Ptger4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptger4
Entrez Gene ID	84023
Full Name	prostaglandin E receptor 4
Synonyms	EP4,Ptger,Ptgerep4
General protein information	Preferred Names prostaglandin E receptor 4 Names prostaglandin E2 receptor EP4 subtype PGE receptor, EP4 subtype PGE2 receptor EP4 subtype prostaglandin E receptor 4 (subtype EP4) prostaglandin E2 receptor type 4 prostanoid EP4 receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q16
Summary	binds prostaglandin estradiol (PGE(2)) and induces cAMP-dependent bone resorption [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006231996.3	XP_006232058.1	prostaglandin E2 receptor EP4 subtype isoform X1
NM_032076.3	NP_114465.3	prostaglandin E2 receptor EP4 subtype

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PTGER4	NP_001009078.1
Rattus norvegicus (Norway rat)	Ptger4	NP_114465.3
Danio rerio (zebrafish)	ptger4b	NP_001121839.1
Canis lupus familiaris (dog)	PTGER4	NP_001003054.1
Bos taurus (cattle)	PTGER4	NP_777014.1
	PTGER4	XP_001085257.1
Homo sapiens (human)	PTGER4	NP_000949.1
Mus musculus (house mouse)	Ptger4	NP_001129551.1
Gallus gallus (chicken)	PTGER4	NP_001074972.1
Xenopus tropicalis (tropical clawed frog)	ptger4	NP_001120554.1

Gene Ontology
Bibliography

Related articles in PubMed

A dose response study of the effect of prostaglandin E2 on thermal nociceptive sensitivity.
Domenichiello AF, Wilhite BC, Keyes GS, Ramsden CE
Prostaglandins, leukotrienes, and essential fatty acids12620-24(2017 Nov)

Preferred recycling pathway by internalized PGE2 EP4 receptor following agonist stimulation in cultured dorsal root ganglion neurons contributes to enhanced EP4 receptor sensitivity.
St-Jacques B, Ma W
Neuroscience32656-68(2016 06)

The renoprotective effects of berberine via the EP4-G?s-cAMP signaling pathway in different stages of diabetes in rats.
Yang Y, Ni W, Cai M, Tang L, Wei W
Journal of receptor and signal transduction research34(6)445-55(2014 Dec)

PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.
Kassem KM, Clevenger MH, Szandzik DL, Peterson E, Harding P
Prostaglandins & other lipid mediators113-11562-8(2014 Oct)

Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy.
Taniguchi H, Anacker C, Wang Q, Andreasson K
Experimental neurology25530-7(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that EP4 recycling contributes to agonist-induced cell surface abundance and consequently enhanced receptor sensitivity. Facilitating EP4 externalization and recycling is a novel mechanism underlying PGE2-induced nociceptor sensitization.
Title: Preferred recycling pathway by internalized PGE2 EP4 receptor following agonist stimulation in cultured dorsal root ganglion neurons contributes to enhanced EP4 receptor sensitivity.

These studies demonstrate, for the first time, that BBR exerts renoprotective effects in different stages of DN via EP4- Galphas- AC-cAMP signaling pathway in STZ-induced DN rats fed a high-sugar and high-fat diet.
Title: The renoprotective effects of berberine via the EP4-G?s-cAMP signaling pathway in different stages of diabetes in rats.

PGE2 uses different receptors and mechanisms to ultimately decrease MMP expression and fibroblast migration.
Title: PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.

Our findings identify vascular PGE2 signaling through its EP4 receptor as protective in hypoxic-ischemic encephalopathy.
Title: Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy.

Elastogenesis is spatially regulated by PGE-EP4 signaling in the ductus arteriosus.
Title: Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling.

The following Ptger4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptger4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08991	NM_032076.3 Latest version!	Rattus norvegicus prostaglandin E receptor 4 (Ptger4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa08991	XM_006231996.3 Latest version!	Rattus norvegicus prostaglandin E receptor 4 (Ptger4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptger4 ( NM_032076.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114465.3 Rattus norvegicus prostaglandin E receptor 4 (Ptger4), mRNA.

Price & Availability↑

CloneID	ORa08991
Clone ID Related Accession (Same CDS sequence)	XM_006231996.3 , NM_032076.3
Accession Version	NM_032076.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	prostaglandin E2 receptor EP4 subtype
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U94709.1. On Jun 10, 2007 this sequence version replaced NM_032076.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U94709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689596 [ECO:0000348] ##Evidence-Data-END##

ATGTCCATCC CCGGAGTCAA CGCGTCCTTC TCCTCCACTC CGGAGAGGTT GAACAGCCCA 
GTGACCATTC CCGCAGTGAT GTTTATCTTC GGGGTGGTGG GCAACCTGGT GGCCATCGTA 
GTATTGTGCA AGTCGCGCAA GGAGCAGAAG GAGACTACCT TTTACACTCT GGTATGTGGG 
CTGGCTGTCA CTGACCTACT GGGCACATTG TTGGTAAGCC CAGTGACCAT CGCCACATAC 
ATGAAGGGCC AGTGGCCCGG AGACCAGGCA TTGTGTGACT ACAGCACCTT CATCCTACTT 
TTCTTCGGCC TGTCGGGTCT CAGCATCATC TGTGCCATGA GCATTGAGCG CTACCTGGCC 
ATCAACCACG CCTACTTCTA CAGCCACTAC GTGGACAAGC GGCTGGCCGG TCTCACGCTC 
TTCGCCGTCT ATGCATCTAA CGTGCTCTTC TGCGCACTGC CCAACATGGG CCTGGGTAGG 
TCCGAGCGGC AGTACCCGGG GACCTGGTGC TTCATCGACT GGACCACCAA CGTAACGGCC 
TACGCCGCCT TCTCTTACAT GTACGCGGGC TTCAGTTCCT TCCTCATCCT CGCCACCGTG 
CTCTGCAATG TGCTGGTGTG CGGCGCGCTG CTCCGCATGC ACCGCCAGTT CATGCGCCGC 
ACCTCGCTGG GCACGGAGCA GCACCACGCG GCCGCTGCAG CAGCGGTGGC TTCGGTGGCC 
TGTCGGGGTC ACGCGGCCGC CTCCCCAGCC CTGCAGCGCC TCAGTGACTT TCGCCGCCGC 
AGGAGCTTCC GGCGCATCGC GGGTGCAGAG ATCCAGATGG TCATCTTACT CATCGCCACC 
TCTCTGGTGG TGCTCATCTG CTCCATTCCG CTCGTGGTGC GAGTGTTCAT CAACCAGTTA 
TATCAGCCAA GTGTGGTGAA AGACATCAGC AGAAACCCGG ATTTGCAGGC CATCAGAATT 
GCTTCTGTGA ACCCCATCCT GGACCCTTGG ATCTACATCC TTCTTCGGAA GACTGTGCTC 
AGTAAAGCCA TAGAAAAGAT CAAGTGCCTC TTCTGCCGCA TTGGTGGTTC TGGCAGAGAC 
GGTTCAGCAC AGCACTGCTC AGAGAGTCGG AGGACATCTT CTGCCATGTC TGGCCACTCC 
CGCTCCTTCC TCTCGCGGGA GTTGAGGGAG ATCAGCAGCA CCTCTCAGAC CCTCCTATAC 
CTGCCAGACC TAACTGAAAG CAGCCTCGGA GGCAAGAATT TGCTTCCAGG TACGCATGGC 
ATGGGCCTGA CCCAAGCAGA CACCACCTCG CTGAGAACTT TGCGAATTTC AGAGACCTCA 
GACTCCTCCC AGGGCCAGGA CTCTGAGAGT GTCTTGTTGG TGGATGAGGT TAGTGGGAGC 
CAGAGAGAGG AGCCTGCCTC TAAGGGGAAC TCTCTGCAAG TCACGTTCCC CAGTGAAACG 
CTGAAATTAT CTGAAAAATG TATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114465.3
CDS	1..1467
Translation	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSQTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI

Target ORF information:

RefSeq Version	NM_032076.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prostaglandin E receptor 4 (Ptger4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032076.3

ORF Insert Sequence:

ATGTCCATCC CCGGAGTCAA CGCGTCCTTC TCCTCCACTC CGGAGAGGTT GAACAGCCCA 
GTGACCATTC CCGCAGTGAT GTTTATCTTC GGGGTGGTGG GCAACCTGGT GGCCATCGTA 
GTATTGTGCA AGTCGCGCAA GGAGCAGAAG GAGACTACCT TTTACACTCT GGTATGTGGG 
CTGGCTGTCA CTGACCTACT GGGCACATTG TTGGTAAGCC CAGTGACCAT CGCCACATAC 
ATGAAGGGCC AGTGGCCCGG AGACCAGGCA TTGTGTGACT ACAGCACCTT CATCCTACTT 
TTCTTCGGCC TGTCGGGTCT CAGCATCATC TGTGCCATGA GCATTGAGCG CTACCTGGCC 
ATCAACCACG CCTACTTCTA CAGCCACTAC GTGGACAAGC GGCTGGCCGG TCTCACGCTC 
TTCGCCGTCT ATGCATCTAA CGTGCTCTTC TGCGCACTGC CCAACATGGG CCTGGGTAGG 
TCCGAGCGGC AGTACCCGGG GACCTGGTGC TTCATCGACT GGACCACCAA CGTAACGGCC 
TACGCCGCCT TCTCTTACAT GTACGCGGGC TTCAGTTCCT TCCTCATCCT CGCCACCGTG 
CTCTGCAATG TGCTGGTGTG CGGCGCGCTG CTCCGCATGC ACCGCCAGTT CATGCGCCGC 
ACCTCGCTGG GCACGGAGCA GCACCACGCG GCCGCTGCAG CAGCGGTGGC TTCGGTGGCC 
TGTCGGGGTC ACGCGGCCGC CTCCCCAGCC CTGCAGCGCC TCAGTGACTT TCGCCGCCGC 
AGGAGCTTCC GGCGCATCGC GGGTGCAGAG ATCCAGATGG TCATCTTACT CATCGCCACC 
TCTCTGGTGG TGCTCATCTG CTCCATTCCG CTCGTGGTGC GAGTGTTCAT CAACCAGTTA 
TATCAGCCAA GTGTGGTGAA AGACATCAGC AGAAACCCGG ATTTGCAGGC CATCAGAATT 
GCTTCTGTGA ACCCCATCCT GGACCCTTGG ATCTACATCC TTCTTCGGAA GACTGTGCTC 
AGTAAAGCCA TAGAAAAGAT CAAGTGCCTC TTCTGCCGCA TTGGTGGTTC TGGCAGAGAC 
GGTTCAGCAC AGCACTGCTC AGAGAGTCGG AGGACATCTT CTGCCATGTC TGGCCACTCC 
CGCTCCTTCC TCTCGCGGGA GTTGAGGGAG ATCAGCAGCA CCTCTCAGAC CCTCCTATAC 
CTGCCAGACC TAACTGAAAG CAGCCTCGGA GGCAAGAATT TGCTTCCAGG TACGCATGGC 
ATGGGCCTGA CCCAAGCAGA CACCACCTCG CTGAGAACTT TGCGAATTTC AGAGACCTCA 
GACTCCTCCC AGGGCCAGGA CTCTGAGAGT GTCTTGTTGG TGGATGAGGT TAGTGGGAGC 
CAGAGAGAGG AGCCTGCCTC TAAGGGGAAC TCTCTGCAAG TCACGTTCCC CAGTGAAACG 
CTGAAATTAT CTGAAAAATG TATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ptger4 ( XM_006231996.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006232058.1 Rattus norvegicus prostaglandin E receptor 4 (Ptger4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08991
Clone ID Related Accession (Same CDS sequence)	XM_006231996.3 , NM_032076.3
Accession Version	XM_006231996.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	prostaglandin E2 receptor EP4 subtype isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006231996.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCATCC CCGGAGTCAA CGCGTCCTTC TCCTCCACTC CGGAGAGGTT GAACAGCCCA 
GTGACCATTC CCGCAGTGAT GTTTATCTTC GGGGTGGTGG GCAACCTGGT GGCCATCGTA 
GTATTGTGCA AGTCGCGCAA GGAGCAGAAG GAGACTACCT TTTACACTCT GGTATGTGGG 
CTGGCTGTCA CTGACCTACT GGGCACATTG TTGGTAAGCC CAGTGACCAT CGCCACATAC 
ATGAAGGGCC AGTGGCCCGG AGACCAGGCA TTGTGTGACT ACAGCACCTT CATCCTACTT 
TTCTTCGGCC TGTCGGGTCT CAGCATCATC TGTGCCATGA GCATTGAGCG CTACCTGGCC 
ATCAACCACG CCTACTTCTA CAGCCACTAC GTGGACAAGC GGCTGGCCGG TCTCACGCTC 
TTCGCCGTCT ATGCATCTAA CGTGCTCTTC TGCGCACTGC CCAACATGGG CCTGGGTAGG 
TCCGAGCGGC AGTACCCGGG GACCTGGTGC TTCATCGACT GGACCACCAA CGTAACGGCC 
TACGCCGCCT TCTCTTACAT GTACGCGGGC TTCAGTTCCT TCCTCATCCT CGCCACCGTG 
CTCTGCAATG TGCTGGTGTG CGGCGCGCTG CTCCGCATGC ACCGCCAGTT CATGCGCCGC 
ACCTCGCTGG GCACGGAGCA GCACCACGCG GCCGCTGCAG CAGCGGTGGC TTCGGTGGCC 
TGTCGGGGTC ACGCGGCCGC CTCCCCAGCC CTGCAGCGCC TCAGTGACTT TCGCCGCCGC 
AGGAGCTTCC GGCGCATCGC GGGTGCAGAG ATCCAGATGG TCATCTTACT CATCGCCACC 
TCTCTGGTGG TGCTCATCTG CTCCATTCCG CTCGTGGTGC GAGTGTTCAT CAACCAGTTA 
TATCAGCCAA GTGTGGTGAA AGACATCAGC AGAAACCCGG ATTTGCAGGC CATCAGAATT 
GCTTCTGTGA ACCCCATCCT GGACCCTTGG ATCTACATCC TTCTTCGGAA GACTGTGCTC 
AGTAAAGCCA TAGAAAAGAT CAAGTGCCTC TTCTGCCGCA TTGGTGGTTC TGGCAGAGAC 
GGTTCAGCAC AGCACTGCTC AGAGAGTCGG AGGACATCTT CTGCCATGTC TGGCCACTCC 
CGCTCCTTCC TCTCGCGGGA GTTGAGGGAG ATCAGCAGCA CCTCTCAGAC CCTCCTATAC 
CTGCCAGACC TAACTGAAAG CAGCCTCGGA GGCAAGAATT TGCTTCCAGG TACGCATGGC 
ATGGGCCTGA CCCAAGCAGA CACCACCTCG CTGAGAACTT TGCGAATTTC AGAGACCTCA 
GACTCCTCCC AGGGCCAGGA CTCTGAGAGT GTCTTGTTGG TGGATGAGGT TAGTGGGAGC 
CAGAGAGAGG AGCCTGCCTC TAAGGGGAAC TCTCTGCAAG TCACGTTCCC CAGTGAAACG 
CTGAAATTAT CTGAAAAATG TATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006232058.1
CDS	2590..4056
Translation	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSQTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI

Target ORF information:

RefSeq Version	XM_006231996.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prostaglandin E receptor 4 (Ptger4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231996.3

ORF Insert Sequence:

ATGTCCATCC CCGGAGTCAA CGCGTCCTTC TCCTCCACTC CGGAGAGGTT GAACAGCCCA 
GTGACCATTC CCGCAGTGAT GTTTATCTTC GGGGTGGTGG GCAACCTGGT GGCCATCGTA 
GTATTGTGCA AGTCGCGCAA GGAGCAGAAG GAGACTACCT TTTACACTCT GGTATGTGGG 
CTGGCTGTCA CTGACCTACT GGGCACATTG TTGGTAAGCC CAGTGACCAT CGCCACATAC 
ATGAAGGGCC AGTGGCCCGG AGACCAGGCA TTGTGTGACT ACAGCACCTT CATCCTACTT 
TTCTTCGGCC TGTCGGGTCT CAGCATCATC TGTGCCATGA GCATTGAGCG CTACCTGGCC 
ATCAACCACG CCTACTTCTA CAGCCACTAC GTGGACAAGC GGCTGGCCGG TCTCACGCTC 
TTCGCCGTCT ATGCATCTAA CGTGCTCTTC TGCGCACTGC CCAACATGGG CCTGGGTAGG 
TCCGAGCGGC AGTACCCGGG GACCTGGTGC TTCATCGACT GGACCACCAA CGTAACGGCC 
TACGCCGCCT TCTCTTACAT GTACGCGGGC TTCAGTTCCT TCCTCATCCT CGCCACCGTG 
CTCTGCAATG TGCTGGTGTG CGGCGCGCTG CTCCGCATGC ACCGCCAGTT CATGCGCCGC 
ACCTCGCTGG GCACGGAGCA GCACCACGCG GCCGCTGCAG CAGCGGTGGC TTCGGTGGCC 
TGTCGGGGTC ACGCGGCCGC CTCCCCAGCC CTGCAGCGCC TCAGTGACTT TCGCCGCCGC 
AGGAGCTTCC GGCGCATCGC GGGTGCAGAG ATCCAGATGG TCATCTTACT CATCGCCACC 
TCTCTGGTGG TGCTCATCTG CTCCATTCCG CTCGTGGTGC GAGTGTTCAT CAACCAGTTA 
TATCAGCCAA GTGTGGTGAA AGACATCAGC AGAAACCCGG ATTTGCAGGC CATCAGAATT 
GCTTCTGTGA ACCCCATCCT GGACCCTTGG ATCTACATCC TTCTTCGGAA GACTGTGCTC 
AGTAAAGCCA TAGAAAAGAT CAAGTGCCTC TTCTGCCGCA TTGGTGGTTC TGGCAGAGAC 
GGTTCAGCAC AGCACTGCTC AGAGAGTCGG AGGACATCTT CTGCCATGTC TGGCCACTCC 
CGCTCCTTCC TCTCGCGGGA GTTGAGGGAG ATCAGCAGCA CCTCTCAGAC CCTCCTATAC 
CTGCCAGACC TAACTGAAAG CAGCCTCGGA GGCAAGAATT TGCTTCCAGG TACGCATGGC 
ATGGGCCTGA CCCAAGCAGA CACCACCTCG CTGAGAACTT TGCGAATTTC AGAGACCTCA 
GACTCCTCCC AGGGCCAGGA CTCTGAGAGT GTCTTGTTGG TGGATGAGGT TAGTGGGAGC 
CAGAGAGAGG AGCCTGCCTC TAAGGGGAAC TCTCTGCAAG TCACGTTCCC CAGTGAAACG 
CTGAAATTAT CTGAAAAATG TATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A dose response study of the effect of prostaglandin E2 on thermal nociceptive sensitivity.
Prostaglandins, leukotrienes, and essential fatty acids12620-24(2017 Nov)
Domenichiello AF,Wilhite BC,Keyes GS,Ramsden CE

Preferred recycling pathway by internalized PGE2 EP4 receptor following agonist stimulation in cultured dorsal root ganglion neurons contributes to enhanced EP4 receptor sensitivity.
Neuroscience32656-68(2016 06)
St-Jacques B,Ma W

The renoprotective effects of berberine via the EP4-G?s-cAMP signaling pathway in different stages of diabetes in rats.
Journal of receptor and signal transduction research34(6)445-55(2014 Dec)
Yang Y,Ni W,Cai M,Tang L,Wei W

PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.
Prostaglandins & other lipid mediators113-11562-8(2014 Oct)
Kassem KM,Clevenger MH,Szandzik DL,Peterson E,Harding P

Protection by vascular prostaglandin E2 signaling in hypoxic-ischemic encephalopathy.
Experimental neurology25530-7(2014 May)
Taniguchi H,Anacker C,Wang Q,Andreasson K

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Ptger4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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