Kcnq1 cDNA ORF clone, Rattus norvegicus(Norway rat)

KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth muscle contractility in vitro.
Huang KC, Li TM, Liu X, Chen JH, Chien WK, Shiao YT, Tsang H, Lin TH, Liao CC, Huang SM, Li JP, Lin CW, Lin JC, Lin CC, Lai CH, Cheng CF, Liang WM, Hung CH, Chen CC, Lin YJ, Tsai FJ
Journal of cellular physiology232(12)3309-3316(2017 Dec)

Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the
Jiang M, Wang Y, Tseng GN
Circulation. Arrhythmia and electrophysiology10(6)(2017 Jun)

Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
Zimmer J, Takahashi T, Hofmann AD, Puri P
Journal of pediatric surgery52(5)702-705(2017 May)

Activation of PPAR?/? prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.
Morales-Cano D, Moreno L, Barreira B, Briones AM, Pandolfi R, Moral-Sanz J, Callejo M, Mondejar-Parre?o G, Cortijo J, Salaices M, Duarte J, Perez-Vizcaino F, Cogolludo A
Clinical science (London, England : 1979)130(20)1823-36(2016 Oct)

YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels.
Fan Z, Liu B, Zhang S, Liu H, Li Y, Wang D, Liu Y, Li J, Wang N, Liu Y, Zhang B
Clinical and experimental hypertension (New York, N.Y. : 1993)37(5)381-7(2015)

In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress.
Title: Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the

Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered.
Title: Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.

Activation of PPARbeta/delta prevents hyperglycaemia-induced impairment of Kv7 channels.
Title: Activation of PPAR?/? prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.

The high expression and function of Kv7 channels in the left coronary artery and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone.
Title: Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.

KV channel expression and activity were upregulated after YM155 treatment. Survivin may play a role in the pathogenesis of CH-PH.
Title: YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels.