Ackr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ackr3
Entrez Gene ID	84348
Full Name	atypical chemokine receptor 3
Synonyms	Cmkor1,Cxcr7,Rdc1
General protein information	Preferred Names atypical chemokine receptor 3 Names atypical chemokine receptor 3 C-X-C chemokine receptor type 7 CXC-R7 CXCR-7 G-protein coupled receptor RDC1 homolog RDC-1 chemokine (C-X-C motif) receptor 7 chemokine orphan receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q36
Summary	human homolog is an orphan G-protein coupled receptor and may be associated with lipomas [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053352.1	NP_445804.1	atypical chemokine receptor 3
XM_006245479.3	XP_006245541.1	atypical chemokine receptor 3 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CXCR7	NP_001091851.1
Pan troglodytes (chimpanzee)	CXCR7	XP_003950047.1
	CXCR7	XP_001083694.1
Canis lupus familiaris (dog)	ACKR3	NP_001003281.1
Rattus norvegicus (Norway rat)	Cxcr7	NP_445804.1
Xenopus tropicalis (tropical clawed frog)	ackr3	NP_001025605.1
Homo sapiens (human)	ACKR3	NP_064707.1
Mus musculus (house mouse)	Ackr3	NP_031748.2
Gallus gallus (chicken)	CXCR7	NP_001076831.1
Danio rerio (zebrafish)	cxcr7b	NP_001138286.1
Danio rerio (zebrafish)	ackr3b	NP_001077301.1

Gene Ontology
Bibliography

Related articles in PubMed

miR-539-5p inhibits experimental choroidal neovascularization by targeting CXCR7.
Feng Y, Wang J, Yuan Y, Zhang X, Shen M, Yuan F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Nov)

Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function.
Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M
Proceedings of the National Academy of Sciences of the United States of America112(13)E1659-68(2015 Mar)

Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular ??-adrenergic receptor function.
Bach HH 4th, Wong YM, Tripathi A, Nevins AM, Gamelli RL, Volkman BF, Byron KL, Majetschak M
Molecular medicine (Cambridge, Mass.)20435-47(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CXCR4 and ACKR3 modulate alpha1-AR reactivity in vascular smooth muscle and regulate hemodynamics in normal and pathological conditions
Title: Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular ??-adrenergic receptor function.

Findings indicate that CXCR-4 and -7 receptors were co-expressed in BMSCs and synergistically promoted BMSC migration.
Title: CXCR-7 receptor promotes SDF-1?-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus.

CXCR4 and CXCR7 form a functional receptor unit in microglial cells, which is up-regulated during activation of microglia both in vitro and in vivo.
Title: CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia.

CXCR7 silencing attenuates cell adaptive response to stromal cell derived factor 1alpha after hypoxia.
Title: CXCR7 silencing attenuates cell adaptive response to stromal cell derived factor 1? after hypoxia.

Grk2 tightly controls CXCR7 signaling in astrocytes by mediating internalization.
Title: Grk2 is an essential regulator of CXCR7 signalling in astrocytes.

The following Ackr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ackr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12767	NM_053352.1 Latest version!	Rattus norvegicus atypical chemokine receptor 3 (Ackr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa12767	XM_006245479.3 Latest version!	Rattus norvegicus atypical chemokine receptor 3 (Ackr3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ackr3 ( NM_053352.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445804.1 Rattus norvegicus atypical chemokine receptor 3 (Ackr3), mRNA.

Price & Availability↑

CloneID	ORa12767
Clone ID Related Accession (Same CDS sequence)	NM_053352.1 , XM_006245479.3
Accession Version	NM_053352.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	atypical chemokine receptor 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF118816.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF118816.1, AJ010828.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATGTGC ATCTGTTTGA CTATGTGGAA CCTGGGAACT ACTCGGACAT CAACTGGCCC 
TGTAACAGTA GCGACTGCAT CGTCGTGGAC ACCGTGCAGT GTCCCGCCAT GCCCAACAAG 
AATGTGCTGC TGTATACCCT CTCCTTCATC TACATTTTCA TCTTCGTGAT CGGTATGATT 
GCCAACTCCG TGGTGGTCTG GGTGAATATC CAGGCCAAGA CTACAGGCTA CGACACACAC 
TGCTACATCT TGAACCTGGC CATTGCCGAT CTGTGGGTCG TCATCACCAT CCCTGTCTGG 
GTGGTCAGTC TCGTGCAGCA TAACCAGTGG CCCATGGGTG AGCTCACGTG CAAGATCACA 
CACCTCATTT TCTCCATCAA CCTCTTTGGG AGCATCTTCT TCCTCGCATG CATGAGCGTG 
GACCGCTATC TCTCCATCAC CTACTTCACC AGCACCTCCA GCTATAAGAA GAAGATGGTA 
CGCCGTGTTG TCTGCGTCTT GGTGTGGCTG CTGGCCTTCT TTGTGTCCCT GCCTGACACC 
TACTACCTGA AGACGGTCAC ATCTGCTTCC AACAACGAGA CCTACTGCAG GTCCTTCTAC 
CCCGAGCACA GCATCAAGGA GTGGCTCATT GGCATGGAGC TGGTCTCCGT CATCTTGGGT 
TTTGCTGTCC CCTTCACCAT CATTGCTATC TTCTACTTCC TGCTCGCCAG AGCCATGTCA 
GCATCCGGTG ACCAGGAGAA ACACAGCAGC CGGAAGATCA TCTTCTCCTA CGTGGTGGTC 
TTCCTGGTGT GTTGGCTGCC GTACCATTTT GTGGTTCTGC TGGACATCTT CTCTATCTTG 
CACTACATCC CGTTCACCTG CCAACTGGAG AATGTGCTCT TTACAGCGCT GCACGTCACG 
CAGTGCCTGT CCCTGGTGCA CTGCTGTGTC AACCCTGTGC TCTACAGCTT CATCAACCGA 
AACTACAGGT ACGAGCTGAT GAAGGCCTTC ATCTTCAAGT ACTCAGCCAA AACAGGACTC 
ACCAAACTCA TCGATGCCTC CAGAGTGTCA GAGACAGAGT ACTCTGCCCT GGAGCAGAAC 
ACCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445804.1
CDS	89..1177
Translation	MDVHLFDYVEPGNYSDINWPCNSSDCIVVDTVQCPAMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTSTSSYKKKMVRRVVCVLVWLLAFFVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAMSASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHYIPFTCQLENVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQNTK

Target ORF information:

RefSeq Version	NM_053352.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus atypical chemokine receptor 3 (Ackr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053352.1

ORF Insert Sequence:

ATGGATGTGC ATCTGTTTGA CTATGTGGAA CCTGGGAACT ACTCGGACAT CAACTGGCCC 
TGTAACAGTA GCGACTGCAT CGTCGTGGAC ACCGTGCAGT GTCCCGCCAT GCCCAACAAG 
AATGTGCTGC TGTATACCCT CTCCTTCATC TACATTTTCA TCTTCGTGAT CGGTATGATT 
GCCAACTCCG TGGTGGTCTG GGTGAATATC CAGGCCAAGA CTACAGGCTA CGACACACAC 
TGCTACATCT TGAACCTGGC CATTGCCGAT CTGTGGGTCG TCATCACCAT CCCTGTCTGG 
GTGGTCAGTC TCGTGCAGCA TAACCAGTGG CCCATGGGTG AGCTCACGTG CAAGATCACA 
CACCTCATTT TCTCCATCAA CCTCTTTGGG AGCATCTTCT TCCTCGCATG CATGAGCGTG 
GACCGCTATC TCTCCATCAC CTACTTCACC AGCACCTCCA GCTATAAGAA GAAGATGGTA 
CGCCGTGTTG TCTGCGTCTT GGTGTGGCTG CTGGCCTTCT TTGTGTCCCT GCCTGACACC 
TACTACCTGA AGACGGTCAC ATCTGCTTCC AACAACGAGA CCTACTGCAG GTCCTTCTAC 
CCCGAGCACA GCATCAAGGA GTGGCTCATT GGCATGGAGC TGGTCTCCGT CATCTTGGGT 
TTTGCTGTCC CCTTCACCAT CATTGCTATC TTCTACTTCC TGCTCGCCAG AGCCATGTCA 
GCATCCGGTG ACCAGGAGAA ACACAGCAGC CGGAAGATCA TCTTCTCCTA CGTGGTGGTC 
TTCCTGGTGT GTTGGCTGCC GTACCATTTT GTGGTTCTGC TGGACATCTT CTCTATCTTG 
CACTACATCC CGTTCACCTG CCAACTGGAG AATGTGCTCT TTACAGCGCT GCACGTCACG 
CAGTGCCTGT CCCTGGTGCA CTGCTGTGTC AACCCTGTGC TCTACAGCTT CATCAACCGA 
AACTACAGGT ACGAGCTGAT GAAGGCCTTC ATCTTCAAGT ACTCAGCCAA AACAGGACTC 
ACCAAACTCA TCGATGCCTC CAGAGTGTCA GAGACAGAGT ACTCTGCCCT GGAGCAGAAC 
ACCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ackr3 ( XM_006245479.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006245541.1 Rattus norvegicus atypical chemokine receptor 3 (Ackr3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12767
Clone ID Related Accession (Same CDS sequence)	NM_053352.1 , XM_006245479.3
Accession Version	XM_006245479.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	atypical chemokine receptor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006245479.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGTGC ATCTGTTTGA CTATGTGGAA CCTGGGAACT ACTCGGACAT CAACTGGCCC 
TGTAACAGTA GCGACTGCAT CGTCGTGGAC ACCGTGCAGT GTCCCGCCAT GCCCAACAAG 
AATGTGCTGC TGTATACCCT CTCCTTCATC TACATTTTCA TCTTCGTGAT CGGTATGATT 
GCCAACTCCG TGGTGGTCTG GGTGAATATC CAGGCCAAGA CTACAGGCTA CGACACACAC 
TGCTACATCT TGAACCTGGC CATTGCCGAT CTGTGGGTCG TCATCACCAT CCCTGTCTGG 
GTGGTCAGTC TCGTGCAGCA TAACCAGTGG CCCATGGGTG AGCTCACGTG CAAGATCACA 
CACCTCATTT TCTCCATCAA CCTCTTTGGG AGCATCTTCT TCCTCGCATG CATGAGCGTG 
GACCGCTATC TCTCCATCAC CTACTTCACC AGCACCTCCA GCTATAAGAA GAAGATGGTA 
CGCCGTGTTG TCTGCGTCTT GGTGTGGCTG CTGGCCTTCT TTGTGTCCCT GCCTGACACC 
TACTACCTGA AGACGGTCAC ATCTGCTTCC AACAACGAGA CCTACTGCAG GTCCTTCTAC 
CCCGAGCACA GCATCAAGGA GTGGCTCATT GGCATGGAGC TGGTCTCCGT CATCTTGGGT 
TTTGCTGTCC CCTTCACCAT CATTGCTATC TTCTACTTCC TGCTCGCCAG AGCCATGTCA 
GCATCCGGTG ACCAGGAGAA ACACAGCAGC CGGAAGATCA TCTTCTCCTA CGTGGTGGTC 
TTCCTGGTGT GTTGGCTGCC GTACCATTTT GTGGTTCTGC TGGACATCTT CTCTATCTTG 
CACTACATCC CGTTCACCTG CCAACTGGAG AATGTGCTCT TTACAGCGCT GCACGTCACG 
CAGTGCCTGT CCCTGGTGCA CTGCTGTGTC AACCCTGTGC TCTACAGCTT CATCAACCGA 
AACTACAGGT ACGAGCTGAT GAAGGCCTTC ATCTTCAAGT ACTCAGCCAA AACAGGACTC 
ACCAAACTCA TCGATGCCTC CAGAGTGTCA GAGACAGAGT ACTCTGCCCT GGAGCAGAAC 
ACCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006245541.1
CDS	281..1369
Translation	MDVHLFDYVEPGNYSDINWPCNSSDCIVVDTVQCPAMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTSTSSYKKKMVRRVVCVLVWLLAFFVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAMSASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHYIPFTCQLENVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQNTK

Target ORF information:

RefSeq Version	XM_006245479.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus atypical chemokine receptor 3 (Ackr3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006245479.3

ORF Insert Sequence:

ATGGATGTGC ATCTGTTTGA CTATGTGGAA CCTGGGAACT ACTCGGACAT CAACTGGCCC 
TGTAACAGTA GCGACTGCAT CGTCGTGGAC ACCGTGCAGT GTCCCGCCAT GCCCAACAAG 
AATGTGCTGC TGTATACCCT CTCCTTCATC TACATTTTCA TCTTCGTGAT CGGTATGATT 
GCCAACTCCG TGGTGGTCTG GGTGAATATC CAGGCCAAGA CTACAGGCTA CGACACACAC 
TGCTACATCT TGAACCTGGC CATTGCCGAT CTGTGGGTCG TCATCACCAT CCCTGTCTGG 
GTGGTCAGTC TCGTGCAGCA TAACCAGTGG CCCATGGGTG AGCTCACGTG CAAGATCACA 
CACCTCATTT TCTCCATCAA CCTCTTTGGG AGCATCTTCT TCCTCGCATG CATGAGCGTG 
GACCGCTATC TCTCCATCAC CTACTTCACC AGCACCTCCA GCTATAAGAA GAAGATGGTA 
CGCCGTGTTG TCTGCGTCTT GGTGTGGCTG CTGGCCTTCT TTGTGTCCCT GCCTGACACC 
TACTACCTGA AGACGGTCAC ATCTGCTTCC AACAACGAGA CCTACTGCAG GTCCTTCTAC 
CCCGAGCACA GCATCAAGGA GTGGCTCATT GGCATGGAGC TGGTCTCCGT CATCTTGGGT 
TTTGCTGTCC CCTTCACCAT CATTGCTATC TTCTACTTCC TGCTCGCCAG AGCCATGTCA 
GCATCCGGTG ACCAGGAGAA ACACAGCAGC CGGAAGATCA TCTTCTCCTA CGTGGTGGTC 
TTCCTGGTGT GTTGGCTGCC GTACCATTTT GTGGTTCTGC TGGACATCTT CTCTATCTTG 
CACTACATCC CGTTCACCTG CCAACTGGAG AATGTGCTCT TTACAGCGCT GCACGTCACG 
CAGTGCCTGT CCCTGGTGCA CTGCTGTGTC AACCCTGTGC TCTACAGCTT CATCAACCGA 
AACTACAGGT ACGAGCTGAT GAAGGCCTTC ATCTTCAAGT ACTCAGCCAA AACAGGACTC 
ACCAAACTCA TCGATGCCTC CAGAGTGTCA GAGACAGAGT ACTCTGCCCT GGAGCAGAAC 
ACCAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-539-5p inhibits experimental choroidal neovascularization by targeting CXCR7.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Nov)
Feng Y,Wang J,Yuan Y,Zhang X,Shen M,Yuan F

Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function.
Proceedings of the National Academy of Sciences of the United States of America112(13)E1659-68(2015 Mar)
Tripathi A,Vana PG,Chavan TS,Brueggemann LI,Byron KL,Tarasova NI,Volkman BF,Gaponenko V,Majetschak M

Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular ??-adrenergic receptor function.
Molecular medicine (Cambridge, Mass.)20435-47(2014 Oct)
Bach HH 4th,Wong YM,Tripathi A,Nevins AM,Gamelli RL,Volkman BF,Byron KL,Majetschak M

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Ackr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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