Jak1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Jak1
Entrez Gene ID	84598
Full Name	Janus kinase 1
General protein information	Preferred Names Janus kinase 1 Names tyrosine-protein kinase JAK1 Janus protein tyrosine kinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q33
Summary	protein-tyrosine kinases; involved in intracellular signal transduction [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006238453.3	XP_006238515.1	tyrosine-protein kinase JAK1 isoform X1
XM_006238452.3	XP_006238514.1	tyrosine-protein kinase JAK1 isoform X1
NM_053466.1	NP_445918.1	tyrosine-protein kinase JAK1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	jak1	XP_002931642.1
Gallus gallus (chicken)	JAK1	NP_990201.1
Danio rerio (zebrafish)	jak1	NP_571148.1
Homo sapiens (human)	JAK1	NP_002218.2
	JAK1	XP_002801666.1
Canis lupus familiaris (dog)	JAK1	XP_536679.2
Rattus norvegicus (Norway rat)	Jak1	NP_445918.1
Pan troglodytes (chimpanzee)	JAK1	XP_001161242.1
Bos taurus (cattle)	JAK1	NP_001193463.1
Mus musculus (house mouse)	Jak1	NP_666257.2

Gene Ontology
Bibliography

Related articles in PubMed

Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway.
Chen L, Zhou D, Liu Z, Huang X, Liu Q, Kang Y, Chen Z, Guo Y, Zhu H, Sun C
Oncology reports(2018 Jan)

MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway.
Yu DL, Zhang T, Wu K, Li Y, Wang J, Chen J, Li XQ, Peng XG, Wang JN, Tan LG
Oncology reports38(2)1075-1082(2017 Aug)

Generation of Janus kinase 1 (JAK1) conditional knockout mice.
Sakamoto K, Wehde BL, R?dler PD, Triplett AA, Wagner KU
Genesis (New York, N.Y. : 2000)54(11)582-588(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Astrocyte expression of GLAST/GFAP was reduced via JAK1/JAK2/STAT3 signaling pathway after exposure to sevoflurane.
Title: Sevoflurane Inhibits Glutamate-Aspartate Transporter and Glial Fibrillary Acidic Protein Expression in Hippocampal Astrocytes of Neonatal Rats Through the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) Pathway.

findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements
Title: Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.

These data demonstrate for the first time that KRV-induced islet destruction is associated with beta cell infection and intra-islet innate immune upregulation early in the disease process.
Title: Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis.

Endogenous synthesis of IL-1beta is diminished in nerve tissue in type 1 diabetes and this defect triggers reduced STAT3 signaling and mitochondrial function.
Title: Diabetes impairs an interleukin-1?-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons.

Both R507 and R545 are potent novel immunosuppressants with favorable pharmacokinetics and high JAK1/3 selectivity to reduce cardiac allograft rejection.
Title: Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.

The following Jak1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jak1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09632	NM_053466.1 Latest version!	Rattus norvegicus Janus kinase 1 (Jak1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
ORa09632	XM_006238453.3 Latest version!	Rattus norvegicus Janus kinase 1 (Jak1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
ORa09632	XM_006238452.3 Latest version!	Rattus norvegicus Janus kinase 1 (Jak1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Jak1 ( NM_053466.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445918.1 Rattus norvegicus Janus kinase 1 (Jak1), mRNA.

Price & Availability↑

CloneID	ORa09632
Clone ID Related Accession (Same CDS sequence)	XM_006238453.3 , XM_006238452.3 , NM_053466.1
Accession Version	NM_053466.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase JAK1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473998.1. On or before Aug 23, 2008 this sequence version replaced XM_342872.3, XM_001061647.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 
AGCTTCAAGA AGACGGAGGT GAAGCAGGTG GCCCCTGAGC CAGGAGTGGA AGTGACTTTC 
TATCTGTTGG ACAGGGAGCC CCTCCGCCTG GGCAGCGGAG AGTACACCGC GGAGGAGCTG 
TGCATCAGGG CCGCACAGGA ATGCAGTATC TCTCCTCTCT GCCACAACCT CTTCGCCTTG 
TATGATGAGA GCACCAAGCT CTGGTATGCT CCAAACCACA TCATCACTGT GGATGACAAA 
ATGTCTCTCC GGCTGCACTA CCGCATGAGG TTCTACTTTA CCAACTGGCA TGGAACCAAT 
GACAATGAAC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAG 
AAAAAGGTTC CAGAAGCAAC CCCACTCCTT GATGCCAGTT CACTGGAGTA TCTGTTTGCG 
CAGGGACAGT ATGATTTGAT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACAGAGCAA 
GATGGACATG ATATTGAGAA TGAGTGCCTG GGCATGGCTG TCCTGGCCAT CTCACACTAT 
GCCATGATGA AGAAGATGCA GTTGCCAGAG CTTCCCAAAG ACATCAGCTA CAAGCGATAT 
ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAATC TTCTTACCAG GATGCGAATA 
AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGT 
GTGTCTACAC ACGACCTGAA GGTGAAGTAC CTGGCTACCT TGGAAACCTT AACCAAGCAT 
TATGGAGCCG AGATATTTGA GACTTCTATG CTCCTGATTT CATCAGAAAA TGAGCTGAGT 
CGGTGCCATT CCAACGACAG TGGCAATGTT CTCTATGAAG TCATGGTAAC AGGAAATCTC 
GGGATCCAGT GGCGGCAGAA ACCAAATGTT CTTCCTGTTG AAAAGGAAAA AAATAAACTG 
AAGCGGAAAA AACTGGACTA TAATAAACAC AAGAAGGAGG ATGACAGAAA CAAACTCCGG 
GAAGAGTGGA ACAGTTTTTC CTATTTCCCC GAGATTACCC ACATTGTTAT CAAGGAGTCT 
GTGGTCAGCA TTAACAAACA GGACAACAAG AACATGGAAC TAAAGCTCTC TTCTCATGAG 
GAAGCCTTGT CCTTCGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACTGC AGATGCTCAC 
CATTACCTCT GTACTGATGT GGCTCCCCCG CTGATTGTCC ACAACATACA GAATGGCTGT 
CACGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAGGAGGG GAGTGAGGAG 
GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATTCTTAT GACTGTCAGC 
TGCTTCGAAA AGTCCGAGGT ATTGGGTAAT CAGAAGCAGT TCAAGAACTT TCAGATTGAG 
GTGCAGAAGG GCCGCTACAG CCTGCATGGC TCTGTTGACC ACTTTCCCAG CCTGAGAGAC 
CTCATGAACC ACCTCAAGAA GCAGATCCTG CGCACGGACA ATATAAGCTT TGTGCTGAAA 
CGCTGCTGTC AGCCTAAGCC TCGAGAAATC TCCAACCTAC TTGTAGCCAC TAAGAAAGCC 
CAGGAGTGGC AGCCTGTCTA CTCTATGAGC CAGCTGAGTT TCGATCGGAT CCTTAAGAAA 
GATATTATCC AAGGTGAGCA CCTTGGCAGA GGCACAAGAA CACATATCTA TTCTGGGACC 
CTGCTGGATT ACAAGGACGA TGAAGGAATT GCTGAAGAAA AGAAGATAAA AGTGATTCTC 
AAAGTCCTAG ACCCTAGCCA CCGGGACATT TCACTGGCCT TCTTTGAGGC AGCCAGCATG 
ATGAGACAGG TTTCCCACAA ACACATCGTG TACCTCTACG GCGTCTGTGT CCGAGATGTG 
GAAAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCAT TGGATCTCTT CATGCACCGG 
AAAAGTGATG CACTTACTAC CCCTTGGAAG TTTAAAGTTG CCAAACAGCT GGCCAGCGCC 
CTGAGTTACT TGGAAGATAA AGACCTCGTT CATGGAAATG TGTGCACTAA AAACCTCCTC 
CTGGCCCGTG AGGGCATTGA CAGTGACATT GGCCCGTTCA TCAAGCTTAG TGACCCTGGC 
ATCCCAGTCT CTGTGCTGAC CAGGCAAGAG TGCATAGAGC GAATTCCCTG GATCGCTCCT 
GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 
ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCACTCA AGGACAAGAC CCTCATTGAG 
AAAGAGAGGT TTTATGAAAG CCGCTGCAGG CCAGTGACAC CATCTTGCAA GGAGCTAGCT 
GACCTCATGA CTCGCTGCAT GAACTATGAT CCCAACCAGA GACCTTTCTT CCGAGCCATC 
ATGAGGGACA TTAACAAGCT GGAGGAGCAG AATCCAGACA TTGTTTCAGA AAAGCAGCCA 
ATAACAGAGG TGGATCCCAC TCATTTTGAA AAGCGTTTCC TAAAGAGGAT TCGTGACTTG 
GGAGAGGGTC ACTTTGGGAA GGTTGAGCTC TGCAGATATG ATCCTGAGGG AGACAACACA 
GGGGAACAGG TAGCTGTCAA GTCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 
CTGAAGAAGG AGATAGAGAT CTTACGGAAC CTCTACCACG AGAACATTGT GAAGTATAAA 
GGAATCTGCA TGGAAGACGG AGGGAATGGT ATCAAGCTCA TCATGGAGTT TCTGCCTTCG 
GGAAGCCTAA AGGAATATCT GCCAAAGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTA 
AAATATGCCA TCCAGATTTG TAAGGGGATG GACTATCTGG GCTCTCGGCA ATATGTTCAC 
CGGGACTTAG CAGCAAGAAA TGTCCTTGTT GAGAGTGAAC ACCAAGTGAA GATCGGAGAC 
TTTGGTTTAA CCAAAGCAAT TGAGACCGAT AAGGAGTACT ACACAGTCAA GGATGACCGG 
GACAGCCCAG TGTTTTGGTA CGCTCCGGAG TGTTTAATCC AGTGTAAATT TTATATCGCC 
TCTGATGTCT GGTCTTTTGG AGTGACACTG CACGAGTTGC TCACGTACTG TGACTCAGAT 
TTTAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTA 
ACACGGCTTG TGAATACTCT GAAAGAAGGA AAGCGCCTGT CCTGTCCACC CAACTGTCCC 
GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCTAA TCGGACAACC 
TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445918.1
CDS	139..3600
Translation	MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKEKNKLKRKKLDYNKHKKEDDRNKLREEWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK

Target ORF information:

RefSeq Version	NM_053466.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Janus kinase 1 (Jak1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053466.1

ORF Insert Sequence:

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 
AGCTTCAAGA AGACGGAGGT GAAGCAGGTG GCCCCTGAGC CAGGAGTGGA AGTGACTTTC 
TATCTGTTGG ACAGGGAGCC CCTCCGCCTG GGCAGCGGAG AGTACACCGC GGAGGAGCTG 
TGCATCAGGG CCGCACAGGA ATGCAGTATC TCTCCTCTCT GCCACAACCT CTTCGCCTTG 
TATGATGAGA GCACCAAGCT CTGGTATGCT CCAAACCACA TCATCACTGT GGATGACAAA 
ATGTCTCTCC GGCTGCACTA CCGCATGAGG TTCTACTTTA CCAACTGGCA TGGAACCAAT 
GACAATGAAC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAG 
AAAAAGGTTC CAGAAGCAAC CCCACTCCTT GATGCCAGTT CACTGGAGTA TCTGTTTGCG 
CAGGGACAGT ATGATTTGAT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACAGAGCAA 
GATGGACATG ATATTGAGAA TGAGTGCCTG GGCATGGCTG TCCTGGCCAT CTCACACTAT 
GCCATGATGA AGAAGATGCA GTTGCCAGAG CTTCCCAAAG ACATCAGCTA CAAGCGATAT 
ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAATC TTCTTACCAG GATGCGAATA 
AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGT 
GTGTCTACAC ACGACCTGAA GGTGAAGTAC CTGGCTACCT TGGAAACCTT AACCAAGCAT 
TATGGAGCCG AGATATTTGA GACTTCTATG CTCCTGATTT CATCAGAAAA TGAGCTGAGT 
CGGTGCCATT CCAACGACAG TGGCAATGTT CTCTATGAAG TCATGGTAAC AGGAAATCTC 
GGGATCCAGT GGCGGCAGAA ACCAAATGTT CTTCCTGTTG AAAAGGAAAA AAATAAACTG 
AAGCGGAAAA AACTGGACTA TAATAAACAC AAGAAGGAGG ATGACAGAAA CAAACTCCGG 
GAAGAGTGGA ACAGTTTTTC CTATTTCCCC GAGATTACCC ACATTGTTAT CAAGGAGTCT 
GTGGTCAGCA TTAACAAACA GGACAACAAG AACATGGAAC TAAAGCTCTC TTCTCATGAG 
GAAGCCTTGT CCTTCGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACTGC AGATGCTCAC 
CATTACCTCT GTACTGATGT GGCTCCCCCG CTGATTGTCC ACAACATACA GAATGGCTGT 
CACGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAGGAGGG GAGTGAGGAG 
GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATTCTTAT GACTGTCAGC 
TGCTTCGAAA AGTCCGAGGT ATTGGGTAAT CAGAAGCAGT TCAAGAACTT TCAGATTGAG 
GTGCAGAAGG GCCGCTACAG CCTGCATGGC TCTGTTGACC ACTTTCCCAG CCTGAGAGAC 
CTCATGAACC ACCTCAAGAA GCAGATCCTG CGCACGGACA ATATAAGCTT TGTGCTGAAA 
CGCTGCTGTC AGCCTAAGCC TCGAGAAATC TCCAACCTAC TTGTAGCCAC TAAGAAAGCC 
CAGGAGTGGC AGCCTGTCTA CTCTATGAGC CAGCTGAGTT TCGATCGGAT CCTTAAGAAA 
GATATTATCC AAGGTGAGCA CCTTGGCAGA GGCACAAGAA CACATATCTA TTCTGGGACC 
CTGCTGGATT ACAAGGACGA TGAAGGAATT GCTGAAGAAA AGAAGATAAA AGTGATTCTC 
AAAGTCCTAG ACCCTAGCCA CCGGGACATT TCACTGGCCT TCTTTGAGGC AGCCAGCATG 
ATGAGACAGG TTTCCCACAA ACACATCGTG TACCTCTACG GCGTCTGTGT CCGAGATGTG 
GAAAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCAT TGGATCTCTT CATGCACCGG 
AAAAGTGATG CACTTACTAC CCCTTGGAAG TTTAAAGTTG CCAAACAGCT GGCCAGCGCC 
CTGAGTTACT TGGAAGATAA AGACCTCGTT CATGGAAATG TGTGCACTAA AAACCTCCTC 
CTGGCCCGTG AGGGCATTGA CAGTGACATT GGCCCGTTCA TCAAGCTTAG TGACCCTGGC 
ATCCCAGTCT CTGTGCTGAC CAGGCAAGAG TGCATAGAGC GAATTCCCTG GATCGCTCCT 
GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 
ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCACTCA AGGACAAGAC CCTCATTGAG 
AAAGAGAGGT TTTATGAAAG CCGCTGCAGG CCAGTGACAC CATCTTGCAA GGAGCTAGCT 
GACCTCATGA CTCGCTGCAT GAACTATGAT CCCAACCAGA GACCTTTCTT CCGAGCCATC 
ATGAGGGACA TTAACAAGCT GGAGGAGCAG AATCCAGACA TTGTTTCAGA AAAGCAGCCA 
ATAACAGAGG TGGATCCCAC TCATTTTGAA AAGCGTTTCC TAAAGAGGAT TCGTGACTTG 
GGAGAGGGTC ACTTTGGGAA GGTTGAGCTC TGCAGATATG ATCCTGAGGG AGACAACACA 
GGGGAACAGG TAGCTGTCAA GTCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 
CTGAAGAAGG AGATAGAGAT CTTACGGAAC CTCTACCACG AGAACATTGT GAAGTATAAA 
GGAATCTGCA TGGAAGACGG AGGGAATGGT ATCAAGCTCA TCATGGAGTT TCTGCCTTCG 
GGAAGCCTAA AGGAATATCT GCCAAAGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTA 
AAATATGCCA TCCAGATTTG TAAGGGGATG GACTATCTGG GCTCTCGGCA ATATGTTCAC 
CGGGACTTAG CAGCAAGAAA TGTCCTTGTT GAGAGTGAAC ACCAAGTGAA GATCGGAGAC 
TTTGGTTTAA CCAAAGCAAT TGAGACCGAT AAGGAGTACT ACACAGTCAA GGATGACCGG 
GACAGCCCAG TGTTTTGGTA CGCTCCGGAG TGTTTAATCC AGTGTAAATT TTATATCGCC 
TCTGATGTCT GGTCTTTTGG AGTGACACTG CACGAGTTGC TCACGTACTG TGACTCAGAT 
TTTAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTA 
ACACGGCTTG TGAATACTCT GAAAGAAGGA AAGCGCCTGT CCTGTCCACC CAACTGTCCC 
GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCTAA TCGGACAACC 
TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jak1 ( XM_006238453.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238515.1 Rattus norvegicus Janus kinase 1 (Jak1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa09632
Clone ID Related Accession (Same CDS sequence)	XM_006238453.3 , XM_006238452.3 , NM_053466.1
Accession Version	XM_006238453.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase JAK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238453.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 
AGCTTCAAGA AGACGGAGGT GAAGCAGGTG GCCCCTGAGC CAGGAGTGGA AGTGACTTTC 
TATCTGTTGG ACAGGGAGCC CCTCCGCCTG GGCAGCGGAG AGTACACCGC GGAGGAGCTG 
TGCATCAGGG CCGCACAGGA ATGCAGTATC TCTCCTCTCT GCCACAACCT CTTCGCCTTG 
TATGATGAGA GCACCAAGCT CTGGTATGCT CCAAACCACA TCATCACTGT GGATGACAAA 
ATGTCTCTCC GGCTGCACTA CCGCATGAGG TTCTACTTTA CCAACTGGCA TGGAACCAAT 
GACAATGAAC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAG 
AAAAAGGTTC CAGAAGCAAC CCCACTCCTT GATGCCAGTT CACTGGAGTA TCTGTTTGCG 
CAGGGACAGT ATGATTTGAT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACAGAGCAA 
GATGGACATG ATATTGAGAA TGAGTGCCTG GGCATGGCTG TCCTGGCCAT CTCACACTAT 
GCCATGATGA AGAAGATGCA GTTGCCAGAG CTTCCCAAAG ACATCAGCTA CAAGCGATAT 
ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAATC TTCTTACCAG GATGCGAATA 
AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGT 
GTGTCTACAC ACGACCTGAA GGTGAAGTAC CTGGCTACCT TGGAAACCTT AACCAAGCAT 
TATGGAGCCG AGATATTTGA GACTTCTATG CTCCTGATTT CATCAGAAAA TGAGCTGAGT 
CGGTGCCATT CCAACGACAG TGGCAATGTT CTCTATGAAG TCATGGTAAC AGGAAATCTC 
GGGATCCAGT GGCGGCAGAA ACCAAATGTT CTTCCTGTTG AAAAGGAAAA AAATAAACTG 
AAGCGGAAAA AACTGGACTA TAATAAACAC AAGAAGGAGG ATGACAGAAA CAAACTCCGG 
GAAGAGTGGA ACAGTTTTTC CTATTTCCCC GAGATTACCC ACATTGTTAT CAAGGAGTCT 
GTGGTCAGCA TTAACAAACA GGACAACAAG AACATGGAAC TAAAGCTCTC TTCTCATGAG 
GAAGCCTTGT CCTTCGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACTGC AGATGCTCAC 
CATTACCTCT GTACTGATGT GGCTCCCCCG CTGATTGTCC ACAACATACA GAATGGCTGT 
CACGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAGGAGGG GAGTGAGGAG 
GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATTCTTAT GACTGTCAGC 
TGCTTCGAAA AGTCCGAGGT ATTGGGTAAT CAGAAGCAGT TCAAGAACTT TCAGATTGAG 
GTGCAGAAGG GCCGCTACAG CCTGCATGGC TCTGTTGACC ACTTTCCCAG CCTGAGAGAC 
CTCATGAACC ACCTCAAGAA GCAGATCCTG CGCACGGACA ATATAAGCTT TGTGCTGAAA 
CGCTGCTGTC AGCCTAAGCC TCGAGAAATC TCCAACCTAC TTGTAGCCAC TAAGAAAGCC 
CAGGAGTGGC AGCCTGTCTA CTCTATGAGC CAGCTGAGTT TCGATCGGAT CCTTAAGAAA 
GATATTATCC AAGGTGAGCA CCTTGGCAGA GGCACAAGAA CACATATCTA TTCTGGGACC 
CTGCTGGATT ACAAGGACGA TGAAGGAATT GCTGAAGAAA AGAAGATAAA AGTGATTCTC 
AAAGTCCTAG ACCCTAGCCA CCGGGACATT TCACTGGCCT TCTTTGAGGC AGCCAGCATG 
ATGAGACAGG TTTCCCACAA ACACATCGTG TACCTCTACG GCGTCTGTGT CCGAGATGTG 
GAAAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCAT TGGATCTCTT CATGCACCGG 
AAAAGTGATG CACTTACTAC CCCTTGGAAG TTTAAAGTTG CCAAACAGCT GGCCAGCGCC 
CTGAGTTACT TGGAAGATAA AGACCTCGTT CATGGAAATG TGTGCACTAA AAACCTCCTC 
CTGGCCCGTG AGGGCATTGA CAGTGACATT GGCCCGTTCA TCAAGCTTAG TGACCCTGGC 
ATCCCAGTCT CTGTGCTGAC CAGGCAAGAG TGCATAGAGC GAATTCCCTG GATCGCTCCT 
GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 
ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCACTCA AGGACAAGAC CCTCATTGAG 
AAAGAGAGGT TTTATGAAAG CCGCTGCAGG CCAGTGACAC CATCTTGCAA GGAGCTAGCT 
GACCTCATGA CTCGCTGCAT GAACTATGAT CCCAACCAGA GACCTTTCTT CCGAGCCATC 
ATGAGGGACA TTAACAAGCT GGAGGAGCAG AATCCAGACA TTGTTTCAGA AAAGCAGCCA 
ATAACAGAGG TGGATCCCAC TCATTTTGAA AAGCGTTTCC TAAAGAGGAT TCGTGACTTG 
GGAGAGGGTC ACTTTGGGAA GGTTGAGCTC TGCAGATATG ATCCTGAGGG AGACAACACA 
GGGGAACAGG TAGCTGTCAA GTCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 
CTGAAGAAGG AGATAGAGAT CTTACGGAAC CTCTACCACG AGAACATTGT GAAGTATAAA 
GGAATCTGCA TGGAAGACGG AGGGAATGGT ATCAAGCTCA TCATGGAGTT TCTGCCTTCG 
GGAAGCCTAA AGGAATATCT GCCAAAGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTA 
AAATATGCCA TCCAGATTTG TAAGGGGATG GACTATCTGG GCTCTCGGCA ATATGTTCAC 
CGGGACTTAG CAGCAAGAAA TGTCCTTGTT GAGAGTGAAC ACCAAGTGAA GATCGGAGAC 
TTTGGTTTAA CCAAAGCAAT TGAGACCGAT AAGGAGTACT ACACAGTCAA GGATGACCGG 
GACAGCCCAG TGTTTTGGTA CGCTCCGGAG TGTTTAATCC AGTGTAAATT TTATATCGCC 
TCTGATGTCT GGTCTTTTGG AGTGACACTG CACGAGTTGC TCACGTACTG TGACTCAGAT 
TTTAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTA 
ACACGGCTTG TGAATACTCT GAAAGAAGGA AAGCGCCTGT CCTGTCCACC CAACTGTCCC 
GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCTAA TCGGACAACC 
TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238515.1
CDS	3936..7397
Translation	MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKEKNKLKRKKLDYNKHKKEDDRNKLREEWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK

Target ORF information:

RefSeq Version	XM_006238453.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Janus kinase 1 (Jak1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006238453.3

ORF Insert Sequence:

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 
AGCTTCAAGA AGACGGAGGT GAAGCAGGTG GCCCCTGAGC CAGGAGTGGA AGTGACTTTC 
TATCTGTTGG ACAGGGAGCC CCTCCGCCTG GGCAGCGGAG AGTACACCGC GGAGGAGCTG 
TGCATCAGGG CCGCACAGGA ATGCAGTATC TCTCCTCTCT GCCACAACCT CTTCGCCTTG 
TATGATGAGA GCACCAAGCT CTGGTATGCT CCAAACCACA TCATCACTGT GGATGACAAA 
ATGTCTCTCC GGCTGCACTA CCGCATGAGG TTCTACTTTA CCAACTGGCA TGGAACCAAT 
GACAATGAAC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAG 
AAAAAGGTTC CAGAAGCAAC CCCACTCCTT GATGCCAGTT CACTGGAGTA TCTGTTTGCG 
CAGGGACAGT ATGATTTGAT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACAGAGCAA 
GATGGACATG ATATTGAGAA TGAGTGCCTG GGCATGGCTG TCCTGGCCAT CTCACACTAT 
GCCATGATGA AGAAGATGCA GTTGCCAGAG CTTCCCAAAG ACATCAGCTA CAAGCGATAT 
ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAATC TTCTTACCAG GATGCGAATA 
AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGT 
GTGTCTACAC ACGACCTGAA GGTGAAGTAC CTGGCTACCT TGGAAACCTT AACCAAGCAT 
TATGGAGCCG AGATATTTGA GACTTCTATG CTCCTGATTT CATCAGAAAA TGAGCTGAGT 
CGGTGCCATT CCAACGACAG TGGCAATGTT CTCTATGAAG TCATGGTAAC AGGAAATCTC 
GGGATCCAGT GGCGGCAGAA ACCAAATGTT CTTCCTGTTG AAAAGGAAAA AAATAAACTG 
AAGCGGAAAA AACTGGACTA TAATAAACAC AAGAAGGAGG ATGACAGAAA CAAACTCCGG 
GAAGAGTGGA ACAGTTTTTC CTATTTCCCC GAGATTACCC ACATTGTTAT CAAGGAGTCT 
GTGGTCAGCA TTAACAAACA GGACAACAAG AACATGGAAC TAAAGCTCTC TTCTCATGAG 
GAAGCCTTGT CCTTCGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACTGC AGATGCTCAC 
CATTACCTCT GTACTGATGT GGCTCCCCCG CTGATTGTCC ACAACATACA GAATGGCTGT 
CACGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAGGAGGG GAGTGAGGAG 
GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATTCTTAT GACTGTCAGC 
TGCTTCGAAA AGTCCGAGGT ATTGGGTAAT CAGAAGCAGT TCAAGAACTT TCAGATTGAG 
GTGCAGAAGG GCCGCTACAG CCTGCATGGC TCTGTTGACC ACTTTCCCAG CCTGAGAGAC 
CTCATGAACC ACCTCAAGAA GCAGATCCTG CGCACGGACA ATATAAGCTT TGTGCTGAAA 
CGCTGCTGTC AGCCTAAGCC TCGAGAAATC TCCAACCTAC TTGTAGCCAC TAAGAAAGCC 
CAGGAGTGGC AGCCTGTCTA CTCTATGAGC CAGCTGAGTT TCGATCGGAT CCTTAAGAAA 
GATATTATCC AAGGTGAGCA CCTTGGCAGA GGCACAAGAA CACATATCTA TTCTGGGACC 
CTGCTGGATT ACAAGGACGA TGAAGGAATT GCTGAAGAAA AGAAGATAAA AGTGATTCTC 
AAAGTCCTAG ACCCTAGCCA CCGGGACATT TCACTGGCCT TCTTTGAGGC AGCCAGCATG 
ATGAGACAGG TTTCCCACAA ACACATCGTG TACCTCTACG GCGTCTGTGT CCGAGATGTG 
GAAAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCAT TGGATCTCTT CATGCACCGG 
AAAAGTGATG CACTTACTAC CCCTTGGAAG TTTAAAGTTG CCAAACAGCT GGCCAGCGCC 
CTGAGTTACT TGGAAGATAA AGACCTCGTT CATGGAAATG TGTGCACTAA AAACCTCCTC 
CTGGCCCGTG AGGGCATTGA CAGTGACATT GGCCCGTTCA TCAAGCTTAG TGACCCTGGC 
ATCCCAGTCT CTGTGCTGAC CAGGCAAGAG TGCATAGAGC GAATTCCCTG GATCGCTCCT 
GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 
ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCACTCA AGGACAAGAC CCTCATTGAG 
AAAGAGAGGT TTTATGAAAG CCGCTGCAGG CCAGTGACAC CATCTTGCAA GGAGCTAGCT 
GACCTCATGA CTCGCTGCAT GAACTATGAT CCCAACCAGA GACCTTTCTT CCGAGCCATC 
ATGAGGGACA TTAACAAGCT GGAGGAGCAG AATCCAGACA TTGTTTCAGA AAAGCAGCCA 
ATAACAGAGG TGGATCCCAC TCATTTTGAA AAGCGTTTCC TAAAGAGGAT TCGTGACTTG 
GGAGAGGGTC ACTTTGGGAA GGTTGAGCTC TGCAGATATG ATCCTGAGGG AGACAACACA 
GGGGAACAGG TAGCTGTCAA GTCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 
CTGAAGAAGG AGATAGAGAT CTTACGGAAC CTCTACCACG AGAACATTGT GAAGTATAAA 
GGAATCTGCA TGGAAGACGG AGGGAATGGT ATCAAGCTCA TCATGGAGTT TCTGCCTTCG 
GGAAGCCTAA AGGAATATCT GCCAAAGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTA 
AAATATGCCA TCCAGATTTG TAAGGGGATG GACTATCTGG GCTCTCGGCA ATATGTTCAC 
CGGGACTTAG CAGCAAGAAA TGTCCTTGTT GAGAGTGAAC ACCAAGTGAA GATCGGAGAC 
TTTGGTTTAA CCAAAGCAAT TGAGACCGAT AAGGAGTACT ACACAGTCAA GGATGACCGG 
GACAGCCCAG TGTTTTGGTA CGCTCCGGAG TGTTTAATCC AGTGTAAATT TTATATCGCC 
TCTGATGTCT GGTCTTTTGG AGTGACACTG CACGAGTTGC TCACGTACTG TGACTCAGAT 
TTTAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTA 
ACACGGCTTG TGAATACTCT GAAAGAAGGA AAGCGCCTGT CCTGTCCACC CAACTGTCCC 
GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCTAA TCGGACAACC 
TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jak1 ( XM_006238452.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238514.1 Rattus norvegicus Janus kinase 1 (Jak1), transcript variant X1, mRNA.

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CloneID	ORa09632
Clone ID Related Accession (Same CDS sequence)	XM_006238453.3 , XM_006238452.3 , NM_053466.1
Accession Version	XM_006238452.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase JAK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006238452.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 
AGCTTCAAGA AGACGGAGGT GAAGCAGGTG GCCCCTGAGC CAGGAGTGGA AGTGACTTTC 
TATCTGTTGG ACAGGGAGCC CCTCCGCCTG GGCAGCGGAG AGTACACCGC GGAGGAGCTG 
TGCATCAGGG CCGCACAGGA ATGCAGTATC TCTCCTCTCT GCCACAACCT CTTCGCCTTG 
TATGATGAGA GCACCAAGCT CTGGTATGCT CCAAACCACA TCATCACTGT GGATGACAAA 
ATGTCTCTCC GGCTGCACTA CCGCATGAGG TTCTACTTTA CCAACTGGCA TGGAACCAAT 
GACAATGAAC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAG 
AAAAAGGTTC CAGAAGCAAC CCCACTCCTT GATGCCAGTT CACTGGAGTA TCTGTTTGCG 
CAGGGACAGT ATGATTTGAT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACAGAGCAA 
GATGGACATG ATATTGAGAA TGAGTGCCTG GGCATGGCTG TCCTGGCCAT CTCACACTAT 
GCCATGATGA AGAAGATGCA GTTGCCAGAG CTTCCCAAAG ACATCAGCTA CAAGCGATAT 
ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAATC TTCTTACCAG GATGCGAATA 
AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGT 
GTGTCTACAC ACGACCTGAA GGTGAAGTAC CTGGCTACCT TGGAAACCTT AACCAAGCAT 
TATGGAGCCG AGATATTTGA GACTTCTATG CTCCTGATTT CATCAGAAAA TGAGCTGAGT 
CGGTGCCATT CCAACGACAG TGGCAATGTT CTCTATGAAG TCATGGTAAC AGGAAATCTC 
GGGATCCAGT GGCGGCAGAA ACCAAATGTT CTTCCTGTTG AAAAGGAAAA AAATAAACTG 
AAGCGGAAAA AACTGGACTA TAATAAACAC AAGAAGGAGG ATGACAGAAA CAAACTCCGG 
GAAGAGTGGA ACAGTTTTTC CTATTTCCCC GAGATTACCC ACATTGTTAT CAAGGAGTCT 
GTGGTCAGCA TTAACAAACA GGACAACAAG AACATGGAAC TAAAGCTCTC TTCTCATGAG 
GAAGCCTTGT CCTTCGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACTGC AGATGCTCAC 
CATTACCTCT GTACTGATGT GGCTCCCCCG CTGATTGTCC ACAACATACA GAATGGCTGT 
CACGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAGGAGGG GAGTGAGGAG 
GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATTCTTAT GACTGTCAGC 
TGCTTCGAAA AGTCCGAGGT ATTGGGTAAT CAGAAGCAGT TCAAGAACTT TCAGATTGAG 
GTGCAGAAGG GCCGCTACAG CCTGCATGGC TCTGTTGACC ACTTTCCCAG CCTGAGAGAC 
CTCATGAACC ACCTCAAGAA GCAGATCCTG CGCACGGACA ATATAAGCTT TGTGCTGAAA 
CGCTGCTGTC AGCCTAAGCC TCGAGAAATC TCCAACCTAC TTGTAGCCAC TAAGAAAGCC 
CAGGAGTGGC AGCCTGTCTA CTCTATGAGC CAGCTGAGTT TCGATCGGAT CCTTAAGAAA 
GATATTATCC AAGGTGAGCA CCTTGGCAGA GGCACAAGAA CACATATCTA TTCTGGGACC 
CTGCTGGATT ACAAGGACGA TGAAGGAATT GCTGAAGAAA AGAAGATAAA AGTGATTCTC 
AAAGTCCTAG ACCCTAGCCA CCGGGACATT TCACTGGCCT TCTTTGAGGC AGCCAGCATG 
ATGAGACAGG TTTCCCACAA ACACATCGTG TACCTCTACG GCGTCTGTGT CCGAGATGTG 
GAAAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCAT TGGATCTCTT CATGCACCGG 
AAAAGTGATG CACTTACTAC CCCTTGGAAG TTTAAAGTTG CCAAACAGCT GGCCAGCGCC 
CTGAGTTACT TGGAAGATAA AGACCTCGTT CATGGAAATG TGTGCACTAA AAACCTCCTC 
CTGGCCCGTG AGGGCATTGA CAGTGACATT GGCCCGTTCA TCAAGCTTAG TGACCCTGGC 
ATCCCAGTCT CTGTGCTGAC CAGGCAAGAG TGCATAGAGC GAATTCCCTG GATCGCTCCT 
GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 
ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCACTCA AGGACAAGAC CCTCATTGAG 
AAAGAGAGGT TTTATGAAAG CCGCTGCAGG CCAGTGACAC CATCTTGCAA GGAGCTAGCT 
GACCTCATGA CTCGCTGCAT GAACTATGAT CCCAACCAGA GACCTTTCTT CCGAGCCATC 
ATGAGGGACA TTAACAAGCT GGAGGAGCAG AATCCAGACA TTGTTTCAGA AAAGCAGCCA 
ATAACAGAGG TGGATCCCAC TCATTTTGAA AAGCGTTTCC TAAAGAGGAT TCGTGACTTG 
GGAGAGGGTC ACTTTGGGAA GGTTGAGCTC TGCAGATATG ATCCTGAGGG AGACAACACA 
GGGGAACAGG TAGCTGTCAA GTCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 
CTGAAGAAGG AGATAGAGAT CTTACGGAAC CTCTACCACG AGAACATTGT GAAGTATAAA 
GGAATCTGCA TGGAAGACGG AGGGAATGGT ATCAAGCTCA TCATGGAGTT TCTGCCTTCG 
GGAAGCCTAA AGGAATATCT GCCAAAGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTA 
AAATATGCCA TCCAGATTTG TAAGGGGATG GACTATCTGG GCTCTCGGCA ATATGTTCAC 
CGGGACTTAG CAGCAAGAAA TGTCCTTGTT GAGAGTGAAC ACCAAGTGAA GATCGGAGAC 
TTTGGTTTAA CCAAAGCAAT TGAGACCGAT AAGGAGTACT ACACAGTCAA GGATGACCGG 
GACAGCCCAG TGTTTTGGTA CGCTCCGGAG TGTTTAATCC AGTGTAAATT TTATATCGCC 
TCTGATGTCT GGTCTTTTGG AGTGACACTG CACGAGTTGC TCACGTACTG TGACTCAGAT 
TTTAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTA 
ACACGGCTTG TGAATACTCT GAAAGAAGGA AAGCGCCTGT CCTGTCCACC CAACTGTCCC 
GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCTAA TCGGACAACC 
TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238514.1
CDS	317..3778
Translation	MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVAPEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNHIITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVLPVEKEKNKLKRKKLDYNKHKKEDDRNKLREEWNSFSYFPEITHIVIKESVVSINKQDNKNMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVSCFEKSEVLGNQKQFKNFQIEVQKGRYSLHGSVDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDDEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPITEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLSCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK

Target ORF information:

RefSeq Version	XM_006238452.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Janus kinase 1 (Jak1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006238452.3

ORF Insert Sequence:

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 
AGCTTCAAGA AGACGGAGGT GAAGCAGGTG GCCCCTGAGC CAGGAGTGGA AGTGACTTTC 
TATCTGTTGG ACAGGGAGCC CCTCCGCCTG GGCAGCGGAG AGTACACCGC GGAGGAGCTG 
TGCATCAGGG CCGCACAGGA ATGCAGTATC TCTCCTCTCT GCCACAACCT CTTCGCCTTG 
TATGATGAGA GCACCAAGCT CTGGTATGCT CCAAACCACA TCATCACTGT GGATGACAAA 
ATGTCTCTCC GGCTGCACTA CCGCATGAGG TTCTACTTTA CCAACTGGCA TGGAACCAAT 
GACAATGAAC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAG 
AAAAAGGTTC CAGAAGCAAC CCCACTCCTT GATGCCAGTT CACTGGAGTA TCTGTTTGCG 
CAGGGACAGT ATGATTTGAT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACAGAGCAA 
GATGGACATG ATATTGAGAA TGAGTGCCTG GGCATGGCTG TCCTGGCCAT CTCACACTAT 
GCCATGATGA AGAAGATGCA GTTGCCAGAG CTTCCCAAAG ACATCAGCTA CAAGCGATAT 
ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAATC TTCTTACCAG GATGCGAATA 
AATAATGTTT TCAAGGATTT CTTGAAGGAA TTTAACAACA AGACCATCTG TGACAGCAGT 
GTGTCTACAC ACGACCTGAA GGTGAAGTAC CTGGCTACCT TGGAAACCTT AACCAAGCAT 
TATGGAGCCG AGATATTTGA GACTTCTATG CTCCTGATTT CATCAGAAAA TGAGCTGAGT 
CGGTGCCATT CCAACGACAG TGGCAATGTT CTCTATGAAG TCATGGTAAC AGGAAATCTC 
GGGATCCAGT GGCGGCAGAA ACCAAATGTT CTTCCTGTTG AAAAGGAAAA AAATAAACTG 
AAGCGGAAAA AACTGGACTA TAATAAACAC AAGAAGGAGG ATGACAGAAA CAAACTCCGG 
GAAGAGTGGA ACAGTTTTTC CTATTTCCCC GAGATTACCC ACATTGTTAT CAAGGAGTCT 
GTGGTCAGCA TTAACAAACA GGACAACAAG AACATGGAAC TAAAGCTCTC TTCTCATGAG 
GAAGCCTTGT CCTTCGTGTC CCTGGTAGAT GGCTACTTCC GGCTCACTGC AGATGCTCAC 
CATTACCTCT GTACTGATGT GGCTCCCCCG CTGATTGTCC ACAACATACA GAATGGCTGT 
CACGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAGGAGGG GAGTGAGGAG 
GGGATGTACG TGCTGAGGTG GAGCTGCACC GACTTTGACA ACATTCTTAT GACTGTCAGC 
TGCTTCGAAA AGTCCGAGGT ATTGGGTAAT CAGAAGCAGT TCAAGAACTT TCAGATTGAG 
GTGCAGAAGG GCCGCTACAG CCTGCATGGC TCTGTTGACC ACTTTCCCAG CCTGAGAGAC 
CTCATGAACC ACCTCAAGAA GCAGATCCTG CGCACGGACA ATATAAGCTT TGTGCTGAAA 
CGCTGCTGTC AGCCTAAGCC TCGAGAAATC TCCAACCTAC TTGTAGCCAC TAAGAAAGCC 
CAGGAGTGGC AGCCTGTCTA CTCTATGAGC CAGCTGAGTT TCGATCGGAT CCTTAAGAAA 
GATATTATCC AAGGTGAGCA CCTTGGCAGA GGCACAAGAA CACATATCTA TTCTGGGACC 
CTGCTGGATT ACAAGGACGA TGAAGGAATT GCTGAAGAAA AGAAGATAAA AGTGATTCTC 
AAAGTCCTAG ACCCTAGCCA CCGGGACATT TCACTGGCCT TCTTTGAGGC AGCCAGCATG 
ATGAGACAGG TTTCCCACAA ACACATCGTG TACCTCTACG GCGTCTGTGT CCGAGATGTG 
GAAAATATCA TGGTGGAAGA GTTTGTGGAG GGGGGGCCAT TGGATCTCTT CATGCACCGG 
AAAAGTGATG CACTTACTAC CCCTTGGAAG TTTAAAGTTG CCAAACAGCT GGCCAGCGCC 
CTGAGTTACT TGGAAGATAA AGACCTCGTT CATGGAAATG TGTGCACTAA AAACCTCCTC 
CTGGCCCGTG AGGGCATTGA CAGTGACATT GGCCCGTTCA TCAAGCTTAG TGACCCTGGC 
ATCCCAGTCT CTGTGCTGAC CAGGCAAGAG TGCATAGAGC GAATTCCCTG GATCGCTCCT 
GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAGTGGAG CTTTGGAACC 
ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCACTCA AGGACAAGAC CCTCATTGAG 
AAAGAGAGGT TTTATGAAAG CCGCTGCAGG CCAGTGACAC CATCTTGCAA GGAGCTAGCT 
GACCTCATGA CTCGCTGCAT GAACTATGAT CCCAACCAGA GACCTTTCTT CCGAGCCATC 
ATGAGGGACA TTAACAAGCT GGAGGAGCAG AATCCAGACA TTGTTTCAGA AAAGCAGCCA 
ATAACAGAGG TGGATCCCAC TCATTTTGAA AAGCGTTTCC TAAAGAGGAT TCGTGACTTG 
GGAGAGGGTC ACTTTGGGAA GGTTGAGCTC TGCAGATATG ATCCTGAGGG AGACAACACA 
GGGGAACAGG TAGCTGTCAA GTCCCTGAAG CCTGAGAGTG GAGGTAACCA CATAGCTGAT 
CTGAAGAAGG AGATAGAGAT CTTACGGAAC CTCTACCACG AGAACATTGT GAAGTATAAA 
GGAATCTGCA TGGAAGACGG AGGGAATGGT ATCAAGCTCA TCATGGAGTT TCTGCCTTCG 
GGAAGCCTAA AGGAATATCT GCCAAAGAAT AAGAACAAAA TCAACCTCAA ACAGCAGCTA 
AAATATGCCA TCCAGATTTG TAAGGGGATG GACTATCTGG GCTCTCGGCA ATATGTTCAC 
CGGGACTTAG CAGCAAGAAA TGTCCTTGTT GAGAGTGAAC ACCAAGTGAA GATCGGAGAC 
TTTGGTTTAA CCAAAGCAAT TGAGACCGAT AAGGAGTACT ACACAGTCAA GGATGACCGG 
GACAGCCCAG TGTTTTGGTA CGCTCCGGAG TGTTTAATCC AGTGTAAATT TTATATCGCC 
TCTGATGTCT GGTCTTTTGG AGTGACACTG CACGAGTTGC TCACGTACTG TGACTCAGAT 
TTTAGTCCCA TGGCCTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTA 
ACACGGCTTG TGAATACTCT GAAAGAAGGA AAGCGCCTGT CCTGTCCACC CAACTGTCCC 
GATGAGGTTT ATCAGCTTAT GAGAAAATGC TGGGAATTCC AACCATCTAA TCGGACAACC 
TTTCAGAACC TTATTGAAGG ATTTGAAGCA CTTTTAAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway.
Oncology reports(2018 Jan)
Chen L,Zhou D,Liu Z,Huang X,Liu Q,Kang Y,Chen Z,Guo Y,Zhu H,Sun C

MicroRNA-448 suppresses metastasis of pancreatic ductal adenocarcinoma through targeting JAK1/STAT3 pathway.
Oncology reports38(2)1075-1082(2017 Aug)
Yu DL,Zhang T,Wu K,Li Y,Wang J,Chen J,Li XQ,Peng XG,Wang JN,Tan LG

Generation of Janus kinase 1 (JAK1) conditional knockout mice.
Genesis (New York, N.Y. : 2000)54(11)582-588(2016 Nov)
Sakamoto K,Wehde BL,R?dler PD,Triplett AA,Wagner KU

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Jak1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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