Fgl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgl2
Entrez Gene ID	84586
Full Name	fibrinogen-like 2
General protein information	Preferred Names fibrinogen-like 2 Names fibroleukin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11
Summary	structurally similar to the beta and gamma chains of fibrinogen; may by involved with physiological functions at mucosal sites; may play a role in the initiation of parturition [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053455.2	NP_445907.2	fibroleukin precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fgl2	NP_445907.2
Bos taurus (cattle)	FGL2	NP_001039562.1
Mus musculus (house mouse)	Fgl2	NP_032039.2
Danio rerio (zebrafish)	fgl2	NP_001020710.1
Pan troglodytes (chimpanzee)	FGL2	XP_003318594.1
Gallus gallus (chicken)	FGL2	NP_001072954.1
Homo sapiens (human)	FGL2	NP_006673.1
	FGL2	XP_001083950.1
Canis lupus familiaris (dog)	FGL2	XP_533109.2
Xenopus tropicalis (tropical clawed frog)	fgl2	XP_002933134.1

Gene Ontology
Bibliography

Related articles in PubMed

Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines.
Zheng Z, Yu Y, Potla R, Wu Y, Wu H
Immunology153(2)246-252(2018 Feb)

Inhibition of the FGL2:Fc?RIIB/RIII Immunosuppressive Pathway Enhances Antiviral T cell and B Cell Responses Leading to Clearance of LCMV cl-13.
Klingberg O, Khattar R, Farrokhi K, Ferri D, Yavorska N, Zhang J, Sadozai H, Adeyi O, Chruscinski A, Levy GA, Selzner N
Immunology(2018 Jan)

FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats.
Zheng Z, Yu L, Wu Y, Wu H
Immunologic research(2017 Nov)

Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2.
Long R, You Y, Li W, Jin N, Huang S, Li T, Liu K, Wang Z
Life sciences1428-18(2015 Dec)

Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved.
Zhenzhong Z, Yafa Y, Jin L
Bioscience reports35(3)(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

STS is able to ameliorate CNR through inhibition of FGL2 expression mediated by Akt and NF-kappaB pathways as well as prevention of MVO by suppressing fibrin deposition and inflammation.
Title: Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2.

Fgl2 role in cardiomyocytes apoptosis and heart function in diabetic rats
Title: Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved.

TNF-alpha-induced flg2 in CMECs mediates the formation of fibrin-rich microthrombus, which may be one of the mechanisms of microvascular dysfunction or obstruction due to MI/R injury.
Title: TNF-? upregulates Fgl2 expression in rat myocardial ischemia/reperfusion injury.

Microthrombosis due to fgl2 overexpression contributes to pancreatic impairment in rats with severe acute pancreatitis, and fgl2 level may serve as a biomarker during early stages of disease.
Title: Correlation of fibrinogen-like protein 2 with progression of acute pancreatitis in rats.

Fgl2 prothrombinase is involved in severe acute pancreatitis-associated liver injury.
Title: Fgl2 prothrombinase is involved in severe acute pancreatitis-associated liver injury.

The following Fgl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12506	NM_053455.2 Latest version!	Rattus norvegicus fibrinogen-like 2 (Fgl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgl2 ( NM_053455.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445907.2 Rattus norvegicus fibrinogen-like 2 (Fgl2), mRNA.

Price & Availability↑

CloneID	ORa12506
Clone ID Related Accession (Same CDS sequence)	NM_053455.2
Accession Version	NM_053455.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	fibroleukin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB582252.1 and BC072502.1. On Oct 3, 2005 this sequence version replaced NM_053455.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107665.1, BC085357.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCTTC CTGGCTGGTT GTGGCTGAGC TCCGCGGTCC TCGCTGCCTG CCGAGCGGCG 
GAGAAGCACA ACCTGACTGA AGGGCTGGAG GATGCGAGCG CCCAGGCTGC CTGCCCCGCG 
AGGCTGGAGG GCAGCGGGAG GTGCGAGGGC AGCCAGTGCC CCTTCCAGCT CACCCTGCCC 
ACGCTGACCC TCCAGCTCCC GCAGCAGTTC GGCAGCATGG AGGAGGTGCT CAAAGAAGTG 
CGGACCCTCC AGGAAGCTGT GGACAGTCTG AAGAAATCCT GCCAGGACTG CAAGTTGCAG 
GCTGATGAAC ATCCAGACCC TGGCGGGAAT GGAGCAGAGA CGGCCGAGGA CAATCGAGTC 
CAGGAACTGG AGAGTCAGGT GAACAAGCTG TCCTCAGAGC TGAAGAATGC AAAGGAGGAG 
ATCCAGGGGC TGCAGGGGCG CCTGGAGTCG CTCCAACTGG TAAATATGAA CAACATCGAG 
AACTACGTGG ACAACAAAGT GGCAAATCTA ACCTCTGTGG TCAACAGTTT GGATAGCAAG 
TGTTTCAAGT GCCCCAGCCA AGAACACAAC CAGCCAAATC CAGTTCAACA TCTAATATAC 
AAAGATTGCT CTGACTACTA CGTGTTAGGG AAGAGAAGCA GTGGGACCTA CAGAGTTACG 
CCTGATCACA GGAACAGCAG CTTTGAGGTC TACTGCGACA TGGAGACCAC GGGTGGAGGC 
TGGACAGTGC TGCAGGCTCG CCTTGATGGG AGCACCAACT TCACCAGAGG GTGGAAGGAC 
TACAAAGCCG GCTTCGGGAA CCTTGAACGA GAATTTTGGC TGGGCAACGA TAAAATTCAT 
CTTCTGACCA AGAGTAAGGA AATGATTTTG AGAATAGATC TCGAAGACTT TAATGGTCTC 
ACACTTTACG CCGTGTACGA TCAGTTTTAT GTGGCTAACG AGTTTCTCAA ATACCGGTTA 
CACCTCGGTA ACTATAATGG CACGGCAGGG GATGCCTTGC GTTTTAGCCG ACATTACAAC 
CACGACCTGA GGTTTTTCAC CACCCCAGAC AGAGACAATG ATCGGTACCC CTCTGGGAAC 
TGTGGGCTCT ATTACAGCTC AGGCTGGTGG TTTGATGCAT GTCTCTCTGC CAACTTAAAT 
GGCAAATATT ATCACCAGAG ATACAAAGGG GTCCGTAATG GGATTTTCTG GGGCACCTGG 
CCTGGTGTAA GTCAGGCACA CCCAGGGGGC TACAAGTTCT CCTTCAAGAA GGCCAAGATG 
ATGATAAGAC CCAAGAGTTT TAAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445907.2
CDS	24..1313
Translation	MRLPGWLWLSSAVLAACRAAEKHNLTEGLEDASAQAACPARLEGSGRCEGSQCPFQLTLPTLTLQLPQQFGSMEEVLKEVRTLQEAVDSLKKSCQDCKLQADEHPDPGGNGAETAEDNRVQELESQVNKLSSELKNAKEEIQGLQGRLESLQLVNMNNIENYVDNKVANLTSVVNSLDSKCFKCPSQEHNQPNPVQHLIYKDCSDYYVLGKRSSGTYRVTPDHRNSSFEVYCDMETTGGGWTVLQARLDGSTNFTRGWKDYKAGFGNLEREFWLGNDKIHLLTKSKEMILRIDLEDFNGLTLYAVYDQFYVANEFLKYRLHLGNYNGTAGDALRFSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQRYKGVRNGIFWGTWPGVSQAHPGGYKFSFKKAKMMIRPKSFKP

Target ORF information:

RefSeq Version	NM_053455.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibrinogen-like 2 (Fgl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053455.2

ORF Insert Sequence:

ATGAGGCTTC CTGGCTGGTT GTGGCTGAGC TCCGCGGTCC TCGCTGCCTG CCGAGCGGCG 
GAGAAGCACA ACCTGACTGA AGGGCTGGAG GATGCGAGCG CCCAGGCTGC CTGCCCCGCG 
AGGCTGGAGG GCAGCGGGAG GTGCGAGGGC AGCCAGTGCC CCTTCCAGCT CACCCTGCCC 
ACGCTGACCC TCCAGCTCCC GCAGCAGTTC GGCAGCATGG AGGAGGTGCT CAAAGAAGTG 
CGGACCCTCC AGGAAGCTGT GGACAGTCTG AAGAAATCCT GCCAGGACTG CAAGTTGCAG 
GCTGATGAAC ATCCAGACCC TGGCGGGAAT GGAGCAGAGA CGGCCGAGGA CAATCGAGTC 
CAGGAACTGG AGAGTCAGGT GAACAAGCTG TCCTCAGAGC TGAAGAATGC AAAGGAGGAG 
ATCCAGGGGC TGCAGGGGCG CCTGGAGTCG CTCCAACTGG TAAATATGAA CAACATCGAG 
AACTACGTGG ACAACAAAGT GGCAAATCTA ACCTCTGTGG TCAACAGTTT GGATAGCAAG 
TGTTTCAAGT GCCCCAGCCA AGAACACAAC CAGCCAAATC CAGTTCAACA TCTAATATAC 
AAAGATTGCT CTGACTACTA CGTGTTAGGG AAGAGAAGCA GTGGGACCTA CAGAGTTACG 
CCTGATCACA GGAACAGCAG CTTTGAGGTC TACTGCGACA TGGAGACCAC GGGTGGAGGC 
TGGACAGTGC TGCAGGCTCG CCTTGATGGG AGCACCAACT TCACCAGAGG GTGGAAGGAC 
TACAAAGCCG GCTTCGGGAA CCTTGAACGA GAATTTTGGC TGGGCAACGA TAAAATTCAT 
CTTCTGACCA AGAGTAAGGA AATGATTTTG AGAATAGATC TCGAAGACTT TAATGGTCTC 
ACACTTTACG CCGTGTACGA TCAGTTTTAT GTGGCTAACG AGTTTCTCAA ATACCGGTTA 
CACCTCGGTA ACTATAATGG CACGGCAGGG GATGCCTTGC GTTTTAGCCG ACATTACAAC 
CACGACCTGA GGTTTTTCAC CACCCCAGAC AGAGACAATG ATCGGTACCC CTCTGGGAAC 
TGTGGGCTCT ATTACAGCTC AGGCTGGTGG TTTGATGCAT GTCTCTCTGC CAACTTAAAT 
GGCAAATATT ATCACCAGAG ATACAAAGGG GTCCGTAATG GGATTTTCTG GGGCACCTGG 
CCTGGTGTAA GTCAGGCACA CCCAGGGGGC TACAAGTTCT CCTTCAAGAA GGCCAAGATG 
ATGATAAGAC CCAAGAGTTT TAAGCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines.
Immunology153(2)246-252(2018 Feb)
Zheng Z,Yu Y,Potla R,Wu Y,Wu H

Inhibition of the FGL2:Fc?RIIB/RIII Immunosuppressive Pathway Enhances Antiviral T cell and B Cell Responses Leading to Clearance of LCMV cl-13.
Immunology(2018 Jan)
Klingberg O,Khattar R,Farrokhi K,Ferri D,Yavorska N,Zhang J,Sadozai H,Adeyi O,Chruscinski A,Levy GA,Selzner N

FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats.
Immunologic research(2017 Nov)
Zheng Z,Yu L,Wu Y,Wu H

Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2.
Life sciences1428-18(2015 Dec)
Long R,You Y,Li W,Jin N,Huang S,Li T,Liu K,Wang Z

Fibrinogen-like protein 2 gene silencing inhibits cardiomyocytes apoptosis, improves heart function of streptozotocin-induced diabetes rats and the molecular mechanism involved.
Bioscience reports35(3)(2015 May)
Zhenzhong Z,Yafa Y,Jin L

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Fgl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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