Abcd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcd2
Entrez Gene ID	84356
Full Name	ATP binding cassette subfamily D member 2
Synonyms	ALDR
General protein information	Preferred Names ATP binding cassette subfamily D member 2 Names ATP-binding cassette sub-family D member 2 ATP-binding cassette, sub-family D (ALD), member 2 ATP-binding cassette, subfamily D (ALD), member 2 adrenoleukodystrophy-related protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q35
Summary	ATP-binding cassette (ABC) peroxisomal half-transporter that assembles with ALDRP to form a functional heterodimer; mutation in ABCD proteins causes X-linked adrenoleukodystrophy [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_033352.1	NP_203503.1	ATP-binding cassette sub-family D member 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Abcd2	NP_036124.2
Homo sapiens (human)	ABCD2	NP_005155.1
Pan troglodytes (chimpanzee)	ABCD2	XP_001168647.1
Canis lupus familiaris (dog)	ABCD2	XP_005637034.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002071	XP_320975.4
Xenopus tropicalis (tropical clawed frog)	abcd2	XP_004913060.1
	ABCD2	XP_002798576.1
Rattus norvegicus (Norway rat)	Abcd2	NP_203503.1
Gallus gallus (chicken)	ABCD2	NP_001186324.1
Drosophila melanogaster (fruit fly)	CG2316	NP_001245409.1

Gene Ontology
Bibliography

Related articles in PubMed

A Thyroid Hormone-Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy.
Hartley MD, Kirkemo LL, Banerji T, Scanlan TS
Endocrinology158(5)1328-1338(2017 May)

Peroxisomal ATP-binding cassette transporters form mainly tetramers.
Geillon F, Gondcaille C, Raas Q, Dias AMM, Pecqueur D, Truntzer C, Lucchi G, Ducoroy P, Falson P, Savary S, Trompier D
The Journal of biological chemistry292(17)6965-6977(2017 04)

Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.
Geillon F, Gondcaille C, Charbonnier S, Van Roermund CW, Lopez TE, Dias AM, Pais de Barros JP, Arnould C, Wanders RJ, Trompier D, Savary S
The Journal of biological chemistry289(35)24511-20(2014 Aug)

Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, B?cavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)

Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).
Genin EC, Geillon F, Gondcaille C, Athias A, Gambert P, Trompier D, Savary S
The Journal of biological chemistry286(10)8075-84(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ABCD1 and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane
Title: Peroxisomal ATP-binding cassette transporters form mainly tetramers.

Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).
Title: Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).

NRH2 utilizes intracellular mechanisms not only to regulate nerve growth factor binding to tropomyosin-related kinase receptor A (TrkA), but also to specifically modulate TrkA receptor signaling.
Title: Neurotrophin receptor homolog-2 regulates nerve growth factor signaling.

in vitro and in vivo effects of DHEA on the expression of peroxisomal ABC transporters, including Abcd2
Title: Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents.

The generated stable cell lines express negligible levels of endogenous ALDRP and doxycycline dosage-dependent levels of normal or mutated ALDRP.
Title: A novel cell model to study the function of the adrenoleukodystrophy-related protein.

The following Abcd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09114	NM_033352.1 Latest version!	Rattus norvegicus ATP binding cassette subfamily D member 2 (Abcd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcd2 ( NM_033352.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_203503.1 Rattus norvegicus ATP binding cassette subfamily D member 2 (Abcd2), mRNA.

Price & Availability↑

CloneID	ORa09114
Clone ID Related Accession (Same CDS sequence)	NM_033352.1
Accession Version	NM_033352.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2226bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-binding cassette sub-family D member 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF131294.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF131294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906358 [ECO:0000348] ##Evidence-Data-END##

ATGATACACA TGCTAAATGC AGCAGCCTAT CGGGTGAAAT GGACCAGATC CGGTGCTGCT 
AAAAGGGCTG CCTGCCTGGT GGCTGCGGCA TATGCTCTGA AAACCCTCTA TCCCATCCTT 
GGCAGGCGTT TAAAGCAGCC TGGCCACCGG AAGGCGAAAG CAGAAGATTA CCCGCCTGCA 
GAGAACAGAG AAAGACTGCA TTGCACAGAG ATCATCTGTA AAAAACCTGC GCCGGGACTA 
AATGCAGATT TTTTCAAACA GCTACTAGAA CTTCGGAAAA TCCTCTTTCC AAAACTTGTG 
ACCACTGAAA CGGGGTGGCT CTGCCTCCAC TCGGTGGCTC TAATCTCACG AACGTTTCTG 
TCTATCTACG TGGCTGGTCT GGATGGGAAA ATCGTGAAAA GCATCGTGGA AAAGAAGCCT 
CGGACTTTCA TCATCAAACT AGTCAAGTGG CTTATGATTG CCGTCCCCGC TACCTTTGTC 
AACAGCGCTA TCAGGTACCT GGAGTGCAAA CTGGCATTGG CCTTTAGAAC TCGCTTAGTG 
GACCATGCCT ATGAGACCTA TTTTGCAAAT CAGACTTATT ATAAGGTGAT AAATATGGAC 
GGGAGGCTGG CAAACCCTGA CCAGTCTCTT ACTGAAGACA TTATGATGTT CTCGCAATCG 
GTGGCTCACC TGTATTCCAA CCTTACCAAA CCGATTTTAG ATGTAATTCT AACCTCCTAT 
ACCCTCATCC GGACAGCTAC ATCCAGAGGA GCAAGCCCCA TCGGGCCCAC CCTGTTAGCA 
GGGCTCGTGG TGTATGCCAC TGCTAAAGTC CTGAAAGCTT GCTCGCCCAA ATTTGGTACT 
CTGGTGGCTG AAGAAGCTCA TAGAAAGGGC TACTTGCGGT ATGTTCACTC CAGAATCATA 
GCCAATGTGG AAGAAATTGC CTTCTACAGA GGACATAAGG TAGAAATGAA GCAACTGCAG 
AAGTGTTACA AGGCTTTAGC TTACCAGATG AACCTTATTC TATCCAAACG TTTGTGGTAC 
ATCATGATAG AACAGTTCCT GATGAAGTAT GTGTGGAGCG GCTGTGGACT AATTATGGTG 
GCCATACCTA TCATCACTGC AACAGGCTTT GCAGATGGTG ATCTGGAGGA TGGCCCTAAG 
CAGGCTATGG TTAGCGATCG GACAGAGGCC TTTACCACTG CTCGGAATTT ACTGGCCTCT 
GGAGCTGACG CGATTGAGAG GATTATGTCT TCATACAAAG AGATCACTGA ACTAGCGGGT 
TATACTGCCA GAGTGTACAA CATGTTCTGG GTCTTCGATG AAGTGAAGAG AGGCATTTAT 
AAGAGAACTG TCACTCAGGA GCCTGAAAAC AATAGCAAGA GTGGAGGTGG CCTGGAGCTG 
CCCCTCAGTG ACACCCTGGC AATCAAAGGG ACAGTCATTG ACGTGGATCA TGGAATCCTT 
TGTGAAAATG TTCCCATAAT CACGCCGGCG GGAGAAGTGG TGGCTTCCAG TCTGAACTTC 
AAAGTAGAAG AAGGGATGCA TCTTTTGATA ACCGGCCCCA ATGGTTGTGG GAAAAGCTCT 
CTGTTCAGAA TCTTAAGTGG GCTCTGGCCT GTGTATGAAG GAGTCCTTTA TAAACCACCT 
CCCCAACATA TGTTCTATAT TCCACAGAGG CCGTACATGT CTCTTGGAAG TCTTCGGGAT 
CAAGTCATTT ATCCTGACTC GGTGGATGAC ATGCATGAGA AAGGTTATAC AGACCGAGAC 
CTAGAGCATA TTCTGCACAG CGTCCACCTC TACCACATAG TCCAAAGAGA AGGAGGATGG 
GATGCAGTCA TGGATTGGAA AGATGTCCTT TCAGGAGGGG AGAAACAGAG AATGGGGATG 
GCACGGATGT TTTACCATAA ACCGAAGTAC GCATTGCTGG ACGAGTGCAC CAGTGCTGTG 
AGCATTGACG TGGAAGGAAA GATATTTCAG GCTGCTATCG GGGCTGGCAT TTCCTTACTG 
TCTATAACGC ACAGGCCTTC TCTGTGGAAA TACCACACCC ACCTATTGCA ATTTGATGGC 
GAAGGAGGTT GGCGCTTTGA ACAGTTGGAC ACTGCTATCC GCTTAACGTT AAGCGAGGAG 
AAACAGAAGT TGGAGTCGCA GCTCGCTGGA ATTCCCAAAA TGCAGCAGAG ACTCAATGAA 
CTGTGCAAAA TTTTGGGGGA AGACTCGGTG CTGAAAACGA TCCAAACTGC AGAGGACACA 
TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203503.1
CDS	203..2428
Translation	MIHMLNAAAYRVKWTRSGAAKRAACLVAAAYALKTLYPILGRRLKQPGHRKAKAEDYPPAENRERLHCTEIICKKPAPGLNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLVKWLMIAVPATFVNSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGTLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLILSKRLWYIMIEQFLMKYVWSGCGLIMVAIPIITATGFADGDLEDGPKQAMVSDRTEAFTTARNLLASGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEPENNSKSGGGLELPLSDTLAIKGTVIDVDHGILCENVPIITPAGEVVASSLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHEKGYTDRDLEHILHSVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAIGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIQTAEDTS

Target ORF information:

RefSeq Version	NM_033352.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily D member 2 (Abcd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033352.1

ORF Insert Sequence:

ATGATACACA TGCTAAATGC AGCAGCCTAT CGGGTGAAAT GGACCAGATC CGGTGCTGCT 
AAAAGGGCTG CCTGCCTGGT GGCTGCGGCA TATGCTCTGA AAACCCTCTA TCCCATCCTT 
GGCAGGCGTT TAAAGCAGCC TGGCCACCGG AAGGCGAAAG CAGAAGATTA CCCGCCTGCA 
GAGAACAGAG AAAGACTGCA TTGCACAGAG ATCATCTGTA AAAAACCTGC GCCGGGACTA 
AATGCAGATT TTTTCAAACA GCTACTAGAA CTTCGGAAAA TCCTCTTTCC AAAACTTGTG 
ACCACTGAAA CGGGGTGGCT CTGCCTCCAC TCGGTGGCTC TAATCTCACG AACGTTTCTG 
TCTATCTACG TGGCTGGTCT GGATGGGAAA ATCGTGAAAA GCATCGTGGA AAAGAAGCCT 
CGGACTTTCA TCATCAAACT AGTCAAGTGG CTTATGATTG CCGTCCCCGC TACCTTTGTC 
AACAGCGCTA TCAGGTACCT GGAGTGCAAA CTGGCATTGG CCTTTAGAAC TCGCTTAGTG 
GACCATGCCT ATGAGACCTA TTTTGCAAAT CAGACTTATT ATAAGGTGAT AAATATGGAC 
GGGAGGCTGG CAAACCCTGA CCAGTCTCTT ACTGAAGACA TTATGATGTT CTCGCAATCG 
GTGGCTCACC TGTATTCCAA CCTTACCAAA CCGATTTTAG ATGTAATTCT AACCTCCTAT 
ACCCTCATCC GGACAGCTAC ATCCAGAGGA GCAAGCCCCA TCGGGCCCAC CCTGTTAGCA 
GGGCTCGTGG TGTATGCCAC TGCTAAAGTC CTGAAAGCTT GCTCGCCCAA ATTTGGTACT 
CTGGTGGCTG AAGAAGCTCA TAGAAAGGGC TACTTGCGGT ATGTTCACTC CAGAATCATA 
GCCAATGTGG AAGAAATTGC CTTCTACAGA GGACATAAGG TAGAAATGAA GCAACTGCAG 
AAGTGTTACA AGGCTTTAGC TTACCAGATG AACCTTATTC TATCCAAACG TTTGTGGTAC 
ATCATGATAG AACAGTTCCT GATGAAGTAT GTGTGGAGCG GCTGTGGACT AATTATGGTG 
GCCATACCTA TCATCACTGC AACAGGCTTT GCAGATGGTG ATCTGGAGGA TGGCCCTAAG 
CAGGCTATGG TTAGCGATCG GACAGAGGCC TTTACCACTG CTCGGAATTT ACTGGCCTCT 
GGAGCTGACG CGATTGAGAG GATTATGTCT TCATACAAAG AGATCACTGA ACTAGCGGGT 
TATACTGCCA GAGTGTACAA CATGTTCTGG GTCTTCGATG AAGTGAAGAG AGGCATTTAT 
AAGAGAACTG TCACTCAGGA GCCTGAAAAC AATAGCAAGA GTGGAGGTGG CCTGGAGCTG 
CCCCTCAGTG ACACCCTGGC AATCAAAGGG ACAGTCATTG ACGTGGATCA TGGAATCCTT 
TGTGAAAATG TTCCCATAAT CACGCCGGCG GGAGAAGTGG TGGCTTCCAG TCTGAACTTC 
AAAGTAGAAG AAGGGATGCA TCTTTTGATA ACCGGCCCCA ATGGTTGTGG GAAAAGCTCT 
CTGTTCAGAA TCTTAAGTGG GCTCTGGCCT GTGTATGAAG GAGTCCTTTA TAAACCACCT 
CCCCAACATA TGTTCTATAT TCCACAGAGG CCGTACATGT CTCTTGGAAG TCTTCGGGAT 
CAAGTCATTT ATCCTGACTC GGTGGATGAC ATGCATGAGA AAGGTTATAC AGACCGAGAC 
CTAGAGCATA TTCTGCACAG CGTCCACCTC TACCACATAG TCCAAAGAGA AGGAGGATGG 
GATGCAGTCA TGGATTGGAA AGATGTCCTT TCAGGAGGGG AGAAACAGAG AATGGGGATG 
GCACGGATGT TTTACCATAA ACCGAAGTAC GCATTGCTGG ACGAGTGCAC CAGTGCTGTG 
AGCATTGACG TGGAAGGAAA GATATTTCAG GCTGCTATCG GGGCTGGCAT TTCCTTACTG 
TCTATAACGC ACAGGCCTTC TCTGTGGAAA TACCACACCC ACCTATTGCA ATTTGATGGC 
GAAGGAGGTT GGCGCTTTGA ACAGTTGGAC ACTGCTATCC GCTTAACGTT AAGCGAGGAG 
AAACAGAAGT TGGAGTCGCA GCTCGCTGGA ATTCCCAAAA TGCAGCAGAG ACTCAATGAA 
CTGTGCAAAA TTTTGGGGGA AGACTCGGTG CTGAAAACGA TCCAAACTGC AGAGGACACA 
TCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Thyroid Hormone-Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy.
Endocrinology158(5)1328-1338(2017 May)
Hartley MD,Kirkemo LL,Banerji T,Scanlan TS

Peroxisomal ATP-binding cassette transporters form mainly tetramers.
The Journal of biological chemistry292(17)6965-6977(2017 04)
Geillon F,Gondcaille C,Raas Q,Dias AMM,Pecqueur D,Truntzer C,Lucchi G,Ducoroy P,Falson P,Savary S,Trompier D

Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers.
The Journal of biological chemistry289(35)24511-20(2014 Aug)
Geillon F,Gondcaille C,Charbonnier S,Van Roermund CW,Lopez TE,Dias AM,Pais de Barros JP,Arnould C,Wanders RJ,Trompier D,Savary S

Impact of lactobacilli on orally acquired listeriosis.
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Archambaud C,Nahori MA,Soubigou G,B?cavin C,Laval L,Lechat P,Smokvina T,Langella P,Lecuit M,Cossart P

Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2).
The Journal of biological chemistry286(10)8075-84(2011 Mar)
Genin EC,Geillon F,Gondcaille C,Athias A,Gambert P,Trompier D,Savary S

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Abcd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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