Dll1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dll1
Entrez Gene ID	84010
Full Name	delta like canonical Notch ligand 1
General protein information	Preferred Names delta like canonical Notch ligand 1 Names delta-like protein 1 delta1 drosophila Delta homolog 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q12
Summary	homolog of the Notch Delta ligand; member of the delta/serrate/jagged family; may play a role in cell fate decisions during hematopoiesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032063.2	NP_114452.1	delta-like protein 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DLL1	XP_520601.2
Bos taurus (cattle)	DLL1	XP_002690447.1
Rattus norvegicus (Norway rat)	Dll1	NP_114452.1
Gallus gallus (chicken)	DLL1	NP_990304.1
Drosophila melanogaster (fruit fly)	Dl	NP_001247193.1
Homo sapiens (human)	DLL1	NP_005609.3
Canis lupus familiaris (dog)	DLL1	XP_005627852.1
Danio rerio (zebrafish)	dld	NP_571030.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010265	XP_319454.4
Xenopus tropicalis (tropical clawed frog)	dll1	NP_001093689.1
Mus musculus (house mouse)	Dll1	NP_031891.2

Gene Ontology
Bibliography

Related articles in PubMed

Notch ligand Delta-like1 enhances degranulation and cytokine production through a novel Notch/Dok-1/MAPKs pathway in vitro.
Jiang S, Da Y, Han S, He Y, Che H
Immunologic research(2017 Nov)

Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
Kakuda S, Haltiwanger RS
Developmental cell40(2)193-201(2017 01)

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
Preu?e K, Tveriakhina L, Schuster-Gossler K, Gaspar C, Rosa AI, Henrique D, Gossler A, Stauber M
PLoS genetics11(6)e1005328(2015 Jun)

Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle.
Czajkowski MT, Rassek C, Lenhard DC, Br?hl D, Birchmeier C
Developmental biology395(2)307-16(2014 Nov)

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
Hatakeyama J, Wakamatsu Y, Nagafuchi A, Kageyama R, Shigemoto R, Shimamura K
Development (Cambridge, England)141(8)1671-82(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The immunolocalisation of the stem cell-specific markers Notch-1, Delta, CD105 and CD166 was studied in rat femoral head articular cartilage. Corticosteroid (methylprednisolone) treatment was found to decrease the activity of these markers.
Title: The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage.

Notch1 ligand Delta-1 mRNA expression in postnatal rat microglia of corpus callosum and subventricular zone is reduced, while that of Notch1 is enhanced.
Title: Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells.

Delta-1/Notch-2/Hes-1 signaling pathway may regulate the regeneration and proliferation of renal tubules during acute kidney injury.
Title: Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury.

The following Dll1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dll1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08944	NM_032063.2 Latest version!	Rattus norvegicus delta like canonical Notch ligand 1 (Dll1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dll1 ( NM_032063.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114452.1 Rattus norvegicus delta like canonical Notch ligand 1 (Dll1), mRNA.

Price & Availability↑

CloneID	ORa08944
Clone ID Related Accession (Same CDS sequence)	NM_032063.2
Accession Version	NM_032063.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2145bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	delta-like protein 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U78889.2. On Apr 26, 2011 this sequence version replaced NM_032063.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U78889.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906356 [ECO:0000348] ##Evidence-Data-END##

ATGGGCCGTC GGAGCGCGCT AGCCCTTGCC GTGGTCTCAG CCCTGCTGTG CCAGGTCTGG 
AGCTCTGGCG TATTTGAGCT GAAGCTGCAG GAGTTCGTCA ACAAGAAGGG GCTGCTGGGG 
AACCGCAACT GCTGCCGCGG GGGCTCTGGC CCGCCGTGCG CCTGCAGGAC CTTCTTTCGC 
GTATGCCTCA AGCATTACCA GGCCAGCGTG TCCCCGGAGC CACCCTGCAC CTACGGCAGT 
GCGGTCACCG CAGTGCTGGG TGTCGACTCC TTCAGCCTGC CTGATGGCGC AGGCATCGAC 
CCCGCCTTCA GCAACCCCAT CCGATTCCCC TTCGGATTCA CCTGGCCAGG TACCTTCTCT 
CTGATCATTG AAGCCCTCCA CACAGATTCT CCTGACGACC TCGCAACAGA AAACCCAGAA 
AGACTCATCA GCCGCCTGAC CACACAGAGG CACCTCACTG TGGGAGAAGA GTGGTCTCAG 
GACCTTCACA GTAGCGGCCG CACAGACCTC CGCTACTCTT ACCGGTTTGT GTGTGATGAA 
CACTACTATG GAGAAGGCTG CTCCGTGTTC TGCCGACCGC GGGATGATGC CTTTGGCCAC 
TTCACCTGCG GGGAGAGAGG GGAGAAGATG TGCGACCCTG GCTGGAAAGG CCAGTACTGC 
ACTGACCCCA TTTGTCTGCC AGGCTGTGAT GACCAACATG GATATTGTGA CAAACCGGGG 
GAATGCAAGT GCAGAGTTGG CTGGCAGGGC CGCTACTGCG ATGAATGCAT CCGATACCCA 
GGCTGTCTCC ATGGTACCTG CCAGCAGCCC TGGCAGTGTA ACTGCCAGGA AGGCTGGGGG 
GGCCTCTTCT GCAACCAGGA TCTGAACTAC TGCACTCACC ATAAGCCATG CAGGAACGGA 
GCCACCTGCA CCAACACGGG CCAGGGGAGC TACACATGCT CTTGCCGACC CGGGTATACA 
GGGGCCAACT GTGAGCTGGA GGTAGATGAG TGTGCTCCCA GCCCCTGCAG GAATGGAGGG 
AGCTGCACGG ATCTTGAGGA CAGCTACTCT TGCACCTGCC CTCCTGGCTT CTATGGCAAG 
GTCTGTGAGC TGAGCGCCAT GACGTGTGCA GATGGTCCTT GCTTCAATGG GGGACGATGT 
TCGGATAACC CCGATGGAGG CTACACCTGC CATTGCCCTG CGGGCTTCTC TGGCTTCAAC 
TGTGAGAAGA AGATTGATCT CTGTAGCTCT TCCCCTTGTT CTAACGGTGC CAAGTGTGTG 
GACCTCGGCA ACTCCTACCT GTGCCGATGT CAGACTGGCT TCTCCGGGAG GTACTGCGAG 
GACAATGTGG ATGACTGTGC CTCTTCTCCC TGTGCAAACG GGGGCACCTG CCGGGACAGT 
GTGAACGATT TCTCCTGTAC CTGCCCACCT GGCTACACAG GCAGGAACTG CAGCGCCCCT 
GTCAGCAGGT GTGAGCATGC ACCCTGTCAT AACGGGGCCA CCTGCCACCA GAGGGGCCAA 
CGCTACATGT GTGAGTGCGC CCAGGGCTAT GGCGGCGCCA ACTGCCAGTT CCTGCTCCCT 
GAGCCACCAC CAGACCTCAT AGTGGCGGCC CAGGGCGGGT CCTTCCCCTG GGTGGCTGTG 
TGTGCCGGGG TGGTGCTTGT CCTCCTGCTG CTGCTGGGCT GTGCTGCTGT GGTGGTCTGC 
GTCCGGCTGA AGCTACAGAA ACACCAGCCT CCGCCTGATC CTTGCGGGGG AGAGACAGAG 
ACCATGAACA ACCTAGCCAA TTGCCAGCGT GAGAAGGATG TTTCTGTTAG CATCATTGGG 
GCTACACAGA TCAAGAACAC CAACAAGAAG GCGGACTTTC ATGGGGACCA TGGTGCTGAC 
AAGAGCAGCT TTAAGGCCCG ATACCCCACT GTGGACTATA ACCTCATTCG AGACCTCAAG 
GGAGATGAAG CCACGGTCAG GGATGCACAC AGCAAACGTG ACACCAAGTG CCAGTCACAG 
GGCTCTGTAG GAGAAGAGAA GAGCACCTCA ACGCTCAGGG GTGGGGAGGT TCCCGACAGA 
AAAAGGCCCG AGTCTGTCTA CTCTACTTCA AAGGACACCA AGTACCAGTC GGTGTATGTT 
CTATCTGCAG AAAAGGATGA GTGTGTTATA GCGACTGAGG TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114452.1
CDS	290..2434
Translation	MGRRSALALAVVSALLCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGSGPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTAVLGVDSFSLPDGAGIDPAFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLTTQRHLTVGEEWSQDLHSSGRTDLRYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKMCDPGWKGQYCTDPICLPGCDDQHGYCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCRNGATCTNTGQGSYTCSCRPGYTGANCELEVDECAPSPCRNGGSCTDLEDSYSCTCPPGFYGKVCELSAMTCADGPCFNGGRCSDNPDGGYTCHCPAGFSGFNCEKKIDLCSSSPCSNGAKCVDLGNSYLCRCQTGFSGRYCEDNVDDCASSPCANGGTCRDSVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHQRGQRYMCECAQGYGGANCQFLLPEPPPDLIVAAQGGSFPWVAVCAGVVLVLLLLLGCAAVVVCVRLKLQKHQPPPDPCGGETETMNNLANCQREKDVSVSIIGATQIKNTNKKADFHGDHGADKSSFKARYPTVDYNLIRDLKGDEATVRDAHSKRDTKCQSQGSVGEEKSTSTLRGGEVPDRKRPESVYSTSKDTKYQSVYVLSAEKDECVIATEV

Target ORF information:

RefSeq Version	NM_032063.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus delta like canonical Notch ligand 1 (Dll1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032063.2

ORF Insert Sequence:

ATGGGCCGTC GGAGCGCGCT AGCCCTTGCC GTGGTCTCAG CCCTGCTGTG CCAGGTCTGG 
AGCTCTGGCG TATTTGAGCT GAAGCTGCAG GAGTTCGTCA ACAAGAAGGG GCTGCTGGGG 
AACCGCAACT GCTGCCGCGG GGGCTCTGGC CCGCCGTGCG CCTGCAGGAC CTTCTTTCGC 
GTATGCCTCA AGCATTACCA GGCCAGCGTG TCCCCGGAGC CACCCTGCAC CTACGGCAGT 
GCGGTCACCG CAGTGCTGGG TGTCGACTCC TTCAGCCTGC CTGATGGCGC AGGCATCGAC 
CCCGCCTTCA GCAACCCCAT CCGATTCCCC TTCGGATTCA CCTGGCCAGG TACCTTCTCT 
CTGATCATTG AAGCCCTCCA CACAGATTCT CCTGACGACC TCGCAACAGA AAACCCAGAA 
AGACTCATCA GCCGCCTGAC CACACAGAGG CACCTCACTG TGGGAGAAGA GTGGTCTCAG 
GACCTTCACA GTAGCGGCCG CACAGACCTC CGCTACTCTT ACCGGTTTGT GTGTGATGAA 
CACTACTATG GAGAAGGCTG CTCCGTGTTC TGCCGACCGC GGGATGATGC CTTTGGCCAC 
TTCACCTGCG GGGAGAGAGG GGAGAAGATG TGCGACCCTG GCTGGAAAGG CCAGTACTGC 
ACTGACCCCA TTTGTCTGCC AGGCTGTGAT GACCAACATG GATATTGTGA CAAACCGGGG 
GAATGCAAGT GCAGAGTTGG CTGGCAGGGC CGCTACTGCG ATGAATGCAT CCGATACCCA 
GGCTGTCTCC ATGGTACCTG CCAGCAGCCC TGGCAGTGTA ACTGCCAGGA AGGCTGGGGG 
GGCCTCTTCT GCAACCAGGA TCTGAACTAC TGCACTCACC ATAAGCCATG CAGGAACGGA 
GCCACCTGCA CCAACACGGG CCAGGGGAGC TACACATGCT CTTGCCGACC CGGGTATACA 
GGGGCCAACT GTGAGCTGGA GGTAGATGAG TGTGCTCCCA GCCCCTGCAG GAATGGAGGG 
AGCTGCACGG ATCTTGAGGA CAGCTACTCT TGCACCTGCC CTCCTGGCTT CTATGGCAAG 
GTCTGTGAGC TGAGCGCCAT GACGTGTGCA GATGGTCCTT GCTTCAATGG GGGACGATGT 
TCGGATAACC CCGATGGAGG CTACACCTGC CATTGCCCTG CGGGCTTCTC TGGCTTCAAC 
TGTGAGAAGA AGATTGATCT CTGTAGCTCT TCCCCTTGTT CTAACGGTGC CAAGTGTGTG 
GACCTCGGCA ACTCCTACCT GTGCCGATGT CAGACTGGCT TCTCCGGGAG GTACTGCGAG 
GACAATGTGG ATGACTGTGC CTCTTCTCCC TGTGCAAACG GGGGCACCTG CCGGGACAGT 
GTGAACGATT TCTCCTGTAC CTGCCCACCT GGCTACACAG GCAGGAACTG CAGCGCCCCT 
GTCAGCAGGT GTGAGCATGC ACCCTGTCAT AACGGGGCCA CCTGCCACCA GAGGGGCCAA 
CGCTACATGT GTGAGTGCGC CCAGGGCTAT GGCGGCGCCA ACTGCCAGTT CCTGCTCCCT 
GAGCCACCAC CAGACCTCAT AGTGGCGGCC CAGGGCGGGT CCTTCCCCTG GGTGGCTGTG 
TGTGCCGGGG TGGTGCTTGT CCTCCTGCTG CTGCTGGGCT GTGCTGCTGT GGTGGTCTGC 
GTCCGGCTGA AGCTACAGAA ACACCAGCCT CCGCCTGATC CTTGCGGGGG AGAGACAGAG 
ACCATGAACA ACCTAGCCAA TTGCCAGCGT GAGAAGGATG TTTCTGTTAG CATCATTGGG 
GCTACACAGA TCAAGAACAC CAACAAGAAG GCGGACTTTC ATGGGGACCA TGGTGCTGAC 
AAGAGCAGCT TTAAGGCCCG ATACCCCACT GTGGACTATA ACCTCATTCG AGACCTCAAG 
GGAGATGAAG CCACGGTCAG GGATGCACAC AGCAAACGTG ACACCAAGTG CCAGTCACAG 
GGCTCTGTAG GAGAAGAGAA GAGCACCTCA ACGCTCAGGG GTGGGGAGGT TCCCGACAGA 
AAAAGGCCCG AGTCTGTCTA CTCTACTTCA AAGGACACCA AGTACCAGTC GGTGTATGTT 
CTATCTGCAG AAAAGGATGA GTGTGTTATA GCGACTGAGG TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Notch ligand Delta-like1 enhances degranulation and cytokine production through a novel Notch/Dok-1/MAPKs pathway in vitro.
Immunologic research(2017 Nov)
Jiang S,Da Y,Han S,He Y,Che H

Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
Developmental cell40(2)193-201(2017 01)
Kakuda S,Haltiwanger RS

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
PLoS genetics11(6)e1005328(2015 Jun)
Preu?e K,Tveriakhina L,Schuster-Gossler K,Gaspar C,Rosa AI,Henrique D,Gossler A,Stauber M

Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle.
Developmental biology395(2)307-16(2014 Nov)
Czajkowski MT,Rassek C,Lenhard DC,Br?hl D,Birchmeier C

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates.
Development (Cambridge, England)141(8)1671-82(2014 Apr)
Hatakeyama J,Wakamatsu Y,Nagafuchi A,Kageyama R,Shigemoto R,Shimamura K

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Dll1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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