Slc26a5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc26a5
Entrez Gene ID	83819
Full Name	solute carrier family 26 member 5
Synonyms	Pres,prestin
General protein information	Preferred Names solute carrier family 26 member 5 Names prestin prestin (motor protein) solute carrier family 26 (anion exchanger), member 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11
Summary	molecular motor protein; involved in the electromechanical properties of hearing [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017592917.1	XP_017448406.1	prestin isoform X1
NM_030840.1	NP_110467.1	prestin

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC26A5	NP_945350.1
Canis lupus familiaris (dog)	SLC26A5	XP_540393.2
Drosophila melanogaster (fruit fly)	Prestin	NP_649024.1
Caenorhabditis elegans (roundworm)	sulp-7	NP_001033571.1
Caenorhabditis elegans (roundworm)	sulp-4	NP_505989.1
Caenorhabditis elegans (roundworm)	sulp-3	NP_509424.2
Rattus norvegicus (Norway rat)	Slc26a5	NP_110467.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010389	XP_559067.3
Caenorhabditis elegans (roundworm)	sulp-8	NP_001256129.1
Xenopus tropicalis (tropical clawed frog)	slc26a5	XP_002933151.2
Gallus gallus (chicken)	SLC26A5	NP_001072945.1
Oryza sativa (rice)	Os04g0652400	NP_001054098.1
Pan troglodytes (chimpanzee)	SLC26A5	XP_003339466.1
Bos taurus (cattle)	SLC26A5	NP_001179807.1
Mus musculus (house mouse)	Slc26a5	NP_109652.3
Danio rerio (zebrafish)	slc26a5	NP_958881.1
Caenorhabditis elegans (roundworm)	sulp-5	NP_505990.2
Arabidopsis thaliana (thale cress)	AST91	NP_173722.1

Gene Ontology
Bibliography

Related articles in PubMed

Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept.
Parham K, Dyhrfjeld-Johnsen J
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology37(9)1217-22(2016 Oct)

The STAS domain of mammalian SLC26A5 prestin harbours an anion-binding site.
Lolli G, Pasqualetto E, Costanzi E, Bonetto G, Battistutta R
The Biochemical journal473(4)365-70(2016 Feb)

Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats.
Hang J, Pan W, Chang A, Li S, Li C, Fu M, Tang J
Neural plasticity20164545826(2016)

Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions.
Sharma AK, Zelikovic I, Alper SL
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology33(3)605-20(2014)

Prestin regulation and function in residual outer hair cells after noise-induced hearing loss.
Xia A, Song Y, Wang R, Gao SS, Clifton W, Raphael P, Chao SI, Pereira FA, Groves AK, Oghalai JS
PloS one8(12)e82602(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

work, for the first time, provides proof of concept that the levels of prestin, an otologic serum biomarker, can change after acoustic trauma and hearing loss
Title: Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept.

in chicken STAS, the anion-binding site is lacking because of a local structural rearrangement, indicating that the presence of the STAS anion-binding site is exclusive to mammalian prestin
Title: The STAS domain of mammalian SLC26A5 prestin harbours an anion-binding site.

Prestin expression first appeared at postnatal day 6 (P6) in the auditory brainstem and reached mature level by P14.
Title: Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats.

Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions.
Title: Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions.

The findings suggest that CASK and the truncated prestin splice isoform contribute to confinement of prestin to the basolateral region of the plasma membrane.
Title: Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell.

The following Slc26a5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc26a5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42706	NM_030840.1 Latest version!	Rattus norvegicus solute carrier family 26 member 5 (Slc26a5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa61027	XM_017592917.1 Latest version!	Rattus norvegicus solute carrier family 26 member 5 (Slc26a5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc26a5 ( NM_030840.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110467.1 Rattus norvegicus solute carrier family 26 member 5 (Slc26a5), mRNA.

Price & Availability↑

CloneID	ORa42706
Clone ID Related Accession (Same CDS sequence)	NM_030840.1
Accession Version	NM_030840.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	prestin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ303372.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ303372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04563757, SAMN04563758 [ECO:0000348] ##Evidence-Data-END##

ATGGATCATG CTGAAGAAAA TGAAATTCCT GCAGAGACTC AGAAGTACCT CGTGGAAAGG 
CCTATCTTCA GTCATCCGGT CCTCCAGGAG AGGCTGCACG TCAAGGACAA AGTCACAGAC 
TCCATCGGGG ATAAGCTGAA GCAGGCATTC ACGTGCACTC CTAAAAAAGT AAGAAACATC 
ATCTACATGT TCTTGCCCAT CACTAAGTGG TTGCCAGCAT ATAAATTCAA GGAGTATGTG 
CTGGGTGACT TGGTCTCGGG CATAAGCACT GGGGTGCTTC AGCTCCCCCA AGGCTTAGCC 
TTCGCGATGC TGGCAGCTGT GCCTCCGGTG TTCGGCCTGT ACTCCTCATT TTACCCCGTT 
ATCATGTACT GTTTCTTTGG AACCTCCAGA CACATATCTA TAGGTCCTTT TGCGGTTATT 
AGCTTGATGA TTGGAGGTGT GGCTGTCCGC TTGGTACCGG ATGACATCGT TATCCCAGGA 
GGAGTAAATG CAACCAATGG GACGGAAGCC AGAGATGCGT TAAGGGTCAA AGTCGCCATG 
TCCGTTACCC TACTTTCAGG AATCATTCAG TTTTGCCTAG GTGTCTGTAG GTTTGGATTT 
GTGGCCATAT ACCTCACGGA GCCGCTAGTG CGAGGCTTTA CCACGGCGGC GGCTGTGCAC 
GTGTTCACCT CCATGTTAAA ATACCTGTTT GGGGTCAAAA CTAAGCGGTA CAGTGGGATC 
TTCTCAGTGG TGTATAGTAC CGTGGCTGTG CTGCAGAATG TTAAAAACCT CAACGTGTGT 
TCCCTAGGCG TCGGCCTCAT GGTTTTTGGT TTGCTGTTGG GTGGCAAGGA GTTTAATGAG 
AGATTTAAAG AGAAACTGCC AGCGCCCATT CCTCTAGAGT TCTTTGCTGT GGTGATGGGG 
ACCGGCATTT CTGCAGGGTT TAACTTGCAC GAGTCCTACA GCGTGGATGT CGTTGGGACA 
CTTCCTCTGG GACTACTCCC ACCCGCCAAC CCGGACACCA GCCTGTTCCA CCTCGTGTAC 
GTGGACGCCA TTGCCATCGC CATTGTTGGG TTTTCAGTGA CGATCTCCAT GGCCAAAACC 
TTGGCAAATA AGCATGGCTA CCAGGTTGAT GGCAACCAGG AGCTCATTGC CTTGGGAATA 
TGCAACTCCA TCGGATCTCT CTTCCAGACC TTCTCAATCT CTTGCTCCTT GTCTCGAAGC 
CTTGTTCAGG AAGGAACTGG AGGGAAGACA CAGCTTGCAG GTTGCTTGGC CTCACTGATG 
ATCCTGCTGG TCATATTAGC CACTGGATTC CTCTTTGAGT CATTACCCCA GGCCGTGCTT 
TCCGCCATTG TGATTGTCAA CCTGAAAGGA ATGTTCATGC AGTTCTCAGA CCTGCCCTTT 
TTCTGGAGAA CCAGCAAAAT CGAGTTGACC ATCTGGCTCA CCACCTTTGT GTCCTCCCTG 
TTCCTGGGCT TGGACTATGG ACTGATTACT GCTGTGATCA TTGCTCTGCT CACTGTGATT 
TACAGAACAC AGAGTCCGAG CTACACAGTC CTGGGACAGC TCCCTGACAC CGATGTATAC 
ATTGACATTG ATGCCTATGA GGAGGTGAAA GAAATTCCTG GAATAAAAAT ATTCCAAATA 
AATGCCCCAA TTTACTATGC AAATAGCGAC TTGTACAGCA GCGCACTGAA AAGAAAGACT 
GGCGTGAACC CAGCAATCAT CATGGGAGCA AGAAGAAAGG CCATGAGGAA GTACGCGAAG 
GAGGTTGGAA ATGCCAACAT AGCTAACGCG ACTGTTGTCA AAGTGGATGC AGAAGTAGAT 
GGAGAAAATG CTACGAAGCC TGAAGAAGAG GACGACGAAG TCAAATTTCC CCCAATAGTC 
ATCAAAACAA CATTTCCTGA AGAGCTGCAG AGGTTTTTGC CCCAGGGGGA AAATATCCAC 
ACTGTCATTC TAGACTTCAC GCAGGTCAAT TTTATGGATT CTGTTGGAGT GAAAACTCTG 
GCTGGGATTG TGAAAGAGTA CGGCGATGTT GGAATTTATG TGTACTTAGC AGGATGCAGT 
GCACAAGTTG TGAATGACCT CACCAGCAAC CGTTTTTTTG AAAATCCTGC CTTAAAGGAG 
CTTCTGTTCC ACAGTATCCA TGACGCGGTC TTGGGCAGCC AAGTCCGTGA GGCGATGGCT 
GAGCAAGAAA CCACGGTTCT GCCTCCCCAG GAAGATATGG AGCCCAATGC CACGCCCACC 
ACACCGGAAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110467.1
CDS	1..2235
Translation	MDHAEENEIPAETQKYLVERPIFSHPVLQERLHVKDKVTDSIGDKLKQAFTCTPKKVRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYTVLGQLPDTDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSSALKRKTGVNPAIIMGARRKAMRKYAKEVGNANIANATVVKVDAEVDGENATKPEEEDDEVKFPPIVIKTTFPEELQRFLPQGENIHTVILDFTQVNFMDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTSNRFFENPALKELLFHSIHDAVLGSQVREAMAEQETTVLPPQEDMEPNATPTTPEA

Target ORF information:

RefSeq Version	NM_030840.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 26 member 5 (Slc26a5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030840.1

ORF Insert Sequence:

ATGGATCATG CTGAAGAAAA TGAAATTCCT GCAGAGACTC AGAAGTACCT CGTGGAAAGG 
CCTATCTTCA GTCATCCGGT CCTCCAGGAG AGGCTGCACG TCAAGGACAA AGTCACAGAC 
TCCATCGGGG ATAAGCTGAA GCAGGCATTC ACGTGCACTC CTAAAAAAGT AAGAAACATC 
ATCTACATGT TCTTGCCCAT CACTAAGTGG TTGCCAGCAT ATAAATTCAA GGAGTATGTG 
CTGGGTGACT TGGTCTCGGG CATAAGCACT GGGGTGCTTC AGCTCCCCCA AGGCTTAGCC 
TTCGCGATGC TGGCAGCTGT GCCTCCGGTG TTCGGCCTGT ACTCCTCATT TTACCCCGTT 
ATCATGTACT GTTTCTTTGG AACCTCCAGA CACATATCTA TAGGTCCTTT TGCGGTTATT 
AGCTTGATGA TTGGAGGTGT GGCTGTCCGC TTGGTACCGG ATGACATCGT TATCCCAGGA 
GGAGTAAATG CAACCAATGG GACGGAAGCC AGAGATGCGT TAAGGGTCAA AGTCGCCATG 
TCCGTTACCC TACTTTCAGG AATCATTCAG TTTTGCCTAG GTGTCTGTAG GTTTGGATTT 
GTGGCCATAT ACCTCACGGA GCCGCTAGTG CGAGGCTTTA CCACGGCGGC GGCTGTGCAC 
GTGTTCACCT CCATGTTAAA ATACCTGTTT GGGGTCAAAA CTAAGCGGTA CAGTGGGATC 
TTCTCAGTGG TGTATAGTAC CGTGGCTGTG CTGCAGAATG TTAAAAACCT CAACGTGTGT 
TCCCTAGGCG TCGGCCTCAT GGTTTTTGGT TTGCTGTTGG GTGGCAAGGA GTTTAATGAG 
AGATTTAAAG AGAAACTGCC AGCGCCCATT CCTCTAGAGT TCTTTGCTGT GGTGATGGGG 
ACCGGCATTT CTGCAGGGTT TAACTTGCAC GAGTCCTACA GCGTGGATGT CGTTGGGACA 
CTTCCTCTGG GACTACTCCC ACCCGCCAAC CCGGACACCA GCCTGTTCCA CCTCGTGTAC 
GTGGACGCCA TTGCCATCGC CATTGTTGGG TTTTCAGTGA CGATCTCCAT GGCCAAAACC 
TTGGCAAATA AGCATGGCTA CCAGGTTGAT GGCAACCAGG AGCTCATTGC CTTGGGAATA 
TGCAACTCCA TCGGATCTCT CTTCCAGACC TTCTCAATCT CTTGCTCCTT GTCTCGAAGC 
CTTGTTCAGG AAGGAACTGG AGGGAAGACA CAGCTTGCAG GTTGCTTGGC CTCACTGATG 
ATCCTGCTGG TCATATTAGC CACTGGATTC CTCTTTGAGT CATTACCCCA GGCCGTGCTT 
TCCGCCATTG TGATTGTCAA CCTGAAAGGA ATGTTCATGC AGTTCTCAGA CCTGCCCTTT 
TTCTGGAGAA CCAGCAAAAT CGAGTTGACC ATCTGGCTCA CCACCTTTGT GTCCTCCCTG 
TTCCTGGGCT TGGACTATGG ACTGATTACT GCTGTGATCA TTGCTCTGCT CACTGTGATT 
TACAGAACAC AGAGTCCGAG CTACACAGTC CTGGGACAGC TCCCTGACAC CGATGTATAC 
ATTGACATTG ATGCCTATGA GGAGGTGAAA GAAATTCCTG GAATAAAAAT ATTCCAAATA 
AATGCCCCAA TTTACTATGC AAATAGCGAC TTGTACAGCA GCGCACTGAA AAGAAAGACT 
GGCGTGAACC CAGCAATCAT CATGGGAGCA AGAAGAAAGG CCATGAGGAA GTACGCGAAG 
GAGGTTGGAA ATGCCAACAT AGCTAACGCG ACTGTTGTCA AAGTGGATGC AGAAGTAGAT 
GGAGAAAATG CTACGAAGCC TGAAGAAGAG GACGACGAAG TCAAATTTCC CCCAATAGTC 
ATCAAAACAA CATTTCCTGA AGAGCTGCAG AGGTTTTTGC CCCAGGGGGA AAATATCCAC 
ACTGTCATTC TAGACTTCAC GCAGGTCAAT TTTATGGATT CTGTTGGAGT GAAAACTCTG 
GCTGGGATTG TGAAAGAGTA CGGCGATGTT GGAATTTATG TGTACTTAGC AGGATGCAGT 
GCACAAGTTG TGAATGACCT CACCAGCAAC CGTTTTTTTG AAAATCCTGC CTTAAAGGAG 
CTTCTGTTCC ACAGTATCCA TGACGCGGTC TTGGGCAGCC AAGTCCGTGA GGCGATGGCT 
GAGCAAGAAA CCACGGTTCT GCCTCCCCAG GAAGATATGG AGCCCAATGC CACGCCCACC 
ACACCGGAAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc26a5 ( XM_017592917.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448406.1 Rattus norvegicus solute carrier family 26 member 5 (Slc26a5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61027
Clone ID Related Accession (Same CDS sequence)	XM_017592917.1
Accession Version	XM_017592917.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	prestin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATCATG CTGAAGAAAA TGAAATTCCT GCAGAGACCC AGAAGTACCT CGTGGAAAGG 
CCTATCTTCA GTCATCCGGT CCTCCAGGAG AGGCTGCACG TCAAGGACAA AGTCACAGAC 
TCCATCGGGG ATAAGCTGAA GCAGGCATTC ACGTGCACTC CTAAAAAAGT AAGAAACATC 
ATCTACATGT TCTTGCCCAT CACTAAGTGG TTGCCAGCAT ATAAATTCAA GGAGTATGTG 
CTGGGTGACT TGGTCTCGGG CATAAGCACT GGGGTGCTTC AGCTCCCCCA AGGCTTAGCC 
TTCGCGATGT TGGCAGCTGT GCCTCCGGTG TTCGGCCTGT ACTCCTCGTT TTACCCCGTT 
ATCATGTACT GTTTCTTTGG AACCTCCAGA CACATATCTA TAGGTCCTTT TGCGGTTATT 
AGCTTGATGA TTGGAGGTGT GGCTGTCCGC TTGGTACCGG ATGACATCGT TATCCCAGGA 
GGAGTAAATG CAACCAATGG GACGGAAGCC AGAGATGCGT TAAGGGTCAA AGTCGCCATG 
TCCGTTACCC TACTTTCAGG AATCATTCAG TTTTGCCTAG GTGTCTGTAG GTTTGGATTT 
GTGGCCATAT ACCTCACGGA GCCGCTAGTG CGAGGCTTTA CCACGGCGGC GGCTGTGCAC 
GTGTTCACCT CCATGTTAAA ATACCTGTTT GGGGTCAAAA CTAAGCGGTA CAGTGGGATC 
TTCTCAGTGG TGTATAGTAC CGTGGCTGTG CTGCAGAATG TTAAAAACCT CAACGTGTGT 
TCCCTAGGCG TCGGCCTCAT GGTTTTTGGT TTGCTGTTGG GTGGCAAGGA GTTTAATGAG 
AGATTTAAAG AGAAACTGCC AGCGCCCATT CCTCTAGAGT TCTTTGCTGT GGTGATGGGG 
ACCGGCATTT CTGCAGGGTT TAACTTGCAC GAGTCCTACA GCGTGGATGT CGTTGGGACA 
CTTCCTCTGG GACTACTCCC ACCCGCCAAC CCGGACACCA GCCTGTTCCA CCTCGTGTAC 
GTGGACGCCA TTGCCATCGC CATTGTTGGG TTTTCAGTGA CGATCTCCAT GGCCAAAACC 
TTGGCAAATA AGCATGGCTA CCAGGTTGAT GGCAACCAGG AGCTCATTGC CTTGGGAATA 
TGCAACTCCA TCGGATCTCT CTTCCAGACC TTCTCAATCT CTTGCTCCTT GTCTCGAAGC 
CTTGTTCAGG AAGGAACTGG AGGGAAGACA CAGCTTGCAG GTTGCTTGGC CTCACTGATG 
ATCCTGCTGG TCATATTAGC CACTGGATTC CTCTTTGAGT CATTACCCCA GGCCGTGCTT 
TCCGCCATTG TGATTGTCAA CCTGAAAGGA ATGTTCATGC AGTTCTCAGA CCTGCCCTTT 
TTCTGGAGAA CCAGCAAAAT CGAGTTGACC ATCTGGCTCA CCACCTTTGT GTCCTCCCTG 
TTCCTGGGCT TGGACTATGG ACTGATTACT GCTGTGATCA TTGCTCTGCT CACTGTGATT 
TACAGAACAC AGAGTCCGAG CTACACAGTC CTGGGACAGC TCCCTGACAC CGATGTATAC 
ATTGACATTG ATGCCTATGA GGAGGTGAAA GAAATTCCTG GAATAAAAAT ATTCCAAATA 
AATGCCCCAA TTTACTATGC AAATAGCGAC TTGTACAGCA GCGCACTGAA AAGAAAGACT 
GGCGTGAACC CAGCAATCAT CATGGGAGCA AGAAGAAAGG CCATGAGGAA GTACGCGAAG 
GAGGTTGGAA ATGCCAACAT AGCTAACGCG ACTGTTGTCA AAGTGGATGC AGAAGTAGAT 
GGAGAAAATG CTACGAAGCC TGAAGAAGAG GACGACGAAG TCAAATTTCC CCCAATAGTC 
ATCAAAACAA CATTTCCTGA AGAGCTGCAG AGGTTTTTGC CCCAGGGGGA AAATATCCAC 
ACTGTCATTC TAGACTTCAC GCAGGTCAAT TTTATGGATT CTGTTGGAGT GAAAACTCTG 
GCTGGGATTG TGAAAGAGTA CGGCGATGTT GGAATTTATG TGTACTTAGC AGGATGCAGT 
GCACAAGTTG TGAATGACCT CACCAGCAAC CGTTTTTTTG AAAATCCTGC CTTAAAGGAG 
CTTCTGTTCC ACAGTATCCA TGACGCGGTC TTGGGCAGCC AAGTCCGTGA GGCGATGGCT 
GAGCAAGAAA CCACGGTTCT GCCTCCCCAG GAAGATATGG AGCCCAATGC CACGCCCACC 
ACACCGGAAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448406.1
CDS	437..2671
Translation	MDHAEENEIPAETQKYLVERPIFSHPVLQERLHVKDKVTDSIGDKLKQAFTCTPKKVRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPVFGLYSSFYPVIMYCFFGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLHESYSVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGICNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYTVLGQLPDTDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSSALKRKTGVNPAIIMGARRKAMRKYAKEVGNANIANATVVKVDAEVDGENATKPEEEDDEVKFPPIVIKTTFPEELQRFLPQGENIHTVILDFTQVNFMDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTSNRFFENPALKELLFHSIHDAVLGSQVREAMAEQETTVLPPQEDMEPNATPTTPEA

Target ORF information:

RefSeq Version	XM_017592917.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 26 member 5 (Slc26a5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592917.1

ORF Insert Sequence:

ATGGATCATG CTGAAGAAAA TGAAATTCCT GCAGAGACCC AGAAGTACCT CGTGGAAAGG 
CCTATCTTCA GTCATCCGGT CCTCCAGGAG AGGCTGCACG TCAAGGACAA AGTCACAGAC 
TCCATCGGGG ATAAGCTGAA GCAGGCATTC ACGTGCACTC CTAAAAAAGT AAGAAACATC 
ATCTACATGT TCTTGCCCAT CACTAAGTGG TTGCCAGCAT ATAAATTCAA GGAGTATGTG 
CTGGGTGACT TGGTCTCGGG CATAAGCACT GGGGTGCTTC AGCTCCCCCA AGGCTTAGCC 
TTCGCGATGT TGGCAGCTGT GCCTCCGGTG TTCGGCCTGT ACTCCTCGTT TTACCCCGTT 
ATCATGTACT GTTTCTTTGG AACCTCCAGA CACATATCTA TAGGTCCTTT TGCGGTTATT 
AGCTTGATGA TTGGAGGTGT GGCTGTCCGC TTGGTACCGG ATGACATCGT TATCCCAGGA 
GGAGTAAATG CAACCAATGG GACGGAAGCC AGAGATGCGT TAAGGGTCAA AGTCGCCATG 
TCCGTTACCC TACTTTCAGG AATCATTCAG TTTTGCCTAG GTGTCTGTAG GTTTGGATTT 
GTGGCCATAT ACCTCACGGA GCCGCTAGTG CGAGGCTTTA CCACGGCGGC GGCTGTGCAC 
GTGTTCACCT CCATGTTAAA ATACCTGTTT GGGGTCAAAA CTAAGCGGTA CAGTGGGATC 
TTCTCAGTGG TGTATAGTAC CGTGGCTGTG CTGCAGAATG TTAAAAACCT CAACGTGTGT 
TCCCTAGGCG TCGGCCTCAT GGTTTTTGGT TTGCTGTTGG GTGGCAAGGA GTTTAATGAG 
AGATTTAAAG AGAAACTGCC AGCGCCCATT CCTCTAGAGT TCTTTGCTGT GGTGATGGGG 
ACCGGCATTT CTGCAGGGTT TAACTTGCAC GAGTCCTACA GCGTGGATGT CGTTGGGACA 
CTTCCTCTGG GACTACTCCC ACCCGCCAAC CCGGACACCA GCCTGTTCCA CCTCGTGTAC 
GTGGACGCCA TTGCCATCGC CATTGTTGGG TTTTCAGTGA CGATCTCCAT GGCCAAAACC 
TTGGCAAATA AGCATGGCTA CCAGGTTGAT GGCAACCAGG AGCTCATTGC CTTGGGAATA 
TGCAACTCCA TCGGATCTCT CTTCCAGACC TTCTCAATCT CTTGCTCCTT GTCTCGAAGC 
CTTGTTCAGG AAGGAACTGG AGGGAAGACA CAGCTTGCAG GTTGCTTGGC CTCACTGATG 
ATCCTGCTGG TCATATTAGC CACTGGATTC CTCTTTGAGT CATTACCCCA GGCCGTGCTT 
TCCGCCATTG TGATTGTCAA CCTGAAAGGA ATGTTCATGC AGTTCTCAGA CCTGCCCTTT 
TTCTGGAGAA CCAGCAAAAT CGAGTTGACC ATCTGGCTCA CCACCTTTGT GTCCTCCCTG 
TTCCTGGGCT TGGACTATGG ACTGATTACT GCTGTGATCA TTGCTCTGCT CACTGTGATT 
TACAGAACAC AGAGTCCGAG CTACACAGTC CTGGGACAGC TCCCTGACAC CGATGTATAC 
ATTGACATTG ATGCCTATGA GGAGGTGAAA GAAATTCCTG GAATAAAAAT ATTCCAAATA 
AATGCCCCAA TTTACTATGC AAATAGCGAC TTGTACAGCA GCGCACTGAA AAGAAAGACT 
GGCGTGAACC CAGCAATCAT CATGGGAGCA AGAAGAAAGG CCATGAGGAA GTACGCGAAG 
GAGGTTGGAA ATGCCAACAT AGCTAACGCG ACTGTTGTCA AAGTGGATGC AGAAGTAGAT 
GGAGAAAATG CTACGAAGCC TGAAGAAGAG GACGACGAAG TCAAATTTCC CCCAATAGTC 
ATCAAAACAA CATTTCCTGA AGAGCTGCAG AGGTTTTTGC CCCAGGGGGA AAATATCCAC 
ACTGTCATTC TAGACTTCAC GCAGGTCAAT TTTATGGATT CTGTTGGAGT GAAAACTCTG 
GCTGGGATTG TGAAAGAGTA CGGCGATGTT GGAATTTATG TGTACTTAGC AGGATGCAGT 
GCACAAGTTG TGAATGACCT CACCAGCAAC CGTTTTTTTG AAAATCCTGC CTTAAAGGAG 
CTTCTGTTCC ACAGTATCCA TGACGCGGTC TTGGGCAGCC AAGTCCGTGA GGCGATGGCT 
GAGCAAGAAA CCACGGTTCT GCCTCCCCAG GAAGATATGG AGCCCAATGC CACGCCCACC 
ACACCGGAAG CATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Outer Hair Cell Molecular Protein, Prestin, as a Serum Biomarker for Hearing Loss: Proof of Concept.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology37(9)1217-22(2016 Oct)
Parham K,Dyhrfjeld-Johnsen J

The STAS domain of mammalian SLC26A5 prestin harbours an anion-binding site.
The Biochemical journal473(4)365-70(2016 Feb)
Lolli G,Pasqualetto E,Costanzi E,Bonetto G,Battistutta R

Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats.
Neural plasticity20164545826(2016)
Hang J,Pan W,Chang A,Li S,Li C,Fu M,Tang J

Molecular dynamics simulations of the STAS domains of rat prestin and human pendrin reveal conformational motions in conserved flexible regions.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology33(3)605-20(2014)
Sharma AK,Zelikovic I,Alper SL

Prestin regulation and function in residual outer hair cells after noise-induced hearing loss.
PloS one8(12)e82602(2013)
Xia A,Song Y,Wang R,Gao SS,Clifton W,Raphael P,Chao SI,Pereira FA,Groves AK,Oghalai JS

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Slc26a5 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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