Gene Symbol | KAR2 |
Entrez Gene ID | 853418 |
Full Name | Hsp70 family ATPase KAR2 |
Synonyms | GRP78 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » KAR2 cDNA ORF clone
Gene Symbol | KAR2 |
Entrez Gene ID | 853418 |
Full Name | Hsp70 family ATPase KAR2 |
Synonyms | GRP78 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181468.3 | NP_012500.3 | Hsp70 family ATPase KAR2 |
Caenorhabditis elegans (roundworm) | hsp-4 | NP_495536.1 |
Schizosaccharomyces pombe (fission yeast) | bip1 | NP_593245.1 |
Arabidopsis thaliana (thale cress) | BIP1 | NP_198206.1 |
Homo sapiens (human) | HSPA5 | NP_005338.1 |
Rattus norvegicus (Norway rat) | Hspa5 | NP_037215.1 |
Danio rerio (zebrafish) | hspa5 | NP_998223.1 |
Neurospora crassa | NCU03982 | XP_956567.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100492570 | XP_002941690.1 |
HSPA5 | XP_001099110.1 | |
Canis lupus familiaris (dog) | HSPA5 | XP_863385.2 |
Bos taurus (cattle) | HSPA5 | NP_001068616.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004192 | XP_313085.3 |
Eremothecium gossypii | AGOS_ACR038W | NP_983441.1 |
Caenorhabditis elegans (roundworm) | hsp-3 | NP_509019.1 |
Saccharomyces cerevisiae (baker's yeast) | KAR2 | NP_012500.3 |
Kluyveromyces lactis | KLLA0D09559g | XP_453488.1 |
Arabidopsis thaliana (thale cress) | BIP2 | NP_851119.1 |
Pan troglodytes (chimpanzee) | HSPA5 | XP_520257.2 |
Mus musculus (house mouse) | Hspa5 | NP_001156906.1 |
Gallus gallus (chicken) | HSPA5 | NP_990822.1 |
Drosophila melanogaster (fruit fly) | Hsc70-3 | NP_727564.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_02503 | XP_003709308.1 |
Oryza sativa (rice) | Os02g0115900 | NP_001045675.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L
The EMBO journal15(9)2031-49(1996 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Increased endoplasmic reticulum glutathione import triggers H2O2-dependent Bip oxidation through Ero1 reductive activation, which inhibits glutathione import in a negative regulatory loop.
Title: Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip.
Here the authors demonstrate that BiP's nucleotide exchange factor - Sil1 - can reverse BiP cysteine oxidation.
Title: An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP.
The authors found that the ATPase activity displayed by unmodified Kar2 is fully maintained when Cys63 is replaced with Ala or Val.
Title: A Conserved Cysteine within the ATPase Domain of the Endoplasmic Reticulum Chaperone BiP is Necessary for a Complete Complement of BiP Activities.
the susceptibility of BiP to modification with glutathione may serve also to prevent irreversible oxidation of BiP by peroxide.
Title: Formation and Reversibility of BiP Protein Cysteine Oxidation Facilitate Cell Survival during and post Oxidative Stress.
Alteration of KAR2 (BiP) activity upon oxidation helps cells cope with disruption to oxidative folding within the endoplasmic reticulum during oxidative stress.
Title: Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress.
The following KAR2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KAR2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi02676 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181468.3 | |
Accession Version | NM_001181468.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Hsp70 family ATPase KAR2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001142). On Jul 30, 2012 this sequence version replaced NM_001181468.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTTTTTCA ACAGACTAAG CGCTGGCAAG CTGCTGGTAC CACTCTCCGT GGTCCTGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_012500.3 |
CDS | 1..2049 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181468.3 |
1 | ATGTTTTTCA ACAGACTAAG CGCTGGCAAG CTGCTGGTAC CACTCTCCGT GGTCCTGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. |