Socs3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Socs3
Entrez Gene ID	89829
Full Name	suppressor of cytokine signaling 3
Synonyms	Cish3,Socs-3,Ssi-3
General protein information	Preferred Names suppressor of cytokine signaling 3 Names suppressor of cytokine signaling 3 cytokine inducible SH2-containing protein 3 cytokine-inducible SH2 protein 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.2
Summary	regulates cytokine levels to modulate inflammation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008768398.1	XP_008766620.1	suppressor of cytokine signaling 3 isoform X1
NM_053565.1	NP_446017.1	suppressor of cytokine signaling 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SOCS3	NP_776891.1
Mus musculus (house mouse)	Socs3	NP_031733.1
Danio rerio (zebrafish)	socs3a	NP_956244.1
Xenopus tropicalis (tropical clawed frog)	socs3	NP_001005696.1
Canis lupus familiaris (dog)	SOCS3	NP_001026801.1
Rattus norvegicus (Norway rat)	Socs3	NP_446017.1
Pan troglodytes (chimpanzee)	SOCS3	XP_001157032.1
Homo sapiens (human)	SOCS3	NP_003946.3
	SOCS3	XP_001106015.2
Gallus gallus (chicken)	SOCS3	NP_989931.1
Danio rerio (zebrafish)	socs3b	NP_998469.1

Gene Ontology
Bibliography

Related articles in PubMed

Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats.
Ma C, Yu H, Xiao Y, Wang H
Pharmaceutical biology55(1)2170-2177(2017 Dec)

Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
Sheu ML, Shen CC, Jheng JR, Chiang CK
Oncotarget8(10)16925-16938(2017 Mar)

Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats.
Wei J, Li M, Wang D, Zhu H, Kong X, Wang S, Zhou YL, Ju Z, Xu GY, Jiang GQ
Molecular pain131744806916688901(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The phosphatidylinositol 3-Kinases (PI3K)/signal transducer and activator of transcription 1 and 3 (STAT1/3) signaling pathway mediated high glucose (HG)-triggered extracellular matrix (ECM) accumulation and suppressor of cytokine signaling-3 (SOCS-3) upregulation in mesangial cells (RMCs).
Title: Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.

Using cultured primary neurons, JEV efficiently replicated in embryonic neurons rather than adult neurons, and the preference was accompanied by higher SOCS3 expression and protein tyrosine phosphatase activity.
Title: Susceptibility of na?ve and differentiated PC12 cells to Japanese encephalitis virus infection.

These results suggest that SOCS3 might be a key molecular involved in the development of complicated cancer pain and that overexpression of SOCS3 might be an important strategy for treatment for mechanical allodynia associated with bone cancer.
Title: Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats.

SOCS3 induces neurite differentiation and promotes neuronal cell survival.SOCS3-induced neurite differentiation was mediated via the PI3 kinase pathway.
Title: SOCS3 induces neurite differentiation and promotes neuronal cell survival.

results suggest that knocking down of SOCS3 enhances dendritic regeneration and prevents demyelination after SCI
Title: Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3) Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury.

The following Socs3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Socs3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13203	NM_053565.1 Latest version!	Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa33983	XM_008768398.1 Latest version!	Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Socs3 ( NM_053565.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446017.1 Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), mRNA.

Price & Availability↑

CloneID	ORa13203
Clone ID Related Accession (Same CDS sequence)	NM_053565.1
Accession Version	NM_053565.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	suppressor of cytokine signaling 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF075383.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF075383.1 [ECO:0000332] ##Evidence-Data-END##

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC CGTGCGCAAG 
CTGCAGGAGA GCGGATTCTA CTGGAGTGCC GTAACCGGCG GCGAGGCGAA CCTGCTGCTC 
AGCGCCGAGC CCGCGGGCAC CTTTCTTATC CGCGACAGCT CGGACCAGCG CCACTTCTTC 
ACACTGAGCG TCGAGACCCA GTCGGGGACC AAGAACCTAC GCATCCAGTG CGAGGGGGGC 
AGCTTTTCGC TGCAGAGTGA CCCCCGGAGC ACGCAGCCAG TGCCCCGCTT TGACTGTGTA 
CTCAAGTTGG TGCACCACTA CATGCCGCCC CCAGGGGCCC CTTCCTTTTC TTTACCACCG 
ACGGAACCTT CCTTTGAGGT TCAGGAGCAG CCACCTGCCC AGGCACTCCC CGGGGGTACC 
CCCAAGAGAG CTTACTACAT CTATTCTGGG GGCGAGAAGA TCCCGCTGGT ACTGAGCCGA 
CCTCTCTCCT CCAACGTGGC TACCCTCCAG CATCTTTGTC GGAAGACTGT CAACGGTCAC 
CTGGACTCCT ATGAGAAAGT GACCCAGCTG CCTGGACCCA TTCGGGAGTT CCTGGACCAG 
TATGATGCTC CACTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446017.1
CDS	18..695
Translation	MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVETQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFSLPPTEPSFEVQEQPPAQALPGGTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

Target ORF information:

RefSeq Version	NM_053565.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053565.1

ORF Insert Sequence:

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC CGTGCGCAAG 
CTGCAGGAGA GCGGATTCTA CTGGAGTGCC GTAACCGGCG GCGAGGCGAA CCTGCTGCTC 
AGCGCCGAGC CCGCGGGCAC CTTTCTTATC CGCGACAGCT CGGACCAGCG CCACTTCTTC 
ACACTGAGCG TCGAGACCCA GTCGGGGACC AAGAACCTAC GCATCCAGTG CGAGGGGGGC 
AGCTTTTCGC TGCAGAGTGA CCCCCGGAGC ACGCAGCCAG TGCCCCGCTT TGACTGTGTA 
CTCAAGTTGG TGCACCACTA CATGCCGCCC CCAGGGGCCC CTTCCTTTTC TTTACCACCG 
ACGGAACCTT CCTTTGAGGT TCAGGAGCAG CCACCTGCCC AGGCACTCCC CGGGGGTACC 
CCCAAGAGAG CTTACTACAT CTATTCTGGG GGCGAGAAGA TCCCGCTGGT ACTGAGCCGA 
CCTCTCTCCT CCAACGTGGC TACCCTCCAG CATCTTTGTC GGAAGACTGT CAACGGTCAC 
CTGGACTCCT ATGAGAAAGT GACCCAGCTG CCTGGACCCA TTCGGGAGTT CCTGGACCAG 
TATGATGCTC CACTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Socs3 ( XM_008768398.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766620.1 Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33983
Clone ID Related Accession (Same CDS sequence)	XM_008768398.1
Accession Version	XM_008768398.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	suppressor of cytokine signaling 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC CGTGCGCAAG 
CTGCAGGAGA GCGGATTCTA CTGGAGTGCC GTAACCGGCG GCGAGGCGAA CCTGCTGCTC 
AGCGCCGAGC CCGCGGGCAC CTTTCTTATC CGCGACAGCT CGGACCAGCG CCACTTCTTC 
ACACTGAGCG TCAAGACCCA GTCGGGGACC AAGAACCTAC GCATCCAGTG CGAGGGGGGC 
AGCTTTTCGC TGCAGAGTGA CCCCCGGAGC ACGCAGCCAG TGCCCCGCTT TGACTGTGTA 
CTCAAGTTGG TGCACCACTA CATGCCGCCC CCAGGGGCCC CCTCCTTCTC TTTACCACCG 
ACGGAACCCT CCTCTGAGGT TCAGGAGCAG CCACCTGCCC AGGCACTCCC CGGGGGTACC 
CCCAAGAGAG CTTACTACAT CTATTCTGGG GGCGAGAAGA TCCCGCTGGT ACTGAGCCGA 
CCTCTCTCCT CCAACGTGGC TACCCTCCAG CATCTTTGTC GGAAGACTGT CAACGGTCAC 
CTGGACTCCT ATGAGAAAGT GACCCAGCTG CCTGGACCCA TTCGGGAGTT CCTGGACCAG 
TATGATGCTC CACTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766620.1
CDS	386..1063
Translation	MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSFSLPPTEPSSEVQEQPPAQALPGGTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

Target ORF information:

RefSeq Version	XM_008768398.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus suppressor of cytokine signaling 3 (Socs3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768398.1

ORF Insert Sequence:

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC CGTGCGCAAG 
CTGCAGGAGA GCGGATTCTA CTGGAGTGCC GTAACCGGCG GCGAGGCGAA CCTGCTGCTC 
AGCGCCGAGC CCGCGGGCAC CTTTCTTATC CGCGACAGCT CGGACCAGCG CCACTTCTTC 
ACACTGAGCG TCAAGACCCA GTCGGGGACC AAGAACCTAC GCATCCAGTG CGAGGGGGGC 
AGCTTTTCGC TGCAGAGTGA CCCCCGGAGC ACGCAGCCAG TGCCCCGCTT TGACTGTGTA 
CTCAAGTTGG TGCACCACTA CATGCCGCCC CCAGGGGCCC CCTCCTTCTC TTTACCACCG 
ACGGAACCCT CCTCTGAGGT TCAGGAGCAG CCACCTGCCC AGGCACTCCC CGGGGGTACC 
CCCAAGAGAG CTTACTACAT CTATTCTGGG GGCGAGAAGA TCCCGCTGGT ACTGAGCCGA 
CCTCTCTCCT CCAACGTGGC TACCCTCCAG CATCTTTGTC GGAAGACTGT CAACGGTCAC 
CTGGACTCCT ATGAGAAAGT GACCCAGCTG CCTGGACCCA TTCGGGAGTT CCTGGACCAG 
TATGATGCTC CACTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats.
Pharmaceutical biology55(1)2170-2177(2017 Dec)
Ma C,Yu H,Xiao Y,Wang H

Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation.
Oncotarget8(10)16925-16938(2017 Mar)
Sheu ML,Shen CC,Jheng JR,Chiang CK

Overexpression of suppressor of cytokine signaling 3 in dorsal root ganglion attenuates cancer-induced pain in rats.
Molecular pain131744806916688901(2017 Jan)
Wei J,Li M,Wang D,Zhu H,Kong X,Wang S,Zhou YL,Ju Z,Xu GY,Jiang GQ

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Socs3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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