Ikbkb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ikbkb
Entrez Gene ID	84351
Full Name	inhibitor of nuclear factor kappa B kinase subunit beta
Synonyms	AIM-1,IKK2
General protein information	Preferred Names inhibitor of nuclear factor kappa B kinase subunit beta Names inhibitor of nuclear factor kappa-B kinase subunit beta I-kappa-B kinase 2 I-kappa-B-kinase beta IKK-B IKK-beta NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta inhibitor of kappaB kinase beta inhibitor of nuclear factor kappa B kinase beta subunit nuclear factor NF-kappa-B inhibitor kinase beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5
Summary	kinase that may be involved in megakaryocyte polyploidization [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053355.2	NP_445807.2	inhibitor of nuclear factor kappa-B kinase subunit beta

Pathways from BioSystems

Homologies

	IKBKB	XP_001096913.1
Mus musculus (house mouse)	Ikbkb	NP_001153246.1
Xenopus tropicalis (tropical clawed frog)	ikbkb	NP_001005651.1
Canis lupus familiaris (dog)	IKBKB	XP_005629860.1
Rattus norvegicus (Norway rat)	Ikbkb	NP_445807.2
Danio rerio (zebrafish)	ikbkb	NP_001116737.1
Bos taurus (cattle)	IKBKB	NP_776778.1
Gallus gallus (chicken)	IKBKB	NP_001026568.1
Homo sapiens (human)	IKBKB	NP_001547.1
Pan troglodytes (chimpanzee)	IKBKB	XP_001142461.2

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of I?B Kinase at 24?Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis.
Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV, Collino M, Yaqoob MM, Thiemermann C
Journal of the American Heart Association6(7)(2017 Jul)

Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-?B signaling pathway in a rat model.
Zhang B, Wang D, Ji TF, Shi L, Yu JL
Oncotarget8(10)17347-17359(2017 Mar)

Targeting I?B Kinase ?/NF-?B Signaling in Human Prostate Cancer by a Novel I?B Kinase ? Inhibitor CmpdA.
Zhang Y, Lapidus RG, Liu P, Choi EY, Adediran S, Hussain A, Wang X, Liu X, Dan HC
Molecular cancer therapeutics15(7)1504-14(2016 07)

Measurement of IKK activity in primary rat T cells: rapid activation and inactivation.
Kupfer R, Scheinman RI
Journal of immunological methods266(1-2)155-64(2002 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpressed long non-coding RNA (lncRNA) ANRIL upregulates vascular endothelial growth factor (VEGF) and promotes angiogenesis by activating NF-kappa B (NF-kappaB) signaling pathway in diabetes mellitus (DM) combined with cerebral infarction (DM + CI) rats.
Title: Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-?B signaling pathway in a rat model.

Data indicate that injury-induced upregulation of inflammatory cytokines within IVDs and increased levels of neuropeptides within DRG neurons can be suppressed by inhibiting IkappaB kinase-beta (IKKbeta).
Title: Inhibiting I?B kinase-? downregulates inflammatory cytokines in injured discs and neuropeptides in dorsal root ganglia innervating injured discs in rats.

IKKbeta could reduce arterial remodeling events by affecting both the inflammatory and the growth-promoting response of Ang II.
Title: Role of I?B kinase-? in the growth-promoting effects of angiotensin II in vitro and in vivo.

H. pylori-induced ERK activation plays a critical role in up-regulation of gastric mucosal PGE2 and NO generation at the level of IKK-b and cPLA2 activation; ghrelin counters these proinflammatory events
Title: Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on MAPK/ERK-mediated activation of IKK-? and cPLA2: modulatory effect of ghrelin.

Selective inhibition of IkappaBbeta-mediated NF-kappaB activation maintains the inflammatory stress-induced upregulation of antioxidant enzyme and preserves cellular growth, as shown in fetal pulmonary vascular endothelial cells.
Title: The NF-?B inhibitory proteins I?B? and I?B? mediate disparate responses to inflammation in fetal pulmonary endothelial cells.

The following Ikbkb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ikbkb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa40025	NM_053355.2 Latest version!	Rattus norvegicus inhibitor of nuclear factor kappa B kinase subunit beta (Ikbkb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ikbkb ( NM_053355.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445807.2 Rattus norvegicus inhibitor of nuclear factor kappa B kinase subunit beta (Ikbkb), mRNA.

Price & Availability↑

CloneID	ORa40025
Clone ID Related Accession (Same CDS sequence)	NM_053355.2
Accession Version	NM_053355.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	inhibitor of nuclear factor kappa-B kinase subunit beta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB810812.1, AF115282.1, AABR07026361.1 and CO383061.1. On Oct 19, 2007 this sequence version replaced NM_053355.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AF115282.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCTGGT CACCTTCTCT CCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAACGC 
CTCGGAACTG GGGGATTTGG AAACGTCATC CGGTGGCACA ATCAGGTGAC AGGTGAACAA 
ATTGCCATCA AGCAATGCCG ACAGGAGCTC AGCCCCAAGA ACCGCGATCG CTGGTGCCTA 
GAGATCCAGA TCATGAGAAG GCTGAACCAT CCCAACGTGG TGGCCGCCCG GGATGTCCCA 
GAGGGGATGC AGAACTTGGC ACCCAATGAT TTGCCTCTGC TGGCCATGGA GTACTGCCAA 
GGAGGAGACC TCCGGAGATA CTTGAACCAG TTCGAAAACT GCTGTGGCCT CCGGGAAGGA 
GCCATCCTCA CCCTGCTGAG TGACATAGCA TCGGCTCTTA GATACCTTCA TGAAAACAGA 
ATCATCCACC GGGACCTGAA GCCAGAGAAC ATTGTCCTAC AGCAAGGAGA GAAAAGATTA 
ATACACAAAA TTATTGATCT AGGATATGCC AAGGAGCTGG ATCAGGGCAG TCTGTGCACG 
TCATTTGTGG GGACCCTGCA ATACCTGGCC CCAGAGCTTC TGGAGCAGCA GAAGTACACC 
GTGACTGTTG ACTACTGGAG CTTCGGCACC CTGGCCTTTG AATGCATCAC CGGCTTCCGG 
CCCTTTCTCC CTAACTGGCA GCCTGTGCAG TGGCACTCTA AAGTCCGGCA GAAGAGCGAA 
GTGGACATTG TTGTTAGCGA GGACTTGAAC GGAACAGTGA AGTTCTCAAG TTCCTTACCC 
TTCCCCAATA ATCTCAACAG TGTCCTGGCT GAGCGTCTGG AGAAGTGGCT TCAGCTGATG 
CTCACGTGGC AACCTCGGCA AAGGGGCGTG GACCCCCAGT ACGGTCCCAA TGGCTGTTTC 
AGGGCCCTCG ATGACATCTT GAACTTAAAG CTGGTTCATA TCTTGAACAT GGTCACAGGC 
ACCATTCACA CATACCCTGT GATGGAGGAT GAAAGTCTGC AGAGCTTAAA AACCAGAATC 
CGGGAAGACA CAGGGATCCT GGAGACAGAC CAGGAACTGC TGCAGGAGGC AGGGCTGGTG 
CTGCTCCCTG ACAAGCCTGC TACTCAGTGC ATCTCAGACA GCAAGACAAA TGAGGGCCTC 
ACACTGGACA TGGATCTCGT CTTTCTCTTT GACAACAGTA AAATGTCCTA TGAGACTCAG 
ATCACCCCCC GACCCCAACC TGAGAGCGTC AGCTGTGTCC TTCAGGAGCC CAAGCGGAAC 
CTCTCCTTCT TCCAGATGAG GAAAGTGTGG GGCCAAGTCT GGCACAGCAT CCAAACGCTG 
AAGGAAGACT GTAACCGGCT GCAGCAGGGA CAGCGAGCTG CCATGATGAA CCTCCTTCGG 
AATAACAGCT GCCTCTCCAA GATGAAGAAT GCCATGGCCT CCACGGCGCA GCAGCTCAAG 
GCCAAGTTGG ACTTCTTCAA AACCAGCATC CAGATTGACC TGGAGAAGTA CAGGGAGCAG 
ACGGAGTTTG GCATCACATC GGACAAACTG CTGCTGGCCT GGCGGGAAAT GGAGCAGGCC 
GTGGAGCAGT GTGGGCGGGA GAATGACGTG AAGGTCCTGG TAGAACGGAT GATGGCACTG 
CAGACCGACA TTGTGGACCT ACAGAGGAGC CCGATGGGTC GGAAGCAGGG GGGCACCTTG 
GATGACCTAG AGGAACAAGC AAGAGAACTC TACAGAAGAC TCAGGGAGAA GCCAAGAGAC 
CAAAGGACAG AAGGTGACAG CCAGGATATG GTACGGCTGC TGCTGCAAGC CATCCAGAGC 
TTCGAGAAGA AAGTGCGGGT GATTTACTCT CAGCTCAGTA AGACCGTGGT TTGTAAGCAG 
AAGGCCCTGG AGCTGCTGCC CAAAGTAGAA GAGGTGGTGA GGCTCATGAA CGAGGATGAG 
AAGACTGTGG TCCGGCTCCA GGAGAAGCGG CAGAAGGAGC TCTGGAACCT CCTGAAGATC 
GCCTGTAGCA AAGTCCGAGG TCCGGTGAGT GGAAGCCCAG ATAGCATGAA TGTGTCTCGA 
CTTAGTCACC CTGGTCATCT AATGTCCCAG CCTTCCAGTG CCTGTGACAG CTTACCTGAT 
TCAGACAAGA AAAGTGAAGA ACTGGTGGCC GAAGCACACG CCCTCTGCTC CCGGCTGGAA 
AGCGCGCTGC AGGACACGGT GAAGCAGCAG GACCGAAGCT TCACGACCCT AGACTGGAGC 
TGGTTACAGA TGGAGGATGA AGAAAGGTGT GGCCTGGAGC AGGCCTGTGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445807.2
CDS	112..2385
Translation	MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQVTGEQIAIKQCRQELSPKNRDRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPFPNNLNSVLAERLEKWLQLMLTWQPRQRGVDPQYGPNGCFRALDDILNLKLVHILNMVTGTIHTYPVMEDESLQSLKTRIREDTGILETDQELLQEAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLFDNSKMSYETQITPRPQPESVSCVLQEPKRNLSFFQMRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVEQCGRENDVKVLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQDMVRLLLQAIQSFEKKVRVIYSQLSKTVVCKQKALELLPKVEEVVRLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGHLMSQPSSACDSLPDSDKKSEELVAEAHALCSRLESALQDTVKQQDRSFTTLDWSWLQMEDEERCGLEQACD

Target ORF information:

RefSeq Version	NM_053355.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inhibitor of nuclear factor kappa B kinase subunit beta (Ikbkb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053355.2

ORF Insert Sequence:

ATGAGCTGGT CACCTTCTCT CCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAACGC 
CTCGGAACTG GGGGATTTGG AAACGTCATC CGGTGGCACA ATCAGGTGAC AGGTGAACAA 
ATTGCCATCA AGCAATGCCG ACAGGAGCTC AGCCCCAAGA ACCGCGATCG CTGGTGCCTA 
GAGATCCAGA TCATGAGAAG GCTGAACCAT CCCAACGTGG TGGCCGCCCG GGATGTCCCA 
GAGGGGATGC AGAACTTGGC ACCCAATGAT TTGCCTCTGC TGGCCATGGA GTACTGCCAA 
GGAGGAGACC TCCGGAGATA CTTGAACCAG TTCGAAAACT GCTGTGGCCT CCGGGAAGGA 
GCCATCCTCA CCCTGCTGAG TGACATAGCA TCGGCTCTTA GATACCTTCA TGAAAACAGA 
ATCATCCACC GGGACCTGAA GCCAGAGAAC ATTGTCCTAC AGCAAGGAGA GAAAAGATTA 
ATACACAAAA TTATTGATCT AGGATATGCC AAGGAGCTGG ATCAGGGCAG TCTGTGCACG 
TCATTTGTGG GGACCCTGCA ATACCTGGCC CCAGAGCTTC TGGAGCAGCA GAAGTACACC 
GTGACTGTTG ACTACTGGAG CTTCGGCACC CTGGCCTTTG AATGCATCAC CGGCTTCCGG 
CCCTTTCTCC CTAACTGGCA GCCTGTGCAG TGGCACTCTA AAGTCCGGCA GAAGAGCGAA 
GTGGACATTG TTGTTAGCGA GGACTTGAAC GGAACAGTGA AGTTCTCAAG TTCCTTACCC 
TTCCCCAATA ATCTCAACAG TGTCCTGGCT GAGCGTCTGG AGAAGTGGCT TCAGCTGATG 
CTCACGTGGC AACCTCGGCA AAGGGGCGTG GACCCCCAGT ACGGTCCCAA TGGCTGTTTC 
AGGGCCCTCG ATGACATCTT GAACTTAAAG CTGGTTCATA TCTTGAACAT GGTCACAGGC 
ACCATTCACA CATACCCTGT GATGGAGGAT GAAAGTCTGC AGAGCTTAAA AACCAGAATC 
CGGGAAGACA CAGGGATCCT GGAGACAGAC CAGGAACTGC TGCAGGAGGC AGGGCTGGTG 
CTGCTCCCTG ACAAGCCTGC TACTCAGTGC ATCTCAGACA GCAAGACAAA TGAGGGCCTC 
ACACTGGACA TGGATCTCGT CTTTCTCTTT GACAACAGTA AAATGTCCTA TGAGACTCAG 
ATCACCCCCC GACCCCAACC TGAGAGCGTC AGCTGTGTCC TTCAGGAGCC CAAGCGGAAC 
CTCTCCTTCT TCCAGATGAG GAAAGTGTGG GGCCAAGTCT GGCACAGCAT CCAAACGCTG 
AAGGAAGACT GTAACCGGCT GCAGCAGGGA CAGCGAGCTG CCATGATGAA CCTCCTTCGG 
AATAACAGCT GCCTCTCCAA GATGAAGAAT GCCATGGCCT CCACGGCGCA GCAGCTCAAG 
GCCAAGTTGG ACTTCTTCAA AACCAGCATC CAGATTGACC TGGAGAAGTA CAGGGAGCAG 
ACGGAGTTTG GCATCACATC GGACAAACTG CTGCTGGCCT GGCGGGAAAT GGAGCAGGCC 
GTGGAGCAGT GTGGGCGGGA GAATGACGTG AAGGTCCTGG TAGAACGGAT GATGGCACTG 
CAGACCGACA TTGTGGACCT ACAGAGGAGC CCGATGGGTC GGAAGCAGGG GGGCACCTTG 
GATGACCTAG AGGAACAAGC AAGAGAACTC TACAGAAGAC TCAGGGAGAA GCCAAGAGAC 
CAAAGGACAG AAGGTGACAG CCAGGATATG GTACGGCTGC TGCTGCAAGC CATCCAGAGC 
TTCGAGAAGA AAGTGCGGGT GATTTACTCT CAGCTCAGTA AGACCGTGGT TTGTAAGCAG 
AAGGCCCTGG AGCTGCTGCC CAAAGTAGAA GAGGTGGTGA GGCTCATGAA CGAGGATGAG 
AAGACTGTGG TCCGGCTCCA GGAGAAGCGG CAGAAGGAGC TCTGGAACCT CCTGAAGATC 
GCCTGTAGCA AAGTCCGAGG TCCGGTGAGT GGAAGCCCAG ATAGCATGAA TGTGTCTCGA 
CTTAGTCACC CTGGTCATCT AATGTCCCAG CCTTCCAGTG CCTGTGACAG CTTACCTGAT 
TCAGACAAGA AAAGTGAAGA ACTGGTGGCC GAAGCACACG CCCTCTGCTC CCGGCTGGAA 
AGCGCGCTGC AGGACACGGT GAAGCAGCAG GACCGAAGCT TCACGACCCT AGACTGGAGC 
TGGTTACAGA TGGAGGATGA AGAAAGGTGT GGCCTGGAGC AGGCCTGTGA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of I?B Kinase at 24?Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis.
Journal of the American Heart Association6(7)(2017 Jul)
Johnson FL,Patel NSA,Purvis GSD,Chiazza F,Chen J,Sordi R,Hache G,Merezhko VV,Collino M,Yaqoob MM,Thiemermann C

Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-?B signaling pathway in a rat model.
Oncotarget8(10)17347-17359(2017 Mar)
Zhang B,Wang D,Ji TF,Shi L,Yu JL

Targeting I?B Kinase ?/NF-?B Signaling in Human Prostate Cancer by a Novel I?B Kinase ? Inhibitor CmpdA.
Molecular cancer therapeutics15(7)1504-14(2016 07)
Zhang Y,Lapidus RG,Liu P,Choi EY,Adediran S,Hussain A,Wang X,Liu X,Dan HC

Measurement of IKK activity in primary rat T cells: rapid activation and inactivation.
Journal of immunological methods266(1-2)155-64(2002 Aug)
Kupfer R,Scheinman RI

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Ikbkb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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