Cxadr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxadr
Entrez Gene ID	89843
Full Name	CXADR, Ig-like cell adhesion molecule
Synonyms	Car1
General protein information	Preferred Names CXADR, Ig-like cell adhesion molecule Names coxsackievirus and adenovirus receptor homolog CAR coxsackie virus and adenovirus receptor rCAR
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11
Summary	cell surface receptor for adenovirus and coxsackie virus; may be a barrier for macromolecule and ion movement across membranes in polarized epithelial cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006248000.3	XP_006248062.1	coxsackievirus and adenovirus receptor homolog isoform X1
NM_053570.1	NP_446022.1	coxsackievirus and adenovirus receptor homolog precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CXADR	XP_005638824.1
Mus musculus (house mouse)	Cxadr	NP_001020363.1
Pan troglodytes (chimpanzee)	CXADR	XP_001156087.2
	LOC716409	XP_001107115.2
Xenopus tropicalis (tropical clawed frog)	cxadr	NP_001011084.1
Homo sapiens (human)	CXADR	NP_001329.1
Bos taurus (cattle)	CXADR	NP_776723.1
Rattus norvegicus (Norway rat)	Cxadr	NP_446022.1
Gallus gallus (chicken)	CXADR	XP_004938411.1
Danio rerio (zebrafish)	cxadr	NP_694480.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.
Lam WY, Cheung AC, Tung CK, Yeung AC, Ngai KL, Lui VW, Chan PK, Tsui SK
FEBS letters589(2)246-54(2015 Jan)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Coxsackievirus and adenovirus receptor-positive cells compose the putative stem/progenitor cell niches in the marginal cell layer and parenchyma of the rat anterior pituitary.
Chen M, Kato T, Higuchi M, Yoshida S, Yako H, Kanno N, Kato Y
Cell and tissue research354(3)823-36(2013 Dec)

Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor.
Su L, Mruk DD, Cheng CY
American journal of physiology. Cell physiology303(8)C843-53(2012 Oct)

Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells.
Borovjagin AV, Dong J, Passineau MJ, Ren C, Lamani E, Mamaeva OA, Wu H, Keyser E, Murakami M, Chen S, MacDougall M
PloS one6(10)e24281(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively
Title: miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.

CAR-positive cells are pituitary stem/progenitor cells and compose putative stem/progenitor cell niches in the MCL and parenchyma.
Title: Coxsackievirus and adenovirus receptor-positive cells compose the putative stem/progenitor cell niches in the marginal cell layer and parenchyma of the rat anterior pituitary.

CAR is not only a structural protein: it is involved in conferring the phosphorylation status of other adhesion proteins at the blood-testis barrier.
Title: Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor.

it is proposed that adenovirus CAV-2 transport in motor neuron is dictated by an innate trafficking of CAR, suggesting an unsuspected function for this adhesion protein during neuronal homeostasis
Title: CAR-associated vesicular transport of an adenovirus in motor neuron axons.

expression of coxsackievirus and adenovirus receptor (CAR), the major receptor of coxsackievirus B5 (CVB5), was down-regulated in mature neurons; data support that level of CAR in neurons is a determinant in age-dependency of CBV5 virulence in CNS
Title: Primary neurons become less susceptible to coxsackievirus B5 following maturation: the correlation with the decreased level of CAR expression on cell surface.

The following Cxadr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxadr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09926	NM_053570.1 Latest version!	Rattus norvegicus CXADR, Ig-like cell adhesion molecule (Cxadr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa34110	XM_006248000.3 Latest version!	Rattus norvegicus coxsackie virus and adenovirus receptor (Cxadr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxadr ( NM_053570.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446022.1 Rattus norvegicus CXADR, Ig-like cell adhesion molecule (Cxadr), mRNA.

Price & Availability↑

CloneID	ORa09926
Clone ID Related Accession (Same CDS sequence)	NM_053570.1
Accession Version	NM_053570.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	coxsackievirus and adenovirus receptor homolog precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088313.1. On Jan 3, 2005 this sequence version replaced XM_340962.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088313.1, AF109643.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCTCC TACTGTGCTT CGTGCTCCTG TGCGGTGTCG CGGATTTCAC CAGCAGTTTG 
AGTATCACTA CACCTGAACA GAGGATCGAA AAAGCTAAAG GGGAAACTGC CTATCTACCC 
TGCAAGTTTA CTCTTGAACC CGAAGACCAG GGACCACTGG ACATTGAATG GCTGATATCC 
CCGTCCGATA ACCAGAAAGT GGATCAAGTG ATCATTTTGT ATTCTGGAGA CAAAATTTAT 
GATAACTACT ATCCGGATCT GAAAGGACGA GTACACTTTA CGAGTAACGA CGTCAAGTCT 
GGTGACGCAT CGATAAATGT GACCAATCTG CAGTTGTCCG ATATTGGCAC TTACCAGTGC 
AAAGTGAAGA AAGCTCCTGG GGTTGCAAAT AGAAAATTTC TGCTGACAGT TCTTGTTAAG 
CCTTCAGGTA CAAGGTGCTT CGTGGATGGC TCGGGAGAGA TTGGAAATGA CTTCAAGCTA 
AAGTGTGAAC CCAAAGAAGG TTCCCTCCCA CTGCAGTATG AATGGCAGAA ATTGTCAGAT 
TCCCAGAAAA TGCCTACTCC ATGGCTAGCA GAAATGACTT CACCGGTTAT ATCTGTGAAA 
AATGCCAGTT CTGAGTATTC TGGGACCTAC AGTTGCACAG TCCAAAACAG AGTGGGCTCT 
GATCAGTGTA TGCTACGACT AGATGTTGTC CCTCCCTCCA ACAGAGCTGG AACGATCGCG 
GGAGCTGTCA TAGGGACGCT GCTTGCCCTT GTGCTCATCG GGGCCATCCT CTTCTGCTGT 
CATAAAAAAC GCAGAGAAGA GAAGTACGAG AAGGAAGTGC ATCACGACAT CAGGGAAGAT 
GTGCCTCCTC CGAAGAGTCG GACATCCACC GCCAGGAGCT ACATCGGCAG CAACCATTCC 
TCCCTGGGGT CCATGTCCCC TTCCAACATG GAAGGGTATT CCAAGACCCA GTATAACCAA 
GTCCCCAGTG AAGACTTTGA ACGTGCTCCT CAGAGTCCGA CTCTGGCACC CGCTAAGTTC 
AAGTACGCTT ACCTGACCGA TGGCATTGCA GTGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446022.1
CDS	72..1130
Translation	MALLLCFVLLCGVADFTSSLSITTPEQRIEKAKGETAYLPCKFTLEPEDQGPLDIEWLISPSDNQKVDQVIILYSGDKIYDNYYPDLKGRVHFTSNDVKSGDASINVTNLQLSDIGTYQCKVKKAPGVANRKFLLTVLVKPSGTRCFVDGSGEIGNDFKLKCEPKEGSLPLQYEWQKLSDSQKMPTPWLAEMTSPVISVKNASSEYSGTYSCTVQNRVGSDQCMLRLDVVPPSNRAGTIAGAVIGTLLALVLIGAILFCCHKKRREEKYEKEVHHDIREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERAPQSPTLAPAKFKYAYLTDGIAVV

Target ORF information:

RefSeq Version	NM_053570.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CXADR, Ig-like cell adhesion molecule (Cxadr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053570.1

ORF Insert Sequence:

ATGGCGCTCC TACTGTGCTT CGTGCTCCTG TGCGGTGTCG CGGATTTCAC CAGCAGTTTG 
AGTATCACTA CACCTGAACA GAGGATCGAA AAAGCTAAAG GGGAAACTGC CTATCTACCC 
TGCAAGTTTA CTCTTGAACC CGAAGACCAG GGACCACTGG ACATTGAATG GCTGATATCC 
CCGTCCGATA ACCAGAAAGT GGATCAAGTG ATCATTTTGT ATTCTGGAGA CAAAATTTAT 
GATAACTACT ATCCGGATCT GAAAGGACGA GTACACTTTA CGAGTAACGA CGTCAAGTCT 
GGTGACGCAT CGATAAATGT GACCAATCTG CAGTTGTCCG ATATTGGCAC TTACCAGTGC 
AAAGTGAAGA AAGCTCCTGG GGTTGCAAAT AGAAAATTTC TGCTGACAGT TCTTGTTAAG 
CCTTCAGGTA CAAGGTGCTT CGTGGATGGC TCGGGAGAGA TTGGAAATGA CTTCAAGCTA 
AAGTGTGAAC CCAAAGAAGG TTCCCTCCCA CTGCAGTATG AATGGCAGAA ATTGTCAGAT 
TCCCAGAAAA TGCCTACTCC ATGGCTAGCA GAAATGACTT CACCGGTTAT ATCTGTGAAA 
AATGCCAGTT CTGAGTATTC TGGGACCTAC AGTTGCACAG TCCAAAACAG AGTGGGCTCT 
GATCAGTGTA TGCTACGACT AGATGTTGTC CCTCCCTCCA ACAGAGCTGG AACGATCGCG 
GGAGCTGTCA TAGGGACGCT GCTTGCCCTT GTGCTCATCG GGGCCATCCT CTTCTGCTGT 
CATAAAAAAC GCAGAGAAGA GAAGTACGAG AAGGAAGTGC ATCACGACAT CAGGGAAGAT 
GTGCCTCCTC CGAAGAGTCG GACATCCACC GCCAGGAGCT ACATCGGCAG CAACCATTCC 
TCCCTGGGGT CCATGTCCCC TTCCAACATG GAAGGGTATT CCAAGACCCA GTATAACCAA 
GTCCCCAGTG AAGACTTTGA ACGTGCTCCT CAGAGTCCGA CTCTGGCACC CGCTAAGTTC 
AAGTACGCTT ACCTGACCGA TGGCATTGCA GTGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cxadr ( XM_006248000.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248062.1 Rattus norvegicus coxsackie virus and adenovirus receptor (Cxadr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa34110
Clone ID Related Accession (Same CDS sequence)	XM_006248000.3
Accession Version	XM_006248000.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	coxsackievirus and adenovirus receptor homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248000.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCTCC TACTGTGCTT CGTGCTCCTG TGCGGTGTCG CGGATTTCAC CAGCAGTTTG 
AGTATCACTA CACCTGAACA GAGGATCGAA AAAGCTAAAG GGGAAACTGC CTATCTACCC 
TGCAAGTTTA CTCTTGAACC CGAAGACCAG GGACCACTGG ACATTGAATG GCTGATATCC 
CCGTCCGATA ACCAGAAAGT GGATCAAGTG ATCATTTTGT ATTCTGGAGA CAAAATTTAT 
GATAACTACT ATCCGGATCT GAAAGGACGA GTACACTTTA CGAGTAACGA CGTCAAGTCT 
GGTGACGCAT CGATAAATGT GACCAATCTG CAGTTGTCCG ATATTGGCAC TTACCAGTGC 
AAAGTGAAGA AAGCTCCTGG GGTTGCAAAT AGAAAATTTC TGCTGACAGT TCTTGTTAAG 
CCTTCAGGTA CAAGGTGCTT CGTGGATGGC TCGGGAGAGA TTGGAAATGA CTTCAAGCTA 
AAGTGTGAAC CCAAAGAAGG TTCCCTCCCA CTGCAGTATG AATGGCAGAA ATTGTCAGAT 
TCCCAGAAAA TGCCTACTCC ATGGCTAGCA GAAATGACTT CACCGGTTAT ATCTGTGAAA 
AATGCCAGTT CTGAGTATTC TGGGACCTAC AGTTGCACAG TCCAAAACAG AGTGGGCTCT 
GATCAGTGTA TGCTACGACT AGATGTTGTC CCTCCCTCCA ACAGAGCTGG AACGATCGCG 
GGAGCTGTCA TAGGGACGCT GCTTGCCCTT GTGCTCATCG GGGCCATCCT CTTCTGCTGT 
CATAAAAAAC GCAGAGAAGA GAAGTACGAG AAGGAAGTGC ATCACGACAT CAGGGAAGAT 
GTGCCTCCTC CGAAGAGTCG GACATCCACC GCCAGGAGCT ACATCGGCAG CAACCATTCC 
TCCCTGGGGT CCATGTCCCC TTCCAACATG GAAGGGTATT CCAAGACCCA GTATAACCAA 
GTCCCCAGTG AAGACTTTGA ACGTGCTCCT CAGAGTCCGA CTCTGGCACC CGCTAAGGTA 
GCTGCCCCTA ATCTAAGTCG AATGGGAGCG GTTCCTGTGA TGATCCCAGC ACAGAGCAAG 
GATGGGTCTA TAGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248062.1
CDS	202..1299
Translation	MALLLCFVLLCGVADFTSSLSITTPEQRIEKAKGETAYLPCKFTLEPEDQGPLDIEWLISPSDNQKVDQVIILYSGDKIYDNYYPDLKGRVHFTSNDVKSGDASINVTNLQLSDIGTYQCKVKKAPGVANRKFLLTVLVKPSGTRCFVDGSGEIGNDFKLKCEPKEGSLPLQYEWQKLSDSQKMPTPWLAEMTSPVISVKNASSEYSGTYSCTVQNRVGSDQCMLRLDVVPPSNRAGTIAGAVIGTLLALVLIGAILFCCHKKRREEKYEKEVHHDIREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERAPQSPTLAPAKVAAPNLSRMGAVPVMIPAQSKDGSIV

Target ORF information:

RefSeq Version	XM_006248000.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coxsackie virus and adenovirus receptor (Cxadr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248000.3

ORF Insert Sequence:

ATGGCGCTCC TACTGTGCTT CGTGCTCCTG TGCGGTGTCG CGGATTTCAC CAGCAGTTTG 
AGTATCACTA CACCTGAACA GAGGATCGAA AAAGCTAAAG GGGAAACTGC CTATCTACCC 
TGCAAGTTTA CTCTTGAACC CGAAGACCAG GGACCACTGG ACATTGAATG GCTGATATCC 
CCGTCCGATA ACCAGAAAGT GGATCAAGTG ATCATTTTGT ATTCTGGAGA CAAAATTTAT 
GATAACTACT ATCCGGATCT GAAAGGACGA GTACACTTTA CGAGTAACGA CGTCAAGTCT 
GGTGACGCAT CGATAAATGT GACCAATCTG CAGTTGTCCG ATATTGGCAC TTACCAGTGC 
AAAGTGAAGA AAGCTCCTGG GGTTGCAAAT AGAAAATTTC TGCTGACAGT TCTTGTTAAG 
CCTTCAGGTA CAAGGTGCTT CGTGGATGGC TCGGGAGAGA TTGGAAATGA CTTCAAGCTA 
AAGTGTGAAC CCAAAGAAGG TTCCCTCCCA CTGCAGTATG AATGGCAGAA ATTGTCAGAT 
TCCCAGAAAA TGCCTACTCC ATGGCTAGCA GAAATGACTT CACCGGTTAT ATCTGTGAAA 
AATGCCAGTT CTGAGTATTC TGGGACCTAC AGTTGCACAG TCCAAAACAG AGTGGGCTCT 
GATCAGTGTA TGCTACGACT AGATGTTGTC CCTCCCTCCA ACAGAGCTGG AACGATCGCG 
GGAGCTGTCA TAGGGACGCT GCTTGCCCTT GTGCTCATCG GGGCCATCCT CTTCTGCTGT 
CATAAAAAAC GCAGAGAAGA GAAGTACGAG AAGGAAGTGC ATCACGACAT CAGGGAAGAT 
GTGCCTCCTC CGAAGAGTCG GACATCCACC GCCAGGAGCT ACATCGGCAG CAACCATTCC 
TCCCTGGGGT CCATGTCCCC TTCCAACATG GAAGGGTATT CCAAGACCCA GTATAACCAA 
GTCCCCAGTG AAGACTTTGA ACGTGCTCCT CAGAGTCCGA CTCTGGCACC CGCTAAGGTA 
GCTGCCCCTA ATCTAAGTCG AATGGGAGCG GTTCCTGTGA TGATCCCAGC ACAGAGCAAG 
GATGGGTCTA TAGTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.
FEBS letters589(2)246-54(2015 Jan)
Lam WY,Cheung AC,Tung CK,Yeung AC,Ngai KL,Lui VW,Chan PK,Tsui SK

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Coxsackievirus and adenovirus receptor-positive cells compose the putative stem/progenitor cell niches in the marginal cell layer and parenchyma of the rat anterior pituitary.
Cell and tissue research354(3)823-36(2013 Dec)
Chen M,Kato T,Higuchi M,Yoshida S,Yako H,Kanno N,Kato Y

Regulation of the blood-testis barrier by coxsackievirus and adenovirus receptor.
American journal of physiology. Cell physiology303(8)C843-53(2012 Oct)
Su L,Mruk DD,Cheng CY

Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells.
PloS one6(10)e24281(2011)
Borovjagin AV,Dong J,Passineau MJ,Ren C,Lamani E,Mamaeva OA,Wu H,Keyser E,Murakami M,Chen S,MacDougall M

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Cxadr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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