Gene Symbol | FPS1 |
Entrez Gene ID | 850683 |
Full Name | Fps1p |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » FPS1 cDNA ORF clone
Gene Symbol | FPS1 |
Entrez Gene ID | 850683 |
Full Name | Fps1p |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001181863.1 | NP_013057.1 | Fps1p |
Saccharomyces cerevisiae (baker's yeast) | FPS1 | NP_013057.1 |
Kluyveromyces lactis | KLLA0E00617g | XP_453974.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Johnston M, Hillier L, Riles L, Albermann K, Andr? B, Ansorge W, Benes V, Br?ckner M, Delius H, Dubois E, D?sterh?ft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, K?tter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD
Nature387(6632 Suppl)87-90(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Report shows that Slt2 is phosphorylated following arsenite treatment. Slt2 and its kinase activity are necessary for full acquisition of arsenite tolerance and this effect appears to be mediated through Fps1. Hence, it appears that two MAPKs, Hog1 and Slt2, collaborate in controlling arsenite influx and efflux through Fps1 suggesting a mechanism where this MAPK collaboration may function on Fps1.
Title: The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1.
Moreover, hyperosmotic conditions block TORC2-dependent Ypk1-mediated Fps1 phosphorylation, causing channel closure, glycerol accumulation, and enhanced survival under hyperosmotic stress.
Title: Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress.
Fps1 is key for downstream signaling in the Sho1-mediated branch of the high-osmolarity glycerol mitogen-activated protein kinase pathway pathway.
Title: A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae.
results show the function of Stl1p and Fps1p transporters contributes to cell's ability to survive during transfer into state of anhydrobiosis; deletion of FPS1 decreases cell's tolerance of hyperosmotic stress; deletion of STL1 results in slight increase in cell size and increase in intracellular pH
Title: The role of glycerol transporters in yeast cells in various physiological and stress conditions.
Activation of Hog1 in response to hyperosmotic shock induces the rapid eviction of Rgc2 from Fps1 and consequent channel closure
Title: MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators.
The following FPS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FPS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00349 | |
Clone ID Related Accession (Same CDS sequence) | NM_001181863.1 | |
Accession Version | NM_001181863.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2010bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Fps1p | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001144). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAGTAATC CTCAAAAAGC TCTAAACGAC TTTCTGTCCA GTGAATCTGT TCATACACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013057.1 |
CDS | 1..2010 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001181863.1 |
1 | ATGAGTAATC CTCAAAAAGC TCTAAACGAC TTTCTGTCCA GTGAATCTGT TCATACACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. |
Life with 6000 genes. |