TRX2 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Br?ckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K
Nature387(6632 Suppl)81-4(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

In fibroblasts from TRX2 deficiency patient, an important role for reactive oxygen species was found for neuronal maintenance.
Title: Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.

Trx2 is required for maintaining the redox status in Saccharomyces cerevisiae under conditions of physiological stress.
Title: A fluorescence resonance energy transfer (FRET)-based redox sensor reveals physiological role of thioredoxin in the yeast Saccharomyces cerevisiae.

Trx2p is a new positive effector in the regulation of the Skn7p transcription factor that controls phosphorylation events and, modulates the oxidative stress response in yeast.
Title: Trx2p-dependent regulation of Saccharomyces cerevisiae oxidative stress response by the Skn7p transcription factor under respiring conditions.

TRX2 is required to maintain the IMS small Tim proteins in reduced forms and facilitate their mitochondrial import
Title: Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins.

Overexpression of TRX2 gene reduced oxidative cellular damage.
Title: Reduction of oxidative cellular damage by overexpression of the thioredoxin TRX2 gene improves yield and quality of wine yeast dry active biomass.