's role in the spindle assembly checkpoint
Title: Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions.
the very same dimerization interface of Mad2 is required for two different, yet fundamental, consecutive steps of SAC signaling: at the kinetochores for priming Cdc20/Mad2 binding, away from kinetochores for stabilizing this complex
Title: Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores.
Mad3 is required for the stable binding of Mad2 to Cdc20 in vivo, which is sufficient to inhibit APC activity and is the most downstream event in spindle checkpoint activation.
Title: Mad2 and Mad3 cooperate to arrest budding yeast in mitosis.
Mad2 is an important meiotic cell cycle regulator that ensures the timely degradation of anaphase-promoting complex substrates and the proper orchestration of the meiotic divisions
Title: The spindle checkpoint protein Mad2 regulates APC/C activity during prometaphase and metaphase of meiosis I in Saccharomyces cerevisiae.
cells need the normal Mad2:Mad1 ratio to respond to chromosomes that are not under tension.
Title: Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis.
The following MAD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi02679 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181464.3 | |
Accession Version | NM_001181464.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | spindle checkpoint protein MAD2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001142). On Jul 30, 2012 this sequence version replaced NM_001181464.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCACAAT CAATATCACT AAAGGGTTCA ACAAGGACAG TTACAGAATT TTTCGAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_012504.3 |
CDS | 1..591 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181464.3 |
1 | ATGTCACAAT CAATATCACT AAAGGGTTCA ACAAGGACAG TTACAGAATT TTTCGAGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. |