Mchr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mchr1
Entrez Gene ID	83567
Full Name	melanin-concentrating hormone receptor 1
Synonyms	Gpr24,Mch-1r,Slc1
General protein information	Preferred Names melanin-concentrating hormone receptor 1 Names melanin-concentrating hormone receptor 1 G-protein coupled receptor 24 MCH receptor 1 MCH-R1 MCH1R MCHR MCHR-1 SLC-1 somatostatin receptor-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	receptor for melanin-concentrating hormone (MCH); may mediate intracellular Ca2+ levels, forskolin-stimulated cyclic AMP production, and activation of mitogen-activated protein kinase; may play role in energy homeostasis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031758.1	NP_113946.1	melanin-concentrating hormone receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCHR1	NP_005288.3
Pan troglodytes (chimpanzee)	MCHR1	NP_001012440.1
Canis lupus familiaris (dog)	MCHR1	NP_001003038.1
Bos taurus (cattle)	MCHR1	NP_001096762.1
Rattus norvegicus (Norway rat)	Mchr1	NP_113946.1
Xenopus tropicalis (tropical clawed frog)	mchr1.2	NP_001072243.1
Danio rerio (zebrafish)	mchr1b	XP_692413.3
Danio rerio (zebrafish)	mchr1a	XP_001343144.1
	MCHR1	NP_001028057.1
Mus musculus (house mouse)	Mchr1	NP_660114.1
Gallus gallus (chicken)	LOC100859572	XP_004946431.1

Gene Ontology
Bibliography

Related articles in PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake.
Karlsson C, Aziz AM, Rehman F, Pitcairn C, Barchiesi R, Barbier E, Wendel Hansen M, Gehlert D, Steensland P, Heilig M, Thorsell A
Alcoholism, clinical and experimental research40(10)2199-2207(2016 Oct)

MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction.
Dias Abdo Agamme AL, Aguilar Calegare BF, Fernandes L, Costa A, Lagos P, Torterolo P, D'Almeida V
Peptides749-15(2015 Dec)

Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1.
Hamamoto A, Kobayashi Y, Saito Y
Cellular signalling27(4)818-27(2015 Apr)

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.
Sun X, Haley J, Bulgakov OV, Cai X, McGinnis J, Li T
Cilia1(1)21(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest a dual role of MCH and the MCH1-R in regulation of alcohol intake, possibly through mechanisms involving caloric intake and reward motivation.
Title: Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake.

MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction were studied in rats.
Title: MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction.

The study identified the amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1.
Title: Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1.

Data indicate that Mch/Mchr1 signal transduction participates in modulation of depression-like behavior through processes in CA1 region of hippocampus. Model of depression involves chronically higher Mch expression and down-regulation of Mchr1.
Title: The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior.

Diet-induced obesity and related metabolic disorders are possibly correlated with up-regulated expression of MCHR1 and down-regulated expression of OB-Rb in adipose tissue.
Title: [High fat diet induces obesity and alters the expression of MCHR1 and OB-Rb in the adipose tissue].

The following Mchr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mchr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08667	NM_031758.1 Latest version!	Rattus norvegicus melanin-concentrating hormone receptor 1 (Mchr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mchr1 ( NM_031758.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113946.1 Rattus norvegicus melanin-concentrating hormone receptor 1 (Mchr1), mRNA.

Price & Availability↑

CloneID	ORa08667
Clone ID Related Accession (Same CDS sequence)	NM_031758.1
Accession Version	NM_031758.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	melanin-concentrating hormone receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF008650.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF008650.1, CO405514.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATCTGC AAACCTCGTT GCTGTCCACT GGCCCCAATG CCAGCAACAT CTCCGATGGC 
CAGGATAATC TCACATTGCC GGGGTCACCT CCTCGCACAG GGAGTGTCTC CTACATCAAC 
ATCATTATGC CTTCCGTGTT TGGTACCATC TGTCTCCTGG GCATCGTGGG AAACTCCACG 
GTCATCTTTG CTGTGGTGAA GAAGTCCAAG CTACACTGGT GCAGCAACGT CCCCGACATC 
TTCATCATCA ACCTCTCTGT GGTGGATCTG CTCTTCCTGC TGGGCATGCC TTTCATGATC 
CACCAGCTCA TGGGGAACGG CGTCTGGCAC TTTGGGGAAA CCATGTGCAC CCTCATCACA 
GCCATGGACG CCAACAGTCA GTTCACTAGC ACCTACATCC TGACTGCCAT GACCATTGAC 
CGCTACTTGG CCACCGTCCA CCCCATCTCC TCCACCAAGT TCCGGAAGCC CTCCATGGCC 
ACCCTGGTGA TCTGCCTCCT GTGGGCGCTC TCCTTCATCA GTATCACCCC TGTGTGGCTC 
TACGCCAGGC TCATTCCCTT CCCAGGGGGT GCTGTGGGCT GTGGCATCCG CCTGCCAAAC 
CCGGACACTG ACCTCTACTG GTTCACTCTG TACCAGTTTT TCCTGGCCTT TGCCCTTCCG 
TTTGTGGTCA TTACCGCCGC ATACGTGAAA ATACTACAGC GCATGACGTC TTCGGTGGCC 
CCAGCCTCCC AACGCAGCAT CCGGCTTCGG ACAAAGAGGG TGACCCGCAC GGCCATTGCC 
ATCTGTCTGG TCTTCTTTGT GTGCTGGGCA CCCTACTATG TGCTGCAGCT GACCCAGCTG 
TCCATCAGCC GCCCGACCCT CACGTTTGTC TACTTGTACA ACGCGGCCAT CAGCTTGGGC 
TATGCTAACA GCTGCCTGAA CCCCTTTGTG TACATAGTGC TCTGTGAGAC CTTTCGAAAA 
CGCTTGGTGT TGTCAGTGAA GCCTGCAGCC CAGGGGCAGC TCCGCACGGT CAGCAACGCT 
CAGACAGCTG ATGAGGAGAG GACAGAAAGC AAAGGCACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113946.1
CDS	23..1084
Translation	MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT

Target ORF information:

RefSeq Version	NM_031758.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus melanin-concentrating hormone receptor 1 (Mchr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031758.1

ORF Insert Sequence:

ATGGATCTGC AAACCTCGTT GCTGTCCACT GGCCCCAATG CCAGCAACAT CTCCGATGGC 
CAGGATAATC TCACATTGCC GGGGTCACCT CCTCGCACAG GGAGTGTCTC CTACATCAAC 
ATCATTATGC CTTCCGTGTT TGGTACCATC TGTCTCCTGG GCATCGTGGG AAACTCCACG 
GTCATCTTTG CTGTGGTGAA GAAGTCCAAG CTACACTGGT GCAGCAACGT CCCCGACATC 
TTCATCATCA ACCTCTCTGT GGTGGATCTG CTCTTCCTGC TGGGCATGCC TTTCATGATC 
CACCAGCTCA TGGGGAACGG CGTCTGGCAC TTTGGGGAAA CCATGTGCAC CCTCATCACA 
GCCATGGACG CCAACAGTCA GTTCACTAGC ACCTACATCC TGACTGCCAT GACCATTGAC 
CGCTACTTGG CCACCGTCCA CCCCATCTCC TCCACCAAGT TCCGGAAGCC CTCCATGGCC 
ACCCTGGTGA TCTGCCTCCT GTGGGCGCTC TCCTTCATCA GTATCACCCC TGTGTGGCTC 
TACGCCAGGC TCATTCCCTT CCCAGGGGGT GCTGTGGGCT GTGGCATCCG CCTGCCAAAC 
CCGGACACTG ACCTCTACTG GTTCACTCTG TACCAGTTTT TCCTGGCCTT TGCCCTTCCG 
TTTGTGGTCA TTACCGCCGC ATACGTGAAA ATACTACAGC GCATGACGTC TTCGGTGGCC 
CCAGCCTCCC AACGCAGCAT CCGGCTTCGG ACAAAGAGGG TGACCCGCAC GGCCATTGCC 
ATCTGTCTGG TCTTCTTTGT GTGCTGGGCA CCCTACTATG TGCTGCAGCT GACCCAGCTG 
TCCATCAGCC GCCCGACCCT CACGTTTGTC TACTTGTACA ACGCGGCCAT CAGCTTGGGC 
TATGCTAACA GCTGCCTGAA CCCCTTTGTG TACATAGTGC TCTGTGAGAC CTTTCGAAAA 
CGCTTGGTGT TGTCAGTGAA GCCTGCAGCC CAGGGGCAGC TCCGCACGGT CAGCAACGCT 
CAGACAGCTG ATGAGGAGAG GACAGAAAGC AAAGGCACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship Between Effects on Alcohol and Caloric Intake.
Alcoholism, clinical and experimental research40(10)2199-2207(2016 Oct)
Karlsson C,Aziz AM,Rehman F,Pitcairn C,Barchiesi R,Barbier E,Wendel Hansen M,Gehlert D,Steensland P,Heilig M,Thorsell A

MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction.
Peptides749-15(2015 Dec)
Dias Abdo Agamme AL,Aguilar Calegare BF,Fernandes L,Costa A,Lagos P,Torterolo P,D'Almeida V

Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1.
Cellular signalling27(4)818-27(2015 Apr)
Hamamoto A,Kobayashi Y,Saito Y

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.
Cilia1(1)21(2012 Nov)
Sun X,Haley J,Bulgakov OV,Cai X,McGinnis J,Li T

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Mchr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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