Gene Symbol | MPS1 |
Entrez Gene ID | 851533 |
Full Name | serine/threonine/tyrosine protein kinase MPS1 |
Synonyms | PAC8,RPK1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MPS1 cDNA ORF clone
Gene Symbol | MPS1 |
Entrez Gene ID | 851533 |
Full Name | serine/threonine/tyrosine protein kinase MPS1 |
Synonyms | PAC8,RPK1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180087.2 | NP_010256.2 | serine/threonine/tyrosine protein kinase MPS1 |
Saccharomyces cerevisiae (baker's yeast) | MPS1 | NP_010256.2 |
Eremothecium gossypii | AGOS_ADR317C | NP_984413.2 |
Kluyveromyces lactis | KLLA0C03828g | XP_452367.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CCT271850 is a potent, selective and orally bioavailable MPS1 kinase inhibitor. On the basis of in vivo pharmacodynamic vs efficacy relationships, we predict that more than 80% inhibition of MPS1 activity for at least 24 h is required to achieve tumour stasis or regression by CCT271850.
Title: Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
These findings highlight MPS1 as a rational therapeutic target for medulloblastoma
Title: MPS1 kinase as a potential therapeutic target in medulloblastoma.
An important role for Mps1 phosphorylation in the spindle assembly checkpoint activation, beyond the direct recruitment of Mad1 and Mad2.
Title: Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions.
Mps1 kinase controls Cnn1 localization and activity at kinetochores through the cell cycle.
Title: The Mps1 kinase modulates the recruitment and activity of Cnn1(CENP-T) at Saccharomyces cerevisiae kinetochores.
Disrupting Mps1 before mitotic entry reduces chromosomal passenger complex (CPC) localization to the centromere. Mps1 plays a minimal role in maintaining CPC localization once cells are in mitosis.
Title: Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.
The following MPS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MPS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01070 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180087.2 | |
Accession Version | NM_001180087.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2295bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | serine/threonine/tyrosine protein kinase MPS1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). On Apr 26, 2011 this sequence version replaced NM_001180087.1. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCAACAA ACTCATTCCA TGATTATGTG GATTTAAAAT CGAGAACTAA TACACGACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010256.2 |
CDS | 1..2295 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180087.2 |
1 | ATGTCAACAA ACTCATTCCA TGATTATGTG GATTTAAAAT CGAGAACTAA TACACGACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |