Kcnj11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnj11
Entrez Gene ID	83535
Full Name	potassium voltage-gated channel subfamily J member 11
Synonyms	Kir6.2
General protein information	Preferred Names potassium voltage-gated channel subfamily J member 11 Names ATP-sensitive inward rectifier potassium channel 11 BIR inward rectifier K(+) channel Kir6.2 potassium channel, inwardly rectifying subfamily J member 11 potassium inwardly rectifying channel, subfamily J, member 11
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	an ATP-sensitive K+ channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031358.3	NP_112648.2	ATP-sensitive inward rectifier potassium channel 11
XM_008759421.2	XP_008757643.1	ATP-sensitive inward rectifier potassium channel 11 isoform X1
XM_017589780.1	XP_017445269.1	ATP-sensitive inward rectifier potassium channel 11 isoform X2
XM_017589782.1	XP_017445271.1	ATP-sensitive inward rectifier potassium channel 11 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KCNJ11	XP_521849.2
Mus musculus (house mouse)	Kcnj11	NP_034732.1
Rattus norvegicus (Norway rat)	Kcnj11	NP_112648.2
Gallus gallus (chicken)	KCNJ11	XP_426402.4
Homo sapiens (human)	KCNJ11	NP_000516.3
Canis lupus familiaris (dog)	KCNJ11	XP_542519.2
Xenopus tropicalis (tropical clawed frog)	LOC100492679	XP_004916335.1
	KCNJ11	XP_001089155.1
Bos taurus (cattle)	KCNJ11	NP_001075067.1
Danio rerio (zebrafish)	kcnj11	NP_001034916.1

Gene Ontology
Bibliography

Related articles in PubMed

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG
The Journal of biological chemistry292(42)17387-17398(2017 10)

The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats.
Feng Y, Liu J, Wang M, Liu M, Shi L, Yuan W, Ye J, Hu D, Wan J
International journal of cardiology232192-198(2017 Apr)

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.
Martin GM, Yoshioka C, Rex EA, Fay JF, Xie Q, Whorton MR, Chen JZ, Shyng SL
eLife6(2017 Jan)

Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis.
Zhang X, Zhang X, Xiong Y, Xu C, Liu X, Lin J, Mu G, Xu S, Liu W
International journal of molecular medicine38(3)758-66(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations.
Title: Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

The E23K variant of the KATP channel increased the susceptibility to ventricular arrhythmia under acute ischemia stress.
Title: The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats.

Data show that sarcolemmal ATP-sensitive K+ (sarcKATP) channel mutant subunit Kir6.2AAA transfection inhibited the channel activity and significantly aggravated the apoptosis of myocytes induced by lipopolysaccharides (LPS).
Title: Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis.

Electrophysiological studies employing SUR2A/Kir6.2-expressing HEK cells showed that increasing endogenous or exogenous Phosphatidylinositol 4,5-bisphosphate diminished the inhibitory effect of Syn-1A on KATP currents.
Title: Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Findings suggest that Kir6.2 expression in the spinal cord is reduced in bone cancer pain and activation of Kir6.2 at the spinal level reduces pain hypersensitivity associated with bone cancer pain
Title: Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.

The following Kcnj11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnj11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13115	NM_031358.3 Latest version!	Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 11 (Kcnj11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa43762	XM_008759421.2 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa56870	XM_017589780.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa56870	XM_017589782.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnj11 ( NM_031358.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112648.2 Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 11 (Kcnj11), mRNA.

Price & Availability↑

CloneID	ORa13115
Clone ID Related Accession (Same CDS sequence)	NM_031358.3
Accession Version	NM_031358.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	ATP-sensitive inward rectifier potassium channel 11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D61687.1, D86039.1, AB043638.1, BF565039.1 and AW527189.1. On Feb 11, 2005 this sequence version replaced NM_031358.2. Sequence Note: This RefSeq record was created using sequences from two different strains, W and Sprague-Dawley, because no single transcript from the same strain was available for the full length of the gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGCTGTCCC GAAAGGGCAT TATCCCTGAG GAATATGTGC TGACCCGGCT GGCAGAGGAC 
CCTACAGAGC CCAGGTACCG TACTCGGGAG AGGAGGGCCC GCTTCGTGTC CAAGAAAGGC 
AACTGCAACG TCGCCCACAA GAACATCCGA GAGCAGGGCC GCTTCCTGCA AGATGTGTTC 
ACCACGCTGG TGGACCTCAA GTGGCCCCAC ACGCTGCTCA TTTTCACCAT GTCCTTCCTG 
TGCAGCTGGC TGCTCTTCGC CATGGTCTGG TGGCTCATCG CCTTTGCCCA CGGTGACTTG 
GCCCCCGGAG AGGGCACCAA TGTGCCCTGC GTCACAAGCA TCCACTCCTT TTCGTCTGCC 
TTCCTTTTCT CCATCGAGGT CCAGGTGACC ATTGGTTTCG GCGGGCGCAT GGTGACAGAG 
GAATGTCCCC TGGCCATCCT TATTCTGATC GTGCAGAATA TCGTAGGGCT AATGATCAAC 
GCCATCATGC TGGGCTGCAT CTTCATGAAA ACGGCACAGG CCCATCGGCG GGCAGAAACC 
CTCATCTTCA GCAAGCATGC CGTGATCACC CTGCGACATG GCCGCCTGTG CTTCATGCTT 
CGCGTAGGGG ACCTCCGAAA AAGCATGATC ATTAGCGCCA CCATTCATAT GCAGGTGGTG 
CGCAAGACCA CCAGCCCGGA GGGCGAGGTT GTGCCTCTCC ACCAGGTGGA CATCCCCATG 
GAGAACGGTG TGGGTGGTAA CAGCATCTTT CTGGTGGCCC CACTCATCAT CTACCACGTC 
ATCGACTCCA ACAGCCCGCT CTACGACCTG GCTCCTAGTG ACCTGCACCA CCACCAGGAC 
CTGGAGATCA TTGTCATCTT GGAAGGTGTG GTAGAAACCA CAGGCATTAC CACCCAGGCC 
CGCACCTCCT ATCTGGCTGA CGAGATTCTG TGGGGGCAGC GTTTTGTCCC CATCGTGGCC 
GAGGAGGATG GCCGCTATTC TGTGGACTAC TCCAAATTCG GGAACACCGT TAAAGTGCCC 
ACACCACTCT GCACAGCCCG CCAGCTTGAT GAGGACCGCA GCCTGCTGGA TGCCCTGACC 
CTCGCCTCGT CGCGAGGGCC CCTGCGCAAG CGCAGTGTGG CTGTGGCAAA GGCCAAGCCC 
AAGTTTAGCA TCTCTCCGGA TTCCTTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112648.2
CDS	237..1409
Translation	MLSRKGIIPEEYVLTRLAEDPTEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS

Target ORF information:

RefSeq Version	NM_031358.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium inwardly-rectifying channel, subfamily J, member 11 (Kcnj11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031358.3

ORF Insert Sequence:

ATGCTGTCCC GAAAGGGCAT TATCCCTGAG GAATATGTGC TGACCCGGCT GGCAGAGGAC 
CCTACAGAGC CCAGGTACCG TACTCGGGAG AGGAGGGCCC GCTTCGTGTC CAAGAAAGGC 
AACTGCAACG TCGCCCACAA GAACATCCGA GAGCAGGGCC GCTTCCTGCA AGATGTGTTC 
ACCACGCTGG TGGACCTCAA GTGGCCCCAC ACGCTGCTCA TTTTCACCAT GTCCTTCCTG 
TGCAGCTGGC TGCTCTTCGC CATGGTCTGG TGGCTCATCG CCTTTGCCCA CGGTGACTTG 
GCCCCCGGAG AGGGCACCAA TGTGCCCTGC GTCACAAGCA TCCACTCCTT TTCGTCTGCC 
TTCCTTTTCT CCATCGAGGT CCAGGTGACC ATTGGTTTCG GCGGGCGCAT GGTGACAGAG 
GAATGTCCCC TGGCCATCCT TATTCTGATC GTGCAGAATA TCGTAGGGCT AATGATCAAC 
GCCATCATGC TGGGCTGCAT CTTCATGAAA ACGGCACAGG CCCATCGGCG GGCAGAAACC 
CTCATCTTCA GCAAGCATGC CGTGATCACC CTGCGACATG GCCGCCTGTG CTTCATGCTT 
CGCGTAGGGG ACCTCCGAAA AAGCATGATC ATTAGCGCCA CCATTCATAT GCAGGTGGTG 
CGCAAGACCA CCAGCCCGGA GGGCGAGGTT GTGCCTCTCC ACCAGGTGGA CATCCCCATG 
GAGAACGGTG TGGGTGGTAA CAGCATCTTT CTGGTGGCCC CACTCATCAT CTACCACGTC 
ATCGACTCCA ACAGCCCGCT CTACGACCTG GCTCCTAGTG ACCTGCACCA CCACCAGGAC 
CTGGAGATCA TTGTCATCTT GGAAGGTGTG GTAGAAACCA CAGGCATTAC CACCCAGGCC 
CGCACCTCCT ATCTGGCTGA CGAGATTCTG TGGGGGCAGC GTTTTGTCCC CATCGTGGCC 
GAGGAGGATG GCCGCTATTC TGTGGACTAC TCCAAATTCG GGAACACCGT TAAAGTGCCC 
ACACCACTCT GCACAGCCCG CCAGCTTGAT GAGGACCGCA GCCTGCTGGA TGCCCTGACC 
CTCGCCTCGT CGCGAGGGCC CCTGCGCAAG CGCAGTGTGG CTGTGGCAAA GGCCAAGCCC 
AAGTTTAGCA TCTCTCCGGA TTCCTTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnj11 ( XM_008759421.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757643.1 Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43762
Clone ID Related Accession (Same CDS sequence)	XM_008759421.2
Accession Version	XM_008759421.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-sensitive inward rectifier potassium channel 11 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759421.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTGGT GGCTCATCGC CTTTGCCCAC GGTGACTTGG CCCCCGGAGA GGGCACCAAT 
GTGCCCTGCG TCACAAGCAT CCACTCCTTT TCGTCTGCCT TCCTTTTCTC CATCGAGGTC 
CAGGTGACCA TTGGTTTCGG CGGGCGCATG GTGACAGAGG AATGTCCCCT GGCCATCCTT 
ATTCTGATCG TGCAGAATAT CGTAGGGCTA ATGATCAACG CCATCATGCT GGGCTGCATC 
TTCATGAAAA CGGCACAGGC CCATCGGCGG GCAGAAACCC TCATCTTCAG CAAGCATGCC 
GTGATCACCC TGCGACATGG CCGCCTGTGC TTCATGCTTC GCGTAGGGGA CCTCCGAAAA 
AGCATGATCA TTAGCGCCAC CATTCATATG CAGGTGGTGC GCAAGACCAC CAGCCCGGAG 
GGCGAGGTTG TGCCTCTCCA CCAGGTGGAC ATCCCCATGG AGAACGGTGT GGGTGGTAAC 
AGCATCTTTC TGGTGGCCCC ACTCATCATC TACCACGTCA TCGACTCCAA CAGCCCGCTC 
TACGACCTGG CTCCTAGTGA CCTGCACCAC CACCAGGACC TGGAGATCAT TGTCATCTTG 
GAAGGTGTGG TAGAAACCAC AGGCATTACC ACCCAGGCCC GCACCTCCTA TCTGGCTGAC 
GAGATTCTGT GGGGGCAGCG TTTTGTCCCC ATCGTGGCCG AGGAGGATGG CCGCTATTCT 
GTGGACTACT CCAAATTCGG GAACACCGTT AAAGTGCCCA CACCACTCTG CACAGCCCGC 
CAGCTTGATG AGGACCGCAG CCTGCTGGAT GCCCTGACCC TCGCCTCGTC GCGAGGGCCC 
CTGCGCAAGC GCAGTGTGGC TGTGGCAAAG GCCAAGCCCA AGTTTAGCAT CTCTCCGGAT 
TCCTTGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757643.1
CDS	551..1462
Translation	MVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS

Target ORF information:

RefSeq Version	XM_008759421.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759421.2

ORF Insert Sequence:

ATGGTCTGGT GGCTCATCGC CTTTGCCCAC GGTGACTTGG CCCCCGGAGA GGGCACCAAT 
GTGCCCTGCG TCACAAGCAT CCACTCCTTT TCGTCTGCCT TCCTTTTCTC CATCGAGGTC 
CAGGTGACCA TTGGTTTCGG CGGGCGCATG GTGACAGAGG AATGTCCCCT GGCCATCCTT 
ATTCTGATCG TGCAGAATAT CGTAGGGCTA ATGATCAACG CCATCATGCT GGGCTGCATC 
TTCATGAAAA CGGCACAGGC CCATCGGCGG GCAGAAACCC TCATCTTCAG CAAGCATGCC 
GTGATCACCC TGCGACATGG CCGCCTGTGC TTCATGCTTC GCGTAGGGGA CCTCCGAAAA 
AGCATGATCA TTAGCGCCAC CATTCATATG CAGGTGGTGC GCAAGACCAC CAGCCCGGAG 
GGCGAGGTTG TGCCTCTCCA CCAGGTGGAC ATCCCCATGG AGAACGGTGT GGGTGGTAAC 
AGCATCTTTC TGGTGGCCCC ACTCATCATC TACCACGTCA TCGACTCCAA CAGCCCGCTC 
TACGACCTGG CTCCTAGTGA CCTGCACCAC CACCAGGACC TGGAGATCAT TGTCATCTTG 
GAAGGTGTGG TAGAAACCAC AGGCATTACC ACCCAGGCCC GCACCTCCTA TCTGGCTGAC 
GAGATTCTGT GGGGGCAGCG TTTTGTCCCC ATCGTGGCCG AGGAGGATGG CCGCTATTCT 
GTGGACTACT CCAAATTCGG GAACACCGTT AAAGTGCCCA CACCACTCTG CACAGCCCGC 
CAGCTTGATG AGGACCGCAG CCTGCTGGAT GCCCTGACCC TCGCCTCGTC GCGAGGGCCC 
CTGCGCAAGC GCAGTGTGGC TGTGGCAAAG GCCAAGCCCA AGTTTAGCAT CTCTCCGGAT 
TCCTTGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnj11 ( XM_017589780.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445269.1 Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa56870
Clone ID Related Accession (Same CDS sequence)	XM_017589780.1 , XM_017589782.1
Accession Version	XM_017589780.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-sensitive inward rectifier potassium channel 11 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCTTCC TGTGCAGCTG GCTGCTCTTC GCCATGGTCT GGTGGCTCAT CGCCTTTGCC 
CACGGTGACT TGGCCCCCGG AGAGGGCACC AATGTGCCCT GCGTCACAAG CATCCACTCC 
TTTTCGTCTG CCTTCCTTTT CTCCATCGAG GTCCAGGTGA CCATTGGTTT CGGCGGGCGC 
ATGGTGACAG AGGAATGTCC CCTGGCCATC CTTATTCTGA TCGTGCAGAA TATCGTAGGG 
CTAATGATCA ACGCCATCAT GCTGGGCTGC ATCTTCATGA AAACGGCACA GGCCCATCGG 
CGGGCAGAAA CCCTCATCTT CAGCAAGCAT GCCGTGATCA CCCTGCGACA TGGCCGCCTG 
TGCTTCATGC TTCGCGTAGG GGACCTCCGA AAAAGCATGA TCATTAGCGC CACCATTCAT 
ATGCAGGTGG TGCGCAAGAC CACCAGCCCG GAGGGCGAGG TTGTGCCTCT CCACCAGGTG 
GACATCCCCA TGGAGAACGG TGTGGGTGGT AACAGCATCT TTCTGGTGGC CCCACTCATC 
ATCTACCACG TCATCGACTC CAACAGCCCG CTCTACGACC TGGCTCCTAG TGACCTGCAC 
CACCACCAGG ACCTGGAGAT CATTGTCATC TTGGAAGGTG TGGTAGAAAC CACAGGCATT 
ACCACCCAGG CCCGCACCTC CTATCTGGCT GACGAGATTC TGTGGGGGCA GCGTTTTGTC 
CCCATCGTGG CCGAGGAGGA TGGCCGCTAT TCTGTGGACT ACTCCAAATT CGGGAACACC 
GTTAAAGTGC CCACACCACT CTGCACAGCC CGCCAGCTTG ATGAGGACCG CAGCCTGCTG 
GATGCCCTGA CCCTCGCCTC GTCGCGAGGG CCCCTGCGCA AGCGCAGTGT GGCTGTGGCA 
AAGGCCAAGC CCAAGTTTAG CATCTCTCCG GATTCCTTGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445269.1
CDS	497..1441
Translation	MSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS

Target ORF information:

RefSeq Version	XM_017589780.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589780.1

ORF Insert Sequence:

ATGTCCTTCC TGTGCAGCTG GCTGCTCTTC GCCATGGTCT GGTGGCTCAT CGCCTTTGCC 
CACGGTGACT TGGCCCCCGG AGAGGGCACC AATGTGCCCT GCGTCACAAG CATCCACTCC 
TTTTCGTCTG CCTTCCTTTT CTCCATCGAG GTCCAGGTGA CCATTGGTTT CGGCGGGCGC 
ATGGTGACAG AGGAATGTCC CCTGGCCATC CTTATTCTGA TCGTGCAGAA TATCGTAGGG 
CTAATGATCA ACGCCATCAT GCTGGGCTGC ATCTTCATGA AAACGGCACA GGCCCATCGG 
CGGGCAGAAA CCCTCATCTT CAGCAAGCAT GCCGTGATCA CCCTGCGACA TGGCCGCCTG 
TGCTTCATGC TTCGCGTAGG GGACCTCCGA AAAAGCATGA TCATTAGCGC CACCATTCAT 
ATGCAGGTGG TGCGCAAGAC CACCAGCCCG GAGGGCGAGG TTGTGCCTCT CCACCAGGTG 
GACATCCCCA TGGAGAACGG TGTGGGTGGT AACAGCATCT TTCTGGTGGC CCCACTCATC 
ATCTACCACG TCATCGACTC CAACAGCCCG CTCTACGACC TGGCTCCTAG TGACCTGCAC 
CACCACCAGG ACCTGGAGAT CATTGTCATC TTGGAAGGTG TGGTAGAAAC CACAGGCATT 
ACCACCCAGG CCCGCACCTC CTATCTGGCT GACGAGATTC TGTGGGGGCA GCGTTTTGTC 
CCCATCGTGG CCGAGGAGGA TGGCCGCTAT TCTGTGGACT ACTCCAAATT CGGGAACACC 
GTTAAAGTGC CCACACCACT CTGCACAGCC CGCCAGCTTG ATGAGGACCG CAGCCTGCTG 
GATGCCCTGA CCCTCGCCTC GTCGCGAGGG CCCCTGCGCA AGCGCAGTGT GGCTGTGGCA 
AAGGCCAAGC CCAAGTTTAG CATCTCTCCG GATTCCTTGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnj11 ( XM_017589782.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017445271.1 Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa56870
Clone ID Related Accession (Same CDS sequence)	XM_017589780.1 , XM_017589782.1
Accession Version	XM_017589782.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-sensitive inward rectifier potassium channel 11 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCTTCC TGTGCAGCTG GCTGCTCTTC GCCATGGTCT GGTGGCTCAT CGCCTTTGCC 
CACGGTGACT TGGCCCCCGG AGAGGGCACC AATGTGCCCT GCGTCACAAG CATCCACTCC 
TTTTCGTCTG CCTTCCTTTT CTCCATCGAG GTCCAGGTGA CCATTGGTTT CGGCGGGCGC 
ATGGTGACAG AGGAATGTCC CCTGGCCATC CTTATTCTGA TCGTGCAGAA TATCGTAGGG 
CTAATGATCA ACGCCATCAT GCTGGGCTGC ATCTTCATGA AAACGGCACA GGCCCATCGG 
CGGGCAGAAA CCCTCATCTT CAGCAAGCAT GCCGTGATCA CCCTGCGACA TGGCCGCCTG 
TGCTTCATGC TTCGCGTAGG GGACCTCCGA AAAAGCATGA TCATTAGCGC CACCATTCAT 
ATGCAGGTGG TGCGCAAGAC CACCAGCCCG GAGGGCGAGG TTGTGCCTCT CCACCAGGTG 
GACATCCCCA TGGAGAACGG TGTGGGTGGT AACAGCATCT TTCTGGTGGC CCCACTCATC 
ATCTACCACG TCATCGACTC CAACAGCCCG CTCTACGACC TGGCTCCTAG TGACCTGCAC 
CACCACCAGG ACCTGGAGAT CATTGTCATC TTGGAAGGTG TGGTAGAAAC CACAGGCATT 
ACCACCCAGG CCCGCACCTC CTATCTGGCT GACGAGATTC TGTGGGGGCA GCGTTTTGTC 
CCCATCGTGG CCGAGGAGGA TGGCCGCTAT TCTGTGGACT ACTCCAAATT CGGGAACACC 
GTTAAAGTGC CCACACCACT CTGCACAGCC CGCCAGCTTG ATGAGGACCG CAGCCTGCTG 
GATGCCCTGA CCCTCGCCTC GTCGCGAGGG CCCCTGCGCA AGCGCAGTGT GGCTGTGGCA 
AAGGCCAAGC CCAAGTTTAG CATCTCTCCG GATTCCTTGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017445271.1
CDS	364..1308
Translation	MSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTVKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS

Target ORF information:

RefSeq Version	XM_017589782.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily J member 11 (Kcnj11), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589782.1

ORF Insert Sequence:

ATGTCCTTCC TGTGCAGCTG GCTGCTCTTC GCCATGGTCT GGTGGCTCAT CGCCTTTGCC 
CACGGTGACT TGGCCCCCGG AGAGGGCACC AATGTGCCCT GCGTCACAAG CATCCACTCC 
TTTTCGTCTG CCTTCCTTTT CTCCATCGAG GTCCAGGTGA CCATTGGTTT CGGCGGGCGC 
ATGGTGACAG AGGAATGTCC CCTGGCCATC CTTATTCTGA TCGTGCAGAA TATCGTAGGG 
CTAATGATCA ACGCCATCAT GCTGGGCTGC ATCTTCATGA AAACGGCACA GGCCCATCGG 
CGGGCAGAAA CCCTCATCTT CAGCAAGCAT GCCGTGATCA CCCTGCGACA TGGCCGCCTG 
TGCTTCATGC TTCGCGTAGG GGACCTCCGA AAAAGCATGA TCATTAGCGC CACCATTCAT 
ATGCAGGTGG TGCGCAAGAC CACCAGCCCG GAGGGCGAGG TTGTGCCTCT CCACCAGGTG 
GACATCCCCA TGGAGAACGG TGTGGGTGGT AACAGCATCT TTCTGGTGGC CCCACTCATC 
ATCTACCACG TCATCGACTC CAACAGCCCG CTCTACGACC TGGCTCCTAG TGACCTGCAC 
CACCACCAGG ACCTGGAGAT CATTGTCATC TTGGAAGGTG TGGTAGAAAC CACAGGCATT 
ACCACCCAGG CCCGCACCTC CTATCTGGCT GACGAGATTC TGTGGGGGCA GCGTTTTGTC 
CCCATCGTGG CCGAGGAGGA TGGCCGCTAT TCTGTGGACT ACTCCAAATT CGGGAACACC 
GTTAAAGTGC CCACACCACT CTGCACAGCC CGCCAGCTTG ATGAGGACCG CAGCCTGCTG 
GATGCCCTGA CCCTCGCCTC GTCGCGAGGG CCCCTGCGCA AGCGCAGTGT GGCTGTGGCA 
AAGGCCAAGC CCAAGTTTAG CATCTCTCCG GATTCCTTGT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
The Journal of biological chemistry292(42)17387-17398(2017 10)
Cooper PE,McClenaghan C,Chen X,Stary-Weinzinger A,Nichols CG

The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats.
International journal of cardiology232192-198(2017 Apr)
Feng Y,Liu J,Wang M,Liu M,Shi L,Yuan W,Ye J,Hu D,Wan J

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.
eLife6(2017 Jan)
Martin GM,Yoshioka C,Rex EA,Fay JF,Xie Q,Whorton MR,Chen JZ,Shyng SL

Sarcolemmal ATP-sensitive potassium channel protects cardiac myocytes against lipopolysaccharide-induced apoptosis.
International journal of molecular medicine38(3)758-66(2016 Sep)
Zhang X,Zhang X,Xiong Y,Xu C,Liu X,Lin J,Mu G,Xu S,Liu W

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Kcnj11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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