Gene Symbol | GCN2 |
Entrez Gene ID | 851877 |
Full Name | serine/threonine-protein kinase GCN2 |
Synonyms | AAS1,AAS102,NDR2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » GCN2 cDNA ORF clone
Gene Symbol | GCN2 |
Entrez Gene ID | 851877 |
Full Name | serine/threonine-protein kinase GCN2 |
Synonyms | AAS1,AAS102,NDR2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180591.3 | NP_010569.3 | serine/threonine-protein kinase GCN2 |
Pan troglodytes (chimpanzee) | EIF2AK4 | XP_001140245.1 |
EIF2AK4 | XP_002804763.1 | |
Gallus gallus (chicken) | EIF2AK4 | XP_004941777.1 |
Eremothecium gossypii | AGOS_AAL083W | NP_982459.1 |
Rattus norvegicus (Norway rat) | Eif2ak4 | NP_001099214.2 |
Danio rerio (zebrafish) | eif2ak4 | XP_002667149.3 |
Drosophila melanogaster (fruit fly) | Gcn2 | NP_001263141.1 |
Saccharomyces cerevisiae (baker's yeast) | GCN2 | NP_010569.3 |
Kluyveromyces lactis | KLLA0C10802g | XP_452681.1 |
Neurospora crassa | NCU01187 | XP_961553.1 |
Xenopus tropicalis (tropical clawed frog) | eif2ak4 | NP_001243855.1 |
Homo sapiens (human) | EIF2AK4 | NP_001013725.2 |
Canis lupus familiaris (dog) | EIF2AK4 | XP_535431.3 |
Bos taurus (cattle) | EIF2AK4 | XP_002690831.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012368 | XP_320188.4 |
Caenorhabditis elegans (roundworm) | gcn-2 | NP_001254370.1 |
Schizosaccharomyces pombe (fission yeast) | gcn2 | NP_595991.2 |
Mus musculus (house mouse) | Eif2ak4 | NP_038747.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_08643 | XP_003711074.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
GCN2 is required for nitrogen catabolite repression-sensitive nuclear Gln3 localization. Gcn2 functions upstream of Ure2.
Title: General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization.
findings demonstrate that TORC1 is an effector of Gcn2 in amino acid signaling, hence defining a novel mechanism by which TORC1 senses amino acid starvation
Title: General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in
To mediate the activation of protein kinase Gcn2, Gcn1 interacts with Rps10.
Title: Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2.
Mutations leading to amino acid substitutions on this surface were identified that activate Gcn2 at low levels of tRNA binding (Gcd- phenotype), while other substitutions block kinase activation (Gcn- phenotype
Title: Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.
Gcd- substitutions enhance YKD-KD interactions in vitro, whereas Gcn- substitutions in alphaE and alphaI suppress both this effect and the constitutive activation of Gcn2 conferred by YKD Gcd- substitutions
Title: Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2? phosphorylation in starved cells.
The following GCN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GCN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01361 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180591.3 | |
Accession Version | NM_001180591.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4980bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | serine/threonine-protein kinase GCN2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). On Jul 30, 2012 this sequence version replaced NM_001180591.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCATTGA GTCATCTCAC TTTAGATCAA TATTATGAAA TACAGTGCAA CGAACTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010569.3 |
CDS | 1..4980 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180591.3 |
1 | ATGTCATTGA GTCATCTCAC TTTAGATCAA TATTATGAAA TACAGTGCAA CGAACTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |