Nbn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nbn
Entrez Gene ID	85482
Full Name	nibrin
Synonyms	Nbs1
General protein information	Preferred Names nibrin Names nibrin nijmegen breakage syndrome protein 1 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q13
Summary	may be involved in regulation of cardiomyocyte proliferation; may act in a complex with MRE11 and RAD50 to play roles in DNA repair, activation of cell cycle checkpoints, and telomere maintenance [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006237916.2	XP_006237978.2	nibrin isoform X1
NM_138873.2	NP_620228.1	nibrin

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	nbn	NP_001014819.1
Mus musculus (house mouse)	Nbn	NP_038780.3
Homo sapiens (human)	NBN	NP_002476.2
Pan troglodytes (chimpanzee)	NBN	XP_519851.3
Canis lupus familiaris (dog)	NBN	XP_005638161.1
Bos taurus (cattle)	NBN	NP_001069305.2
Gallus gallus (chicken)	NBN	NP_989668.1
Xenopus tropicalis (tropical clawed frog)	nbn	XP_004915210.1
	NBN	XP_001085033.1
Rattus norvegicus (Norway rat)	Nbn	NP_620228.1

Gene Ontology
Bibliography

Related articles in PubMed

A balance between elongation and trimming regulates telomere stability in stem cells.
Rivera T, Haggblom C, Cosconati S, Karlseder J
Nature structural & molecular biology24(1)30-39(2017 Jan)

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.
Chang FT, McGhie JD, Chan FL, Tang MC, Anderson MA, Mann JR, Andy Choo KH, Wong LH
Nucleic acids research41(8)4447-58(2013 Apr)

Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins.
Lovric J, Mano M, Zentilin L, Eulalio A, Zacchigna S, Giacca M
Molecular therapy : the journal of the American Society of Gene Therapy20(11)2087-97(2012 Nov)

ATM protein kinase: the linchpin of cellular defenses to stress.
Bhatti S, Kozlov S, Farooqi AA, Naqi A, Lavin M, Khanna KK
Cellular and molecular life sciences : CMLS68(18)2977-3006(2011 Sep)

Regulation of homologous recombination in eukaryotes.
Heyer WD, Ehmsen KT, Liu J
Annual review of genetics44113-39(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nbn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nbn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01830	NM_138873.2 Latest version!	Rattus norvegicus nibrin (Nbn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$440.30 $629.00
ORa61403	XM_006237916.2 Latest version!	Rattus norvegicus nibrin (Nbn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nbn ( NM_138873.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620228.1 Rattus norvegicus nibrin (Nbn), mRNA.

Price & Availability↑

CloneID	ORa01830
Clone ID Related Accession (Same CDS sequence)	NM_138873.2
Accession Version	NM_138873.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2253bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	nibrin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF218575.1. On Aug 30, 2012 this sequence version replaced NM_138873.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF218575.1, BC085700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTGGAAGC TGCTCCCGGC CGCAAGTGCG GCTCCAGGAG AACCATGTCG ACTTTTGGCT 
GGCGTAGAGT ACATTGTTGG GAGGAAAAAC TGTGCCATTC TAATCGAAAA TGATCAGTCA 
ATCAGTCGAA ATCATGCTGT ATTAAGAGTA AACTTTCCTG TAACCAGTTT GAGTCAAACG 
GATGAAATTC CTACATTAAT AATAAAAGAT AATTCTAAGT ATGGAACCTT TATTAACGAA 
GAAAAAATGC AGAATGGCCT TTCTTCCACT TTGAAGACAG GAGATAGAGT TACCTTTGGG 
GTGTTTGAAA GTAAATTCAG AGTAGAATAC GAGCCTTTGG TTGTTTGCTC TTCTTGTTTA 
GATGTCTCTG GGAAAACTGT TTTAAACCAA GCTATATTAC AGCTTGGAGG ACTCACTGCA 
AACAGCTGGA CAGAAGAGTG TACTCACCTT GCCATGTCAT CAGTCAAAGT CACCATTAAA 
ACTATATGTG CACTCATTTG TGGACGTCCA ATTGTAAAGC CAGAATACTT TTCTGAATTT 
CTCAAAGCAG TTGAGTCCAA GACACAACCT CCAGAAATTG AAAGTTTTTA CCCACCCATC 
GATGAACCAG CTATTGGAAA TAAAAGTGTC GATCTGTCCG GACGACGTGA AAGAAAACAA 
ATCTTCAAAG GAAAAACATT CGTGTTTTTA AATGCCAAGC AGCATAAGAA ACTCGGCTCG 
GCAGTTGTTT TCGGAGGTGG GGAAGCCAGG CTGATGGCAG AAGGAGGTGA AGAGGAACAG 
AGCTTCTTCT CAGCTCCCGG AACCTGTGTT GTTGACGTAG GAATAACAAA CACACAGCTC 
ATAATTACGG ACTCCCAGAG GAAGTGGATT CATTTGATAA TGGATATACT TCAAAGGCAT 
GATCTCAGAC CTATTCCTGA AGCAGAGATT GGATTGGCTG TTATTTTTAT GACTACAGAG 
AGTTACTGTA ATCCGCAGGG CCAGCCTTGT ACAGAGGTAA AGACGACGAC TCCAGGACCA 
AGCCTTTCCC AGGGCCTGTC AGCCAATGGA AAAGTCATCC CCAGTGCGCC AATGAATATG 
ACCACATACG TAGCTGACAC AGAATCAGAG CCAGCAGATA CATGTATGTC TCTGAGTGAA 
AGACCAGAAG AAGTAAAGAT CTTTGGACTC GATCAAAACT CTAGAAAGCT TTTACAAGGA 
ACATGCAATA TAAAGGAGAC CTCTAATCAA AGCTCCAATT CTAACAATGC AGCATCAAAT 
ACACTGGTTA GGGGAAAGGC CCCGAACTAT CAGCTTTCAC CAATGAAATG TCCTGCTGCA 
AGTAAAAATA AAGATTGGTC TTCTCAGCAG CAGCTGAACT CCATCAAAAA CTACTTCCAG 
CCATGCTCCA GAAAAAGGGA AAGGGATGAA GAAAATCCAG AACAGTCCTC ATGCAAATCG 
TCAAGAGTGG AACTGTCTTG TTCTCTTTTA GAACAAACGC AACCTGCAGA ACCCTCACTG 
TGGAAAAGCA AAGACCATGA GTCTCAGAGT GAGACTCTGG GCAGGGCATC CAATGCCTCA 
TCTGTGGGTG GAATAGACAT AAAACCCAAT GGGAAGAGTC CTGACAGTAA GTCATTTTCC 
ACAGAAGATC TTAGAGCAAG AAAAAGAAAA GAAGTGGATT TGTCTACAGA AGAGGAAGTG 
TTGGAAGAGT TACTCAGGAG CACAAAGCCA GAGCTGGCAG TTCAAGTGAA GGTTGAAAAG 
CAGGAGGCAG ATGTCAGCAT CAGAAAGAAG CCCAGGATGG ATGCAGAGAG GAATCAGCAC 
CTGAACGGTG GCCCAGTGCC AGAAAGCAAC AGCGCACTTC AAGAAGATGA AACAGAAAAG 
AAAGATGAGC TTCAGATAGA AGCATGGTCA ACAAAACGTG AAGTATCTAA TACTGATGAG 
CTTCAGGACA GCAGTGAGGA ACTTCCAAGA AAACTGCTGC TGACTGAATT TAGGTCACTG 
GTTGTCCATA ATAACTCTTC CAGAAATCTG TGCCCACTAA ATGGTCGTGG TGAACTGAAG 
AATTTCAAGA AATTCAAGAA GGCTACGTGT CCTGGAGCAG GAAAGCTTCC ACACATTATT 
GGAGGATCAG ATTTAATAGG TCACCATGCT CGAAAGAATA CTGAATTAGA AGAGTGGTTG 
AAACATGAAA TGGAGGTACA GAAACAACAA GCGAAAGAAG ACTCTCTTGC TGATGATCTG 
TTTAGATATA ATCCTAATGT AAAAAGAAGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620228.1
CDS	36..2288
Translation	MWKLLPAASAAPGEPCRLLAGVEYIVGRKNCAILIENDQSISRNHAVLRVNFPVTSLSQTDEIPTLIIKDNSKYGTFINEEKMQNGLSSTLKTGDRVTFGVFESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANSWTEECTHLAMSSVKVTIKTICALICGRPIVKPEYFSEFLKAVESKTQPPEIESFYPPIDEPAIGNKSVDLSGRRERKQIFKGKTFVFLNAKQHKKLGSAVVFGGGEARLMAEGGEEEQSFFSAPGTCVVDVGITNTQLIITDSQRKWIHLIMDILQRHDLRPIPEAEIGLAVIFMTTESYCNPQGQPCTEVKTTTPGPSLSQGLSANGKVIPSAPMNMTTYVADTESEPADTCMSLSERPEEVKIFGLDQNSRKLLQGTCNIKETSNQSSNSNNAASNTLVRGKAPNYQLSPMKCPAASKNKDWSSQQQLNSIKNYFQPCSRKRERDEENPEQSSCKSSRVELSCSLLEQTQPAEPSLWKSKDHESQSETLGRASNASSVGGIDIKPNGKSPDSKSFSTEDLRARKRKEVDLSTEEEVLEELLRSTKPELAVQVKVEKQEADVSIRKKPRMDAERNQHLNGGPVPESNSALQEDETEKKDELQIEAWSTKREVSNTDELQDSSEELPRKLLLTEFRSLVVHNNSSRNLCPLNGRGELKNFKKFKKATCPGAGKLPHIIGGSDLIGHHARKNTELEEWLKHEMEVQKQQAKEDSLADDLFRYNPNVKRR

Target ORF information:

RefSeq Version	NM_138873.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nibrin (Nbn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138873.2

ORF Insert Sequence:

ATGTGGAAGC TGCTCCCGGC CGCAAGTGCG GCTCCAGGAG AACCATGTCG ACTTTTGGCT 
GGCGTAGAGT ACATTGTTGG GAGGAAAAAC TGTGCCATTC TAATCGAAAA TGATCAGTCA 
ATCAGTCGAA ATCATGCTGT ATTAAGAGTA AACTTTCCTG TAACCAGTTT GAGTCAAACG 
GATGAAATTC CTACATTAAT AATAAAAGAT AATTCTAAGT ATGGAACCTT TATTAACGAA 
GAAAAAATGC AGAATGGCCT TTCTTCCACT TTGAAGACAG GAGATAGAGT TACCTTTGGG 
GTGTTTGAAA GTAAATTCAG AGTAGAATAC GAGCCTTTGG TTGTTTGCTC TTCTTGTTTA 
GATGTCTCTG GGAAAACTGT TTTAAACCAA GCTATATTAC AGCTTGGAGG ACTCACTGCA 
AACAGCTGGA CAGAAGAGTG TACTCACCTT GCCATGTCAT CAGTCAAAGT CACCATTAAA 
ACTATATGTG CACTCATTTG TGGACGTCCA ATTGTAAAGC CAGAATACTT TTCTGAATTT 
CTCAAAGCAG TTGAGTCCAA GACACAACCT CCAGAAATTG AAAGTTTTTA CCCACCCATC 
GATGAACCAG CTATTGGAAA TAAAAGTGTC GATCTGTCCG GACGACGTGA AAGAAAACAA 
ATCTTCAAAG GAAAAACATT CGTGTTTTTA AATGCCAAGC AGCATAAGAA ACTCGGCTCG 
GCAGTTGTTT TCGGAGGTGG GGAAGCCAGG CTGATGGCAG AAGGAGGTGA AGAGGAACAG 
AGCTTCTTCT CAGCTCCCGG AACCTGTGTT GTTGACGTAG GAATAACAAA CACACAGCTC 
ATAATTACGG ACTCCCAGAG GAAGTGGATT CATTTGATAA TGGATATACT TCAAAGGCAT 
GATCTCAGAC CTATTCCTGA AGCAGAGATT GGATTGGCTG TTATTTTTAT GACTACAGAG 
AGTTACTGTA ATCCGCAGGG CCAGCCTTGT ACAGAGGTAA AGACGACGAC TCCAGGACCA 
AGCCTTTCCC AGGGCCTGTC AGCCAATGGA AAAGTCATCC CCAGTGCGCC AATGAATATG 
ACCACATACG TAGCTGACAC AGAATCAGAG CCAGCAGATA CATGTATGTC TCTGAGTGAA 
AGACCAGAAG AAGTAAAGAT CTTTGGACTC GATCAAAACT CTAGAAAGCT TTTACAAGGA 
ACATGCAATA TAAAGGAGAC CTCTAATCAA AGCTCCAATT CTAACAATGC AGCATCAAAT 
ACACTGGTTA GGGGAAAGGC CCCGAACTAT CAGCTTTCAC CAATGAAATG TCCTGCTGCA 
AGTAAAAATA AAGATTGGTC TTCTCAGCAG CAGCTGAACT CCATCAAAAA CTACTTCCAG 
CCATGCTCCA GAAAAAGGGA AAGGGATGAA GAAAATCCAG AACAGTCCTC ATGCAAATCG 
TCAAGAGTGG AACTGTCTTG TTCTCTTTTA GAACAAACGC AACCTGCAGA ACCCTCACTG 
TGGAAAAGCA AAGACCATGA GTCTCAGAGT GAGACTCTGG GCAGGGCATC CAATGCCTCA 
TCTGTGGGTG GAATAGACAT AAAACCCAAT GGGAAGAGTC CTGACAGTAA GTCATTTTCC 
ACAGAAGATC TTAGAGCAAG AAAAAGAAAA GAAGTGGATT TGTCTACAGA AGAGGAAGTG 
TTGGAAGAGT TACTCAGGAG CACAAAGCCA GAGCTGGCAG TTCAAGTGAA GGTTGAAAAG 
CAGGAGGCAG ATGTCAGCAT CAGAAAGAAG CCCAGGATGG ATGCAGAGAG GAATCAGCAC 
CTGAACGGTG GCCCAGTGCC AGAAAGCAAC AGCGCACTTC AAGAAGATGA AACAGAAAAG 
AAAGATGAGC TTCAGATAGA AGCATGGTCA ACAAAACGTG AAGTATCTAA TACTGATGAG 
CTTCAGGACA GCAGTGAGGA ACTTCCAAGA AAACTGCTGC TGACTGAATT TAGGTCACTG 
GTTGTCCATA ATAACTCTTC CAGAAATCTG TGCCCACTAA ATGGTCGTGG TGAACTGAAG 
AATTTCAAGA AATTCAAGAA GGCTACGTGT CCTGGAGCAG GAAAGCTTCC ACACATTATT 
GGAGGATCAG ATTTAATAGG TCACCATGCT CGAAAGAATA CTGAATTAGA AGAGTGGTTG 
AAACATGAAA TGGAGGTACA GAAACAACAA GCGAAAGAAG ACTCTCTTGC TGATGATCTG 
TTTAGATATA ATCCTAATGT AAAAAGAAGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nbn ( XM_006237916.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237978.2 Rattus norvegicus nibrin (Nbn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61403
Clone ID Related Accession (Same CDS sequence)	XM_006237916.2
Accession Version	XM_006237916.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2007bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	nibrin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237916.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAATG GCCTTTCTTC CACTTTGAAG ACAGGAGATA GAGTTACCTT TGGGGTGTTT 
GAAAGTAAAT TCAGAGTAGA ATACGAGCCT TTGGTTGTTT GCTCTTCTTG TTTAGATGTC 
TCTGGGAAAA CTGTTTTAAA CCAAGCTATA TTACAGCTTG GAGGACTCAC TGCAAACAGC 
TGGACAGAAG AGTGTACTCA CCTTGCCATG TCATCAGTCA AAGTCACCAT TAAAACTATA 
TGTGCACTCA TTTGTGGACG TCCAATTGTA AAGCCAGAAT ACTTTTCTGA ATTTCTCAAA 
GCAGTTGAGT CCAAGACACA ACCTCCAGAA ATTGAAAGTT TTTACCCACC CATCGATGAA 
CCAGCTATTG GAAATAAAAG TGTCGATCTG TCCGGACGAC GTGAAAGAAA ACAAATCTTC 
AAAGGAAAAA CATTCGTGTT TTTAAATGCC AAGCAGCATA AGAAACTCGG CTCGGCAGTT 
GTTTTCGGAG GTGGGGAAGC CAGGCTGATG GCAGAAGGAG GTGAAGAGGA ACAGAGCTTC 
TTCTCAGCTC CCGGAACCTG TGTTGTTGAC GTAGGAATAA CAAACACACA GCTCATAATT 
ACAGACTCCC AGAGGAAGTG GATTCATTTG ATAATGGATA TACTTCAAAG GCATGGCCTC 
AGACCTATTC CTGAAGCAGA GATTGGATTG GCTGTTATTT TTATGACTAC AGAGAGTTAC 
TGTAATCCGC AGGGCCAGCC TTGTACAGAG GTAAAGACGA CGACTCCAGG ACCAAGCCTT 
TCCCAGGGCC TGTCAGCCAA TGGAAAAGTC ATCCCCAGTG CGCCAATGAA TATGACCACA 
TACGTAGCTG ACACAGAATC AGAGCCAGCA GATACATGTA TGTCTTTGAG TGAAAGACCA 
GAAGAAGTAA AGATCTTTGG ACTCGATCAA AACTCTAGAA AGCTTTTACA AGGAACATGC 
AATATAAAGG AGACCTCTAA TCAAAGCTCC AATTCTAACA ATGCAGCATC AAATACACTG 
GTTAGGGGAA AGGCCCCGAA CTATCAGCTT TCACCAATGA AATGTCCTGC TGCAAGTAAA 
AATAAAGATT GGTCTTCTCA GCAGCAGCTG AACTCCATCA AAAACTACTT CCAGCCATGC 
TCCAGAAAAA GGGAAAGGGA TGAAGAAAAT CCAGAACAGT CCTCATGCAA ATCGTCAAGA 
GTGGAACTGT CTTGTTCTCT TTTAGAACAA ACGCAACCTG CAGGACCCTC ACTGTGGAAA 
AGCAAAGACC ATGAGTCTCA GAGTGAGACT CTGGACAGGG CATCCAATGC CTCATCTGTG 
GGTGGAATAG ACATAAAACC CAATGGGAAG AGTCCTGACA GTAAGTCATT TTCCACAGAA 
GATCTTAGAG CAAGAAAAAG AAAAGAAGTG GATTTGTCTA CAGAAGAGGA AGTGTTGGAA 
GAGTTACTCA GGAGCACAAA GCCAGAGCTG GCAGTTCAAG TGAAGGTTGA AAAGCAGGAG 
GCAGATGTCA GCATCAGAAA GAAGCCCAGG ATGGATGCAG AGAGGAATCA GCACCTGAAC 
GGTGGCCCAG TGCCAGAAAG CAACAGCGCA CTTCAAGAAG ATGAAACAGG AAAGAAAGAT 
GAGCTTCAGA TAGAAGCATG GTCAACAAAA CGTGAAGTAT CTAATACTGA CGAGCTTCCG 
GACAGCAGTG AGGAGCTTCC AAGAAAACTG CTGCTGACTG AATTTAGGTC ACTGGTTGTC 
CATAATAACT CTTCCAGAAA TCTGTGCGTA CTAAATGGTC GTGGCGAACT GAAGAATTTC 
AAGAAATTCA AGAAGGCTAC GTGTCCTGGA GCAGGAAAGC TTCCACACAT TATTGGAGGA 
TCAGATTTAA TAGGTCACCA TGCTCGAAAG AATACTGAAT TAGAAGAGTG GTTGAAACAT 
GAAATGGAGG TACAGAAACA ACAAGCGAAA GAAGACTCTC TTGCTGATGA TCTGTTTAGA 
TATAATCCTA ATGTAAAAAG AAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237978.2
CDS	305..2311
Translation	MLNGLSSTLKTGDRVTFGVFESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANSWTEECTHLAMSSVKVTIKTICALICGRPIVKPEYFSEFLKAVESKTQPPEIESFYPPIDEPAIGNKSVDLSGRRERKQIFKGKTFVFLNAKQHKKLGSAVVFGGGEARLMAEGGEEEQSFFSAPGTCVVDVGITNTQLIITDSQRKWIHLIMDILQRHGLRPIPEAEIGLAVIFMTTESYCNPQGQPCTEVKTTTPGPSLSQGLSANGKVIPSAPMNMTTYVADTESEPADTCMSLSERPEEVKIFGLDQNSRKLLQGTCNIKETSNQSSNSNNAASNTLVRGKAPNYQLSPMKCPAASKNKDWSSQQQLNSIKNYFQPCSRKRERDEENPEQSSCKSSRVELSCSLLEQTQPAGPSLWKSKDHESQSETLDRASNASSVGGIDIKPNGKSPDSKSFSTEDLRARKRKEVDLSTEEEVLEELLRSTKPELAVQVKVEKQEADVSIRKKPRMDAERNQHLNGGPVPESNSALQEDETGKKDELQIEAWSTKREVSNTDELPDSSEELPRKLLLTEFRSLVVHNNSSRNLCVLNGRGELKNFKKFKKATCPGAGKLPHIIGGSDLIGHHARKNTELEEWLKHEMEVQKQQAKEDSLADDLFRYNPNVKRR

Target ORF information:

RefSeq Version	XM_006237916.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nibrin (Nbn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237916.2

ORF Insert Sequence:

ATGCTGAATG GCCTTTCTTC CACTTTGAAG ACAGGAGATA GAGTTACCTT TGGGGTGTTT 
GAAAGTAAAT TCAGAGTAGA ATACGAGCCT TTGGTTGTTT GCTCTTCTTG TTTAGATGTC 
TCTGGGAAAA CTGTTTTAAA CCAAGCTATA TTACAGCTTG GAGGACTCAC TGCAAACAGC 
TGGACAGAAG AGTGTACTCA CCTTGCCATG TCATCAGTCA AAGTCACCAT TAAAACTATA 
TGTGCACTCA TTTGTGGACG TCCAATTGTA AAGCCAGAAT ACTTTTCTGA ATTTCTCAAA 
GCAGTTGAGT CCAAGACACA ACCTCCAGAA ATTGAAAGTT TTTACCCACC CATCGATGAA 
CCAGCTATTG GAAATAAAAG TGTCGATCTG TCCGGACGAC GTGAAAGAAA ACAAATCTTC 
AAAGGAAAAA CATTCGTGTT TTTAAATGCC AAGCAGCATA AGAAACTCGG CTCGGCAGTT 
GTTTTCGGAG GTGGGGAAGC CAGGCTGATG GCAGAAGGAG GTGAAGAGGA ACAGAGCTTC 
TTCTCAGCTC CCGGAACCTG TGTTGTTGAC GTAGGAATAA CAAACACACA GCTCATAATT 
ACAGACTCCC AGAGGAAGTG GATTCATTTG ATAATGGATA TACTTCAAAG GCATGGCCTC 
AGACCTATTC CTGAAGCAGA GATTGGATTG GCTGTTATTT TTATGACTAC AGAGAGTTAC 
TGTAATCCGC AGGGCCAGCC TTGTACAGAG GTAAAGACGA CGACTCCAGG ACCAAGCCTT 
TCCCAGGGCC TGTCAGCCAA TGGAAAAGTC ATCCCCAGTG CGCCAATGAA TATGACCACA 
TACGTAGCTG ACACAGAATC AGAGCCAGCA GATACATGTA TGTCTTTGAG TGAAAGACCA 
GAAGAAGTAA AGATCTTTGG ACTCGATCAA AACTCTAGAA AGCTTTTACA AGGAACATGC 
AATATAAAGG AGACCTCTAA TCAAAGCTCC AATTCTAACA ATGCAGCATC AAATACACTG 
GTTAGGGGAA AGGCCCCGAA CTATCAGCTT TCACCAATGA AATGTCCTGC TGCAAGTAAA 
AATAAAGATT GGTCTTCTCA GCAGCAGCTG AACTCCATCA AAAACTACTT CCAGCCATGC 
TCCAGAAAAA GGGAAAGGGA TGAAGAAAAT CCAGAACAGT CCTCATGCAA ATCGTCAAGA 
GTGGAACTGT CTTGTTCTCT TTTAGAACAA ACGCAACCTG CAGGACCCTC ACTGTGGAAA 
AGCAAAGACC ATGAGTCTCA GAGTGAGACT CTGGACAGGG CATCCAATGC CTCATCTGTG 
GGTGGAATAG ACATAAAACC CAATGGGAAG AGTCCTGACA GTAAGTCATT TTCCACAGAA 
GATCTTAGAG CAAGAAAAAG AAAAGAAGTG GATTTGTCTA CAGAAGAGGA AGTGTTGGAA 
GAGTTACTCA GGAGCACAAA GCCAGAGCTG GCAGTTCAAG TGAAGGTTGA AAAGCAGGAG 
GCAGATGTCA GCATCAGAAA GAAGCCCAGG ATGGATGCAG AGAGGAATCA GCACCTGAAC 
GGTGGCCCAG TGCCAGAAAG CAACAGCGCA CTTCAAGAAG ATGAAACAGG AAAGAAAGAT 
GAGCTTCAGA TAGAAGCATG GTCAACAAAA CGTGAAGTAT CTAATACTGA CGAGCTTCCG 
GACAGCAGTG AGGAGCTTCC AAGAAAACTG CTGCTGACTG AATTTAGGTC ACTGGTTGTC 
CATAATAACT CTTCCAGAAA TCTGTGCGTA CTAAATGGTC GTGGCGAACT GAAGAATTTC 
AAGAAATTCA AGAAGGCTAC GTGTCCTGGA GCAGGAAAGC TTCCACACAT TATTGGAGGA 
TCAGATTTAA TAGGTCACCA TGCTCGAAAG AATACTGAAT TAGAAGAGTG GTTGAAACAT 
GAAATGGAGG TACAGAAACA ACAAGCGAAA GAAGACTCTC TTGCTGATGA TCTGTTTAGA 
TATAATCCTA ATGTAAAAAG AAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A balance between elongation and trimming regulates telomere stability in stem cells.
Nature structural & molecular biology24(1)30-39(2017 Jan)
Rivera T,Haggblom C,Cosconati S,Karlseder J

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.
Nucleic acids research41(8)4447-58(2013 Apr)
Chang FT,McGhie JD,Chan FL,Tang MC,Anderson MA,Mann JR,Andy Choo KH,Wong LH

Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins.
Molecular therapy : the journal of the American Society of Gene Therapy20(11)2087-97(2012 Nov)
Lovric J,Mano M,Zentilin L,Eulalio A,Zacchigna S,Giacca M

ATM protein kinase: the linchpin of cellular defenses to stress.
Cellular and molecular life sciences : CMLS68(18)2977-3006(2011 Sep)
Bhatti S,Kozlov S,Farooqi AA,Naqi A,Lavin M,Khanna KK

Regulation of homologous recombination in eukaryotes.
Annual review of genetics44113-39(2010)
Heyer WD,Ehmsen KT,Liu J

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Nbn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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