Slc24a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc24a2
Entrez Gene ID	84550
Full Name	solute carrier family 24 member 2
Synonyms	Nckx2
General protein information	Preferred Names solute carrier family 24 member 2 Names sodium/potassium/calcium exchanger 2 Na(+)/K(+)/Ca(2+)-exchange protein 2 potassium-dependent sodium-calcium exchanger retinal cone Na-Ca+K exchanger solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q32
Summary	catalyzes potassium ion dependent exchange of sodium and calcium ions; may facilitate calcium mediated signalling and calcium homeostasis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031743.2	NP_113931.1	sodium/potassium/calcium exchanger 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC24A2	XP_005626726.1
Mus musculus (house mouse)	Slc24a2	NP_766014.1
Xenopus tropicalis (tropical clawed frog)	slc24a2	XP_002935711.2
Homo sapiens (human)	SLC24A2	NP_065077.1
	SLC24A2	XP_001108751.1
Drosophila melanogaster (fruit fly)	Nckx30C	NP_001188761.1
Bos taurus (cattle)	SLC24A2	NP_001137566.1
Gallus gallus (chicken)	SLC24A2	NP_001001772.1
Pan troglodytes (chimpanzee)	SLC24A2	XP_528551.2
Rattus norvegicus (Norway rat)	Slc24a2	NP_113931.1

Gene Ontology
Bibliography

Related articles in PubMed

SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.
Ginger RS, Askew SE, Ogborne RM, Wilson S, Ferdinando D, Dadd T, Smith AM, Kazi S, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Green MR
The Journal of biological chemistry283(9)5486-95(2008 Feb)

Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.
Lytton J
The Biochemical journal406(3)365-82(2007 Sep)

Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles.
Altimimi HF, Schnetkamp PP
Channels (Austin, Tex.)1(2)62-9(2007 Mar-Apr)

Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells.
Lee JY, Visser F, Lee JS, Lee KH, Soh JW, Ho WK, Lytton J, Lee SH
The Journal of biological chemistry281(51)39205-16(2006 Dec)

Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory.
Li XF, Kiedrowski L, Tremblay F, Fernandez FR, Perizzolo M, Winkfein RJ, Turner RW, Bains JS, Rancourt DE, Lytton J
The Journal of biological chemistry281(10)6273-82(2006 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PKC-mediated activation of NCKX2 is sensitive to mutation of multiple PKC consensus sites via a mechanism that may involve several phosphorylation events
Title: Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells.

association as a dimer, an interaction that does not require, but may be stabilized by, a disulfide linkage through Cys-395
Title: A novel topology and redox regulation of the rat brain K+-dependent Na+/Ca2+ exchanger, NCKX2.

topological studies of this protein in rat brain
Title: Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2.

Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
Title: Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.

The following Slc24a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc24a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42476	NM_031743.2 Latest version!	Rattus norvegicus solute carrier family 24 member 2 (Slc24a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc24a2 ( NM_031743.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113931.1 Rattus norvegicus solute carrier family 24 member 2 (Slc24a2), mRNA.

Price & Availability↑

CloneID	ORa42476
Clone ID Related Accession (Same CDS sequence)	NM_031743.2
Accession Version	NM_031743.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	sodium/potassium/calcium exchanger 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF021923.1. On Apr 14, 2007 this sequence version replaced NM_031743.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF021923.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATCTCC ATCAAAGCGC CACAGTCAGG CTCCTGCAGG AATGGTGTTC CCATGAGTCA 
CCATCTGGCT GCAGGAGACA TTATAATACC AGGAAAAAAC TGAAGCTAAT TCGAGTCATT 
GGCCTTGTCA TGGGCCTGGT AGCCGTGAGC ACTGTCCCGT TTTCAATCAG TGCCTTTACT 
GAGACATACT CTCAGAACAA CAGAGGAGAA GCCAGTGATG TGACGGGCCC TAGGGCAGCA 
CCCGGTCACC GTCAAAGAAC TCTCTTAGAC TTAAATGACA AGATTCGAGA TTACACCCCA 
CAGCCACCTG CTTCTCAGGA AGACCGATCT GAGAACGGTA CTGATCACGC CCAGGGAGAC 
TACCCAAAGG ATGTCTTTTC CCTGGAGGAG CGAAGGAAAG GTGCCATCAT TCTCCATGTC 
ATCGGAATGA TCTATATGTT CATAGCCTTA GCCATCGTCT GTGATGAGTT CTTTGTTCCT 
TCTCTAACTG TCATCACTGA AAAACTGGGA ATCTCTGATG ATGTGGCCGG AGCCACCTTC 
ATGGCCGCAG GCGGGTCAGC CCCAGAACTT TTCACATCTC TCATAGGGGT TTTCATTGCG 
CACAGCAACG TGGGCATTGG CACCATCGTA GGTTCCGCCG TGTTCAATAT CCTCTTTGTT 
ATTGGCATGT GTGCTCTGTT TTCTAGAGAA ATCTTAAACC TGACCTGGTG GCCGCTCTTT 
CGGGATGTGT CCTTCTACAT CGTTGATTTG ATCATGTTGA TCATATTTTT CCTGGATAAC 
GTTATCATGT GGTGGGAAAG CTTACTCCTC TTAACAGCTT ATTTCGCCTA TGTGGTTTTC 
ATGAAGTTCA ACGTCCAAGT AGAGAGATGG GTGAAGCAAA TGATAAATCG CAATAAAGTT 
GTCAAGGTGA CAGTGTCAGA AGCCCAAGCC AAGGCATCTA CAGCTGGGGA CAAGGAAGAG 
CCGACGTTAC CGAATAAGCC GCGCCTCCAG CGAGGTGGAA GCTCTGCTTC CCTCCACAAC 
AGTCTCATGA GGAACAGCAT CTTCCAGCTC ATGATACACA CCCTTGACCC ACTCGCTGAA 
GAACTTGGAT CATATGGAAA ACTAAAATAT TATGACACAA TGACTGAAGA AGGGAGGTTC 
AGAGAAAAAG CTTCAATTCT CCACAAGATT GCCAAGAAGA AATGCCAAGT GGATGAGAAT 
GAGAGGCAAA ATGGAGCTGC CAATCATGTG GATTATGCCG CAGAAAAAAT TGAGCTCCCC 
AACAGCACGA GCACAGAGGT GGAAATGACT CCATCAAGCG AAGCTTCAGA ACCTGTGCAG 
AATGGAAACC TCTCTCACAG CATCGAAGCT GCAGACGCCC CGCAGGCCAC AGAGACCGCC 
GAGGAAGATG ATGACCAGCC CCTCAGCCTG TCCTGGCCGT CCAACACCCG CAAGCAGATC 
ACCTTCCTAA TCGTTCTTCC CATCGTGTTC CCTCTCTGGA TCACCTTACC CGACGTCCGC 
AAACCTGCTT CCAAGAAGTT CTTCCCTATC ACGTTCTTCG GCTCCATCAC CTGGATCGCA 
GTTTTCTCGT ACCTGATGGT GTGGTGGGCA CACCAGGTTG GAGAGACAAT CGGCATTAGT 
GAGGAGATCA TGGGCCTCAC CATCTTGGCA GCTGGAACCT CTATCCCCGA TCTCATCACC 
AGTGTCATAG TGGCCCGAAA GGGCCTGGGG GACATGGCTG TGTCCAGCTC CGTTGGAAGC 
AACATCTTTG ACATCACTGT GGGGCTCCCA CTGCCCTGGC TCCTCTACAC CATCATCCAC 
AGATTCAAGC CAGTGACTGT CAGCAGCAAT GGCCTCTTCT GTGCCATCGT CCTCCTCTTC 
ATCATGTTGA TTTTTGTCAT CCTCTCCATC GCCCTCTGCA AGTGGCGGAT GAACAAAATC 
CTCGGCTTCA TCATGTTTGG CCTCTACTTC GCGTTCCTGG TGGTCAGCGT CCTCCTGGAA 
GACAAAGTTC TCGAGTGCCC TGTCTCCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113931.1
CDS	149..2161
Translation	MDLHQSATVRLLQEWCSHESPSGCRRHYNTRKKLKLIRVIGLVMGLVAVSTVPFSISAFTETYSQNNRGEASDVTGPRAAPGHRQRTLLDLNDKIRDYTPQPPASQEDRSENGTDHAQGDYPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKVTVSEAQAKASTAGDKEEPTLPNKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCQVDENERQNGAANHVDYAAEKIELPNSTSTEVEMTPSSEASEPVQNGNLSHSIEAADAPQATETAEEDDDQPLSLSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILSIALCKWRMNKILGFIMFGLYFAFLVVSVLLEDKVLECPVSI

Target ORF information:

RefSeq Version	NM_031743.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 24 member 2 (Slc24a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031743.2

ORF Insert Sequence:

ATGGATCTCC ATCAAAGCGC CACAGTCAGG CTCCTGCAGG AATGGTGTTC CCATGAGTCA 
CCATCTGGCT GCAGGAGACA TTATAATACC AGGAAAAAAC TGAAGCTAAT TCGAGTCATT 
GGCCTTGTCA TGGGCCTGGT AGCCGTGAGC ACTGTCCCGT TTTCAATCAG TGCCTTTACT 
GAGACATACT CTCAGAACAA CAGAGGAGAA GCCAGTGATG TGACGGGCCC TAGGGCAGCA 
CCCGGTCACC GTCAAAGAAC TCTCTTAGAC TTAAATGACA AGATTCGAGA TTACACCCCA 
CAGCCACCTG CTTCTCAGGA AGACCGATCT GAGAACGGTA CTGATCACGC CCAGGGAGAC 
TACCCAAAGG ATGTCTTTTC CCTGGAGGAG CGAAGGAAAG GTGCCATCAT TCTCCATGTC 
ATCGGAATGA TCTATATGTT CATAGCCTTA GCCATCGTCT GTGATGAGTT CTTTGTTCCT 
TCTCTAACTG TCATCACTGA AAAACTGGGA ATCTCTGATG ATGTGGCCGG AGCCACCTTC 
ATGGCCGCAG GCGGGTCAGC CCCAGAACTT TTCACATCTC TCATAGGGGT TTTCATTGCG 
CACAGCAACG TGGGCATTGG CACCATCGTA GGTTCCGCCG TGTTCAATAT CCTCTTTGTT 
ATTGGCATGT GTGCTCTGTT TTCTAGAGAA ATCTTAAACC TGACCTGGTG GCCGCTCTTT 
CGGGATGTGT CCTTCTACAT CGTTGATTTG ATCATGTTGA TCATATTTTT CCTGGATAAC 
GTTATCATGT GGTGGGAAAG CTTACTCCTC TTAACAGCTT ATTTCGCCTA TGTGGTTTTC 
ATGAAGTTCA ACGTCCAAGT AGAGAGATGG GTGAAGCAAA TGATAAATCG CAATAAAGTT 
GTCAAGGTGA CAGTGTCAGA AGCCCAAGCC AAGGCATCTA CAGCTGGGGA CAAGGAAGAG 
CCGACGTTAC CGAATAAGCC GCGCCTCCAG CGAGGTGGAA GCTCTGCTTC CCTCCACAAC 
AGTCTCATGA GGAACAGCAT CTTCCAGCTC ATGATACACA CCCTTGACCC ACTCGCTGAA 
GAACTTGGAT CATATGGAAA ACTAAAATAT TATGACACAA TGACTGAAGA AGGGAGGTTC 
AGAGAAAAAG CTTCAATTCT CCACAAGATT GCCAAGAAGA AATGCCAAGT GGATGAGAAT 
GAGAGGCAAA ATGGAGCTGC CAATCATGTG GATTATGCCG CAGAAAAAAT TGAGCTCCCC 
AACAGCACGA GCACAGAGGT GGAAATGACT CCATCAAGCG AAGCTTCAGA ACCTGTGCAG 
AATGGAAACC TCTCTCACAG CATCGAAGCT GCAGACGCCC CGCAGGCCAC AGAGACCGCC 
GAGGAAGATG ATGACCAGCC CCTCAGCCTG TCCTGGCCGT CCAACACCCG CAAGCAGATC 
ACCTTCCTAA TCGTTCTTCC CATCGTGTTC CCTCTCTGGA TCACCTTACC CGACGTCCGC 
AAACCTGCTT CCAAGAAGTT CTTCCCTATC ACGTTCTTCG GCTCCATCAC CTGGATCGCA 
GTTTTCTCGT ACCTGATGGT GTGGTGGGCA CACCAGGTTG GAGAGACAAT CGGCATTAGT 
GAGGAGATCA TGGGCCTCAC CATCTTGGCA GCTGGAACCT CTATCCCCGA TCTCATCACC 
AGTGTCATAG TGGCCCGAAA GGGCCTGGGG GACATGGCTG TGTCCAGCTC CGTTGGAAGC 
AACATCTTTG ACATCACTGT GGGGCTCCCA CTGCCCTGGC TCCTCTACAC CATCATCCAC 
AGATTCAAGC CAGTGACTGT CAGCAGCAAT GGCCTCTTCT GTGCCATCGT CCTCCTCTTC 
ATCATGTTGA TTTTTGTCAT CCTCTCCATC GCCCTCTGCA AGTGGCGGAT GAACAAAATC 
CTCGGCTTCA TCATGTTTGG CCTCTACTTC GCGTTCCTGG TGGTCAGCGT CCTCCTGGAA 
GACAAAGTTC TCGAGTGCCC TGTCTCCATC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.
The Journal of biological chemistry283(9)5486-95(2008 Feb)
Ginger RS,Askew SE,Ogborne RM,Wilson S,Ferdinando D,Dadd T,Smith AM,Kazi S,Szerencsei RT,Winkfein RJ,Schnetkamp PP,Green MR

Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.
The Biochemical journal406(3)365-82(2007 Sep)
Lytton J

Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles.
Channels (Austin, Tex.)1(2)62-9(2007 Mar-Apr)
Altimimi HF,Schnetkamp PP

Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells.
The Journal of biological chemistry281(51)39205-16(2006 Dec)
Lee JY,Visser F,Lee JS,Lee KH,Soh JW,Ho WK,Lytton J,Lee SH

Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory.
The Journal of biological chemistry281(10)6273-82(2006 Mar)
Li XF,Kiedrowski L,Tremblay F,Fernandez FR,Perizzolo M,Winkfein RJ,Turner RW,Bains JS,Rancourt DE,Lytton J

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Slc24a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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