Gene Symbol | CDC45 |
Entrez Gene ID | 850793 |
Full Name | DNA replication initiation factor CDC45 |
Synonyms | SLD4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » CDC45 cDNA ORF clone
Gene Symbol | CDC45 |
Entrez Gene ID | 850793 |
Full Name | DNA replication initiation factor CDC45 |
Synonyms | SLD4 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181990.1 | NP_013204.1 | DNA replication initiation factor CDC45 |
Danio rerio (zebrafish) | cdc45 | NP_998551.1 |
Drosophila melanogaster (fruit fly) | CDC45L | NP_569880.1 |
Pan troglodytes (chimpanzee) | CDC45 | XP_003317140.1 |
CDC45 | XP_001104872.2 | |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011961 | XP_320573.1 |
Caenorhabditis elegans (roundworm) | F34D10.2 | NP_497756.2 |
Saccharomyces cerevisiae (baker's yeast) | CDC45 | NP_013204.1 |
Xenopus tropicalis (tropical clawed frog) | cdc45 | XP_004910630.1 |
Homo sapiens (human) | CDC45 | NP_001171481.1 |
Canis lupus familiaris (dog) | CDC45 | XP_543547.3 |
Bos taurus (cattle) | CDC45 | NP_001019661.1 |
Eremothecium gossypii | AGOS_AGR071C | NP_986736.1 |
Neurospora crassa | NCU04378 | XP_957455.1 |
Arabidopsis thaliana (thale cress) | CDC45 | NP_189146.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_01549 | XP_003714523.1 |
Oryza sativa (rice) | Os11g0128400 | NP_001065635.1 |
Mus musculus (house mouse) | Cdc45 | NP_033992.2 |
Rattus norvegicus (Norway rat) | Cdc45 | NP_001099336.1 |
Gallus gallus (chicken) | CDC45 | XP_415070.2 |
Kluyveromyces lactis | KLLA0F19822g | XP_455970.1 |
Schizosaccharomyces pombe (fission yeast) | cdc45 | NP_594693.1 |
Oryza sativa (rice) | Os12g0124700 | NP_001066041.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Johnston M, Hillier L, Riles L, Albermann K, Andr? B, Ansorge W, Benes V, Br?ckner M, Delius H, Dubois E, D?sterh?ft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, K?tter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD
Nature387(6632 Suppl)87-90(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that Dbf4-dependent kinase (DDK)-phosphoryled MCM DNA helicase complex subunit MCM2 preferentially interacts with DNA replication initiation factor CDC45.
Title: Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.
Upon extrusion of ssDNA from the central channel of Mcm2-7, Dpb11 dissociates from Mcm2-7, and Dpb11 binds to ssDNA, thereby allowing GINS to bind to Cdc45.Mcm2-7
Title: Dpb11 protein helps control assembly of the Cdc45?Mcm2-7?GINS replication fork helicase.
cdc45-ssDNA interaction is important for stalling the helicase during replication stress
Title: Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.
The low-abundance replication proteins Sld3, Sld7, and Cdc45 form a complex and associate with the early-firing origins in G1 phase in a manner that depends on Dbf4-dependent kinase (DDK), which is essential for the initiation of DNA replication.
Title: Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing.
GINS (Psf1, Psf2, Psf3, and Sld5) and Sld3 compete with one another for Mcm2-7 and Cdc45 binding
Title: GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding.
The following CDC45 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC45 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00453 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181990.1 | |
Accession Version | NM_001181990.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1953bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | DNA replication initiation factor CDC45 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001144). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTATTATG GAATCAGCCA GTTTAGCGAA GCCTACAACA AAATCTTAAG GAATTCATCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013204.1 |
CDS | 1..1953 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181990.1 |
1 | ATGTATTATG GAATCAGCCA GTTTAGCGAA GCCTACAACA AAATCTTAAG GAATTCATCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. |
Life with 6000 genes. |