Gene Symbol | HRD3 |
Entrez Gene ID | 850904 |
Full Name | ubiquitin ligase complex subunit HRD3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » HRD3 cDNA ORF clone
Gene Symbol | HRD3 |
Entrez Gene ID | 850904 |
Full Name | ubiquitin ligase complex subunit HRD3 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182094.1 | NP_013308.1 | ubiquitin ligase complex subunit HRD3 |
Saccharomyces cerevisiae (baker's yeast) | HRD3 | NP_013308.1 |
Kluyveromyces lactis | KLLA0C16665g | XP_452945.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Johnston M, Hillier L, Riles L, Albermann K, Andr? B, Ansorge W, Benes V, Br?ckner M, Delius H, Dubois E, D?sterh?ft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, K?tter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD
Nature387(6632 Suppl)87-90(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3: results suggest that Hrd1 forms a retro-translocation channel for the movement of misfolded polypeptides through the endoplasmic reticulum membrane
Title: Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.
direct component of Hrd3 is phenotypically as important as Hrd1 in the native HRD complex. Hrd3 was required the E3 activity of Hrd1, rather than substrate or E2 recruitment to Hrd1. Although Hrd1 can function in some circumstances independent of Hrd3, these studies show an indispensable role for Hrd3 in living cells.
Title: Direct and essential function for Hrd3 in ER-associated degradation.
Data indicate that lysine arginine (KR) mutation causes moderate structural changes in Hrd3 protein.
Title: The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.
Data show that Der1p appears to have a role in a pathway that is parallel to that involving Hrd3p.
Title: Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking.
Results suggest that Hrd3p recognises proteins that deviate from their native conformation.
Title: A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.
The following HRD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HRD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00543 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182094.1 | |
Accession Version | NM_001182094.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2502bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | ubiquitin ligase complex subunit HRD3 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001144). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGATAACAC TCTTATTATA CCTGTGCGTA ATATGTAACG CAATAGTGTT AATAAGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013308.1 |
CDS | 1..2502 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001182094.1 |
1 | ATGATAACAC TCTTATTATA CCTGTGCGTA ATATGTAACG CAATAGTGTT AATAAGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. |
Life with 6000 genes. |