Lgals3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lgals3
Entrez Gene ID	83781
Full Name	galectin 3
Synonyms	AGE-R3,CBP30,L-34,gal-3
General protein information	Preferred Names galectin 3 Names galectin-3 35 kDa lectin CBP 35 IgE binding protein carbohydrate-binding protein 35 epsilon BP galactose-specific lectin 3 igE-binding protein laminin-binding protein lectin L-29 lectin galactoside-binding soluble 3 protein lectin, galactose binding, soluble 3 lectin, galactoside-binding, soluble, 3 mac-2 antigen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p14
Summary	lectin molecule that binds IgE; may have role in immune function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031832.1	NP_114020.1	galectin-3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LGALS3	XP_001148424.2
Bos taurus (cattle)	LGALS3	NP_001095811.1
Danio rerio (zebrafish)	si:ch211-67f24.5	XP_704272.2
Homo sapiens (human)	LGALS3	NP_002297.2
	LGALS3	XP_002805130.1
Rattus norvegicus (Norway rat)	Lgals3	NP_114020.1
Gallus gallus (chicken)	LGALS3	NP_999756.1
Mus musculus (house mouse)	Lgals3	NP_001139425.1
Canis lupus familiaris (dog)	LGALS3	NP_001183972.1
Xenopus tropicalis (tropical clawed frog)	lgals3	NP_988986.1

Gene Ontology
Bibliography

Related articles in PubMed

Therapeutic inhibition of galectin?3 improves cardiomyocyte apoptosis and survival during heart failure.
Li X, Tang X, Lu J, Yuan S
Molecular medicine reports(2017 Dec)

Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension.
Luo H, Liu B, Zhao L, He J, Li T, Zha L, Li X, Qi Q, Liu Y, Yu Z
Journal of the American Society of Hypertension : JASH11(10)673-683.e3(2017 Oct)

Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats.
Mart?nez-Mart?nez E, Ibarrola J, Fern?ndez-Celis A, Calvier L, Leroy C, Cachofeiro V, Rossignol P, L?pez-Andr?s N
Journal of hypertension(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study concludes that activated microglia release Gal-3 and a neuraminidase that desialylates microglial and PC12 surfaces, enabling Gal-3 binding to PC12 (neuron-like) cells and their phagocytosis via Mer tyrosine kinase (MerTK).
Title: Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase.

The increase in myocardial Gal-3 expression was associated with cardiac fibrosis and inflammation.
Title: A role for galectin-3?in the development of early molecular alterations in short-term aortic stenosis.

These findings demonstrate that Gal-3 is required for TGF-beta1-stimulated vascular fibrosis via a STAT3 signaling cascade and that MMP-9 is also involved in TGF-beta1/Gal-3-induced vascular fibrosis.
Title: Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.

galectin-3 expression in the rat brain seems to be regulated by developmental cascades, and functionally and neuroanatomically related brain nuclei constitutively express galectin-3 in adulthood.
Title: Neuroanatomical distribution of galectin-3 in the adult rat brain.

Data suggest that inhibition of galectin-3 (here, by soluble dietary fiber supplement, modified citrus pectin) prevents initiation/progression of liver cirrhosis by inducing apoptosis in liver stellate cells.
Title: Modified citrus pectin stops progression of liver fibrosis by inhibiting galectin-3 and inducing apoptosis of stellate cells.

The following Lgals3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lgals3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08837	NM_031832.1 Latest version!	Rattus norvegicus galectin 3 (Lgals3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lgals3 ( NM_031832.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114020.1 Rattus norvegicus galectin 3 (Lgals3), mRNA.

Price & Availability↑

CloneID	ORa08837
Clone ID Related Accession (Same CDS sequence)	NM_031832.1
Accession Version	NM_031832.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	galectin-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J02962.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ218337.1, FQ219929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGACG GCTTCTCACT TAATGATGCC TTAGCTGGCT CTGGAAACCC AAACCCTCGA 
GGATGGCCTG GTGCATGGGG GAACCAGCCT GGGGCAGGAG GCTACCCAGG GGCCTCCTAT 
CCTGGGGCCT ACCCAGGACA GGCTCCTCCA GGGGGTTATC CTGGACAGGC TCCTCCTAGT 
GCCTATCCGG GCCCAACTGG CCCTAGTGCT TATCCTGGCC CAACTGCCCC TGGAGCTTAT 
CCTGGCCCAA CTGCCCCCGG AGCCTTCCCA GGGCAACCTG GGGGACCTGG AGCCTACCCC 
AGTGCTCCTG GGGCCTACCC CAGTGCTCCT GGGGCCTATC CTGCTACTGG CCCCTTTGGT 
GCCCCGACTG GACCACTGAC AGTGCCCTAC GATATGCCCT TGCCTGGAGG AGTCATGCCT 
CGCATGCTGA TCACAATCAT AGGCACAGTG AAGCCCAACG CAAACAGTAT CACTCTGAAT 
TTCAAGAAAG GGAACGACAT CGCCTTCCAC TTTAACCCCC GCTTCAATGA GAACAACAGA 
AGAGTCATCG TGTGCAACAC GAAGCAGGAC AATAACTGGG GAAGGGAAGA AAGACAGTCA 
GCTTTCCCCT TTGAGAGCGG CAAACCATTC AAAATACAGG TCCTGGTTGA AGCCGACCAC 
TTCAAGGTTG CGGTCAATGA TGTTCATCTG TTGCAGTATA ACCATCGGAT GAAGAACCTC 
AGGGAAATCA GCCAACTGGG GATCATTGGT GACATAACCC TCACCAGCGC TTCCCACGCC 
ATGATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114020.1
CDS	41..829
Translation	MADGFSLNDALAGSGNPNPRGWPGAWGNQPGAGGYPGASYPGAYPGQAPPGGYPGQAPPSAYPGPTGPSAYPGPTAPGAYPGPTAPGAFPGQPGGPGAYPSAPGAYPSAPGAYPATGPFGAPTGPLTVPYDMPLPGGVMPRMLITIIGTVKPNANSITLNFKKGNDIAFHFNPRFNENNRRVIVCNTKQDNNWGREERQSAFPFESGKPFKIQVLVEADHFKVAVNDVHLLQYNHRMKNLREISQLGIIGDITLTSASHAMI

Target ORF information:

RefSeq Version	NM_031832.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus galectin 3 (Lgals3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031832.1

ORF Insert Sequence:

ATGGCAGACG GCTTCTCACT TAATGATGCC TTAGCTGGCT CTGGAAACCC AAACCCTCGA 
GGATGGCCTG GTGCATGGGG GAACCAGCCT GGGGCAGGAG GCTACCCAGG GGCCTCCTAT 
CCTGGGGCCT ACCCAGGACA GGCTCCTCCA GGGGGTTATC CTGGACAGGC TCCTCCTAGT 
GCCTATCCGG GCCCAACTGG CCCTAGTGCT TATCCTGGCC CAACTGCCCC TGGAGCTTAT 
CCTGGCCCAA CTGCCCCCGG AGCCTTCCCA GGGCAACCTG GGGGACCTGG AGCCTACCCC 
AGTGCTCCTG GGGCCTACCC CAGTGCTCCT GGGGCCTATC CTGCTACTGG CCCCTTTGGT 
GCCCCGACTG GACCACTGAC AGTGCCCTAC GATATGCCCT TGCCTGGAGG AGTCATGCCT 
CGCATGCTGA TCACAATCAT AGGCACAGTG AAGCCCAACG CAAACAGTAT CACTCTGAAT 
TTCAAGAAAG GGAACGACAT CGCCTTCCAC TTTAACCCCC GCTTCAATGA GAACAACAGA 
AGAGTCATCG TGTGCAACAC GAAGCAGGAC AATAACTGGG GAAGGGAAGA AAGACAGTCA 
GCTTTCCCCT TTGAGAGCGG CAAACCATTC AAAATACAGG TCCTGGTTGA AGCCGACCAC 
TTCAAGGTTG CGGTCAATGA TGTTCATCTG TTGCAGTATA ACCATCGGAT GAAGAACCTC 
AGGGAAATCA GCCAACTGGG GATCATTGGT GACATAACCC TCACCAGCGC TTCCCACGCC 
ATGATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Therapeutic inhibition of galectin?3 improves cardiomyocyte apoptosis and survival during heart failure.
Molecular medicine reports(2017 Dec)
Li X,Tang X,Lu J,Yuan S

Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension.
Journal of the American Society of Hypertension : JASH11(10)673-683.e3(2017 Oct)
Luo H,Liu B,Zhao L,He J,Li T,Zha L,Li X,Qi Q,Liu Y,Yu Z

Galectin-3 pharmacological inhibition attenuates early renal damage in spontaneously hypertensive rats.
Journal of hypertension(2017 Aug)
Mart?nez-Mart?nez E,Ibarrola J,Fern?ndez-Celis A,Calvier L,Leroy C,Cachofeiro V,Rossignol P,L?pez-Andr?s N

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Lgals3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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