Nr5a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nr5a1
Entrez Gene ID	83826
Full Name	nuclear receptor subfamily 5, group A, member 1
Synonyms	Ad4BP/SF-1,Ad4bp,Ftzf1,Sf-1
General protein information	Preferred Names nuclear receptor subfamily 5, group A, member 1 Names steroidogenic factor 1 STF-1 adrenal 4-binding protein fushi tarazu factor homolog 1 steroid hormone receptor Ad4BP
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q12
Summary	transcription factor; essential for adrenal and gonadal development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191099.1	NP_001178028.1	steroidogenic factor 1
XM_006234106.2	XP_006234168.1	steroidogenic factor 1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NR5A1	NP_004950.2
Canis lupus familiaris (dog)	LOC609642	XP_005625439.1
Mus musculus (house mouse)	Nr5a1	NP_620639.1
Gallus gallus (chicken)	NR5A1	NP_990408.1
Xenopus tropicalis (tropical clawed frog)	nr5a1	NP_001139213.1
	NR5A1	XP_002800023.1
Bos taurus (cattle)	NR5A1	NP_776828.1
Rattus norvegicus (Norway rat)	Nr5a1	NP_001178028.1
Pan troglodytes (chimpanzee)	NR5A1	XP_520248.3

Gene Ontology
Bibliography

Related articles in PubMed

Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern.
Wang W, Sun Y, Guo Y, Cai P, Li Y, Liu J, Cai G, Kiyoshi A, Zhang W
Toxicology letters281175-183(2017 Nov)

NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development.
Baetens D, Stoop H, Peelman F, Todeschini AL, Rosseel T, Coppieters F, Veitia RA, Looijenga LH, De Baere E, Cools M
Genetics in medicine : official journal of the American College of Medical Genetics19(4)367-376(2017 Apr)

A 46,XX Ovotesticular Disorder of Sex Development Likely Caused by a Steroidogenic Factor-1 (NR5A1) Variant.
Swartz JM, Ciarlo R, Guo MH, Abrha A, Weaver B, Diamond DA, Chan YM, Hirschhorn JN
Hormone research in paediatrics87(3)191-195(2017)

Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues.
Igarashi M, Takasawa K, Hakoda A, Kanno J, Takada S, Miyado M, Baba T, Morohashi KI, Tajima T, Hata K, Nakabayashi K, Matsubara Y, Sekido R, Ogata T, Kashimada K, Fukami M
Human mutation38(1)39-42(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DNA methylation might play a role in the downregulation of SF-1 gene expression induced by soy isoflavones.
Title: Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern.

These results suggest that the low level of DAX-1 may enhance the transcriptional activity of SF-1 and expression of genes related to glucocorticoid synthesis, which are targeted by SF-1, in adrenals from SHR.
Title: Characteristic induction of steroidogenic factor 1 (SF-1) and DAX-1 and enhanced expression of glucocorticoid synthesis-related genes in adrenals from spontaneously hypertensive rats.

Upstream stimulatory factors (USF1 and USF2) induce Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.
Title: Upstream stimulatory factor induces Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.

Binding of steroidogenic factor-1 (SF-1) to the StAR promoter region was also enhanced by PTU treatment, which suggests that propylthiouracil could upregulate StAR gene expression.
Title: Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells.

FXR is able to compete with steroidogenic factor 1 in binding to a common sequence present in the aromatase promoter region interfering negatively with its activity.
Title: Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

The following Nr5a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nr5a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06890	NM_001191099.1 Latest version!	Rattus norvegicus nuclear receptor subfamily 5, group A, member 1 (Nr5a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa25817	XM_006234106.2 Latest version!	Rattus norvegicus nuclear receptor subfamily 5, group A, member 1 (Nr5a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nr5a1 ( NM_001191099.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178028.1 Rattus norvegicus nuclear receptor subfamily 5, group A, member 1 (Nr5a1), mRNA.

Price & Availability↑

CloneID	ORa06890
Clone ID Related Accession (Same CDS sequence)	NM_001191099.1
Accession Version	NM_001191099.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Rattus norvegicus(Norway rat)
Product	steroidogenic factor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07051818.1. On Jul 17, 2010 this sequence version replaced XM_001072904.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN02642601 [ECO:0000348] ##Evidence-Data-END##

ATGGACTATT CGTACGACGA GGACCTGGAC GAGCTGTGTC CAGTGTGTGG TGACAAGGTG 
TCGGGCTACC ACTACGGGCT GCTCACGTGC GAGAGCTGCA AGGGCTTCTT CAAGCGCACA 
GTCCAGAACA ACAAGCATTA CACGTGCACC GAGAGTCAGA GCTGCAAAAT CGACAAGACG 
CAGCGTAAGC GCTGTCCCTT CTGCCGCTTC CAGAAGTGCC TGACGGTGGG CATGCGCCTG 
GAAGCTGTGC GTGCTGATCG AATGCGGGGC GGCCGGAACA AGTTTGGGCC CATGTACAAG 
AGAGACCGGG CCTTGAAGCA GCAGAAGAAA GCACAGATTC GGGCCAATGG CTTCAAACTG 
GAGACCGGAC CACCGATGGG GGTTCCCCCG CCACCCCCTC CCCCACCGGA CTACATGTTA 
CCCCCTAGCC TGCATGCACC GGAGCCCAAG GCCCTGGTCT CTGGCCCACC CAGTGGGCCG 
CTGGGTGACT TTGGAGCCCC ATCTCTGCCC ATGGCCGTGC CTGGTCCCCA CGGGCCTCTG 
GCTGGCTACC TCTATCCTGC CTTCTCTAAC CGCACCATCA AGTCTGAGTA TCCAGAGCCC 
TACGCCAGCC CCCCTCAACA GCCAGGGCCA CCCTACAGCT ATCCGGAGCC CTTCTCAGGA 
GGGCCCAATG TACCAGAGCT CATATTGCAG CTGCTGCAAC TAGAGCCAGA GGAGGACCAG 
GTGCGTGCTC GCATCGTGGG CTGCCTGCAG GAGCCAGCCA AAAGCCGCCC TGACCAGCCA 
GCGCCCTTCA GCCTCCTCTG CAGGATGGCG GACCAGACCT TTATCTCCAT TGTCGACTGG 
GCACGAAGGT GCATGGTATT TAAGGAGCTG GAGGTGGCTG ACCAGATGAC ACTGCTGCAG 
AACTGCTGGA GTGAGCTGCT GGTGCTGGAC CACATCTACC GCCAGGTCCA GTACGGCAAG 
GAAGACAGCA TCTTGCTGGT CACTGGACAG GAGGTGGAGC TGAGCACGGT GGCTGTGCAG 
GCTGGCTCCC TGCTGCACAG CCTGGTGCTG CGGGCACAGG AGTTGGTGCT GCAGCTGCAT 
GCCCTGCAAC TGGACCGCCA GGAGTTTGTC TGTCTCAAGT TCCTCATCCT CTTCAGCCTC 
GATGTGAAAT TCCTGAACAA CCACAGCCTG GTAAAGGACG CCCAGGAGAA GGCCAACGCC 
GCCCTGCTGG ATTACACCTT GTGTCACTAC CCACACTGCG GGGACAAATT CCAGCAGTTG 
CTATTGTGCC TGGTGGAGGT GCGGGCACTG AGCATGCAGG CCAAGGAGTA TCTGTACCAT 
AAGCATTTGG GCAACGAGAT GCCCCGCAAC AACCTTCTCA TTGAGATGCT GCAGGCCAAG 
CAGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178028.1
CDS	145..1533
Translation	MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT

Target ORF information:

RefSeq Version	NM_001191099.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor subfamily 5, group A, member 1 (Nr5a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191099.1

ORF Insert Sequence:

ATGGACTATT CGTACGACGA GGACCTGGAC GAGCTGTGTC CAGTGTGTGG TGACAAGGTG 
TCGGGCTACC ACTACGGGCT GCTCACGTGC GAGAGCTGCA AGGGCTTCTT CAAGCGCACA 
GTCCAGAACA ACAAGCATTA CACGTGCACC GAGAGTCAGA GCTGCAAAAT CGACAAGACG 
CAGCGTAAGC GCTGTCCCTT CTGCCGCTTC CAGAAGTGCC TGACGGTGGG CATGCGCCTG 
GAAGCTGTGC GTGCTGATCG AATGCGGGGC GGCCGGAACA AGTTTGGGCC CATGTACAAG 
AGAGACCGGG CCTTGAAGCA GCAGAAGAAA GCACAGATTC GGGCCAATGG CTTCAAACTG 
GAGACCGGAC CACCGATGGG GGTTCCCCCG CCACCCCCTC CCCCACCGGA CTACATGTTA 
CCCCCTAGCC TGCATGCACC GGAGCCCAAG GCCCTGGTCT CTGGCCCACC CAGTGGGCCG 
CTGGGTGACT TTGGAGCCCC ATCTCTGCCC ATGGCCGTGC CTGGTCCCCA CGGGCCTCTG 
GCTGGCTACC TCTATCCTGC CTTCTCTAAC CGCACCATCA AGTCTGAGTA TCCAGAGCCC 
TACGCCAGCC CCCCTCAACA GCCAGGGCCA CCCTACAGCT ATCCGGAGCC CTTCTCAGGA 
GGGCCCAATG TACCAGAGCT CATATTGCAG CTGCTGCAAC TAGAGCCAGA GGAGGACCAG 
GTGCGTGCTC GCATCGTGGG CTGCCTGCAG GAGCCAGCCA AAAGCCGCCC TGACCAGCCA 
GCGCCCTTCA GCCTCCTCTG CAGGATGGCG GACCAGACCT TTATCTCCAT TGTCGACTGG 
GCACGAAGGT GCATGGTATT TAAGGAGCTG GAGGTGGCTG ACCAGATGAC ACTGCTGCAG 
AACTGCTGGA GTGAGCTGCT GGTGCTGGAC CACATCTACC GCCAGGTCCA GTACGGCAAG 
GAAGACAGCA TCTTGCTGGT CACTGGACAG GAGGTGGAGC TGAGCACGGT GGCTGTGCAG 
GCTGGCTCCC TGCTGCACAG CCTGGTGCTG CGGGCACAGG AGTTGGTGCT GCAGCTGCAT 
GCCCTGCAAC TGGACCGCCA GGAGTTTGTC TGTCTCAAGT TCCTCATCCT CTTCAGCCTC 
GATGTGAAAT TCCTGAACAA CCACAGCCTG GTAAAGGACG CCCAGGAGAA GGCCAACGCC 
GCCCTGCTGG ATTACACCTT GTGTCACTAC CCACACTGCG GGGACAAATT CCAGCAGTTG 
CTATTGTGCC TGGTGGAGGT GCGGGCACTG AGCATGCAGG CCAAGGAGTA TCTGTACCAT 
AAGCATTTGG GCAACGAGAT GCCCCGCAAC AACCTTCTCA TTGAGATGCT GCAGGCCAAG 
CAGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nr5a1 ( XM_006234106.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234168.1 Rattus norvegicus nuclear receptor subfamily 5, group A, member 1 (Nr5a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25817
Clone ID Related Accession (Same CDS sequence)	XM_006234106.2
Accession Version	XM_006234106.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	steroidogenic factor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006234106.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGGGGCG GCCGGAACAA GTTTGGGCCC ATGTACAAGA GAGACCGGGC CTTGAAGCAG 
CAGAAGAAAG CACAGATTCG GGCCAATGGC TTCAAACTGG AGACCGGACC ACCGATGGGG 
GTTCCCCCGC CACCCCCTCC CCCACCGGAC TACATGTTAC CCCCTAGCCT GCATGCACCG 
GAGCCCAAGG CCCTGGTCTC TGGCCCACCC AGTGGGCCGC TGGGTGACTT TGGAGCCCCA 
TCTCTGCCCA TGGCCGTGCC TGGTCCCCAC GGGCCTCTGG CTGGCTACCT CTATCCTGCC 
TTCTCTAACC GCACCATCAA GTCTGAGTAT CCAGAGCCCT ACGCCAGCCC CCCTCAACAG 
CCAGGGCCAC CCTACAGCTA TCCGGAGCCC TTCTCAGGAG GGCCCAATGT ACCAGAGCTC 
ATATTGCAGC TGCTGCAACT AGAGCCAGAG GAGGACCAGG TGCGTGCTCG CATCGTGGGC 
TGCCTGCAGG AGCCAGCCAA AAGCCGCCCT GACCAGCCAG CGCCCTTCAG CCTCCTCTGC 
AGGATGGCGG ACCAGACCTT TATCTCCATT GTCGACTGGG CACGAAGGTG CATGGTATTT 
AAGGAGCTGG AGGTGGCTGA CCAGATGACA CTGCTGCAGA ACTGCTGGAG TGAGCTGCTG 
GTGCTGGACC ACATCTACCG CCAGGTCCAG TACGGCAAGG AAGACAGCAT CTTGCTGGTC 
ACTGGACAGG AGGTGGAGCT GAGCACGGTG GCTGTGCAGG CTGGCTCCCT GCTGCACAGC 
CTGGTGCTGC GGGCACAGGA GTTGGTGCTG CAGCTGCATG CCCTGCAACT GGACCGCCAG 
GAGTTTGTCT GTCTCAAGTT CCTCATCCTC TTCAGCCTCG ATGTGAAATT CCTGAACAAC 
CACAGCCTGG TAAAGGACGC CCAGGAGAAG GCCAACGCCG CCCTGCTGGA TTACACCTTG 
TGTCACTACC CACACTGCGG GGACAAATTC CAGCAGTTGC TATTGTGCCT GGTGGAGGTG 
CGGGCACTGA GCATGCAGGC CAAGGAGTAT CTGTACCATA AGCATTTGGG CAACGAGATG 
CCCCGCAACA ACCTTCTCAT TGAGATGCTG CAGGCCAAGC AGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234168.1
CDS	1417..2544
Translation	MRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT

Target ORF information:

RefSeq Version	XM_006234106.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear receptor subfamily 5, group A, member 1 (Nr5a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234106.2

ORF Insert Sequence:

ATGCGGGGCG GCCGGAACAA GTTTGGGCCC ATGTACAAGA GAGACCGGGC CTTGAAGCAG 
CAGAAGAAAG CACAGATTCG GGCCAATGGC TTCAAACTGG AGACCGGACC ACCGATGGGG 
GTTCCCCCGC CACCCCCTCC CCCACCGGAC TACATGTTAC CCCCTAGCCT GCATGCACCG 
GAGCCCAAGG CCCTGGTCTC TGGCCCACCC AGTGGGCCGC TGGGTGACTT TGGAGCCCCA 
TCTCTGCCCA TGGCCGTGCC TGGTCCCCAC GGGCCTCTGG CTGGCTACCT CTATCCTGCC 
TTCTCTAACC GCACCATCAA GTCTGAGTAT CCAGAGCCCT ACGCCAGCCC CCCTCAACAG 
CCAGGGCCAC CCTACAGCTA TCCGGAGCCC TTCTCAGGAG GGCCCAATGT ACCAGAGCTC 
ATATTGCAGC TGCTGCAACT AGAGCCAGAG GAGGACCAGG TGCGTGCTCG CATCGTGGGC 
TGCCTGCAGG AGCCAGCCAA AAGCCGCCCT GACCAGCCAG CGCCCTTCAG CCTCCTCTGC 
AGGATGGCGG ACCAGACCTT TATCTCCATT GTCGACTGGG CACGAAGGTG CATGGTATTT 
AAGGAGCTGG AGGTGGCTGA CCAGATGACA CTGCTGCAGA ACTGCTGGAG TGAGCTGCTG 
GTGCTGGACC ACATCTACCG CCAGGTCCAG TACGGCAAGG AAGACAGCAT CTTGCTGGTC 
ACTGGACAGG AGGTGGAGCT GAGCACGGTG GCTGTGCAGG CTGGCTCCCT GCTGCACAGC 
CTGGTGCTGC GGGCACAGGA GTTGGTGCTG CAGCTGCATG CCCTGCAACT GGACCGCCAG 
GAGTTTGTCT GTCTCAAGTT CCTCATCCTC TTCAGCCTCG ATGTGAAATT CCTGAACAAC 
CACAGCCTGG TAAAGGACGC CCAGGAGAAG GCCAACGCCG CCCTGCTGGA TTACACCTTG 
TGTCACTACC CACACTGCGG GGACAAATTC CAGCAGTTGC TATTGTGCCT GGTGGAGGTG 
CGGGCACTGA GCATGCAGGC CAAGGAGTAT CTGTACCATA AGCATTTGGG CAACGAGATG 
CCCCGCAACA ACCTTCTCAT TGAGATGCTG CAGGCCAAGC AGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern.
Toxicology letters281175-183(2017 Nov)
Wang W,Sun Y,Guo Y,Cai P,Li Y,Liu J,Cai G,Kiyoshi A,Zhang W

NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development.
Genetics in medicine : official journal of the American College of Medical Genetics19(4)367-376(2017 Apr)
Baetens D,Stoop H,Peelman F,Todeschini AL,Rosseel T,Coppieters F,Veitia RA,Looijenga LH,De Baere E,Cools M

A 46,XX Ovotesticular Disorder of Sex Development Likely Caused by a Steroidogenic Factor-1 (NR5A1) Variant.
Hormone research in paediatrics87(3)191-195(2017)
Swartz JM,Ciarlo R,Guo MH,Abrha A,Weaver B,Diamond DA,Chan YM,Hirschhorn JN

Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues.
Human mutation38(1)39-42(2017 Jan)
Igarashi M,Takasawa K,Hakoda A,Kanno J,Takada S,Miyado M,Baba T,Morohashi KI,Tajima T,Hata K,Nakabayashi K,Matsubara Y,Sekido R,Ogata T,Kashimada K,Fukami M

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Nr5a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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