Aifm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aifm1
Entrez Gene ID	83533
Full Name	apoptosis inducing factor, mitochondria associated 1
Synonyms	Aif,Pdcd8
General protein information	Preferred Names apoptosis inducing factor, mitochondria associated 1 Names apoptosis-inducing factor 1, mitochondrial apoptosis-inducing factor, mitochondrion-associated 1 programmed cell death 8 (apoptosis-inducing factor) programmed cell death protein 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq36
Summary	may facilitate apoptotic chromatin condensation and DNA degradation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031356.1	NP_112646.1	apoptosis-inducing factor 1, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AIFM1	NP_001179913.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008044	XP_317418.4
Caenorhabditis elegans (roundworm)	wah-1	NP_499564.2
Canis lupus familiaris (dog)	AIFM1	XP_538170.2
Mus musculus (house mouse)	Aifm1	NP_036149.1
Gallus gallus (chicken)	AIFM1	NP_001007491.1
Drosophila melanogaster (fruit fly)	AIF	NP_001259907.1
Rattus norvegicus (Norway rat)	Aifm1	NP_112646.1
Homo sapiens (human)	AIFM1	NP_004199.1
Danio rerio (zebrafish)	aifm1	NP_956396.2
Pan troglodytes (chimpanzee)	AIFM1	XP_003317723.1
	AIFM1	XP_001092025.1
Xenopus tropicalis (tropical clawed frog)	aifm1	NP_001017244.1

Gene Ontology
Bibliography

Related articles in PubMed

Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
Lin H, Zhao L, Ma X, Wang BC, Deng XY, Cui M, Chen SF, Shao ZW
Biochemical and biophysical research communications487(1)181-188(2017 May)

Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway.
Wang F, Wei ZL, Sun XR, Zhang Q, Zhang CX, Jiang WX, Yan X, Liu JN, Yuan X
Journal of cellular biochemistry118(4)829-838(2017 Apr)

Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
Yang X, Cheng J, Gao Y, Ding J, Ni X
Neuroscience34674-80(2017 Mar)

RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
Xu Y, Wang J, Song X, Qu L, Wei R, He F, Wang K, Luo B
Scientific reports629362(2016 Jul)

PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.
Song Y, Fan Z, Bai X, Liu W, Han Y, Xu L, Wang M, Li J, Zheng Q, Zhang D, Wang H
Acta oto-laryngologica136(6)545-50(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data indicates that Drp1 mediates compression-induced programmed necrosis of NP cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
Title: Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.

investigated the mechanobiological roles of caspase-9 and Apoptosis Inducing Factor (AIF), two important components in mitochondrial pathway, in stretch-induced apoptosis of myoblasts
Title: Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway.

Results suggest that apoptosis-inducing factor nuclear translocation and neuronal cell death are associated with Iduna loss after severe hypoxic-ischemic in the immature brain.
Title: Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.

involved in streptomycin ototoxicity by translocation from mitochondria to cytosol and nucleus of cochlear hair cells
Title: PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.

Data indicate that mitochondrial apoptosis-inducing factor (AIF) silencing prevents doxorubicin toxicity on cardiomyoblasts.
Title: Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.

The following Aifm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aifm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12427	NM_031356.1 Latest version!	Rattus norvegicus apoptosis inducing factor, mitochondria associated 1 (Aifm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aifm1 ( NM_031356.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112646.1 Rattus norvegicus apoptosis inducing factor, mitochondria associated 1 (Aifm1), mRNA.

Price & Availability↑

CloneID	ORa12427
Clone ID Related Accession (Same CDS sequence)	NM_031356.1
Accession Version	NM_031356.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1839bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	apoptosis-inducing factor 1, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB041723.1. Sequence Note: This sequence has been modified as follows: removed 16 bp suspected to be vector contamination from the 5' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB041723.1, AF375656.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTTCCGGT GTGGAGGCCT GGCGGGTGCT TTCAAGCAGA AACTGGTGCC CTTGGTGCGG 
TCGGTGTGCG TCCAGAGGCC GAAACAGAGG AACCGGCTTC CAGGCAACTT GTTCCAGCAA 
TGGCGTGTTC CTCTAGAACT CCAGATGGCA AGACAAATGG CTAGCTCTGG TCCATCAGGG 
GGCAAAATGG ATAATTCTGT GTTAGTCCTT ATTGTGGGCT TATCAACAAT AGGAGCTGGT 
GCATATGCCT ACAAGACTAT TAAAGAAGAC CAAAAAAGAT ATAATGAAAG AATAATGGGA 
TTAGGACTGT CACCAGAAGA GAAACAGAGA AGAGCCATTG CCTCTGCTGC AGAAGGAGGC 
TCAGTTCCTC CAATCAGGGT ACCAAGTCAC GTCCCTTTCC TGCTGATTGG TGGAGGTACT 
GCTGCCTTTG CAGCAGCTAG ATCCATCCGG GCTCGGGATC CTGGGGCCAG GGTCCTCATC 
GTATCTGAAG ACCCTGAACT ACCATACATG CGACCTCCTC TTTCAAAAGA ATTGTGGTTT 
TCAGATGACC CAAATGTCAC AAAGACACTG CAGTTCAGAC AGTGGAATGG AAAAGAGAGA 
AGCATCTATT TCCAGCCACC TTCTTTCTAT GTCTCTGCTC AGGACCTGCC TCATATTGAG 
AATGGTGGTG TGGCTGTCCT CACCGGGAAG AAGGTAGTCC ACCTGGATGT AAGAGGCAAC 
ATGGTGAAAC TTAATGATGG CTCTCAGATT ACCTTTGAAA AGTGCTTGAT TGCAACGGGA 
GGCACTCCAA GAAGTCTGTC TGCTATCGAT AGGGCTGGAG CAGAGGTGAA GAGTAGAACA 
ACACTTTTCA GAAAGATTGG AGATTTTAGA GCCTTGGAGA AGATCTCCCG GGAAGTCAAG 
TCAATTACAG TTATTGGTGG AGGCTTCCTT GGGAGCGAAC TGGCCTGTGC TCTTGGCAGA 
AAGTCTCAAG CCTCAGGCAT AGAAGTGATT CAGCTCTTCC CTGAGAAAGG AAATATGGGG 
AAGATCCTTC CTGAATACCT CAGCAACTGG ACCATGGAAA AAGTCAAACG AGAGGGAGTG 
AAAGTGATGC CCAATGCAAT TGTACAATCA GTTGGAGTCA GCGGTGGCAA GTTACTCATT 
AAGCTAAAGG ACGGAAGGAA GGTAGAAACT GACCACATAG TAACAGCTGT GGGCCTAGAA 
CCCAATGTCG AGTTGGCCAA GACTGGTGGG CTGGAAATAG ATTCCGATTT TGGTGGCTTC 
CGGGTAAATG CAGAGCTTCA AGCACGTTCT AACATCTGGG TGGCAGGAGA TGCTGCATGC 
TTCTATGATA TAAAGTTGGG TCGAAGGAGA GTAGAACATC ATGATCACGC TGTTGTGAGT 
GGAAGACTGG CTGGAGAAAA TATGACTGGA GCTGCTAAGC CATACTGGCA TCAGTCAATG 
TTCTGGAGTG ATTTGGGTCC TGATGTTGGC TATGAAGCTA TTGGTCTGGT GGATAGTAGT 
TTGCCCACAG TTGGTGTTTT TGCAAAAGCA ACTGCACAAG ACAACCCAAA ATCTGCCACA 
GAGCAGTCAG GAACTGGTAT CCGTTCGGAG AGTGAGACAG AGTCTGAAGC TTCTGAAATC 
ACAATCCCTC CCAGTGACCC TGCAGTCCCA CAGGTCCCTG TTGAAGGGGA GGACTACGGC 
AAAGGTGTCA TCTTCTACCT CAGGGACAAA GTTGTGGTGG GGATTGTGCT ATGGAACGTC 
TTTAACCGAA TGCCGATTGC AAGGAAGATC ATTAAAGACG GTGAGCAACA TGAAGACCTC 
AATGAAGTAG CCAAACTCTT CAACATTCAT GAAGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112646.1
CDS	75..1913
Translation	MFRCGGLAGAFKQKLVPLVRSVCVQRPKQRNRLPGNLFQQWRVPLELQMARQMASSGPSGGKMDNSVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERIMGLGLSPEEKQRRAIASAAEGGSVPPIRVPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASGIEVIQLFPEKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIPPSDPAVPQVPVEGEDYGKGVIFYLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED

Target ORF information:

RefSeq Version	NM_031356.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apoptosis inducing factor, mitochondria associated 1 (Aifm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031356.1

ORF Insert Sequence:

ATGTTCCGGT GTGGAGGCCT GGCGGGTGCT TTCAAGCAGA AACTGGTGCC CTTGGTGCGG 
TCGGTGTGCG TCCAGAGGCC GAAACAGAGG AACCGGCTTC CAGGCAACTT GTTCCAGCAA 
TGGCGTGTTC CTCTAGAACT CCAGATGGCA AGACAAATGG CTAGCTCTGG TCCATCAGGG 
GGCAAAATGG ATAATTCTGT GTTAGTCCTT ATTGTGGGCT TATCAACAAT AGGAGCTGGT 
GCATATGCCT ACAAGACTAT TAAAGAAGAC CAAAAAAGAT ATAATGAAAG AATAATGGGA 
TTAGGACTGT CACCAGAAGA GAAACAGAGA AGAGCCATTG CCTCTGCTGC AGAAGGAGGC 
TCAGTTCCTC CAATCAGGGT ACCAAGTCAC GTCCCTTTCC TGCTGATTGG TGGAGGTACT 
GCTGCCTTTG CAGCAGCTAG ATCCATCCGG GCTCGGGATC CTGGGGCCAG GGTCCTCATC 
GTATCTGAAG ACCCTGAACT ACCATACATG CGACCTCCTC TTTCAAAAGA ATTGTGGTTT 
TCAGATGACC CAAATGTCAC AAAGACACTG CAGTTCAGAC AGTGGAATGG AAAAGAGAGA 
AGCATCTATT TCCAGCCACC TTCTTTCTAT GTCTCTGCTC AGGACCTGCC TCATATTGAG 
AATGGTGGTG TGGCTGTCCT CACCGGGAAG AAGGTAGTCC ACCTGGATGT AAGAGGCAAC 
ATGGTGAAAC TTAATGATGG CTCTCAGATT ACCTTTGAAA AGTGCTTGAT TGCAACGGGA 
GGCACTCCAA GAAGTCTGTC TGCTATCGAT AGGGCTGGAG CAGAGGTGAA GAGTAGAACA 
ACACTTTTCA GAAAGATTGG AGATTTTAGA GCCTTGGAGA AGATCTCCCG GGAAGTCAAG 
TCAATTACAG TTATTGGTGG AGGCTTCCTT GGGAGCGAAC TGGCCTGTGC TCTTGGCAGA 
AAGTCTCAAG CCTCAGGCAT AGAAGTGATT CAGCTCTTCC CTGAGAAAGG AAATATGGGG 
AAGATCCTTC CTGAATACCT CAGCAACTGG ACCATGGAAA AAGTCAAACG AGAGGGAGTG 
AAAGTGATGC CCAATGCAAT TGTACAATCA GTTGGAGTCA GCGGTGGCAA GTTACTCATT 
AAGCTAAAGG ACGGAAGGAA GGTAGAAACT GACCACATAG TAACAGCTGT GGGCCTAGAA 
CCCAATGTCG AGTTGGCCAA GACTGGTGGG CTGGAAATAG ATTCCGATTT TGGTGGCTTC 
CGGGTAAATG CAGAGCTTCA AGCACGTTCT AACATCTGGG TGGCAGGAGA TGCTGCATGC 
TTCTATGATA TAAAGTTGGG TCGAAGGAGA GTAGAACATC ATGATCACGC TGTTGTGAGT 
GGAAGACTGG CTGGAGAAAA TATGACTGGA GCTGCTAAGC CATACTGGCA TCAGTCAATG 
TTCTGGAGTG ATTTGGGTCC TGATGTTGGC TATGAAGCTA TTGGTCTGGT GGATAGTAGT 
TTGCCCACAG TTGGTGTTTT TGCAAAAGCA ACTGCACAAG ACAACCCAAA ATCTGCCACA 
GAGCAGTCAG GAACTGGTAT CCGTTCGGAG AGTGAGACAG AGTCTGAAGC TTCTGAAATC 
ACAATCCCTC CCAGTGACCC TGCAGTCCCA CAGGTCCCTG TTGAAGGGGA GGACTACGGC 
AAAGGTGTCA TCTTCTACCT CAGGGACAAA GTTGTGGTGG GGATTGTGCT ATGGAACGTC 
TTTAACCGAA TGCCGATTGC AAGGAAGATC ATTAAAGACG GTGAGCAACA TGAAGACCTC 
AATGAAGTAG CCAAACTCTT CAACATTCAT GAAGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Drp1 mediates compression-induced programmed necrosis of rat nucleus pulposus cells by promoting mitochondrial translocation of p53 and nuclear translocation of AIF.
Biochemical and biophysical research communications487(1)181-188(2017 May)
Lin H,Zhao L,Ma X,Wang BC,Deng XY,Cui M,Chen SF,Shao ZW

Apoptosis Inducing Factor Is Involved in Stretch-Induced Apoptosis of Myoblast via a Caspase-9 Independent Pathway.
Journal of cellular biochemistry118(4)829-838(2017 Apr)
Wang F,Wei ZL,Sun XR,Zhang Q,Zhang CX,Jiang WX,Yan X,Liu JN,Yuan X

Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
Neuroscience34674-80(2017 Mar)
Yang X,Cheng J,Gao Y,Ding J,Ni X

RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
Scientific reports629362(2016 Jul)
Xu Y,Wang J,Song X,Qu L,Wei R,He F,Wang K,Luo B

PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death.
Acta oto-laryngologica136(6)545-50(2016 Jun)
Song Y,Fan Z,Bai X,Liu W,Han Y,Xu L,Wang M,Li J,Zheng Q,Zhang D,Wang H

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Aifm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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