Bnip3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bnip3
Entrez Gene ID	84480
Full Name	BCL2 interacting protein 3
General protein information	Preferred Names BCL2 interacting protein 3 Names BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BCL2/adenovirus E1B 19 kDa-interacting protein 3 BCL2/adenovirus E1B interacting protein 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41
Summary	heterodimerizes and antagonizes the activity of prosurvival proteins (Bcl-2, Bcl-XL) and promotes apoptosis; provokes mitochondrial defects and cell death of ventricular myocytes during hypoxia [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053420.3	NP_445872.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC607408	XP_849147.4
Pan troglodytes (chimpanzee)	BNIP3	XP_508116.2
Bos taurus (cattle)	BNIP3	NP_001069834.1
Rattus norvegicus (Norway rat)	Bnip3	NP_445872.1
Danio rerio (zebrafish)	bnip3	NP_001012245.1
Mus musculus (house mouse)	Bnip3	NP_033890.1
Gallus gallus (chicken)	BNIP3	XP_421829.3
Homo sapiens (human)	BNIP3	NP_004043.2
Xenopus tropicalis (tropical clawed frog)	bnip3	NP_001015859.1

Gene Ontology
Bibliography

Related articles in PubMed

Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes.
Dhingra A, Jayas R, Afshar P, Guberman M, Maddaford G, Gerstein J, Lieberman B, Nepon H, Margulets V, Dhingra R, Kirshenbaum LA
Free radical biology & medicine112411-422(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-210 plays a protective role in H2O2-induced cardiomyocyte apoptosis at least by regulating the pro-apoptotic BNIP3
Title: MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3.

Study demonstrated that Popdc1/Bves plays a role in the preservation of cardiomyocyte viability by affecting Rac1 activity and Bnip3 expression.
Title: Popdc1/Bves Functions in the Preservation of Cardiomyocyte Viability While Affecting Rac1 Activity and Bnip3 Expression.

The results implicate BNIP3 and calpain as dependent components of cardiac myocyte death caused by hypoxia-acidosis.
Title: BNIP3 promotes calcium and calpain-dependent cell death.

Cardiac myocyte redox status determines cell susceptibility to BNIP3-mediated cell death.
Title: Cellular redox status determines sensitivity to BNIP3-mediated cell death in cardiac myocytes.

Results suggest that Bnip3 regulates cardiac gene expression and perhaps myocyte morphology by activating nuclear p300 acetyltransferase and hyperacetylating histones and its selective transcription factors.
Title: Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.

The following Bnip3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bnip3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09510	NM_053420.3 Latest version!	Rattus norvegicus BCL2 interacting protein 3 (Bnip3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bnip3 ( NM_053420.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445872.1 Rattus norvegicus BCL2 interacting protein 3 (Bnip3), mRNA.

Price & Availability↑

CloneID	ORa09510
Clone ID Related Accession (Same CDS sequence)	NM_053420.3
Accession Version	NM_053420.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CO403082.1 and BC070958.1. On Mar 19, 2010 this sequence version replaced NM_053420.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ212788.1, FQ216807.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTCGCAGA GCGGGGAGGA GAACCTGCAG GGCTCCTGGG TAGAACTGCA CTTCAGCAAT 
GGGAATGGGA GCAGCGTTCC AGCTTCCGTC TCTATTTATA ATGGTGACAT GGAAAAAATA 
CTGCTGGATG CGCAGCATGA ATCTGGACGA AGCAGCTCCA AGAGCTCTCA CTGTGACAGC 
CCACCTCGCT CCCAGACACC ACAAGATACC AACAGAGCTG AAATAGACAC CCACAGCTTT 
GGTGAGAAAA ACAGCACTCT GTCTGAGGAA GATTATATTG AGAGAAGAAG AGAAGTTGAA 
AGTATCCTGA AGAAAAACTC AGATTGGATA TGGGATTGGT CAAGTCGGCC AGAAAATGTT 
CCCCCCAAGG AGTTCCTTTT TAAACACCCG AAGCGCACAG CTACTCTCAG CATGAGAAAC 
ACAAGCGTTA TGAAGAAAGG GGGTATTTTC TCAGCAGACT TTCTGAAGGT TTTCCTTCCA 
TCTCTGTTAC TGTCTCATCT GTTAGCCATT GGATTGGGGA TCTACATTGG AAGGCGTCTG 
ACAACTTCCA CTAGTACCTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445872.1
CDS	122..685
Translation	MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRAEIDTHSFGEKNSTLSEEDYIERRREVESILKKNSDWIWDWSSRPENVPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF

Target ORF information:

RefSeq Version	NM_053420.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BCL2 interacting protein 3 (Bnip3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053420.3

ORF Insert Sequence:

ATGTCGCAGA GCGGGGAGGA GAACCTGCAG GGCTCCTGGG TAGAACTGCA CTTCAGCAAT 
GGGAATGGGA GCAGCGTTCC AGCTTCCGTC TCTATTTATA ATGGTGACAT GGAAAAAATA 
CTGCTGGATG CGCAGCATGA ATCTGGACGA AGCAGCTCCA AGAGCTCTCA CTGTGACAGC 
CCACCTCGCT CCCAGACACC ACAAGATACC AACAGAGCTG AAATAGACAC CCACAGCTTT 
GGTGAGAAAA ACAGCACTCT GTCTGAGGAA GATTATATTG AGAGAAGAAG AGAAGTTGAA 
AGTATCCTGA AGAAAAACTC AGATTGGATA TGGGATTGGT CAAGTCGGCC AGAAAATGTT 
CCCCCCAAGG AGTTCCTTTT TAAACACCCG AAGCGCACAG CTACTCTCAG CATGAGAAAC 
ACAAGCGTTA TGAAGAAAGG GGGTATTTTC TCAGCAGACT TTCTGAAGGT TTTCCTTCCA 
TCTCTGTTAC TGTCTCATCT GTTAGCCATT GGATTGGGGA TCTACATTGG AAGGCGTCTG 
ACAACTTCCA CTAGTACCTT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes.
Free radical biology & medicine112411-422(2017 Nov)
Dhingra A,Jayas R,Afshar P,Guberman M,Maddaford G,Gerstein J,Lieberman B,Nepon H,Margulets V,Dhingra R,Kirshenbaum LA

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Bnip3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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