APL3 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	APL3
Entrez Gene ID	852243
Full Name	Apl3p
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001178277.1	NP_009516.1	Apl3p

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0B12243g	XP_452075.1
Eremothecium gossypii	AGOS_ADL302W	NP_983794.1
Saccharomyces cerevisiae (baker's yeast)	APL3	NP_009516.1

Gene Ontology
Bibliography

Related articles in PubMed

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Complete DNA sequence of yeast chromosome II.
Feldmann H, Aigle M, Aljinovic G, Andr? B, Baclet MC, Barthe C, Baur A, B?cam AM, Biteau N, Boles E, Brandt T, Brendel M, Br?ckner M, Bussereau F, Christiansen C, Contreras R, Crouzet M, Cziepluch C, D?molis N, Delaveau T, Doignon F, Domdey H, D?sterhus S, Dubois E, Dujon B, El Bakkoury M, Entian KD, Feurmann M, Fiers W, Fobo GM, Fritz C, Gassenhuber H, Glandsdorff N, Goffeau A, Grivell LA, de Haan M, Hein C, Herbert CJ, Hollenberg CP, Holmstr?m K, Jacq C, Jacquet M, Jauniaux JC, Jonniaux JL, Kalles?e T, Kiesau P, Kirchrath L, K?tter P, Korol S, Liebl S, Logghe M, Lohan AJ, Louis EJ, Li ZY, Maat MJ, Mallet L, Mannhaupt G, Messenguy F, Miosga T, Molemans F, M?ller S, Nasr F, Obermaier B, Perea J, Pi?rard A, Piravandi E, Pohl FM, Pohl TM, Potier S, Proft M, Purnelle B, Ramezani Rad M, Rieger M, Rose M, Schaaff-Gerstenschl?ger I, Scherens B, Schwarzlose C, Skala J, Slonimski PP, Smits PH, Souciet JL, Steensma HY, Stucka R, Urrestarazu A, van der Aart QJ, van Dyck L, Vassarotti A, Vetter I, Vierendeels F, Vissers S, Wagner G, de Wergifosse P, Wolfe KH, Zagulski M, Zimmermann FK, Mewes HW, Kleine K
The EMBO journal13(24)5795-809(1994 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following APL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi01672	NM_001178277.1 Latest version!	Saccharomyces cerevisiae S288C Apl3p (APL3), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$629.30 $899.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

APL3 ( NM_001178277.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_009516.1 Saccharomyces cerevisiae S288C Apl3p (APL3), partial mRNA.

Price & Availability↑

CloneID	OSi01672
Clone ID Related Accession (Same CDS sequence)	NM_001178277.1
Accession Version	NM_001178277.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3078bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	Apl3p
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001134). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGGATCGCA AAAAAACACT TATAAACTCA AGTGTTTCTA ATAATAACAG TACCATCAAG 
GGCCTACAGT TATTCATTGC AGATCTTCGT TCTGCACAAC AAGCACAAGA GCAGGAAAAG 
AGAATACAAT CTGAAATTGT CAAAATTAAA CAGCATTTCG ATGCTGCAAA GAAAAAACAA 
GGCAATCACG ACAGATTAGG TGGCTATCAA AGAAAGAAGT ACGTTGCCAA GCTAGCCTAT 
ATATATATTA CTTCTAATAC GACAAAACTA AATGAAATTT TATTCGGGTT GGAGCAAACG 
GTAGAGCTGT TGAAGTCCAG CATATTTTCT GAAAAATTCA TTGGATATAT GACCCTTGAG 
TTGCTTTATG AACGTAGTGA AGTTGTTGCC AAAGTTAACG ATGAGGTGAA TTATCAACTG 
ATGAAAGATC TCTCTTCTTC CGATGATAAT TTCGTAATGT TGGCGCTGAA TTTTGTTGGT 
GTAGTAGGAG AACTTACGAA CCGTCTAGCG TACAACGATG ATATCACAAC AGGAGTATTC 
AAGATATTAA GATCACCGAC CTCCTCCATT TATCTCAAGA AAAAATCAGC ATTGTCATTT 
CTAGCACTAT TGAAAAGTAA TCATTCTATA CTGACCGAAG ATTTACAACG TAAGCAACTA 
TGGATACAAA GGATATTAAG CTTATTGGAT GATACGGAAA ACTATAGGTT AACTTTAGCT 
ACGATTCCGT TAATAGAATT CATTGCAAAA TACATTGATC CCAGTTACTG TACGAGACTA 
TTACCACAGC TAACAGAAAT TTTGTACAAT TGTGTTGTTG TTGGTACTTC AAGATCTAGT 
GACAATCAGT TTCCGTTAGA ATATACGTTC GCGAATATGC CAAATCCTTG GCTTATCACA 
AAAGTTGTCT CTTTGTTGAG CATATTGATT GCCTCACCAA CTGAGAGGGA TTCTGGCTCA 
TTACTACAAA CCAACAACAT AGATAATGAA TTACTAAATA AACTTCGAAA GTGTGTTTCC 
GTTGCCATCG AATTAGGAAC CAGACAAGCT CAAGATCCCA TGGAACGTAT CGTCCAAAAC 
ACAGTATTGT TTTCATTGAT CAATTTCGCC TCTAAGCTAG ATCCGTCGGA TGAAGCTATC 
AGCAATTCTG TGACAGCCTT ATGTTCCCTG CTAACATCTA AGGAAATTAA TATTCGGTAT 
TTAACGCTAG ATTCATTGGT CAAATTATGC TCATCAAGCG GGAAACCTGC AATTGATGCC 
GTTCGTTACA AGAATTTGGA TATGATTTTT CATCTTTTGA ACACAGAAAG AGATTCATCT 
ATTGTTAGGA AGGTTGTTGA CTTGTTATAT ACCTTTACTG ATGTTGAAAA CGTTAAGATT 
ATTGTGGACG GTTTACTGCA GTATATTTTA TCTCCGAAAA ATCTTGCTGA ACCGCAAATA 
AAATCTGATA TTGCAGTTAA AATAGCTATT TTGACCGAGA AATATGCCAC GGATATCAAT 
TGGTTTGTAA TTATTTCGTT GCAGTTGCTA TCATTAACTT CAAATACAAC TATTAACGAT 
GATGAGATCT GGCAACGACT ATGTCAAATT GTAGTGAACA ATCCATCTTT ACATAGAATA 
ACATGTGAAC GGTTGGTGGA CTATTTATGT AAAAAGCAAG CATCTGAAGC TATTATTAAA 
GCTGCGGCTT TTCTACTAGG GGAGTACTCA AGTCTCATAA CAGACAGGAT TTCAAGCGCA 
AATTTATTTA CTTTGTTTGC CGAGAAATAT TTTAGTGCAC CAAATGTGGC TAAGGCGATG 
ATATTGACTA CGATGATCAA GTTGTACAAG ACCTCACCTG AGATCGGCTC CAACGTCATC 
AAATTTTTCC AATTGGAATT GAACTCTCTT GATATTGAGT TGCAAACAAG ATCCTTCGAA 
TATCTCAACA TTATTCAACT GGCTAAGGTG AACGGAAATA CAGATATTTT GCAAATTTTA 
TTTGAACCAA TGCCGCCTTT TAACAGCAAA TCTAATCCAT TATTGAAGAG ATTAGGGTCA 
CTGCCGGCAT CAGCGGGTAG CACAACTTTA ATAAATACAC CATCCGAAGC ATCCTCCTCC 
ACGCCTGACT TACTATCAAA AAGAGCAAAC TCTTCCAGGT CGATCATGGT TCCCATGCCC 
CCACCATCTC GTAGGAACAC CATTGATGAT GTAAATTCCA AAATTAGTTC ATCTGAAGAC 
TTTTCAGGAA AGGACTCTTA TTATTCAAGG CAGATCCTCG CTCCAAATTG GAGGGAAGGT 
TTCACAAGAA TGATTTCGCA TAAGCAGGGT GTGCTTTTCA CATCATCTTT GATGAAAGTT 
TTCTATCGGA TAACCACTCC TGATGCACAA CAGCCATACG TGTTTCATAT ATCTCTTGCC 
TTCATTAACC TGACTGAGTG GGAAATCACG GGATTATCCA CACAGATTAT CCCTTCAAAA 
ACGCAAGGTA ATCCTGAGTA TTTAATTATG AATATTAATA CACCTTCTAC TGCTACTATT 
GGGCCCCATA AAAGGGCAGA GCAAAGCTAT GAAGTTTCAA TAAGAAAACC TTTCGACGTT 
GAAGATAGTC CAATTTTGGC AATTCATTTC AAATGTGGCG GTAGTACAAA CACTATCAAT 
TTGAAAACTG CCATAGGCAT GACTACAACA CTAATTAGCA GCGATGTCAA TCCTAGCATG 
CATTTGAATT TGGCACAGTT CATCAGCCGT TGGAAGACTT TGAGCGATGC TTTGGGAAAA 
GAGGGAGAAT ACCAAAAATC TGGCATAAAG CTCAACAAGG ATTTTAGAAA AGTTGAAACA 
ATCAGTTTAG AAGACGGACT TCTACTATTG ACGCAAACAG TGAAGAGGTT GGGCTTTGAT 
ATAGTCGATC AGACCAGTGT TCGTAGTACA TTGTTTGTCT CGGGTATTAT TCATACGAAA 
AGTGAGGGAA ACTTCGGTTG TTTAATGAAG ATACAATACC AGGTAAATGG AACAGTTAAT 
GTTACCTGTA AAACAACGAC GGCCGGTCCC CTGGCGAAGT ACATTGTCGA ATGTATAAAG 
AATGTGCTTA CGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009516.1
CDS	1..3078
Translation	MDRKKTLINSSVSNNNSTIKGLQLFIADLRSAQQAQEQEKRIQSEIVKIKQHFDAAKKKQGNHDRLGGYQRKKYVAKLAYIYITSNTTKLNEILFGLEQTVELLKSSIFSEKFIGYMTLELLYERSEVVAKVNDEVNYQLMKDLSSSDDNFVMLALNFVGVVGELTNRLAYNDDITTGVFKILRSPTSSIYLKKKSALSFLALLKSNHSILTEDLQRKQLWIQRILSLLDDTENYRLTLATIPLIEFIAKYIDPSYCTRLLPQLTEILYNCVVVGTSRSSDNQFPLEYTFANMPNPWLITKVVSLLSILIASPTERDSGSLLQTNNIDNELLNKLRKCVSVAIELGTRQAQDPMERIVQNTVLFSLINFASKLDPSDEAISNSVTALCSLLTSKEINIRYLTLDSLVKLCSSSGKPAIDAVRYKNLDMIFHLLNTERDSSIVRKVVDLLYTFTDVENVKIIVDGLLQYILSPKNLAEPQIKSDIAVKIAILTEKYATDINWFVIISLQLLSLTSNTTINDDEIWQRLCQIVVNNPSLHRITCERLVDYLCKKQASEAIIKAAAFLLGEYSSLITDRISSANLFTLFAEKYFSAPNVAKAMILTTMIKLYKTSPEIGSNVIKFFQLELNSLDIELQTRSFEYLNIIQLAKVNGNTDILQILFEPMPPFNSKSNPLLKRLGSLPASAGSTTLINTPSEASSSTPDLLSKRANSSRSIMVPMPPPSRRNTIDDVNSKISSSEDFSGKDSYYSRQILAPNWREGFTRMISHKQGVLFTSSLMKVFYRITTPDAQQPYVFHISLAFINLTEWEITGLSTQIIPSKTQGNPEYLIMNINTPSTATIGPHKRAEQSYEVSIRKPFDVEDSPILAIHFKCGGSTNTINLKTAIGMTTTLISSDVNPSMHLNLAQFISRWKTLSDALGKEGEYQKSGIKLNKDFRKVETISLEDGLLLLTQTVKRLGFDIVDQTSVRSTLFVSGIIHTKSEGNFGCLMKIQYQVNGTVNVTCKTTTAGPLAKYIVECIKNVLTK

Target ORF information:

RefSeq Version	NM_001178277.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C Apl3p (APL3), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001178277.1

ORF Insert Sequence:

ATGGATCGCA AAAAAACACT TATAAACTCA AGTGTTTCTA ATAATAACAG TACCATCAAG 
GGCCTACAGT TATTCATTGC AGATCTTCGT TCTGCACAAC AAGCACAAGA GCAGGAAAAG 
AGAATACAAT CTGAAATTGT CAAAATTAAA CAGCATTTCG ATGCTGCAAA GAAAAAACAA 
GGCAATCACG ACAGATTAGG TGGCTATCAA AGAAAGAAGT ACGTTGCCAA GCTAGCCTAT 
ATATATATTA CTTCTAATAC GACAAAACTA AATGAAATTT TATTCGGGTT GGAGCAAACG 
GTAGAGCTGT TGAAGTCCAG CATATTTTCT GAAAAATTCA TTGGATATAT GACCCTTGAG 
TTGCTTTATG AACGTAGTGA AGTTGTTGCC AAAGTTAACG ATGAGGTGAA TTATCAACTG 
ATGAAAGATC TCTCTTCTTC CGATGATAAT TTCGTAATGT TGGCGCTGAA TTTTGTTGGT 
GTAGTAGGAG AACTTACGAA CCGTCTAGCG TACAACGATG ATATCACAAC AGGAGTATTC 
AAGATATTAA GATCACCGAC CTCCTCCATT TATCTCAAGA AAAAATCAGC ATTGTCATTT 
CTAGCACTAT TGAAAAGTAA TCATTCTATA CTGACCGAAG ATTTACAACG TAAGCAACTA 
TGGATACAAA GGATATTAAG CTTATTGGAT GATACGGAAA ACTATAGGTT AACTTTAGCT 
ACGATTCCGT TAATAGAATT CATTGCAAAA TACATTGATC CCAGTTACTG TACGAGACTA 
TTACCACAGC TAACAGAAAT TTTGTACAAT TGTGTTGTTG TTGGTACTTC AAGATCTAGT 
GACAATCAGT TTCCGTTAGA ATATACGTTC GCGAATATGC CAAATCCTTG GCTTATCACA 
AAAGTTGTCT CTTTGTTGAG CATATTGATT GCCTCACCAA CTGAGAGGGA TTCTGGCTCA 
TTACTACAAA CCAACAACAT AGATAATGAA TTACTAAATA AACTTCGAAA GTGTGTTTCC 
GTTGCCATCG AATTAGGAAC CAGACAAGCT CAAGATCCCA TGGAACGTAT CGTCCAAAAC 
ACAGTATTGT TTTCATTGAT CAATTTCGCC TCTAAGCTAG ATCCGTCGGA TGAAGCTATC 
AGCAATTCTG TGACAGCCTT ATGTTCCCTG CTAACATCTA AGGAAATTAA TATTCGGTAT 
TTAACGCTAG ATTCATTGGT CAAATTATGC TCATCAAGCG GGAAACCTGC AATTGATGCC 
GTTCGTTACA AGAATTTGGA TATGATTTTT CATCTTTTGA ACACAGAAAG AGATTCATCT 
ATTGTTAGGA AGGTTGTTGA CTTGTTATAT ACCTTTACTG ATGTTGAAAA CGTTAAGATT 
ATTGTGGACG GTTTACTGCA GTATATTTTA TCTCCGAAAA ATCTTGCTGA ACCGCAAATA 
AAATCTGATA TTGCAGTTAA AATAGCTATT TTGACCGAGA AATATGCCAC GGATATCAAT 
TGGTTTGTAA TTATTTCGTT GCAGTTGCTA TCATTAACTT CAAATACAAC TATTAACGAT 
GATGAGATCT GGCAACGACT ATGTCAAATT GTAGTGAACA ATCCATCTTT ACATAGAATA 
ACATGTGAAC GGTTGGTGGA CTATTTATGT AAAAAGCAAG CATCTGAAGC TATTATTAAA 
GCTGCGGCTT TTCTACTAGG GGAGTACTCA AGTCTCATAA CAGACAGGAT TTCAAGCGCA 
AATTTATTTA CTTTGTTTGC CGAGAAATAT TTTAGTGCAC CAAATGTGGC TAAGGCGATG 
ATATTGACTA CGATGATCAA GTTGTACAAG ACCTCACCTG AGATCGGCTC CAACGTCATC 
AAATTTTTCC AATTGGAATT GAACTCTCTT GATATTGAGT TGCAAACAAG ATCCTTCGAA 
TATCTCAACA TTATTCAACT GGCTAAGGTG AACGGAAATA CAGATATTTT GCAAATTTTA 
TTTGAACCAA TGCCGCCTTT TAACAGCAAA TCTAATCCAT TATTGAAGAG ATTAGGGTCA 
CTGCCGGCAT CAGCGGGTAG CACAACTTTA ATAAATACAC CATCCGAAGC ATCCTCCTCC 
ACGCCTGACT TACTATCAAA AAGAGCAAAC TCTTCCAGGT CGATCATGGT TCCCATGCCC 
CCACCATCTC GTAGGAACAC CATTGATGAT GTAAATTCCA AAATTAGTTC ATCTGAAGAC 
TTTTCAGGAA AGGACTCTTA TTATTCAAGG CAGATCCTCG CTCCAAATTG GAGGGAAGGT 
TTCACAAGAA TGATTTCGCA TAAGCAGGGT GTGCTTTTCA CATCATCTTT GATGAAAGTT 
TTCTATCGGA TAACCACTCC TGATGCACAA CAGCCATACG TGTTTCATAT ATCTCTTGCC 
TTCATTAACC TGACTGAGTG GGAAATCACG GGATTATCCA CACAGATTAT CCCTTCAAAA 
ACGCAAGGTA ATCCTGAGTA TTTAATTATG AATATTAATA CACCTTCTAC TGCTACTATT 
GGGCCCCATA AAAGGGCAGA GCAAAGCTAT GAAGTTTCAA TAAGAAAACC TTTCGACGTT 
GAAGATAGTC CAATTTTGGC AATTCATTTC AAATGTGGCG GTAGTACAAA CACTATCAAT 
TTGAAAACTG CCATAGGCAT GACTACAACA CTAATTAGCA GCGATGTCAA TCCTAGCATG 
CATTTGAATT TGGCACAGTT CATCAGCCGT TGGAAGACTT TGAGCGATGC TTTGGGAAAA 
GAGGGAGAAT ACCAAAAATC TGGCATAAAG CTCAACAAGG ATTTTAGAAA AGTTGAAACA 
ATCAGTTTAG AAGACGGACT TCTACTATTG ACGCAAACAG TGAAGAGGTT GGGCTTTGAT 
ATAGTCGATC AGACCAGTGT TCGTAGTACA TTGTTTGTCT CGGGTATTAT TCATACGAAA 
AGTGAGGGAA ACTTCGGTTG TTTAATGAAG ATACAATACC AGGTAAATGG AACAGTTAAT 
GTTACCTGTA AAACAACGAC GGCCGGTCCC CTGGCGAAGT ACATTGTCGA ATGTATAAAG 
AATGTGCTTA CGAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

Complete DNA sequence of yeast chromosome II.
The EMBO journal13(24)5795-809(1994 Dec)
Feldmann H,Aigle M,Aljinovic G,Andr? B,Baclet MC,Barthe C,Baur A,B?cam AM,Biteau N,Boles E,Brandt T,Brendel M,Br?ckner M,Bussereau F,Christiansen C,Contreras R,Crouzet M,Cziepluch C,D?molis N,Delaveau T,Doignon F,Domdey H,D?sterhus S,Dubois E,Dujon B,El Bakkoury M,Entian KD,Feurmann M,Fiers W,Fobo GM,Fritz C,Gassenhuber H,Glandsdorff N,Goffeau A,Grivell LA,de Haan M,Hein C,Herbert CJ,Hollenberg CP,Holmstr?m K,Jacq C,Jacquet M,Jauniaux JC,Jonniaux JL,Kalles?e T,Kiesau P,Kirchrath L,K?tter P,Korol S,Liebl S,Logghe M,Lohan AJ,Louis EJ,Li ZY,Maat MJ,Mallet L,Mannhaupt G,Messenguy F,Miosga T,Molemans F,M?ller S,Nasr F,Obermaier B,Perea J,Pi?rard A,Piravandi E,Pohl FM,Pohl TM,Potier S,Proft M,Purnelle B,Ramezani Rad M,Rieger M,Rose M,Schaaff-Gerstenschl?ger I,Scherens B,Schwarzlose C,Skala J,Slonimski PP,Smits PH,Souciet JL,Steensma HY,Stucka R,Urrestarazu A,van der Aart QJ,van Dyck L,Vassarotti A,Vetter I,Vierendeels F,Vissers S,Wagner G,de Wergifosse P,Wolfe KH,Zagulski M,Zimmermann FK,Mewes HW,Kleine K

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APL3 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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