Thbd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Thbd
Entrez Gene ID	83580
Full Name	thrombomodulin
General protein information	Preferred Names thrombomodulin Names thrombomodulin thrombomdulin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q41
Summary	cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031771.2	NP_113959.1	thrombomodulin precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	THBD	XP_004940194.1
Pan troglodytes (chimpanzee)	THBD	XP_525283.2
	THBD	XP_001095416.1
Canis lupus familiaris (dog)	THBD	NP_001006954.1
Rattus norvegicus (Norway rat)	Thbd	NP_113959.1
Xenopus tropicalis (tropical clawed frog)	LOC100497748	XP_002936963.1
Bos taurus (cattle)	THBD	NP_001159994.1
Xenopus tropicalis (tropical clawed frog)	thbd	XP_002936969.1
Homo sapiens (human)	THBD	NP_000352.1
Mus musculus (house mouse)	Thbd	NP_033404.1

Gene Ontology
Bibliography

Related articles in PubMed

Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.
Friedrich V, Bi W, Sehba FA
Neurological research37(12)1054-9(2015)

Changes in cardiac thrombomodulin and heat shock transcription factor 1 expression and peripheral thrombomodulin and catecholamines during hypothermia in rats.
Kaija H, Pakanen L, Uusitalo J, Nikkil? S, Kortelainen ML, Porvari KS
Stress (Amsterdam, Netherlands)17(6)504-11(2014 Dec)

The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes.
Cao Y, Zhang Z, Xu J, Yuan W, Wang J, Huang X, Shen Y, Du J
Gene530(2)248-52(2013 Nov)

Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats.
Tanaka J, Seki Y, Ishikura H, Tsubota M, Sekiguchi F, Yamaguchi K, Murai A, Umemura T, Kawabata A
British journal of pharmacology170(6)1233-41(2013 Nov)

Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
PloS one8(9)e75961(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study demonstrated that Thbd increases in male rat with aneurysmal subarachnoid hemorrhage.
Title: Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.

Cellular and soluble levels of thrombomodulin are modified by cold stress in healthy rats, possibly via catecholamines and HSF1.
Title: Changes in cardiac thrombomodulin and heat shock transcription factor 1 expression and peripheral thrombomodulin and catecholamines during hypothermia in rats.

Data show that bladder wall distension leads to PDGF receptor activation and identify thrombomodulin as an Akt and Fra-1 target in smooth muscle cells.
Title: An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration.

Activated protein C could augment the anti-coagulation and anti-inflammatory activity by up-regulating endothelial cell protein C receptor and thrombomodulin expression, thus attenuating the severity of severe acute pancreatis.
Title: Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin.

The expression of thrombomodulin and endothelial protein C receptor mRNAs of rats after paraquat intoxication is increased, and can significantly be decreased after administered with Na-DMPS.
Title: [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate].

The following Thbd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Thbd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41882	NM_031771.2 Latest version!	Rattus norvegicus thrombomodulin (Thbd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Thbd ( NM_031771.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113959.1 Rattus norvegicus thrombomodulin (Thbd), mRNA.

Price & Availability↑

CloneID	ORa41882
Clone ID Related Accession (Same CDS sequence)	NM_031771.2
Accession Version	NM_031771.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	thrombomodulin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070903.1. On May 24, 2004 this sequence version replaced NM_031771.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070903.1 [ECO:0000332] ##Evidence-Data-END##

ATGCTTGGGG TTTTCCTTCT GGGTGTGCTG GCTCCAGCTG GCCTGGGGAT CTCTGCACTA 
GCCAAGCTGC AGCCCAAAGG CAGTCAATGC GTGGGGAATG AGTGCTTCGC GCTTTTCCAG 
GACCCCGTGA CCTTCCTCGA TGCCAGCCAG GCCTGCCAGC GCCTGCAGGG ACATTTGATG 
ACAGTGCGCT CCTCGGTGGC TGCGGATGTC ATCTCCCTTC TGGTGAGCGA CAGTAGTATG 
GACTCACGGC CCTGGATCGG TTTACAGCTC CCTCAGGGCT GTGGTGACCC GGTGCATCTC 
GGGCCCCTGC GCGGCTTCCA GTGGGTTACT GGGGATAACC ACACCAGTTA CAGCAGGTGG 
GCGCGGCCCA ACGACCAGTC GCCTCCACTT TGCGGTCCGC TGTGCGTCAC GGTCTCAACA 
GCAACAGAAG CTGCACCAGG CGAGCCGGCC TGGGAAGAGA AGCCGTGCGA GAACGAGACC 
AAGGGTTTTC TCTGCGAGTT TTACTTCGCA GCTTTCTGCA GGCCTTTACG GGTGAATACC 
CGAGATCCTG AGGGTGCCCA CATCTCTAGC ACCTACAATA CCCCATTGGG GGTCAGCGGC 
GCGGATTTTC AGACGCTGCC GATAGGCAGT TCTGCTACCG TGGCGCCCTT TGGCTTGGAG 
CTGGTGTGCA GGGCCCTGCC CGGAACTTCA GAGGGACACT GGACTCGGGA AGTGACAGGA 
GCTTGGAACT GCAGCGTGGA GAATGGTGGC TGCGAGTACA TGTGCAACAG GAGCGCTAAC 
GGACCCAGAT GCGTCTGCCC CAGCGGCGGG GACCTGCAGG CTGATGGCCG TTCGTGCGCA 
AAACCTGTGG CTCAATTGTG CAACGAACTC TGCCAGCATT TTTGCGTCAA CAACTCTGAT 
GTGCCAGGCT CTTATTCCTG TATGTGCGAA ACAGGCTACC AGTTGGCGGC AGACGGACAT 
CGGTGTGAGG ACGTGGATGA CTGTAAGCAG GGGCCCAATC CATGCCCTCA GCTCTGTTCT 
AACACCGAGG GCGGCTTCGA ATGCCGCTGC TATGATGGCT ATGAGTTGGT GGACGGAGAG 
TGCGTGGAGC AACTGGATCC GTGCTTCAGA TCTAAATGCG AGTATCAGTG CCAGCCAGTA 
AACTCCACGC ACTACAATTG CATCTGTGCT GAGGGCTTCG CACCTAAGCT GGATGATCCC 
GACAGGTGCG AAATGTTCTG CAATGAAACT TCGTGCCCAG CAGACTGTGA CCCCAACTCC 
CCAAGCTTTT GTCAATGCCC TGAGGGCTTC ATCCTGGACG AGGGTTCCAT ATGCACAGAC 
ATTGATGAGT GCAGTCAAGG CGAATGCCTC ACCAATGAAT GTCGAAACCT TCCTGGCTCC 
TATGAGTGCA TCTGCGGACC TGACACAGCC CTTGCTGGTC AGATTAGCAA GGACTGTGAC 
CCCATCCCTG TTCTGGAGGA CTCAGAGGAT GGTGGCTCTG GGGAGCACCC ATCAAGCAAT 
CCGACGGTAG TCTCTTCGAC AGTTCCCCCT TCTGCAAGAC CAATGCACTC TGGTGTGCTC 
ATTGGGATCT CCATTGCCAG CCTGTCCCTG GTGGTGGCGC TTTTGGCGCT TCTTTGTCAC 
CTGCGCAAGA AGCAGGGCAC TGCTCGCGCA GAGCTGGAGT ACAAGTGTAC CTCTTCAGCC 
AAGGAGGTAG TACTGCAGCA CGTGAGGACT GATCGGACGC TGCAGAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113959.1
CDS	154..1887
Translation	MLGVFLLGVLAPAGLGISALAKLQPKGSQCVGNECFALFQDPVTFLDASQACQRLQGHLMTVRSSVAADVISLLVSDSSMDSRPWIGLQLPQGCGDPVHLGPLRGFQWVTGDNHTSYSRWARPNDQSPPLCGPLCVTVSTATEAAPGEPAWEEKPCENETKGFLCEFYFAAFCRPLRVNTRDPEGAHISSTYNTPLGVSGADFQTLPIGSSATVAPFGLELVCRALPGTSEGHWTREVTGAWNCSVENGGCEYMCNRSANGPRCVCPSGGDLQADGRSCAKPVAQLCNELCQHFCVNNSDVPGSYSCMCETGYQLAADGHRCEDVDDCKQGPNPCPQLCSNTEGGFECRCYDGYELVDGECVEQLDPCFRSKCEYQCQPVNSTHYNCICAEGFAPKLDDPDRCEMFCNETSCPADCDPNSPSFCQCPEGFILDEGSICTDIDECSQGECLTNECRNLPGSYECICGPDTALAGQISKDCDPIPVLEDSEDGGSGEHPSSNPTVVSSTVPPSARPMHSGVLIGISIASLSLVVALLALLCHLRKKQGTARAELEYKCTSSAKEVVLQHVRTDRTLQKF

Target ORF information:

RefSeq Version	NM_031771.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thrombomodulin (Thbd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031771.2

ORF Insert Sequence:

ATGCTTGGGG TTTTCCTTCT GGGTGTGCTG GCTCCAGCTG GCCTGGGGAT CTCTGCACTA 
GCCAAGCTGC AGCCCAAAGG CAGTCAATGC GTGGGGAATG AGTGCTTCGC GCTTTTCCAG 
GACCCCGTGA CCTTCCTCGA TGCCAGCCAG GCCTGCCAGC GCCTGCAGGG ACATTTGATG 
ACAGTGCGCT CCTCGGTGGC TGCGGATGTC ATCTCCCTTC TGGTGAGCGA CAGTAGTATG 
GACTCACGGC CCTGGATCGG TTTACAGCTC CCTCAGGGCT GTGGTGACCC GGTGCATCTC 
GGGCCCCTGC GCGGCTTCCA GTGGGTTACT GGGGATAACC ACACCAGTTA CAGCAGGTGG 
GCGCGGCCCA ACGACCAGTC GCCTCCACTT TGCGGTCCGC TGTGCGTCAC GGTCTCAACA 
GCAACAGAAG CTGCACCAGG CGAGCCGGCC TGGGAAGAGA AGCCGTGCGA GAACGAGACC 
AAGGGTTTTC TCTGCGAGTT TTACTTCGCA GCTTTCTGCA GGCCTTTACG GGTGAATACC 
CGAGATCCTG AGGGTGCCCA CATCTCTAGC ACCTACAATA CCCCATTGGG GGTCAGCGGC 
GCGGATTTTC AGACGCTGCC GATAGGCAGT TCTGCTACCG TGGCGCCCTT TGGCTTGGAG 
CTGGTGTGCA GGGCCCTGCC CGGAACTTCA GAGGGACACT GGACTCGGGA AGTGACAGGA 
GCTTGGAACT GCAGCGTGGA GAATGGTGGC TGCGAGTACA TGTGCAACAG GAGCGCTAAC 
GGACCCAGAT GCGTCTGCCC CAGCGGCGGG GACCTGCAGG CTGATGGCCG TTCGTGCGCA 
AAACCTGTGG CTCAATTGTG CAACGAACTC TGCCAGCATT TTTGCGTCAA CAACTCTGAT 
GTGCCAGGCT CTTATTCCTG TATGTGCGAA ACAGGCTACC AGTTGGCGGC AGACGGACAT 
CGGTGTGAGG ACGTGGATGA CTGTAAGCAG GGGCCCAATC CATGCCCTCA GCTCTGTTCT 
AACACCGAGG GCGGCTTCGA ATGCCGCTGC TATGATGGCT ATGAGTTGGT GGACGGAGAG 
TGCGTGGAGC AACTGGATCC GTGCTTCAGA TCTAAATGCG AGTATCAGTG CCAGCCAGTA 
AACTCCACGC ACTACAATTG CATCTGTGCT GAGGGCTTCG CACCTAAGCT GGATGATCCC 
GACAGGTGCG AAATGTTCTG CAATGAAACT TCGTGCCCAG CAGACTGTGA CCCCAACTCC 
CCAAGCTTTT GTCAATGCCC TGAGGGCTTC ATCCTGGACG AGGGTTCCAT ATGCACAGAC 
ATTGATGAGT GCAGTCAAGG CGAATGCCTC ACCAATGAAT GTCGAAACCT TCCTGGCTCC 
TATGAGTGCA TCTGCGGACC TGACACAGCC CTTGCTGGTC AGATTAGCAA GGACTGTGAC 
CCCATCCCTG TTCTGGAGGA CTCAGAGGAT GGTGGCTCTG GGGAGCACCC ATCAAGCAAT 
CCGACGGTAG TCTCTTCGAC AGTTCCCCCT TCTGCAAGAC CAATGCACTC TGGTGTGCTC 
ATTGGGATCT CCATTGCCAG CCTGTCCCTG GTGGTGGCGC TTTTGGCGCT TCTTTGTCAC 
CTGCGCAAGA AGCAGGGCAC TGCTCGCGCA GAGCTGGAGT ACAAGTGTAC CTCTTCAGCC 
AAGGAGGTAG TACTGCAGCA CGTGAGGACT GATCGGACGC TGCAGAAGTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.
Neurological research37(12)1054-9(2015)
Friedrich V,Bi W,Sehba FA

Changes in cardiac thrombomodulin and heat shock transcription factor 1 expression and peripheral thrombomodulin and catecholamines during hypothermia in rats.
Stress (Amsterdam, Netherlands)17(6)504-11(2014 Dec)
Kaija H,Pakanen L,Uusitalo J,Nikkil? S,Kortelainen ML,Porvari KS

The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes.
Gene530(2)248-52(2013 Nov)
Cao Y,Zhang Z,Xu J,Yuan W,Wang J,Huang X,Shen Y,Du J

Recombinant human soluble thrombomodulin prevents peripheral HMGB1-dependent hyperalgesia in rats.
British journal of pharmacology170(6)1233-41(2013 Nov)
Tanaka J,Seki Y,Ishikura H,Tsubota M,Sekiguchi F,Yamaguchi K,Murai A,Umemura T,Kawabata A

Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
PloS one8(9)e75961(2013)
Nakahara M,Ito T,Kawahara K,Yamamoto M,Nagasato T,Shrestha B,Yamada S,Miyauchi T,Higuchi K,Takenaka T,Yasuda T,Matsunaga A,Kakihana Y,Hashiguchi T,Kanmura Y,Maruyama I

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Thbd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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