Gene Symbol | UBC4 |
Entrez Gene ID | 852376 |
Full Name | E2 ubiquitin-conjugating protein UBC4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » UBC4 cDNA ORF clone
Gene Symbol | UBC4 |
Entrez Gene ID | 852376 |
Full Name | E2 ubiquitin-conjugating protein UBC4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001178430.1 | NP_009638.1 | E2 ubiquitin-conjugating protein UBC4 |
Homo sapiens (human) | UBE2D2 | NP_003330.1 |
Pan troglodytes (chimpanzee) | UBE2D2 | XP_517968.1 |
Rattus norvegicus (Norway rat) | Ube2d2 | NP_001032369.1 |
Kluyveromyces lactis | KLLA0E12563g | XP_454516.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06562 | XP_003716978.1 |
Neurospora crassa | NCU02289 | XP_959933.2 |
LOC694667 | XP_002804584.1 | |
Canis lupus familiaris (dog) | UBE2D2 | XP_855983.1 |
Bos taurus (cattle) | UBE2D2 | NP_001039961.1 |
Mus musculus (house mouse) | Ube2d2a | NP_064296.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000145 | XP_310998.2 |
Caenorhabditis elegans (roundworm) | let-70 | NP_502065.1 |
Oryza sativa (rice) | Os09g0293400 | NP_001062791.1 |
Xenopus tropicalis (tropical clawed frog) | ube2d3 | NP_001016064.1 |
Gallus gallus (chicken) | UBE2D2 | XP_414470.4 |
Danio rerio (zebrafish) | zgc:77149 | NP_957253.1 |
Saccharomyces cerevisiae (baker's yeast) | UBC4 | NP_009638.1 |
Eremothecium gossypii | AGOS_AER173C | NP_985031.1 |
Schizosaccharomyces pombe (fission yeast) | ubc4 | NP_595283.1 |
Drosophila melanogaster (fruit fly) | eff | NP_001262578.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Complete DNA sequence of yeast chromosome II.
Feldmann H, Aigle M, Aljinovic G, Andr? B, Baclet MC, Barthe C, Baur A, B?cam AM, Biteau N, Boles E, Brandt T, Brendel M, Br?ckner M, Bussereau F, Christiansen C, Contreras R, Crouzet M, Cziepluch C, D?molis N, Delaveau T, Doignon F, Domdey H, D?sterhus S, Dubois E, Dujon B, El Bakkoury M, Entian KD, Feurmann M, Fiers W, Fobo GM, Fritz C, Gassenhuber H, Glandsdorff N, Goffeau A, Grivell LA, de Haan M, Hein C, Herbert CJ, Hollenberg CP, Holmstr?m K, Jacq C, Jacquet M, Jauniaux JC, Jonniaux JL, Kalles?e T, Kiesau P, Kirchrath L, K?tter P, Korol S, Liebl S, Logghe M, Lohan AJ, Louis EJ, Li ZY, Maat MJ, Mallet L, Mannhaupt G, Messenguy F, Miosga T, Molemans F, M?ller S, Nasr F, Obermaier B, Perea J, Pi?rard A, Piravandi E, Pohl FM, Pohl TM, Potier S, Proft M, Purnelle B, Ramezani Rad M, Rieger M, Rose M, Schaaff-Gerstenschl?ger I, Scherens B, Schwarzlose C, Skala J, Slonimski PP, Smits PH, Souciet JL, Steensma HY, Stucka R, Urrestarazu A, van der Aart QJ, van Dyck L, Vassarotti A, Vetter I, Vierendeels F, Vissers S, Wagner G, de Wergifosse P, Wolfe KH, Zagulski M, Zimmermann FK, Mewes HW, Kleine K
The EMBO journal13(24)5795-809(1994 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Together, these data point to an important role for Tom1, Ubc4 and Ubc5 in normal physiology and prompt the authors to refer to this pathway as ERISQ, for excess ribosomal protein quality control.
Title: A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins.
the UBA domain of Ubc1 ensures efficient polyubiquitination of substrate by balancing Ubc1 affinity with that of Ubc4
Title: An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.
Rad25 turnover requires the ubiquitin-conjugating enzyme Ubc4 and the ubiquitin ligase Ufd4.
Title: Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway.
The major ubiquitin ligase targeting the superfluous Fas2 subunit to the proteasome is Ubr1. The ubiquitin-conjugating enzymes Ubc2 and Ubc4 assist the degradation process.
Title: Quality control of a cytoplasmic protein complex: chaperone motors and the ubiquitin-proteasome system govern the fate of orphan fatty acid synthase subunit Fas2 of yeast.
Ubc4 and Ubc5 are 1) the primary E2s for Rsp5 in yeast and 2) act as monoubiquitinating E2s in RING E3-catalyzed pathways
Title: The essential Ubc4/Ubc5 function in yeast is HECT E3-dependent, and RING E3-dependent pathways require only monoubiquitin transfer by Ubc4.
The following UBC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01789 | |
Clone ID Related Accession (Same CDS sequence) | NM_001178430.1 | |
Accession Version | NM_001178430.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | E2 ubiquitin-conjugating protein UBC4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001134). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCTTCTT CTAAACGTAT TGCTAAAGAA CTAAGTGATC TAGAAAGAGA TCCACCTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_009638.1 |
CDS | 1..447 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001178430.1 |
1 | ATGTCTTCTT CTAAACGTAT TGCTAAAGAA CTAAGTGATC TAGAAAGAGA TCCACCTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
Complete DNA sequence of yeast chromosome II. |