CDC13 cDNA ORF clone, Saccharomyces cerevisiae S288C

Gene
Clones
gRNAs

Summary

Gene Symbol	CDC13
Entrez Gene ID	851306
Full Name	telomere-binding protein CDC13
Synonyms	EST4
Gene Type	protein-coding
Organism	Saccharomyces cerevisiae S288C

mRNA and Protein(s)

mRNA	Protein	Name
NM_001180280.1	NP_010061.1	telomere-binding protein CDC13

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0F20922g	XP_456019.1
Saccharomyces cerevisiae (baker's yeast)	CDC13	NP_010061.1
Eremothecium gossypii	AGOS_ABL155C	NP_982792.1

Gene Ontology
Bibliography

Related articles in PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that by controlling the timing of Cdc13 and Stn1 phosphorylations, Cdk1 regulates the temporal recruitment of telomerase complexes and Cdc13-Stn1-Ten1 (CST) complexes to the telomeres to facilitate telomere maintenance.
Title: Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.

The core Cdc13 ssDNA-binding activity is wholly contained within a single tight-binding oligosaccharide/oligonucleotide/oligopeptide binding (OB)-fold.
Title: The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain.

regulated binding of Cdc13 to chromosome termini dictates subsequent interaction of a recruitment-competent telomerase complex with telomeres
Title: A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.

Dimerization of the OB2 domain of Cdc13 is required for proper Cdc13, Stn1, Ten1 (CST) assembly and productive telomere capping.
Title: Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance.

Cdc13, and a S314D mutation negatively affected telomere length. Our findings provide new targets in Cdc13 - a key telomerase regulatory protein for modulation of telomere dynamics
Title: Novel phosphorylation sites in the S. cerevisiae Cdc13 protein reveal new targets for telomere length regulation.

The following CDC13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSi00870	NM_001180280.1 Latest version!	Saccharomyces cerevisiae S288C telomere-binding protein CDC13 (CDC13), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDC13 ( NM_001180280.1 ) cDNA ORF clone, Saccharomyces cerevisiae S288C -> NP_010061.1 Saccharomyces cerevisiae S288C telomere-binding protein CDC13 (CDC13), partial mRNA.

Price & Availability↑

CloneID	OSi00870
Clone ID Related Accession (Same CDS sequence)	NM_001180280.1
Accession Version	NM_001180280.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2775bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-31
Organism	Saccharomyces cerevisiae S288C
Product	telomere-binding protein CDC13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends.

ATGGATACCT TAGAAGAGCC TGAGTGTCCT CCACATAAAA ATCGTATTTT TGTGAGCTCG 
AGTAAAGATT TTGAAGGCTA TCCCAGCAAA GCAATAGTTC CCGTGCAATT CGTGGCGCTT 
TTAACCTCAA TACACCTGAC TGAAACAAAA TGTTTGCTAG GCTTTTCTAA TTTTGAGAGG 
CGAGGAGATC AATCCCAAGA AGATCAATAT TTAATCAAAC TGAAGTTCAA AGATAGGGGC 
TCGGAGAGGT TAGCCCGGAT CACTATTTCC TTACTTTGCC AATACTTTGA TATTGAACTG 
CCAGATTTAG ATTCTGACTC AGGCGCATCC CCAACAGTAA TACTGAGAGA TATTCACCTT 
GAAAGGTTAT GTTTTTCAAG TTGTAAAGCT TTATATGTAT CAAAACACGG GAACTATACT 
CTATTCTTAG AGGACATAAA ACCGTTGGAT TTGGTAAGTG TGATAAGCAC CATATCTACA 
AAATCGACAA ATAGCAGCAA GCATTCGTCA TCAGAACTTA TTTCAGAATG TGATTTGAAC 
AACTCACTTG TGGATATCTT CAACAATTTA ATAGAAATGA ATAGAGACGA GAAAAACAGG 
TTTAAATTTG TAAAGTTGAT TCACTACGAT ATAGAACTAA AAAAGTTCGT TCAAGACCAA 
CAAAAGGTAT TATCGCAGAA ATCAAAAGCC GCAGCAATTA ATCCTTTCTT TGTGCCAAAT 
AGACTAGGGA TACCTTACAT TGAATCCCAA AACGAATTCA ACTCGCAGCT TATGACGCTT 
AATGTAGATG AACCGACCAC AGATATAAGC AACATGGGAG AGGAAATGCA TGACAGCGCA 
GATCCCATTG AGGATTCAGA TTCCTCAACT ACCTCCTCTA CCGGGAAATA TTTCAGCTCA 
AAATCCTACA TCCAGTCACA GACACCTGAA AGGAAAACAA GCGTACCAAA TAATTGGCAC 
GATGATGATT CCGGAAGCAA GAGGAAGAGA AAGCTTTCTT TCCACAGTCC GAACGCGTCC 
TCAATCCGCA AAGCCATCAG TTATGAGCAA CTTTCCCTAG CTAGTGTAGG CTCAGTTGAA 
AGGTTAGAGG GCAAAATTGT TGGCATGAAT CCACCTCAAT TCGCCAGTAT AAATGAGTTC 
AAATATTGCA CATTGAAATT ATATTTTACG CAGCTCTTAC CAAATGTCCC AGACAAGGTC 
CTGGTGCCAG GCGTCAATTG CATTGAGATC GTTATCCCGA CGAGAGAGCG AATCTGTGAG 
CTCTTCGGTG TTTTAAACTG TCAAAGCGAC AAGATATCGG ATATTTTACT ACTGGAAAAG 
CCTGATCGAA TTTCCGTCGA AGTTGAAAGG ATCCTGTGGG ACAATGACAA GACCGCCAGC 
CCAGGTATGG CAGTATGGAG TTTGAAGAAC ATTAGCACCG ACACGCAGGC GCAGGCGCAG 
GTGCAGGTGC CTGCGCAATC GTCGGCGTCA ATCGATCCGT CTCGCACAAG GATGAGCAAA 
ATGGCAAGGA AAGACCCCAC CATCGAATTC TGTCAGTTGG GACTCGACAC TTTTGAGACC 
AAATACATAA CAATGTTTGG CATGCTAGTC TCCTGCTCGT TTGATAAACC TGCCTTTATA 
TCTTTTGTCT TTAGCGATTT TACCAAGAAC GATATCGTCC AAAACTATCT TTACGACAGA 
TATCTAATAG ATTACGAGAA CAAGTTAGAG CTGAACGAGG GCTTCAAAGC CATCATGTAC 
AAAAACCAAT TCGAAACGTT TGACTCTAAG CTCAGAAAAA TATTCAACAA CGGGCTAAGA 
GATCTACAGA ACGGCCGCGA TGAAAACCTT TCGCAATACG GCATAGTTTG TAAGATGAAT 
ATAAAAGTGA AAATGTACAA CGGCAAATTG AATGCCATTG TGCGCGAATG TGAGCCGGTC 
CCGCATTCCC AAATAAGCAG CATCGCCTCG CCTTCACAGT GCGAACATTT AAGATTGTTC 
TACCAACGAG CGTTCAAGAG AATTGGCGAA TCCGCAATTT CACGCTATTT CGAAGAGTAC 
CGGAGGTTTT TCCCCATACA TAGAAACGGT TCTCATCTCG CGAAACTGAG GTTCGATGAA 
GTAAAGCATG AACCAAAAAA ATCACCCACT ACACCAGCTC TCGCAGAACA CATACCCGAC 
CTGAATGCAG ACGTGTCCTC CTTCGATGTA AAGTTCACAG ATATATCTTC TCTCTTGGAC 
TCCTCGGCTC GCCTCCCGCG CCCACAGCAA ACACACAAGA GCAACACATT ATACAGTTGC 
GAGGGCCGTA TCATCGCCAT CGAGTACCAC GCATCTGATC TCTGCTTCCA TATCACGAAT 
GAGCTCCCAC TTTTACAAAC CCGCGGCTTG GCCCCGGAGC GAGTGTTGCA ACTACACATC 
ATTACCTCCA AGAACTTTGC TTATTTTTTC AACCGCTCAA GCGCCTACTT ACAGCGTCAG 
CCTCTTGAGG AAAAATATAC GCAATTGGCA CAATTTCTCG GCCATTCATT TAAATTCAAT 
ATAACCTCCT CGCTCACGCT GTTCCCTGAC ACTACCGTGG CACTCCAGAT CTGGTGCCCA 
ATTGAATGCA CCTTTCGGGA ATTGCAACAA CAGCTGGCCC ATCCGAAGGT TGCAGCGGCT 
CCTGATTCAG GGAGTCTTGA TTGCGCAATT AATGCTACCG TCAATCCTCT GCGACTTCTT 
GCCGCGCAAA ATGGCGTCAC CGTGAAAAAG GAGGAGGATA ATGACGATGA CGCCGGAGCC 
GTTCCCACCT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_010061.1
CDS	1..2775
Translation	MDTLEEPECPPHKNRIFVSSSKDFEGYPSKAIVPVQFVALLTSIHLTETKCLLGFSNFERRGDQSQEDQYLIKLKFKDRGSERLARITISLLCQYFDIELPDLDSDSGASPTVILRDIHLERLCFSSCKALYVSKHGNYTLFLEDIKPLDLVSVISTISTKSTNSSKHSSSELISECDLNNSLVDIFNNLIEMNRDEKNRFKFVKLIHYDIELKKFVQDQQKVLSQKSKAAAINPFFVPNRLGIPYIESQNEFNSQLMTLNVDEPTTDISNMGEEMHDSADPIEDSDSSTTSSTGKYFSSKSYIQSQTPERKTSVPNNWHDDDSGSKRKRKLSFHSPNASSIRKAISYEQLSLASVGSVERLEGKIVGMNPPQFASINEFKYCTLKLYFTQLLPNVPDKVLVPGVNCIEIVIPTRERICELFGVLNCQSDKISDILLLEKPDRISVEVERILWDNDKTASPGMAVWSLKNISTDTQAQAQVQVPAQSSASIDPSRTRMSKMARKDPTIEFCQLGLDTFETKYITMFGMLVSCSFDKPAFISFVFSDFTKNDIVQNYLYDRYLIDYENKLELNEGFKAIMYKNQFETFDSKLRKIFNNGLRDLQNGRDENLSQYGIVCKMNIKVKMYNGKLNAIVRECEPVPHSQISSIASPSQCEHLRLFYQRAFKRIGESAISRYFEEYRRFFPIHRNGSHLAKLRFDEVKHEPKKSPTTPALAEHIPDLNADVSSFDVKFTDISSLLDSSARLPRPQQTHKSNTLYSCEGRIIAIEYHASDLCFHITNELPLLQTRGLAPERVLQLHIITSKNFAYFFNRSSAYLQRQPLEEKYTQLAQFLGHSFKFNITSSLTLFPDTTVALQIWCPIECTFRELQQQLAHPKVAAAPDSGSLDCAINATVNPLRLLAAQNGVTVKKEEDNDDDAGAVPTS

Target ORF information:

RefSeq Version	NM_001180280.1
Organism	Saccharomyces cerevisiae S288C
Definition	Saccharomyces cerevisiae S288C telomere-binding protein CDC13 (CDC13), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001180280.1

ORF Insert Sequence:

ATGGATACCT TAGAAGAGCC TGAGTGTCCT CCACATAAAA ATCGTATTTT TGTGAGCTCG 
AGTAAAGATT TTGAAGGCTA TCCCAGCAAA GCAATAGTTC CCGTGCAATT CGTGGCGCTT 
TTAACCTCAA TACACCTGAC TGAAACAAAA TGTTTGCTAG GCTTTTCTAA TTTTGAGAGG 
CGAGGAGATC AATCCCAAGA AGATCAATAT TTAATCAAAC TGAAGTTCAA AGATAGGGGC 
TCGGAGAGGT TAGCCCGGAT CACTATTTCC TTACTTTGCC AATACTTTGA TATTGAACTG 
CCAGATTTAG ATTCTGACTC AGGCGCATCC CCAACAGTAA TACTGAGAGA TATTCACCTT 
GAAAGGTTAT GTTTTTCAAG TTGTAAAGCT TTATATGTAT CAAAACACGG GAACTATACT 
CTATTCTTAG AGGACATAAA ACCGTTGGAT TTGGTAAGTG TGATAAGCAC CATATCTACA 
AAATCGACAA ATAGCAGCAA GCATTCGTCA TCAGAACTTA TTTCAGAATG TGATTTGAAC 
AACTCACTTG TGGATATCTT CAACAATTTA ATAGAAATGA ATAGAGACGA GAAAAACAGG 
TTTAAATTTG TAAAGTTGAT TCACTACGAT ATAGAACTAA AAAAGTTCGT TCAAGACCAA 
CAAAAGGTAT TATCGCAGAA ATCAAAAGCC GCAGCAATTA ATCCTTTCTT TGTGCCAAAT 
AGACTAGGGA TACCTTACAT TGAATCCCAA AACGAATTCA ACTCGCAGCT TATGACGCTT 
AATGTAGATG AACCGACCAC AGATATAAGC AACATGGGAG AGGAAATGCA TGACAGCGCA 
GATCCCATTG AGGATTCAGA TTCCTCAACT ACCTCCTCTA CCGGGAAATA TTTCAGCTCA 
AAATCCTACA TCCAGTCACA GACACCTGAA AGGAAAACAA GCGTACCAAA TAATTGGCAC 
GATGATGATT CCGGAAGCAA GAGGAAGAGA AAGCTTTCTT TCCACAGTCC GAACGCGTCC 
TCAATCCGCA AAGCCATCAG TTATGAGCAA CTTTCCCTAG CTAGTGTAGG CTCAGTTGAA 
AGGTTAGAGG GCAAAATTGT TGGCATGAAT CCACCTCAAT TCGCCAGTAT AAATGAGTTC 
AAATATTGCA CATTGAAATT ATATTTTACG CAGCTCTTAC CAAATGTCCC AGACAAGGTC 
CTGGTGCCAG GCGTCAATTG CATTGAGATC GTTATCCCGA CGAGAGAGCG AATCTGTGAG 
CTCTTCGGTG TTTTAAACTG TCAAAGCGAC AAGATATCGG ATATTTTACT ACTGGAAAAG 
CCTGATCGAA TTTCCGTCGA AGTTGAAAGG ATCCTGTGGG ACAATGACAA GACCGCCAGC 
CCAGGTATGG CAGTATGGAG TTTGAAGAAC ATTAGCACCG ACACGCAGGC GCAGGCGCAG 
GTGCAGGTGC CTGCGCAATC GTCGGCGTCA ATCGATCCGT CTCGCACAAG GATGAGCAAA 
ATGGCAAGGA AAGACCCCAC CATCGAATTC TGTCAGTTGG GACTCGACAC TTTTGAGACC 
AAATACATAA CAATGTTTGG CATGCTAGTC TCCTGCTCGT TTGATAAACC TGCCTTTATA 
TCTTTTGTCT TTAGCGATTT TACCAAGAAC GATATCGTCC AAAACTATCT TTACGACAGA 
TATCTAATAG ATTACGAGAA CAAGTTAGAG CTGAACGAGG GCTTCAAAGC CATCATGTAC 
AAAAACCAAT TCGAAACGTT TGACTCTAAG CTCAGAAAAA TATTCAACAA CGGGCTAAGA 
GATCTACAGA ACGGCCGCGA TGAAAACCTT TCGCAATACG GCATAGTTTG TAAGATGAAT 
ATAAAAGTGA AAATGTACAA CGGCAAATTG AATGCCATTG TGCGCGAATG TGAGCCGGTC 
CCGCATTCCC AAATAAGCAG CATCGCCTCG CCTTCACAGT GCGAACATTT AAGATTGTTC 
TACCAACGAG CGTTCAAGAG AATTGGCGAA TCCGCAATTT CACGCTATTT CGAAGAGTAC 
CGGAGGTTTT TCCCCATACA TAGAAACGGT TCTCATCTCG CGAAACTGAG GTTCGATGAA 
GTAAAGCATG AACCAAAAAA ATCACCCACT ACACCAGCTC TCGCAGAACA CATACCCGAC 
CTGAATGCAG ACGTGTCCTC CTTCGATGTA AAGTTCACAG ATATATCTTC TCTCTTGGAC 
TCCTCGGCTC GCCTCCCGCG CCCACAGCAA ACACACAAGA GCAACACATT ATACAGTTGC 
GAGGGCCGTA TCATCGCCAT CGAGTACCAC GCATCTGATC TCTGCTTCCA TATCACGAAT 
GAGCTCCCAC TTTTACAAAC CCGCGGCTTG GCCCCGGAGC GAGTGTTGCA ACTACACATC 
ATTACCTCCA AGAACTTTGC TTATTTTTTC AACCGCTCAA GCGCCTACTT ACAGCGTCAG 
CCTCTTGAGG AAAAATATAC GCAATTGGCA CAATTTCTCG GCCATTCATT TAAATTCAAT 
ATAACCTCCT CGCTCACGCT GTTCCCTGAC ACTACCGTGG CACTCCAGAT CTGGTGCCCA 
ATTGAATGCA CCTTTCGGGA ATTGCAACAA CAGCTGGCCC ATCCGAAGGT TGCAGCGGCT 
CCTGATTCAG GGAGTCTTGA TTGCGCAATT AATGCTACCG TCAATCCTCT GCGACTTCTT 
GCCGCGCAAA ATGGCGTCAC CGTGAAAAAG GAGGAGGATA ATGACGATGA CGCCGGAGCC 
GTTCCCACCT CGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Nature387(6632 Suppl)75-8(1997 May)
Jacq C,Alt-M?rbe J,Andre B,Arnold W,Bahr A,Ballesta JP,Bargues M,Baron L,Becker A,Biteau N,Bl?cker H,Blugeon C,Boskovic J,Brandt P,Br?ckner M,Buitrago MJ,Coster F,Delaveau T,del Rey F,Dujon B,Eide LG,Garcia-Cantalejo JM,Goffeau A,Gomez-Peris A,Zaccaria P

Life with 6000 genes.
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
Goffeau A,Barrell BG,Bussey H,Davis RW,Dujon B,Feldmann H,Galibert F,Hoheisel JD,Jacq C,Johnston M,Louis EJ,Mewes HW,Murakami Y,Philippsen P,Tettelin H,Oliver SG

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CDC13 cDNA ORF clone, Saccharomyces cerevisiae S288C

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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