Gene Symbol | POL3 |
Entrez Gene ID | 851456 |
Full Name | DNA-directed DNA polymerase delta POL3 |
Synonyms | CDC2,HPR6,TEX1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » POL3 cDNA ORF clone
Gene Symbol | POL3 |
Entrez Gene ID | 851456 |
Full Name | DNA-directed DNA polymerase delta POL3 |
Synonyms | CDC2,HPR6,TEX1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180161.2 | NP_010181.2 | DNA-directed DNA polymerase delta POL3 |
Homo sapiens (human) | POLD1 | NP_001243778.1 |
Saccharomyces cerevisiae (baker's yeast) | POL3 | NP_010181.2 |
Xenopus tropicalis (tropical clawed frog) | pold1 | NP_001039204.1 |
Rattus norvegicus (Norway rat) | Pold1 | NP_067694.1 |
Danio rerio (zebrafish) | pold1 | NP_001034899.1 |
Neurospora crassa | NCU01192 | XP_961558.1 |
Bos taurus (cattle) | POLD1 | NP_776852.1 |
Mus musculus (house mouse) | Pold1 | NP_035261.3 |
Drosophila melanogaster (fruit fly) | DNApol-delta | NP_524099.2 |
Caenorhabditis elegans (roundworm) | F10C2.4 | NP_506017.1 |
Arabidopsis thaliana (thale cress) | EMB2780 | NP_201201.2 |
Oryza sativa (rice) | Os11g0186400 | NP_001067405.1 |
POLD1 | XP_001116065.1 | |
Canis lupus familiaris (dog) | POLD1 | XP_851285.1 |
Schizosaccharomyces pombe (fission yeast) | cdc6 | NP_596124.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08071 | XP_003715024.1 |
Pan troglodytes (chimpanzee) | POLD1 | XP_003316601.2 |
Kluyveromyces lactis | KLLA0E01607g | XP_454020.1 |
Eremothecium gossypii | AGOS_AFL189W | NP_985361.2 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Induced and spontaneous mutagenesis in pol3-13 mutant yeast strains and its dependence on theREV3 gene, encoding the catalytic subunit of pol delta were studied. The defect in coordination of the Fe-S cluster in pol delta conferred by the pol3-13 mutation abolishes UV-mutagenesis, but found that it elevates the incidence of spontaneous Rev3-dependent base-substitution mutations and deletions.
Title: Defect of Fe-S cluster binding by DNA polymerase ? in yeast suppresses UV-induced mutagenesis, but enhances DNA polymerase ? - dependent spontaneous mutagenesis.
genetic studies with Pol3 and Pol2 mutator alleles support the conclusion that Poldelta, and not Polepsilon, is the major DNA polymerase for carrying out both leading and lagging DNA synthesis
Title: A Major Role of DNA Polymerase ? in Replication of Both the Leading and Lagging DNA Strands.
The effect of mutations in beta hairpin structure in POL3 on its proofreading DNA polymerase 3'-->5' exonuclease activity is studied.
Title: DNA polymerase 3'?5' exonuclease activity: Different roles of the beta hairpin structure in family-B DNA polymerases.
Poldelta-R696W promotes its own infidelity by expansion of dNTP pools
Title: Colon cancer-associated mutator DNA polymerase ? variant causes expansion of dNTP pools increasing its own infidelity.
Study finds that wild-type Pol epsilon molecules cannot proofread errors created by proofreading-defective Pol epsilon molecules, whereas Pol delta can not only proofread errors created by proofreading-defective Pol delta molecules, but can also proofread errors created by Pol epsilon-defective molecules.
Title: Replicative DNA polymerase ? but not ? proofreads errors in Cis and in Trans.
The following POL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01004 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180161.2 | |
Accession Version | NM_001180161.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3294bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | DNA-directed DNA polymerase delta POL3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). On Apr 26, 2011 this sequence version replaced NM_001180161.1. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAGTGAAA AAAGATCCCT TCCCATGGTT GATGTGAAGA TCGATGACGA GGATACTCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010181.2 |
CDS | 1..3294 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180161.2 |
1 | ATGAGTGAAA AAAGATCCCT TCCCATGGTT GATGTGAAGA TCGATGACGA GGATACTCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |